醒腦靜聯(lián)合高壓氧對急性一氧化碳中毒患者治療效果及對肝、腎功能影響的分析

徐冬

【摘要】 目的：分析醒腦靜聯(lián)合高壓氧對急性一氧化碳中毒患者治療效果及對肝、腎功能影響。方法：選取筆者所在醫(yī)院收治的64例急性一氧化碳中毒患者，將其隨機(jī)分為對照組（n=32）及觀察組（n=32）。對照組經(jīng)高壓氧治療，觀察組經(jīng)醒腦靜聯(lián)合高壓氧治療，比較兩組蘇醒時(shí)間、意識恢復(fù)時(shí)間及治療前后肝腎功能。結(jié)果：觀察組蘇醒時(shí)間、意識恢復(fù)時(shí)間均早于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組TP、ALT、AST水平均明顯降低，且觀察組ALT、AST水平均低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組BUN、Scr水平均較治療前降低，且觀察組Scr水平低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：醒腦靜聯(lián)合高壓氧治療急性一氧化碳中毒效果理想，可明顯改善患者肝腎功能，臨床價(jià)值高，值得推廣應(yīng)用。

【關(guān)鍵詞】 醒腦靜; 高壓氧; 急性一氧化碳中毒; 肝、腎功能

doi：10.14033/j.cnki.cfmr.2019.24.025 文獻(xiàn)標(biāo)識碼 B 文章編號 1674-6805（2019）24-00-03

【Abstract】 Objective：To analyze the therapeutic effect of Xingnaojing combined with hyperbaric oxygen on patients with acute carbon monoxide poisoning and its effect on liver and kidney function.Method：A total of 64 patients with acute carbon monoxide poisoning admitted in our hospital were enrolled.They were randomly divided into control group（n=32） and observation group（n=32）.The control group was treated with hyperbaric oxygen.The observation group was treated with Xingnaojing combined with hyperbaric oxygen therapy.The recovery time，recovery time of consciousness and liver and kidney function before and after treatment were compared between the two groups.Result：The recovery time and consciousness recovery time of the observation group were earlier than those of the control group，and the differences were statistically significant（P<0.05）.After treatment，the levels of TP，ALT and AST in the two groups were significantly reduced，and the levels of ALT and AST in the observation group were lower than those in the control group，the differences were statistically significant（P<0.05）.After treatment，the levels of BUN and Scr in the two groups were lower than those before treatment，and the Scr level in the observation group was lower than that in the control group，the difference was statistically significant（P<0.05）.Conclusion：Xingnaojing combined with hyperbaric oxygen in the treatment of acute carbon monoxide poisoning has an ideal effect，which can significantly improve the liver and kidney function of patients，and has high clinical value，which is worthy of popularization and application.

【Key words】 Xingnaojing; Hyperbaric oxygen; Acute carbon monoxide poisoning; Liver and kidney function

First-authors address：Xianning Central Hospital，Xianning 437100，China

一氧化碳中毒是因碳物質(zhì)不完全燃燒后，有害物質(zhì)進(jìn)入機(jī)體并結(jié)合血紅蛋白，誘發(fā)機(jī)體中毒[1-2]。急性一氧化碳中毒以頭痛、嘔吐、乏力、昏迷等中毒癥狀為主，一般碳氧血紅蛋白定量決定患者病情嚴(yán)重程度，若血中碳氧血紅蛋白量超過40.0%，患者表現(xiàn)為中、重度中毒癥狀，全身各臟器功能明顯受損，中樞神經(jīng)系統(tǒng)受損嚴(yán)重，甚至導(dǎo)致患者快速死亡[3-4]。高壓氧是治療急性一氧化碳中毒的首選方式，可增加機(jī)體血液組織內(nèi)氧含量，改善缺氧狀態(tài)[5]，但單獨(dú)應(yīng)用高壓氧治療，患者蘇醒較慢，而加快患者清醒速度是當(dāng)前臨床重點(diǎn)研究方向。筆者根據(jù)多年臨床經(jīng)驗(yàn)，結(jié)合急性一氧化碳中毒患者具體特點(diǎn)，采取高壓氧聯(lián)合醒腦靜治療，旨為臨床用藥提供參考依據(jù)，現(xiàn)報(bào)道如下。