孟莉 林愛華 許可 徐大偉 張海潮
[摘要] 目的 探討PiCCO監(jiān)測技術(shù)指導(dǎo)治療感染性休克的臨床價(jià)值。方法 便利選擇2016年1月—2019年12月該院重癥醫(yī)學(xué)科124例感染性休克病例,隨機(jī)分為實(shí)驗(yàn)組(PiCCO監(jiān)測參數(shù)指導(dǎo)臨床液體復(fù)蘇治療,63例)和對照組(CVP變化指導(dǎo)補(bǔ)液治療,61例)。比較觀察兩組干預(yù)前及干預(yù)24 h后液體復(fù)蘇相關(guān)指標(biāo)及基該治療指標(biāo),統(tǒng)計(jì)救治成功率。結(jié)果 實(shí)驗(yàn)組干預(yù)后尿量(0.44±0.07)mL/(kg·h),BLA(1.97±0.82)mmol/L,MAP(66.73±9.15)mmHg,ScvO2(69.58±9.13)%,PaO2/FiO2(286.42±30.13),液體總?cè)肓浚? 875±360)mL,總液體復(fù)蘇時(shí)間(96.75±22.14)h,早期復(fù)蘇達(dá)標(biāo)時(shí)間(5.2±1.9)h,機(jī)械通氣時(shí)間(90.36±11.54)h,ICU留置時(shí)間(7.86±2.05)d,救治成功率82.54%,各項(xiàng)指標(biāo)均優(yōu)于對照組,差異有統(tǒng)計(jì)學(xué)意義(t=3.295、3.776、4.512、4.380、6.871、9.551、7.219、3.726、8.514、3.956,χ2=4.803,P<0.05)。結(jié)論 PiCCO監(jiān)測能夠準(zhǔn)確反映血容量狀態(tài),以此指導(dǎo)感染性休克液體復(fù)蘇治療效果確切,可以更好地改善患者心肺功能,同時(shí)避免過度輸液,有效提高救治成功率,促進(jìn)早期康復(fù)。
[關(guān)鍵詞] 感染性休克;液體復(fù)蘇;PiCCO監(jiān)測技術(shù)
[中圖分類號] R631? ? ? ? ? [文獻(xiàn)標(biāo)識碼] A? ? ? ? ? [文章編號] 1674-0742(2020)09(c)-0062-03
[Abstract] Objective To explore the clinical value of PiCCO monitoring technology to guide the treatment of septic shock. Methods From January 2016 to December 2019, 124 cases of septic shock in the Department of Critical Care Medicine of the hospital were convenienty selected and randomly divided into experimental group (PiCCO monitoring parameters to guide clinical fluid resuscitation treatment, 63 cases) and control group (CVP changes guide fluid therapy, 61 cases). Comparing and observing the related indexes and basic treatment indexes of fluid resuscitation before intervention and 24 h after intervention in the two groups, and statistical treatment success rate. Results The urine output of the experimental group after intervention was (0.44±0.07) mL/(kg·h), BLA(1.97±0.82)mmol/L, MAP(66.73±9.15)mmHg, ScvO2(69.58±9.13)%, PaO2/FiO2(286.42±30.13), total amount of liquid (2 875±360)mL,total fluid resuscitation time (96.75±22.14)h, early resuscitation up to standard time (5.2±1.9)h, mechanical ventilation time (90.36±11.54)h, ICU indwelling time (7.86±2.05)d, treatment success rate 82.54%, all indicators were better than the control group, the difference was statistically significant(t=3.295,3.776,4.512,4.380,6.871,9.551,7.219,3.726,8.514,3.956,χ2=4.803,P<0.05). Conclusion PiCCO monitoring can accurately reflect the blood volume status, which can guide the exact effect of fluid resuscitation in septic shock, which can better improve the cardiopulmonary function of patients, while avoiding excessive fluid infusion, and effectively improve treatment success rate and early recovery.
[Key words] Septic shock; Fluid resuscitation; PiCCO monitoring technology
感染性休克指病原微生物及其毒素產(chǎn)物直接或間接引起微循環(huán)功能紊亂與組織灌注不足,導(dǎo)致細(xì)胞代謝與臟器功能障礙的循環(huán)衰竭綜合征,是重癥醫(yī)學(xué)科常見急危重癥[1]。該病多見于免疫功能低下、醫(yī)院內(nèi)感染、大手術(shù)后及嚴(yán)重外傷者,病理病機(jī)復(fù)雜,致死率高,是ICU危重患者死亡主要原因。臨床救治該病,早期液體復(fù)蘇是關(guān)鍵,離不開有效的血流動力學(xué)監(jiān)測為其提供依據(jù)和指導(dǎo)[2]。脈搏分析連續(xù)心排量監(jiān)測(PiCCO)是基于經(jīng)肺熱稀釋技術(shù)和脈搏波型輪廓分析計(jì)數(shù)發(fā)展而來的一種血流動力學(xué)參數(shù)監(jiān)測與容量管理技術(shù),具有精確、簡便、微創(chuàng)、高效費(fèi)比的技術(shù)特點(diǎn)和優(yōu)勢,可用以連續(xù)動態(tài)監(jiān)測血流動力學(xué)變化,評估心臟收縮功能,為液體復(fù)蘇治療提供準(zhǔn)確指導(dǎo)[3]。便利選擇于2016年1月—2019年12月該院124例感染性休克病例,分析探討PiCCO在該病臨床治療中的指導(dǎo)作用,現(xiàn)報(bào)道如下。