參麥注射液在頭頸部腫瘤放療中減輕放射性不良反應(yīng)的臨床觀察

陳飛　余婷婷　劉曉安

[摘要] 目的 觀察參麥注射液在頭頸部腫瘤放療中減輕放射性不良反應(yīng)的臨床效果。 方法 分析2015年3月～2017年3月我院收治的128例頭頸部腫瘤放療患者的臨床資料，計(jì)算總有效率；總的放療2～4級(jí)急性損傷發(fā)生率、中重度疼痛發(fā)生率、生活質(zhì)量降低發(fā)生率；放療完成1個(gè)月后的生活質(zhì)量改善發(fā)生率。 結(jié)果 觀察組患者治療的總有效率[93.75%（60/64）]明顯高于對(duì)照組[81.25%（52/64）]，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；總的放療2～4級(jí)急性損傷發(fā)生率明顯低于對(duì)照組，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），中重度疼痛發(fā)生率31.25%（20/64）明顯低于對(duì)照組的68.75%（44/64），差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；放療完成1個(gè)月后觀察組患者的生活質(zhì)量改善發(fā)生率93.75%（60/64），明顯高于對(duì)照組62.50%（40/64），差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），觀察組患者生活質(zhì)量降低發(fā)生率0%（0/64），明顯低于對(duì)照組的15.63%（10/64），差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。 結(jié)論 參麥注射液在頭頸部腫瘤放療中減輕放射性不良反應(yīng)的臨床效果顯著。

[關(guān)鍵詞] 參麥注射液；頭頸部腫瘤放療；臨床療效；放射性不良反應(yīng)

[中圖分類(lèi)號(hào)] R273 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2017）28-0095-03

[Abstract] Objective To observe the clinical effect of Shenmai injection on reducing radioactive adverse reactions in head and neck tumor radiotherapy. Methods The clinical data of 128 patients with head and neck tumor radiotherapy who were admitted to our hospital from March 2015 to March 2017 were statistically analyzed. The total effective rate was calculated； total incidence rate of grade 2-4 acute injury by radiotherapy； incidence rate of moderate to severe pain； incidence rate of quality of life reduction； incidence rate of improvement in quality of life after one month of radiotherapy were compared. Results The total effective rate was 93.75%（60/64） in the observation group， which was significantly higher than that of 81.25%（52/64） in the control group，the difference was significant（P<0.05）； the total incidence rate of grade 2-4 acute injury was significantly lower than that in the control group，the difference was significant（P<0.05）. The incidence rate of moderate to severe pain was 31.25%（20/64）， which was significantly lower than that of 68.75%（44/64） in the control group， the difference was significant（P<0.05）； the improvement rate of quality of life in the observation group was 93.75%（60/64）， the difference was significant， which was significantly higher than that of 62.50%（40/64） in the control group， the difference was significant（P<0.05）. The incidence rate of life quality reduction was 0%（0/64） in the observation group， which was significantly lower than that of 15.63%（10/64） in the control group， the difference was significant（P<0.05）. Conclusion Shenmai injection in the head and neck tumor radiotherapy has a significant clinical effect of reducing radioactive adverse effects.

[Key words] Shenmai injection； Head and neck tumor radiotherapy； Clinical efficacy； Radioactive adverse reactions

放射治療為頭頸部惡性腫瘤重要的治療手段，雖然放療的設(shè)備和技術(shù)有了長(zhǎng)足的進(jìn)步，如適形、調(diào)強(qiáng)、立體定向放療，但無(wú)法避免放療的毒副反應(yīng)及并發(fā)癥的發(fā)生，因此放療過(guò)程中出現(xiàn)的不良反應(yīng)常使患者中斷治療，使療效降低，病程延長(zhǎng)，患者生存質(zhì)量嚴(yán)重下降。祖國(guó)醫(yī)學(xué)認(rèn)為放射線是火熱陽(yáng)毒之邪，可傷陰耗氣，灼傷津液，而參麥注射液屬于純中藥抗癌藥物，主要功效為清熱解毒、鎮(zhèn)痛等[1]。本研究對(duì)2015年3月～2017年3月我院收治的128例頭頸部腫瘤放療患者的臨床資料進(jìn)行統(tǒng)計(jì)分析，觀察參麥注射液在頭頸部腫瘤放療中減輕放射性不良反應(yīng)的臨床效果，現(xiàn)報(bào)道如下。endprint