袁迎九 后建麗 丁文清
[摘要]目的 研究與觀察多囊卵巢綜合征(PCOS)患者抗氧化及蛋白代謝的變化情況。方法 選取2016年10月~2017年6月在我院就診的70例PCOS患者為觀察組,選擇同期70名健康同齡婦女為對(duì)照組。檢測兩組研究對(duì)象的抗氧化及代謝指標(biāo),并比較兩組的檢測結(jié)果,同時(shí)比較觀察組不同嚴(yán)重程度PCOS患者的檢測結(jié)果,以Logistic回歸分析處理上述檢測指標(biāo)與PCOS的關(guān)系。結(jié)果 觀察組的清蛋白代謝指標(biāo)及MDA高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05),其他血清抗氧化指標(biāo)低于對(duì)照組(P<0.05),不同嚴(yán)重程度PCOS患者的檢測結(jié)果比較,差異有統(tǒng)計(jì)學(xué)意義(P<0.05),且Logistic回歸分析處理結(jié)果顯示,上述檢測指標(biāo)與PCOS有密切的關(guān)系(P<0.05)。結(jié)論 PCOS患者抗氧化及蛋白代謝指標(biāo)明顯不同健康同齡婦女,上述指標(biāo)與PCOS有密切的關(guān)系,可作為疾病診斷與治療的指導(dǎo)性指標(biāo)。
[關(guān)鍵詞]多囊卵巢綜合征;抗氧化指標(biāo);蛋白代謝指標(biāo)
[中圖分類號(hào)] R711.6 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2017)12(b)-0162-03
[Abstract]Objective To study and observe the change status of antioxidation and protein metabolism of patients with polycystic ovary syndrome (PCOS).Methods 70 patients with PCOS in our hospital from October 2016 to June 2017 were selected as the observation group,70 healthy women with the same age at the same time were selected as the control group.Then the antioxidation and protein metabolism indexes of two groups were detected,and the detection results of two groups were compared,the detection results of observation group with different severity degree of PCOS were compared too,and the relationship between those detection indexes and PCOS were analyzed by the Logistic regression analysis.Results The serum protein metabolism indexes and MDA of observation group were all higher than those of control group(P<0.05),other serum antioxidation indexes were lower than those of control group(P<0.05),the detection results of observation group with different severity degree of PCOS were compared,there were significant differences (P<0.05),and the results of Logistic regression analysis showed,those detection indexes all had close relationship to PCOS,the difference was statistically significant(P<0.05).Conclusion The antioxidation and protein metabolism of patients with PCOS are obviously different to the results of healthy women with the same age,and those indexes all have close relationship to PCOS,and they can be as the guidance indexes of the disease.
[Key words]Polycystic ovary syndrome;Antioxidation indexes;Protein metabolism indexes
多囊卵巢綜合征(PCOS)是育齡婦女的常見病,患者可表現(xiàn)出多毛、月經(jīng)異常甚至不孕,而上述表現(xiàn)也是患者就診的主要原因。臨床關(guān)于PCOS的研究多見[1-2],而本病作為內(nèi)分泌與代謝異常所致疾病,對(duì)于患者機(jī)體代謝方面的研究則相對(duì)多見,而蛋白代謝方面的研究雖可見,但研究結(jié)果的差異較大。另外,抗氧化能力作為反應(yīng)機(jī)體代謝的重要方面[3],其在PCOS發(fā)生發(fā)展中的作用研究也可見,但也存在研究差異明顯的情況。因此,本文對(duì)PCOS患者抗氧化及蛋白代謝的變化情況進(jìn)行探究,現(xiàn)報(bào)道如下。
1資料與方法
1.1一般資料
選取2016年10月~2017年6月在我院就診的70例PCOS患者為觀察組,選取同期70例健康同齡婦女為對(duì)照組。對(duì)照組年齡21~38歲,平均(29.9±6.7)歲;有生育史40例,無生育史30例。觀察組年齡22~38歲,平均(29.6±7.1)歲;有生育史38例,無生育史32例;病程7~50.5個(gè)月,平均(26.3±5.7)個(gè)月;嚴(yán)重程度:輕度20例,中度32例,重度18例。兩組婦女的年齡與生育史等情況比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),具有可比性。本研究經(jīng)我院醫(yī)學(xué)倫理學(xué)委員會(huì)批準(zhǔn)。endprint