陳美娜
DOI:10.16662/j.cnki.1674-0742.2019.35.067
[摘要] 目的 分析使用腹腔鏡手術(shù)治療良性卵巢腫瘤的臨床效果。方法 在該醫(yī)院2016年1月—2019年1月急診的良性卵巢腫瘤患者中,方便抽取50例常規(guī)開腹手術(shù)患者和50例腹腔鏡手術(shù)患者,共100例,進(jìn)行回顧性分析,分別設(shè)為參照組與觀察組,對(duì)比兩組的手術(shù)時(shí)間、術(shù)中出血量、肛門排氣時(shí)間和住院時(shí)間,術(shù)后血清生殖激素水平和免疫功能情況,并觀察兩組患者的并發(fā)癥發(fā)生率。結(jié)果 ①觀察組的手術(shù)時(shí)間、術(shù)中出血量、住院時(shí)間和肛門排氣時(shí)間均短于參照組,兩組差異有統(tǒng)計(jì)學(xué)意義(t=10.826、9.466、19.527、7.134,P<0.05)。②對(duì)比兩組患者的血清生殖激素水平,觀察組的LH、FSH參數(shù)指標(biāo)(14.01±1.29)U/L、(17.02±1.51)U/L均高于參照組(10.17±1.69)U/L、(12.68±1.10)U/L,而E2(60.95±2.61)mmol/L則低于參照組(69.04±3.29)mmol/L,兩組差異有統(tǒng)計(jì)學(xué)意義(t=12.771、16.427、13.621,P<0.05)。③比較兩組治療后患者各項(xiàng)免疫功能指標(biāo),觀察組的CD3+、CD4+和CD4+/CD8+指標(biāo)均高于參照組,而CD8+指標(biāo)則均低于參照組,兩組差異有統(tǒng)計(jì)學(xué)意義(t=12.949、14.411、7.068、9.141,P<0.05)。④比較患者術(shù)后并發(fā)癥率,兩組分別為10.0%和44.0%,兩組有效率分別為90.0%和56.0%,觀察組均優(yōu)于參照組,差異有統(tǒng)計(jì)學(xué)意義(χ2=7.68,P<0.05)。結(jié)論 使用腹腔鏡手術(shù)治療良性卵巢腫瘤,可有效降低對(duì)患者的傷害和血清生殖激素,增強(qiáng)其免疫功能,降低術(shù)后并發(fā)癥,利于加強(qiáng)對(duì)卵巢功能的保護(hù)效果,臨床應(yīng)用效果顯著。
[關(guān)鍵詞] 腹腔鏡手術(shù);良性;卵巢腫瘤
[中圖分類號(hào)] R5 ? ? ? ? ?[文獻(xiàn)標(biāo)識(shí)碼] A ? ? ? ? ?[文章編號(hào)] 1674-0742(2019)12(b)-0067-03
Clinical Analysis of Laparoscopic Surgery for Benign Ovarian Tumors
CHEN Mei-na
Department of Gynecology, General Hospital of Lexian, Jiangle, Fujian Province, 353300 China
[Abstract] ObjectiveTo analyze the clinical effect of laparoscopic surgery for benign ovarian tumors. Methods A total of 100 patients with benign ovarian tumors were convenient selected in the hospital from January 2016 to January 2019. A total of 100 patients were 50 patients with conventional open surgery and 50 patients undergoing laparoscopic surgery. The reference group and the observation group were compared for the operation time, intraoperative blood loss, anal exhaust time and hospitalization time, postoperative serum reproductive hormone levels and immune function, and the complication rate of the two groups was observed. Results 1.The operation time, intraoperative blood loss, hospital stay and anal exhaust time of the observation group were shorter than the reference group. The difference between the two groups was statistically significant(t=10.826, 9.466, 19.527, 7.134,P<0.05). 2.Comparing the serum reproductive hormone levels of the two groups, the LH and FSH of the observation group were higher than the reference group (10.17±1.69) U/L, (12.68±1.10) U/L, while E2(60.95±2.61) mmol/L was lower than the reference group(69.04±3.29) mmol/L, and the difference between the two groups was statistically significant(t=12.771,16.427, 13.621,P<0.05). 3. Comparing the immune function indexes of the two groups after treatment, the CD3+, CD4+ and CD4+/CD8+ of the observation group were higher than the reference group, while the CD8+ indicators were lower than the reference group, the difference between the two groups was statistically significant(t=12.949, 14.411, 7.068, 9.141,P<0.05).4. Comparing the postoperative complication rate of the patients, the two groups were 10.0% and 44.0%, the effective rate of the two groups were 90.0% and 56.0% , the observation group was better than the reference group, the difference was statistically significant(χ2=7.68,P<0.05). Conclusion The use of laparoscopic surgery for benign ovarian tumors can effectively reduce the damage to patients and serum reproductive hormones, enhance their immune function, reduce postoperative complications, and strengthen the protective effect on ovarian function. The clinical application effect is remarkable.
分析患者術(shù)后并發(fā)癥情況,觀察組發(fā)生率為10.0%,明顯低于參照組44.0%,兩組的總有效率分別為92.0%和74.0%,相較于參照組,觀察組更佳,兩組差異有統(tǒng)計(jì)學(xué)意義(P<0.05),見表3。
表3 ? 術(shù)后兩組并發(fā)癥發(fā)生率和有效率比較[n(%)]
注:與參照組相比,=14.663,*P<0.05
3 ?討論
以往治療卵巢腫瘤中以開腹手術(shù)為主,取得了較高的治療效果,但由于手術(shù)切口大及開放,會(huì)延長(zhǎng)手術(shù)時(shí)間,增大術(shù)中出血量,不利于創(chuàng)口快速恢復(fù),并且會(huì)增大術(shù)后并發(fā)癥發(fā)生率,帶來(lái)強(qiáng)烈疼痛感[5]。同時(shí)術(shù)中還會(huì)造成大量卵巢血管和神經(jīng)組織損傷,甚至壞死,會(huì)影響患者的卵泡發(fā)育功能、內(nèi)分泌穩(wěn)定性和生育功能,康復(fù)還會(huì)留有嚴(yán)重傷疤[6]。而隨著醫(yī)學(xué)技術(shù)的發(fā)展,腹腔鏡手術(shù)的應(yīng)用,進(jìn)一步降低了對(duì)其他腹腔內(nèi)組織的損傷,彌補(bǔ)了開腹手術(shù)不足,臨床效果顯著,已成為很多醫(yī)院首選手術(shù)方式。該次研究主要分析腹腔鏡手術(shù)治療卵巢腫瘤的效果,結(jié)果如下:①比較兩組的手術(shù)時(shí)間、術(shù)中出血量、住院時(shí)間和肛門排氣時(shí)間,觀察組均少于參照組(P<0.05),相較于開腹手術(shù),腹腔鏡手術(shù)開口較小,可有效減少出血量,加快手術(shù)速度和患者康復(fù)速度,降低手術(shù)對(duì)患者的損傷,提高患者的生存質(zhì)量,與朱春霞[7]“腹腔鏡手術(shù)治療良性卵巢腫瘤的臨床分析”中的研究結(jié)果比較,其研究中顯示,兩組患者的住院時(shí)間、排氣時(shí)間、術(shù)中出血量和手術(shù)時(shí)間分值分別為(4.97±1.36)dvs(7.17±2.52)d(t=4.859)、(21.64±5.15)hvs(39.02±10.41)h(t=9.464)、(69.78±10.62)mL vs(106.35±22.56)mL(t=9.276)和(69.04±11.63)min vs(77.73±11.24)min(t=3.398),研究對(duì)比,結(jié)果一致。②兩組患者血清生殖激素水平比較,其中,LH、FSH參數(shù)指標(biāo),觀察組均高于參照組,而E2則低于參照組(P<0.05),說(shuō)明通過(guò)腹腔鏡手術(shù)可有效控制患者的血清生殖激素水平,研究。③觀察組與參照組治療后患者各項(xiàng)免疫功能指標(biāo)比較,其中CD3+、CD4+和CD4+/CD8+ 3項(xiàng),觀察組更高,其CD8+參數(shù)指標(biāo)則均低于參照組(P<0.05),與開腹手術(shù)相比,腹腔鏡手術(shù)可以幫助患者快速恢復(fù)自身免疫力,研究結(jié)果與狄華[8]“腹腔鏡手術(shù)治療卵巢良性腫瘤的臨床效果及抗體免疫的功能分析”中對(duì)CD3+、CD4+、CD8+和CD4+/CD8+指標(biāo)的分析一致,觀察組更高,④其術(shù)后患者并發(fā)癥發(fā)生率對(duì)比,觀察組(10.0%)低于參照組(44.0%)。治療有效率比較,觀察組(90.0%)明顯高于參照組(56.0%),相較于參照組,觀察組更加佳(P<0.05),腹腔鏡手術(shù)應(yīng)用中可減少并發(fā)癥,治療方式安全性更高。
綜上所述,對(duì)患有良性卵巢腫瘤的婦科患者使用腹腔鏡手術(shù),可縮減手術(shù)用時(shí),降低術(shù)中出血量,減少住院時(shí)間,弱化手術(shù)對(duì)患者身體的損傷。并且可以加強(qiáng)對(duì)血清生殖激素水平的控制,提高患者的免疫能力,降低了患者術(shù)后并發(fā)癥出現(xiàn)率,提升了患者的生存質(zhì)量和治療效果,具有極高臨床推廣意義。
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(收稿日期:2019-09-07)