陸永霞
【摘要】目的:分析不同方案治療糖尿病合并甲狀腺功能亢進(jìn)癥的效果。方法:選擇2020年4月—2022年4月期間的68例糖尿病合并甲狀腺功能亢進(jìn)癥患者,隨機(jī)分為兩組,分析兩組治療前后甲狀腺體積大小及甲狀腺功能變化、血糖指標(biāo)。結(jié)果:治療前,兩組甲狀腺體積大小及甲狀腺功能變化、血糖指標(biāo)對(duì)比均無顯著差異(P>0.05);治療后,觀察組甲狀腺體積、FT3、TT3、FT4、TT4水平均明顯低于對(duì)照組,觀察組TSH水平明顯高于對(duì)照組,觀察組FPG、2h PG、HbAlc水平均明顯低于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論:和丙硫氧嘧啶相比,對(duì)糖尿病合并甲狀腺功能亢進(jìn)癥患者使用甲巰咪唑效果更為顯著,值得推廣和應(yīng)用。
【關(guān)鍵詞】糖尿病;甲狀腺功能亢進(jìn)癥;治療效果;甲巰咪唑;丙硫氧嘧啶
Comparison of effects of different regimens in the treatment of diabetes mellitus with hyperthyroidism
LU Yongxia
The First Peoples Hospital of Yuzhong County, Gansu Province, Lanzhou, Gansu 730100, China
【Abstract】Objective: To analyze the effect of different regimens in the treatment of diabetes mellitus with hyperthyroidism. Methods: 68 patients with diabetes mellitus complicated with hyperthyroidism from April 2020 to April 2022 were randomly divided into two groups. The changes of thyroid volume, thyroid function and blood glucose indexes before and after treatment were analyzed. Results: Before treatment, there were no significant differences in thyroid volume, thyroid function and blood glucose index between 2 groups(P>0.05). After treatment, the thyroid volume, FT3, TT3, FT4 and TT4 levels in the observation group were significantly lower than those in the control group, the TSH level in the observation group was significantly higher than that in the control group, and the FPG, 2h PG and HbAlc levels in the observation group were significantly lower than those in the control group, with statistical significance(P<0.05). Conclusions: Compared with propylthiouracil, methimazole is more effective in diabetic patients with hyperthyroidism, which is worth popularizing and applying.
【Key Words】Diabetes mellitus; Hyperthyroidism; Therapeutic effect; Methimazole; Propylthiouracil
糖尿病作為一種代謝性疾病,會(huì)導(dǎo)致患者出現(xiàn)胰島素分泌缺陷,使得該疾病顯示出高血糖的特征[1]。除遺傳因素以外,環(huán)境因素也會(huì)導(dǎo)致該疾病發(fā)生?;颊咄ǔG闆r下會(huì)出現(xiàn)多飲、多尿以及多食的明顯癥狀,并且會(huì)明顯消瘦,部分患者還可能會(huì)出現(xiàn)疲乏無力的情況。甲狀腺功能亢進(jìn)癥是一種臨床綜合征,當(dāng)產(chǎn)生的甲狀腺激素過多,很容易引發(fā)該疾病,使得患者逐漸消瘦,并且也會(huì)導(dǎo)致患者出現(xiàn)脖子粗等問題[2]。兩種疾病之間具有一定聯(lián)系,均屬于內(nèi)分泌系統(tǒng)疾病,而且經(jīng)過相關(guān)調(diào)查研究可以發(fā)現(xiàn),在發(fā)病機(jī)制方面,兩種疾病具有一定的相似性。目前,糖尿病合并甲狀腺功能亢進(jìn)癥患者不在少數(shù),該疾病除飲食量增加等典型癥狀以外,還可能會(huì)引發(fā)一系列并發(fā)癥,比如心衰等,進(jìn)而影響患者的生命健康[3]。面對(duì)該疾病,需要積極采取藥物治療的方式,然而由于該疾病較為復(fù)雜,病情相對(duì)來說也比較難控制,在丙硫氧嘧啶這一常用藥物的支持下,效果不盡人意。鑒于此,文章主要探討不同方案治療糖尿病合并甲狀腺功能亢進(jìn)癥的效果,將本文內(nèi)容作如下報(bào)告。
1.1 一般資料
選取2020年4月—2022年4月的68例糖尿病合并甲狀腺功能亢進(jìn)癥患者,隨機(jī)分為兩組。對(duì)照組,年齡48~63歲,平均年齡(55.22±5.45)歲;觀察組,年齡49~61歲,平均年齡(55.43±5.21)歲。兩組一般資料對(duì)比無統(tǒng)計(jì)學(xué)差異(P>0.05)。
1.2 方法