Cavitation erosion in bloods*

Jian-hua Wu (吳建華), Yu Wang (王宇), Fei Ma (馬飛), Wen-juan Gou (緱文娟)

1.College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, China, E-mail: jhwu@hhu.edu.cn

2.State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Tianjin 300072, China

Cavitation erosion in bloods*

Jian-hua Wu (吳建華)1, Yu Wang (王宇)1, Fei Ma (馬飛)1, Wen-juan Gou (緱文娟)2

1.College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, China, E-mail: jhwu@hhu.edu.cn

2.State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Tianjin 300072, China

The cavitation in a mechanical heart valve (MHV) is a serious concern. In most of the investigations of the MHV cavitation in vitro, the tap water, the distilled water, or the glycerin are used as the test liquids, instead of the real blood. Therefore, the effects of the liquid properties on the cavitation can not be well revealed. In this paper, the cavitation erosion in the porcine bloods is experimentally investigated as well as in the tap water and the distilled water by means of a vibratory apparatus. The results show that the blood produces a weaker intensity of the cavitation erosion than the tap water or the distilled water. The cavitation erosion decreases with the decrease of the liquid temperature or with the increase of the concentration of the blood, especially with the increase of the liquid viscosity. It is the viscosity that could be a major dominant factor affecting this erosion. The temperature or the concentration of the blood changes the viscosity, and in turns changes the intensity of the cavitation erosion.

Cavitation erosion, blood, concentration, temperature, in vitro

Early in 1952 the prosthetic valve started to be implanted clinically in patients with aortic insufficiency. Since then, various mechanical heart valves (MHVs) were designed for use in both aortic and mitral positions[1]. Today, approximately 1.2×106MHVs[2]are implanted each year worldwide on the basis of estimations of 10% patients. There have been the cases of leaflet escape[3,4], and it was observed that were the confined areas of pitting and erosion on the leaflet and the housing surfaces[5]. Now, it is convinced that the pitting and the erosion are the results of the cavitation of the blood, and the failure of the MHV is closely related to the cavitation erosion.

The previous investigations of the MHV cavitation in vitro mainly include following four aspects:

(1) Structure and function of MHVs: tilting disk valve and Bileaflet valve, or Bj?rk Shiley ConvexoConcave, Carbomedics, Medtronic Hall, St. Jude Medical, Sorin and Duromedics Edwards[6-9].

(2) Materials of MHVs: various prosthetic materials and pyrolitic carbon[6,10].

(3) Flow and characteristics of cavitation: squeeze flow, water hammer, and vortex[6,8,11-13].

(4) Effect of test liquids and their properties on the cavitation and its erosion: the tap water, the distilled water, and the glycerin solution, or the nuclei, and the viscosity[12-15].

With respect to the effect of test liquids and their properties on the cavitation and its erosion of the MHV in vitro, the tap water is a main liquid before 2004. After that, the distilled water, and the glycerin solution are used in the investigations of the field[14,15].

It is well-known that, it is the cavitation nuclei in the liquid that are the internal cause of the cavitation occurrence, and the cavitation will not occur without such nuclei in the liquid. The ambient pressure fields round the nuclei are the external conditions that make the nuclei grow into cavitation bubbles. So, it is crucial to understand the effects of the liquid property on the cavitation and its erosion.

Lee et al. conducted experiments of the MHV cavitation by using three liquids: the tap water, thedistilled water and the 40% glycerin solution. Their results suggest that, the cavitation intensity in the glycerin solution is greater, but the cavitation occurrence probability is less than in the tap water (see Figs.1, 2). These results are related to the cavitation nuclei and the viscosity of the liquids[14,15]. It is difficult to understand and accept these results. Since the tap water has much more cavitation nuclei than the distilled water or the glycerin solution, it should bring about an intenser cavitation. Secondly, generally, the viscosity of the glycerin solution is larger than the tap water or the distilled water. The results show that a large viscosity of liquid results in a large cavitation intensity.

Fig.1 Cavitation occurrence probability for various testing liquids[14]

Fig.2 Cavitation bubbles at a heart rate of 100 bpm in MHV[14]

In order to clarify the effects of the liquid properties on the cavitation and its erosion, experiments of the cavitation erosion are conducted in the High-Speed Flow Lab at Hohai University (Nanjing, China). The experimental setup is shown in Fig.3. The cavitation erosion tests are performed by means ofa vibratoryapparatus[16,17], which produces longitudinal oscillations of a test specimen at a frequency off=20±2 kHz with an amplitude ofA=50±5μ m, in accordance with the GB/T6383-2009 test method[18]at the different liquid temperatures. The test liquids include the tap water, the distilled water, and the porcine blood of different concentrations, and the material of the test specimen for the cavitation erosion is No. 45 steel.

Fig.3 Experimental setup

Fig.4 Variation ofWLwithtfor different blood concentrations (38oC)

Fig.5 Variation ofWLwithtat different blood temperatures (100% blood)

Figure 4 shows the variation of the weight loss (WL) of the specimen cavitation erosion against the exposure time (t) at the liquid temperature of 38oC for the different blood concentrations (C), where,C=0, for the test liquid of the tap water. It could be noticed that,WLincreases with the increase oft, and decreases with the increase ofCat the samet. Figure 5 shows the variation ofWLvs.tat different temperatures (T) for the 100% blood. Clearly,WLincreases with the increase ofT. Besides, it could be seen that, when the blood concentration changes from 0% to 100% and the temperature changes from 10oC to 45oC,WLincrements are about 30 mg and 6 mg att= 240 min, respectively. That is to say, the blood concentration is sensitive to the cavitation erosion.

Figures 6 and 7 show the variations ofWLwithtat the differentTfor the tap water and the distilled water. Comparing with the result shown in Fig.5, the effects ofTonWLare very similar, i.e.,WLincreases with the increase ofTfor either the tap water or the distilled water. Meanwhile, it could be noticed thatWLin the tap water is slightly larger than that in the distilled water at the sameTand the samet.

Fig.6 Variation ofWLwithtat different tap water temperatures

Fig.7 Variation ofWLwithtat different distilled water temperatures

Figure 8 shows the variation of the viscosity (μ) withCatT=38oC .μ(C) is a linear function, and its slope is larger than zero. Figure 9 shows the variation ofμwithTfor three test liquids, andμ(T) is also a linear function, but its slope is less than zero. Meanwhile, the value ofμfor the blood is much larger than that for the tap water or the distilled water.

Fig.8 Variation ofμwithCatT=38oC

Fig.9 Variation ofμwithTfor three test liquids

Fig.10 Variation ofWLwithμatt=240 minunder different test conditions

Figure 10 demonstrates the variation ofWLwithμatt=240 min under different test conditions. It could be noted that, this figure contains the data of three test liquids of the tap water, the distilled water, and the blood, of seven different concentrations of the blood, and of five test temperatures for each liquid. For the data of the figure, the best fit is (R2=0.98)

It is well known that the cavitation erosion is closely related to several factors as well as the characteristics of the damaged materials. As far as the liquid property is concerned, it is crucial to consider the temperature, the concentration of the test liquid, and the difference between different test liquids. Equation (1) implies that,WLseems to be directly dominated by the value ofμof the test liquids, whatever the test liquid conditions are. Here, we could conclude that, several factors of the test liquids, such as the temperature, the concentration, and the difference between the liquids, affect the viscosity of the liquids, and it is the viscosity that directly affects the cavitation erosion.

[1] DeWall R. A., Qasim N., Carr L. Evolution of mechanical heart valves [J].Annals of Thoracic Surgery, 2000, 69(5): 1612-1621.

[2] Xinhua Daily Telegraph. Heart valve implantation surgery entering “minute level” in China [EB/OL]. (2016-04-01) [2017-04-14]. http://news.xinhuanet.com/mrdx/ 2016-04/01/c_135242373.html (in Chinese).

[3] Klepetko W., Moritz A., Mlczoch J. et al. Leaflet fracture in Edwards-Duromedics bileaflet valves [J].Journal of Thoracic and Cardiovascular Surgery, 1989, 97(1): 90-94.

[4] Bottio T., Casarotto D., Thiene G. et al. Leaflet escape in a new bileaflet mechanical valve: TRI technologies [J].Circulation, 2003, 107(18): 2303-2306.

[5] Mastroroberto P., Chello M., Bevacqua E. et al. Duromedics original prosthesis: What do we really know about diagnosis and mechanism of leaflet escape? [J].Canadian Journal of Cardiology.2000, 16(10): 1269-1272.

[6] Johansen P. Mechanical heart valve cavitation [J].Expert Review of Medical Devices, 2004, 1(1): 95-104.

[7] Eichler M. J., Reul H. M. Mechanical heart valve cavitation: Valve specific parameters [J].The International Journal of Artificial Organs, 2004, 27(10): 855-867.

[8] Wu C., Retta S. M., Robinson R. A. et al. A novel study of mechanical heart valve cavitation in a pressurized pulsatile duplicator [J].ASAIO Journal, 2009, 55: 455-461.

[9] LI C. P., Chen S. F., LO C. W. et al. Role of vortices in cavitation formation in the flow at the closure of a bileaflet mitral mechanical heart valve [J].Journal of Artificial Organs, 2012, 15(1): 57-64.

[10] Kafesjian R., Howanec M., Ward G. D. et al. Cavitation damage of pyrolytic carbon in mechanical heart valves [J].Journal of Heart Valve Disease, 1994, (3 Suppl. 1): 2-7.

[11] Milo S, Gutfinger C., CHU G. Y. C. et al. Bubble formation on St. Jude Medical mechanical heart valve: An in vitro study [J].Journal of Heart Valve Disease, 2003, 12(3): 406-410.

[12] Lo C. W., Chen S. F., Li C. P. et al. Cavitation phenomena in mechanical heart valves: Studied by using a physical impinging rod system [J].Annals of Biomedical Engineering, 2010, 38(10): 3162-3172.

[13] Lee H., Homma A., Tatsumi E. et al. Observation of cavitation pits on mechanical heart valve surfaces in an artificial heart used in in vitro testing [J].Journal of Artificial Organs, 2010, 13(1): 17-23.

[14] Lee H., Taenaka Y., Kitamura S. Mechanism for cavitation in the mechanical heart valve with an artificial heart: Nuclei and viscosity dependence [J].Artificial Organs, 2005, 29(1): 41-46.

[15] Lee H., Taenaka Y., Kitamura S. Estimation of mechanical heart valve cavitation in an electro-hydraulic total artificial heart [J].Artificial Organs, 2006, 30(1): 16-23.

[16] Wu J. H., Su K. P., Wang Y. et al. Effect of air bubble size on cavitation erosion reduction [J].Science China Technology Science, 2017, 60(4): 523-528.

[17] Wu J. H., Luo C. Effects of entrained air manner on cavitation damage [J].Journal of Hydrodynamics, 2011, 23(3): 333-338.

[18] State Standard of the People’s Republic of China. The method of vibration cavitation erosion test [S]. GB/T6383-2009, 2009.

(Received May 11, 2017, Revised May 17, 2017)

* Project supported by the National Natural Science Foundation of China (Grant No. 51409187), the Fundamental Research Funds for the Central Universities (Grant No. 2016B09914).

Biography:Jian-hua Wu (1958-), Male, Ph. D., Professor