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    A new scoring system to evaluate adjuvant chemotherapy for patients with T2N0M0 gastric cancer after D2 gastrectomy

    2022-10-24 09:15:46QuanXuWenZheKangJianPingXiongXinXinShaoWeiKunLiHaiTaoHuYanTaoTian
    World Journal of Gastroenterology 2022年38期

    Quan Xu, Wen-Zhe Kang, Jian-Ping Xiong, Xin-Xin Shao, Wei-Kun Li, Hai-Tao Hu, Yan-Tao Tian

    Abstract

    Key Words: Gastric cancer; Risk score; T2N0M0; Adjuvant chemotherapy; D2 gastrectomy; Survival

    lNTRODUCTlON

    Gastric cancer is one of the most common malignancies worldwide[1-3]. D2 gastrectomy combined with postoperative adjuvant chemotherapy is the main treatment modality for advanced gastric cancer[4-8].According to the 8th edition of the American Joint Committee on Cancer (AJCC) guidelines for gastric cancer, T2 was defined as tumor invasion of the muscularis propria[9]. It is controversial whether adjuvant chemotherapy is necessary for stage T2N0M0 gastric cancer[10-16]. Previous studies have suggested that patients with stage I gastric cancer cannot benefit from adjuvant chemotherapy[17].However, there are some risk factors for recurrence of T2N0M0 gastric cancer, such as lymphatic and/or blood vessel invasion, tumor diameter, perineural invasion, proximal tumor location, and poor differentiation[14,18]. Postoperative adjuvant chemotherapy may inhibit the recurrence in these patients. To further clarify the indications for the use of postoperative adjuvant chemotherapy in T2N0M0 gastric cancer, we reviewed 325 patients with T2N0M0 gastric cancer admitted to the National Cancer Center between 2011 and 2018. In this study, we assessed the risk score of patients with pathologic T2N0M0 gastric cancer after D2 gastrectomy based on clinicopathological factors and identified a high-risk subgroup that could benefit from postoperative adjuvant chemotherapy.

    MATERlALS AND METHODS

    Patient selection

    We identified 402 patients with pathological T2N0M0 stage primary gastric carcinoma and gastroesophageal junction carcinoma (as defined by the AJCC guidelines, 8thedition) who were admitted to the Department of Pancreatic and Gastric Surgery, National Cancer Center, from 2011 to 2018. Three hundred and twenty-five patients were included in our study, all of whom underwent D2 gastrectomy.A total of 63 patients received post-operative adjuvant chemotherapy. The major chemotherapy regimens included platinum + 5-FU; paclitaxel + platinum + 5-FU; and others. Adjuvant chemotherapy is usually performed for 4-6 cycles. Exclusion criteria included loss to follow-up, lack of adenocarcinoma, neoadjuvant chemotherapy, adjuvant radiotherapy, Siewert I type/Siewert II type gastroesophageal junction carcinoma invading the dentate line, and postoperative survival time < 1 mo. Patients were followed-up by telephone. The follow-up was completed on April 30, 2020. The median follow-up time was 65.4 mo.

    Statistical analyses

    Univariate and multivariate Cox regression analyses were performed to screen for prognostic variables.Variables with aPvalue < 0.05 and < 0.25 in the univariate and multivariable Cox regression analyses were included in the study. Three variables were included in total: Vascular invasion, tumor site, and body mass index (BMI). The tumor site was classified as cardiac or non-cardiac. Cardiac cancer refers to Siewert type II gastroesophageal junction carcinoma that does not invade the dentate line and Siewert type III gastroesophageal junction carcinoma. BMI of < 18.5 or > 23.9, positive result of vascular invasion, and cardiac cancer were defined as risk factors. Each risk factor was assigned one point, and a total of four groups were obtained, which were defined as scores 0, 1, 2, and 3, respectively. We found that patients with a score ≥ 2 had a poor prognosis, and chemotherapy significantly improvedprognosis. According to the study results, scores of 2-3 were defined as the high-risk group. The Kaplan-Meier method was used to calculate the 5-year survival rate and compare the overall survival(OS) between the different score groups.

    Table 1 Clinicopathologic variables of 325 T2N0M0 gastric cancer patients

    Statistical analysis was performed using the R software 4.0.5 (R Foundation for Statistical Computing,Vienna, Austria) and the SPSS 22.0 software (SPSS Inc., Chicago, IL, United States). Each test was bilateral, and statistical significance was set atP< 0.05.

    RESULTS

    Clinicopathological characteristics, univariate and multivariable cox regression analyses

    A total of 325 patients were recruited for this study. Table 1 summarizes the clinicopathological characteristics of the patients enrolled in this study. Univariate Cox regression analysis demonstrated that the tumor site (P= 0.022, Table 2), vascular invasion (P< 0.001, Table 2), and BMI (P= 0.036, Table 2) weresignificant risk factors for OS. Multivariate Cox regression analysis demonstrated that vascular invasion was an independent risk factor for OS (P< 0.001, Table 3).

    Table 2 Univariate Cox Proportional Hazards Modeling for overall survival

    Vascular invasion, tumor site, and BMI were assessed in the study, and a scoring system was established.

    Survival results of different groups

    Figure 1A summarizes the survival curves of patients with scores of 0, 1, 2, and 3. There were significant differences among all groups except for the score 0 and 1 groups (score 0 groupvsscore 1 group,P=0.537; score 0 groupvsscore 2 group,P= 0.049; score 0 groupvsscore 3 group,P< 0.001; score 1 groupvsscore 2 group,P= 0.003; score 1 groupvsscore 3 group,P< 0.001; score 2 groupvsscore 3 group,P=0.008). For all patients, 5-year survival rates of the adjuvant chemotherapy and postoperative observation groups were 96% and 90%, respectively (P= 0.676, Table 4). Five-year survival rates of the score 0, 1, 2, and 3 groups were 92%, 95%, 80%, and 50%, respectively (P< 0.001, Table 4). In the score 0 and score 1 groups, there were no differences in the 5-year survival rates between the postoperative observation and adjuvant chemotherapy groups. In the score 2-3 group, 5-year survival rates for patients in the adjuvant chemotherapy group and postoperative observation group were 95% and 61%,respectively (P= 0.021, Table 4).

    Figure 1B-D summarizes the survival curves of patients with scores of 0, 1, and score 2-3 T2N0M0 gastric cancer in the adjuvant chemotherapy and postoperative observation groups. Table 5 summarizes the distribution of the different risk factors in each risk score group.

    Table 3 Multivariable Cox Proportional Hazards Modeling for overall survival

    DlSCUSSlON

    Our study found that adjuvant chemotherapy is necessary for the treatment of T2N0M0 gastric cancer patients with two or more risk factors. The risk factors included vascular invasion, BMI, and tumor site.Based on these results, we obtained a simple risk score to assess the need for adjuvant chemotherapy in patients with T2N0M0 gastric cancer. Patients with a score 2-3 were assigned to the high-risk group.Previous studies have shown that adjuvant chemotherapy can prolong OS in advanced gastric cancer and reduce recurrence[19]. However, evidence of the survival benefits of adjuvant chemotherapy for early gastric cancer is lacking. Although there is no lymph node metastasis in T2N0M0 gastric cancer, some patients still experience recurrence[10-16]. Therefore, it is important to identify patients with stage T2N0M0 gastric cancer who are at high risk of recurrence and may require adjuvant chemotherapy. Univariate Cox regression analysis demonstrated that tumor site (P= 0.022, Table 2),vascular invasion (P< 0.001, Table 2), and BMI (P= 0.036, Table 2) were significant risk factors for OS in patients with T2N0M0 disease. Multivariate Cox regression analysis showed that vascular invasion was an independent prognostic indicator in patients with T2N0M0 disease[14]. Tumor site has been reported to be a prognostic risk factor for stage IB gastric cancer[11]. The 5-year OS rate of patients with stage IB gastric cancer whose tumors are located in the upper third of the stomach is only 81.8%, which is lower than that of patients with stage II disease receiving S-1 adjuvant chemotherapy[5]. Another study that followed 532 patients reported poorer long-term survival in patients with proximal gastric cancer than in those with distal gastric cancer[20]. Proximal gastric cancer has a higher proportion of undifferentiated tumors, and tumors located in this region can metastasize to almost all lymph nodes, except in thefive groups[11]. These factors may account for the lower survival rates of patients with proximal gastric cancer. Several studies have shown that BMI affects the prognosis of patients with gastric cancer[21-26].Low BMI was associated with malnutrition, whereas high BMI was associated with a higher risk of surgery and a higher rate of postoperative complications. A high BMI also increases the risk of stomach cancer[27]. The degree of tumor differentiation was not included in the study, possibly because poorly differentiated tumors do not show significant aggressiveness in the early stages of tumor development.

    Table 4 Five-year survival rates of different groups

    Table 5 Distribution of three different risk factors in each score group

    Based on these findings, we developed a scoring system to assess the need for the use of adjuvant chemotherapy in patients with T2N0M0 gastric cancer. Patients with no or only one risk factor had good prognosis after D2 gastrectomy and did not require adjuvant chemotherapy. Patients in the score 2-3 group had a significantly worse prognosis and could benefit from adjuvant chemotherapy. Our study may help to provide targeted treatment for patients with stage T2N0M0 gastric cancer.This study had some limitations. This was a single-center retrospective study with a lower level of evidence than that of a prospective study. We did not classify the patients into subgroups based on the number of lymph nodes removed. The number of lymph node dissections has a significant effect on OS. For patients with stage T1-2 node-negative gastric cancer, the 5-year survival rate increased by 7.6% for every 10 Lymph nodes examined[28]. No recurrence-free survival or recurrence pattern was observed. We did not discuss the genetic characteristics of patients with gastric cancer included in the study. Genetic characteristics of patients with gastric cancer may influence the efficacy of adjuvant chemotherapy.

    Figure 1 Survival curves. A: The survival curves of score 0 group, score 1 group, score 2 group and score 3 group patients; B: The survival curves of score 0 T2N0Μ0 gastric cancer patients in adjuvant chemotherapy group and postoperative observation group; C: The survival curves of score 1 T2N0Μ0 gastric cancer patients in adjuvant chemotherapy group and postoperative observation group; D: The survival curves of score 2-3 T2N0Μ0 gastric cancer patients in adjuvant chemotherapy group and postoperative observation group. OS: Overall survival.

    CONCLUSlON

    For patients with T2N0M0 stage gastric cancer and two or more risk factors, adjuvant chemotherapy after D2 gastrectomy may have a survival benefit. Individualized treatment should be adopted according to examination and pathological results in patients with T2N0M0 gastric cancer.

    ARTlCLE HlGHLlGHTS

    Research results

    Five-year survival rates of the score 0, 1, 2, and 3 groups were 92%, 95%, 80%, and 50%, respectively (P<0.001). In the score 2-3 group, five-year survival rates for patients in the adjuvant chemotherapy group and postoperative observation group were 95% and 61%, respectively (P= 0.021).

    Research conclusions

    For patients with T2N0M0 stage gastric cancer and two or more risk factors, adjuvant chemotherapy after D2 gastrectomy may have a survival benefit.

    Research perspectives

    Individualized treatment should be adopted according to examination and pathological results in patients with T2N0M0 gastric cancer.

    FOOTNOTES

    Author contributions:Xu Q and Kang WZ contributed equally to this work; Tian YT and Xu Q designed the research;Kang WZ, Xiong JP, and Shao XX analyzed the data and wrote the paper; Li WK and Hu HT collected the patient’s clinical data.

    Supported bythe National Natural Science Foundation of China, No. 82072734.

    lnstitutional review board statement:The study was reviewed and approved by the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Institutional Review Board (Approval No. 17-156/1412).

    Conflict-of-interest statement:All the authors report no relevant conflicts of interest for this article.

    Data sharing statement:Dataset available from the author at kwz@whu.edu.cn.

    Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

    Country/Territory of origin:China

    ORClD number:Quan Xu 0000-0001-6177-9503; Wen-Zhe Kang 0000-0001-9965-8109; Jian-Ping Xiong 0000-0001-6593-6377; Xin-Xin Shao 0000-0002-1826-3832; Wei-Kun Li 0000-0002-3883-1497; Hai-Tao Hu 0000-0003-0585-6070; Yan-Tao Tian 0000-0001-6479-7547.

    S-Editor:Chen YL

    L-Editor:A

    P-Editor:Chen YL

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