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    烏司他丁治療急性肺損傷的臨床療效研究

    2018-05-12 08:07:42杜國強(qiáng)歐少佳王華洪梁劍毅張森丁延齡
    中國實(shí)用醫(yī)藥 2018年13期
    關(guān)鍵詞:急性肺損傷烏司他丁療效

    杜國強(qiáng) 歐少佳 王華洪 梁劍毅 張森 丁延齡

    【摘要】 目的 探討烏司他丁治療急性肺損傷的臨床療效。方法 80例急性肺損傷患者, 隨機(jī)分為對(duì)照組和實(shí)驗(yàn)組, 各40例。對(duì)照組患者采用常規(guī)治療, 實(shí)驗(yàn)組患者在對(duì)照組基礎(chǔ)上聯(lián)合烏司他丁治療, 觀察比較兩組患者治療效果、呼吸頻率(RR)、動(dòng)脈血氧分壓(PaO2)、動(dòng)脈血二氧化碳分壓(PaCO2)、氧合指數(shù)(PaO2/FiO2)、C反應(yīng)蛋白(CRP)和乳酸水平差異。結(jié)果 實(shí)驗(yàn)組患者總有效率為90.00%, 明顯高于對(duì)照組的70.00%, 差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。實(shí)驗(yàn)組患者RR為(23.46±1.56)次/min, PaO2為(92.62±6.38)mm Hg(1 mm Hg=0.133 kPa), PaCO2為(33.99±4.95)mm Hg, PaO2/FiO2為(281.42±21.83)mm Hg,優(yōu)于對(duì)照組的(27.86±1.74)次/min、(81.05±7.14)mm Hg、(38.85±5.29)mm Hg、(219.74±18.82)mm Hg, 差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。實(shí)驗(yàn)組患者CRP為(30.24±3.81)mg/L, 乳酸為(1.01±0.15)mmol/L, 低于對(duì)照組的(41.75±3.53)mg/L、(1.52±0.37)mmol/L, 差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 針對(duì)急性肺損傷患者應(yīng)用烏司他丁治療可明顯提高治療效果, 改善血?dú)庵笜?biāo)和炎性指標(biāo), 促進(jìn)患者康復(fù), 值得推廣應(yīng)用。

    【關(guān)鍵詞】 烏司他?。患毙苑螕p傷;療效

    DOI:10.14163/j.cnki.11-5547/r.2018.13.002

    【Abstract】 Objective To discuss the clinical efficacy of ulinastatin in the treatment of acute lung injury. Methods A total of 80 acute lung injury patients were randomly divided into control group and experimental group, with 40 cases in each group. The control group received conventional therapy, and the experimental group received ulinastatin on the basis of the conventional group. Observation and comparison were made on differences in treatment effect, respiratory rate (RR), partial pressure of oxygen (PaO2) partial pressure of carbon dioxide (PaCO2), oxygenation index (PaO2 /FiO2), C reactive protein (CRP) and lactic acid level between the two groups. Results The experimental group had obviously higher total effective rate as 90.00% than 70.00% in the control group, and the difference was statistically significant (P<0.05). The experimental group had RR as (23.46±1.56) times/min, PaO2 as (92.62±6.38) mm Hg (1mm Hg=0.133 kPa), PaCO2 as (33.99±4.95) mm Hg andPaO2 / FiO2 as (281.42±21.83) mm Hg, which were all better than (27.86±1.74) times/min, (81.05±7.14) mm Hg,(38.85±5.29) mm Hg and(219.74±18.82) mm Hg in the control group, and their difference was statistically significant (P<0.05). The experimental group had lower CRP as (30.24±3.81) mg/L, lactate as (1.01±0.15) mmol/Lthan (41.75±3.53)mg/L and (1.52±0.37) mmol/L in the control group, and their difference was statistically significant (P<0.05). Conclusion Application of ulinastatin in treating acute lung injury patients can obviously improve treatment effect, improve blood gas index and inflammatory index, and promote rehabilitation of patients. It is worthy of promotion and application.

    【Key words】 Ulinastatin; Acute lung injury; Efficacy

    急性肺損傷為臨床常見呼吸系統(tǒng)急癥, 若治療不及時(shí)可引起急性呼吸窘迫綜合征, 影響患者生活質(zhì)量。如何提高急性肺損傷救治成功率, 避免病情發(fā)展, 為臨床關(guān)注的焦點(diǎn)。烏司他丁為光譜水解酶抑制糖蛋白, 具有調(diào)節(jié)炎性細(xì)胞、炎性介質(zhì)水平和氧自由基水平作用, 可保護(hù)肺功能[1]。本文通過對(duì)本院收治的80例急性肺損傷患者進(jìn)行分組, 討論臨床治療方案, 現(xiàn)報(bào)告如下。

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