羥芐羥麻黃堿對(duì)妊娠期糖尿病先兆早產(chǎn)的價(jià)值

吳曉俠

[摘要] 目的 探討妊娠期糖尿病并發(fā)先兆早產(chǎn)的患者采用羥芐羥麻黃堿治療總有效率及預(yù)后。方法 2018年1月—2019年1月間選擇該院婦產(chǎn)科妊娠期糖尿病患者80例，隨機(jī)分組，對(duì)照組40例采用硫酸鎂治療，觀察組40例采用羥芐羥麻黃堿治療。 結(jié)果 觀察組先兆早產(chǎn)病例總有效率、保胎成功率均高于對(duì)照組（P<0.05）;觀察組累積用藥時(shí)間、陰道出血時(shí)間均少于對(duì)照組，延長(zhǎng)孕期時(shí)間長(zhǎng)于對(duì)照組，新生兒體重量高于對(duì)照組（P<0.05）;觀察組不良反應(yīng)率低于對(duì)照組（P<0.05）。 結(jié)論 妊娠期糖尿病合并先兆早產(chǎn)的患者，應(yīng)用羥芐羥麻黃堿治療，可提高總有效率及保胎成功率，縮短用藥及陰道流血時(shí)間，延長(zhǎng)孕期，改善新生兒體重量，且具較高安全性。

[關(guān)鍵詞] 妊娠期糖尿病;先兆早產(chǎn);羥芐羥麻黃堿;總有效率;保胎率

[中圖分類號(hào)] R587.1? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1672-4062（2019）06（a）-0079-02

[Abstract] Objective To investigate the total effective rate and prognosis of patients with gestational diabetes mellitus complicated with threatened preterm labor with hydroxybensamine. Methods 80 patients with gestational diabetes mellitus in obstetrics and gynecology in our hospital from January 2018 to January 2019 were randomly divided into two groups. 40 patients in the control group were treated with magnesium sulfate， and 40 patients in the observation group were treated with hydroxybenzylephedrine. Results The total effective rate and the success rate of fetus prevalence in the observation group were higher than those in the control group （P<0.05）. The cumulative medication time and vaginal bleeding time in the observation group were less than the control group， and the prolonged pregnancy time was longer than the control group. The weight was higher than that of the control group （P<0.05）; the adverse reaction rate of the observation group was lower than that of the control group （P<0.05）. Conclusion Patients with gestational diabetes mellitus and threatened preterm labor with oxymethyl hydroxyephedrine can improve the total effective rate and success rate of fetus， shorten the time of medication and vaginal bleeding， prolong pregnancy， improve the weight of newborns， and have higher safety.

[Key words] Gestational diabetes; Threatened premature labor; Hydroxybenzyl hydroxyephedrine; Total effective rate; Miscarriages prevention rate

先兆早產(chǎn)為妊娠期多發(fā)性高危疾病類型，臨床以未足月前，孕婦有呈規(guī)則性或不規(guī)則性宮縮出現(xiàn)，且宮頸管存在進(jìn)行性縮短變化為特征?？蓢?yán)重威脅到母嬰健康，尤其是妊娠糖尿病患者，在病發(fā)先兆早產(chǎn)時(shí)，病情更為復(fù)雜，進(jìn)一步加大了病情控制難度。硫酸鎂為常用對(duì)本病治療的藥物，屬宮縮抑制劑，但長(zhǎng)期或過(guò)量使用，可引發(fā)呼吸抑制等系列不良事件。而羥芐羥麻黃堿可有效規(guī)避上述不足，在抑制宮縮、保障臨床安全同時(shí)，還可延長(zhǎng)子宮收縮周期，具有非常重要的應(yīng)用價(jià)值[1-2]。該次研究對(duì)相關(guān)病例予以選取，探討采用芐羥麻黃堿治療的作用，以指導(dǎo)臨床，現(xiàn)報(bào)道如下。

1? 資料與方法

1.1? 一般資料

選擇該院婦產(chǎn)科月收治妊娠期糖尿病患者80例。隨機(jī)分組，觀察組40例，年齡介于27～35歲之間，平均（29.8±1.3）歲;孕周介于33～35周之間，平均（34.6±0.3）周;對(duì)照組40例，年齡介于25～37歲之間，平均（29.5±1.4）歲;孕周介于33～36周之間，平均（34.9±0.4）周;組間自然信息均衡可比（P>0.05）。

1.2? 納排標(biāo)準(zhǔn)

納入標(biāo)準(zhǔn)：經(jīng)臨床檢查、血糖水平檢測(cè)，與診斷標(biāo)準(zhǔn)符合;自愿簽署知情同意書。排除標(biāo)準(zhǔn)：對(duì)該次所用藥物存在過(guò)敏反應(yīng)者;肝腎功能異常者。