豬瘦肉精類藥物應(yīng)激的代謝組學(xué)研究

孟慶勇 唐中林 吳珍芳 李長春 劉德武

摘 要：該研究圍繞豬瘦肉精類藥物（β2腎上腺素受體激動(dòng)劑）促生長的機(jī)制，探討經(jīng)瘦肉精類藥物處理后，豬內(nèi)臟組織器官、血液、尿液和糞便等內(nèi)的代謝物質(zhì)的動(dòng)態(tài)變化，結(jié)合功能基因組學(xué)的研究成果，在系統(tǒng)生物學(xué)的基礎(chǔ)上深入解析β2腎上腺素受體激動(dòng)劑促進(jìn)豬生長、提高瘦肉率、加快脂肪代謝的調(diào)控機(jī)制，揭示動(dòng)物體肌肉脂肪生長、發(fā)育及代謝的普遍規(guī)律。發(fā)展可能被生產(chǎn)育種實(shí)踐應(yīng)用的代謝小分子及育種標(biāo)記，加速我國豬養(yǎng)殖育種的進(jìn)程，提升我國農(nóng)業(yè)現(xiàn)代化能力。

關(guān)鍵詞：豬 藥物代謝組學(xué) 生長發(fā)育

Abstract：This study revealed the mechanisms of clenbuterol drugs （beta 2 adrenergic agonists） for promoting growth in pig.After drug treatment， we explore the dynamic change of metabolites in visceral organs， blood， urine and feces. Combined with the functional genomics research， we explain the mechanism of beta 2 adrenergic agonists for promoting pig growth， improving the lean meat， speeding up the fat metabolism. Based on this work， we revealed the rule of growth， development and metabolism in muscle and fat. All of these should be contribute the knowledge of animal breeding.

Key Words：Pig；Metabolomics for Drug Stress；Growth and Development

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