A study of the characteristics of alexithymia and emotion regulation in patients with depression

Hao ZHANG, Qing FAN, Yan SUN, Jianyin QIU*, Lisheng SONG*

?Original research article?

A study of the characteristics of alexithymia and emotion regulation in patients with depression

Hao ZHANG, Qing FAN, Yan SUN, Jianyin QIU*, Lisheng SONG*

depression; alexithymia; emotion regulation; emotion reappraisal; emotion suppression

1. Introduction

Depression is a common mood disorder which is characterized by significant and lasting depressive mood, lack of internal vitality or losing interest in things.[1]The characteristics of depression are a high prevalence, high recurrence rate, high disability rate and high suicide rate; and the incidence of disease is around 10% (WHO, 2002). Epidemiological investigations in China have shown that the point prevalence is 6.1% to 7.5%.[2] Recently, the prevalence of depression has been climbing every year, and it is estimated that by 2020 depression will be ranked number one in China’s burden of disease. Depression causes severe impairments in an individuals’ emotions,cognitive ability, behavior and physical development,and can lead to a decrease in social functioning, bring about a heavy economic burden and affect the normal order of family life.[3]

The cause of depression still remains unclear.Biological and psychological social factors both significantly affect the incidence of depression.According to the social cognition theory, depression is the result of an interaction between cognitive psychological factors and stress. Cognitive psychological factors include an individual’s traits, concept of the self, cognitive appraisals, attribution and coping styles,and so forth; and these are all likely correlated with susceptibility to depression.

Alexithymia is a cognitive processing and regulation disorder in emotions, and its symptoms are having difficulty in recognizing and describing emotions, in distinguishing emotional and physical perceptions, and lacking externally oriented thinking. Clinical research has shown that the incidence of alexithymia in patients with depression is significantly higher than that of the general population.[5]However, the mechanism of alexithymia in patients with depression is still unclear. Some researchers suggest that alexithymia is a personality trait, and it is a predisposing factor for depression,[6]while other researchers view alexithymia as a state reaction to depression[7-8](i.e. a defense mechanism).[9]

Emotion regulation is an individual’s monitoring and regulation process for the internal processing and external presentation of emotions. It has an adaptive function, and it is an individual trait. There are different kinds of emotion regulation. According to one theory,there is antecedent-focused emotion regulation and response-focused emotion regulation. Antecedentfocused emotion regulation is referred to as regulating the causes of emotions (e.g., cognitive reappraisal);while response-focused emotion regulation is regulating the emotions which have already emerged on the emotional expression level (e.g., expression suppression). Currently, it is generally accepted that cognitive reappraisal is an adaptive emotion regulation strategy, while expression suppression is a nonadaptive emotion regulation strategy. Previous research indicates that in comparison with healthy controls,patients with depression are more inclined to employ non-adaptive emotion regulation strategies than to use adaptive emotion regulation strategies spontaneously.[10]This phenomenon applies to the patients with depression in both active and remissive phases.[11]To this day, there is little research utilizing experimental methods to evaluate depressive patients’ ability to employ different emotion regulation strategies (e.g.,cognitive reappraisal and expression suppression).

The present study aims to further explore the characteristics of alexithymia in patients with depression, and the relationships between depressive symptoms, alexithymia and individual emotion regulation ability.

2. Methods

2.1 Subjects

2.1.1 Depression group

Subjects in this group were recruited through the recommendations of nurses, the diagnoses of doctors and other methods in the outpatient department of Shanghai psychological consultation and treatment center, and they were recruited from May to September in 2016.

The inclusion criteria were the following: (a)meeting diagnostic criteria for depression according to the DSM-IV; (b) ratings of no less than 20 on the Hamilton Depression Scale-24 (HAMD-24); (c) age range from 18 to 55; (d) female or male; (e) education level being no less than junior high; (f) visual and auditory senses were good enough to complete the examinations; (g) provided written informed consent to participate in the study. The exclusion criteria were the following: (a) previous brain injury or history of stroke;(b) currently suffering from a severe medical condition;(c) having severe risk of suicide or self-injury; (d)currently pregnant or lactating; presence of comorbid psychotic disorder, psychotic symptoms, psychoactive substance dependency or abuse, personality disorder,or mental retardation.

In total thirty-six patients with depression were included in the present study, including 6 males and 30 females. The mean(sd) age was 27.33 (7.26), and 33(91.7%) of them had a college education or higher.

2.1.2 Control group

All participants in the control group were recruited via advertisements and social contacts. The inclusion criteria were the following: (a) individuals who were determined as having no mental disorders after being evaluated by psychiatrists; (b) HAMD-24 scores less than 8; (c) Hamilton Anxiety Scale (HAMA) scores less than 6; (d) aged from 18 to 55; (e) female or male; (f)junior high school education or higher; (g) no history of taking psychiatric drugs; (h) no family history of mental disorders; (i) visual and auditory senses were good enough to complete the examinations; (j) providing written informed consent to participate in this study.

Exclusion criteria were the following: (a) individuals with risk of self-injury or suicide; (b) currently suffering from a severe medical condition or central nervous system disease; (c) current substance abuse;(d) pregnant or lactating women. Thirty-one healthy volunteers were included in the control group,including 4 males and 27 females. The mean(sd) age was 27.2 (6.4), and 28 (90.3%) of them had a college education or more.

2.2 Assessment tools

HAMD-24 and HAMA were employed to evaluate the depression and anxiety levels of participants. Toronto Alexithymia Scale (TAS) was used to evaluate the degrees of alexithymia.

The computer emotion regulation experiment programmed with E-Prime was employed to measure the emotion regulation ability. This experiment procedure was programmed by the researchers in the Institute of Psychology at the Chinese Academy of Sciences. It was provided by Chuqiao Chen and Yi Wang, and was operated under their supervision.

Seventy-two pictures were presented in the experiment, with 18 neutral emotion pictures and 54 negative emotion pictures. The negative emotion pictures were divided into three groups with 18 pictures in each group, and manipulated in three conditions. There were four conditions in total:neutral pictures-watched freely, negative pictureswatched freely, negative pictures-cognitive reappraisal and negative pictures-expression suppression. Their abbreviations were watch-neutral, watch-negative,negative-reappraisal, and negative-suppression. The four conditions were presented randomly.

Before the experiment began, the subjects were informed that there were neutral and negative pictures in the experiment with most of them being negative. There were three cues during the experiment: “watch freely”, “cognitive reappraisal”and “expression suppression”. “Watch freely” was referred to as watching the picture naturally. “Cognitive reappraisal” meant understanding the pictures that caused negative emotions in a more positive way. For example, the pictures that induce negative emotions can be comprehended as movies’ special effects instead of real situations, or can be explained as something irrelevant to themselves. “Expression suppression” was controlling their facial expressions and refraining from expressing the negative emotions when they saw the unpleasant pictures.

Ten negative emotion pictures were prepared as a practice for the participants. These pictures were not presented in the formal experiments. They were presented to the participants one by one. The experimenter used the first two as examples to explain how to perform cognitive reappraisal, and the participants practiced cognitive reappraisal orally by themselves with the remaining images until they were proficient in performing this task.

After the experiment began, a cue was presented on the screen for two seconds, which was either“watch freely”, “cognitive reappraisal” or “expression suppression” tasks. Then a neutral or negative picture was presented on the screen for ten seconds. During this period, according to the cue, the subjects eitherwatched the picture naturally or regulated their emotions with the emotion regulation strategies that they just learned (i.e., cognitive reappraisal and expression suppression). Following this, a rating interface was presented. The subjects were requested to rate the intensity of their emotions at that moment on a scale of 1 to 7. The lowest emotional intensity was 1; while the highest was 7. The subjects were supposed to react by pressing buttons on the keyboard.The rating interface was presented for four seconds.It would not disappear after the subjects pressed the button, and it would go to the next interface automatically after four seconds if the subjects did not press any buttons. Then a cue saying “relax” was presented for four seconds, which allowed the subjects to relax for a bit. Then another experiment would continue to other blocks with the same procedure. The total duration of the experiment was 24 minutes with one break during the whole time.

Figure 1. Flowchart of the study

2.3 Statistical methods

SPSS 17.0 statistics software package was used to conduct statistical analysis. The main statistical methods included descriptive statistical methods, χ2tests,independent sample t tests, and Pearson correlation analysis. Statistical significance was set at p<0.05.

3. Results

3.1 Demographic characteristics of the participants and the clinical features of the patient group

Thirty-six depressive patients were enrolled into the present study, including 6 males and 30 females. The mean (sd) age was 27.3 (7.3) years old, and 33 (91.7%)of them had a college education or more. There were 31 healthy volunteers in the control group, including 4 males and 27 females. The mean (sd) age was 27.2(6.4), and 28 (90.3%) of them had a college education or more. There were no significant differences between two groups’ in gender (χ2=0.186, p=0.666),educational level (χ2=0.037, p=0.848) and age(t=0.102, p=0.919).

The patient group mainly consisted of newly diagnosed female patients with depression. The onset of depression was mostly during adolescence, and most of them had not received any systematic medical treatment or psychological therapy in the past. The mean (sd) score on HAMD-24 was 27.78 (5.78), and the mean (sd) score on HAMA was 19.28 (5.52).

3.2 The comparison of TAS scores between the two groups

The ratio of individuals with alexithymia in the patient group was 66.67%, while that in the control group was 3.23%. The difference between two ratios was significant (χ2=28.661, p<0.001). The total scores of TAS in the patient group were significantly higher than those in the control group (t=7.378, p<0.001). The patient group was significantly higher than the control group in scores reflecting having difficulty recognizing one’s own emotions factor (t=7.182, p<0.001),having difficulty describing one’s own emotions factor(t=6.688, p<0.001) and externally oriented thinking factor (t=3.337, p<0.001). See table 1.

3.3 Comparison of the emotion regulation experiment results between the two groups

Among the 36 subjects in the patient group, 27 of them completed the emotion regulation experiment.The rest dropped out of the experiment due to feeling uncomfortable while watching the negative pictures,the relatively long duration of the experiment and other reasons. Among the 31 subjects in the control group, 30 of them finished the experiment; while one quit due to not being able to use a computer. The data of one healthy control group member was lost due to the experimenter’s operational error. Therefore,the data for 27 subjects in the patient group and 29 subjects in the control group were collected in total.

There were no significant differences between two groups under the negative-watch, negative-reappraisal and negative-suppression conditions. But the patient group’s scores under neutral-watch condition was significantly higher than those of the control group(t=2.080, p=0.043). See Table 2.

After comparing the patient group’s scores under four conditions, it was found that the score under the negative-watch condition was significantly higher than that under neutral-watch condition (t=11.160, p<0.001),negative-reappraisal condition (t=4.652, p<0.001) and negative-suppression condition (t=3.857, p=0.001). The score under negative-reappraisal was not significantly different from that under the negative-suppression condition (p=0.279). After comparing the control group’s scores under four conditions, it was shown that the score under negative-watch was also significantly higher than that under neutral-watch condition (t=14.558, p<0.001),negative-reappraisal condition (t=5.042, p<0.001) and negative-suppression (t=4.631, p<0.001). The scores under negative-reappraisal and negative-suppression conditions were not significantly different from each other (p=0.225). See Table 3.

3.4 Correlations of the scores of HAMD-24, HAMA and TAS in the patient group

In the patient group, the TAS total score had significant positive correlations with the HAMD-24 total score (Pearson correlation coefficient (r) was 0.388, p=0.019) and the HAMA total score (Pearson correlation coefficient (r) was 0.379, p=0.023). The score measuring having difficulty recognizing own emotions factor was positively correlated with theHAMD-24 total score (Pearson correlation coefficient (r)was 0.491, p=0.002) and the HAMA total score (Pearson correlation coefficient (r) was 0.465, p=0.004) which statistically significant. See Table 4.

Table 2. Comparison of emotion regulation experiments’ scores between the patient group and the control group

Table 3. The comparison of the scores of four emotion regulation conditions between the patient group(n=27) and the control group (n=29)

3.5 Correlations of the scores of HAMD-24, HAMA,TAS and the emotion regulation experiment in the patient group

In the patient group, the scores of the emotion experiment, HAMD-24, HAMA and TAS were not correlated with each other significantly. See Table 5.

4. Discussion

4.1 Main findings

According to the results of the present study, the rate of incidence of alexithymia in the patient group was 66.7%, which was significantly higher than that of the control group (3.2%). It indicates that depressive patients are more likely to have alexithymia than the general population. Generally speaking, patients with depression showed more obvious symptoms of alexithymia, such as having difficulty recognizing and describing their own emotions, paying more attention to the details of the external world than inner experiences and so forth; and this is in accordance with the findings of previous studies.[12-13]

Previous studies indicate that the severity of alexithymia might be affected by gender, education level, the severity of depression and other factors.[14]Meanwhile, the degree of depression and the severity of somatization symptoms might also be affected by the severity of alexithymia.[15]Supporting this point of view,the present study’s result demonstrates that the TAS total score of depressive patients has a significant positive correlation with their depression and anxiety levels.

Table 4. Pearson correlations of HAMD-24, HAMA, TAS total scores and factor scores in patients with depression

Table 5. Correlations of HAMD-24, HAMA total scores, TAS total scores, factor scores and the scores of four emotion regulation experiments in patients with depression

It has been found that in the clinical and normal groups, alexithymia and its factors have relatively high stability.[16]This suggests that alexithymia might be a personality trait or a predisposing factor of depression.[6]However, other scholars propose that alexithymia is a state reaction of depression. According to Haviland and colleagues’ study, alexithymia is a kind of defense mechanism for patients.[17]In the patient group of the present study, most of the subjects were young females with mild to moderate depression, who had a relatively high education, were being diagnosed with depression for the first time and had received no psychiatric or psychological treatment. These features may have affected their degrees of alexithymia. Based on the information collected during the recruitment interviews and results of the present study, alexithymia might be a relatively stable personality trait, which is probably a predisposing factor for depression. When facing a stressful event, individuals with alexithymia employ response-focused emotion regulation instead of using antecedent-focused emotion regulation automatically, because it is common for them to have difficulty recognizing their own emotions. Responsefocused emotion regulation is regulating the results of emotions, which is suppressing emotions; so it is not an effective method of truly regulating negative emotions.Therefore, it is possible that alexithymia influences individuals’ depression levels as an emotion cognitive processing and regulation defect. However, based on the data of the emotion regulation experiment,we did not find any correlation between depressive patients’ emotion regulating ability and the severity of alexithymia. The reason for this phenomenon could be that alexithymia is correlated with the emotion regulation methods which individuals tend to employ in real life. By contrast, the subjects were asked to consciously employ specific strategies to regulate emotions according to the experimenter’s requests.This is an important ability, but it might be irrelevant to alexithymia.

The results of the emotion regulation experiment have shown that negative pictures evoked depressive patients’ negative emotions effectively, and after learning, depressive patients were able to employ cognition reappraisal and expression suppression emotion regulation strategies to regulate negative emotions successfully under guidance. The regulation effects of two strategies were not different from each other. The control group showed the same results.Some previous studies had similar findings. For example, Erk and colleagues suggest that patients with depression can reduce the intensity of negative emotions through cognition reappraisal, but emotion regulation is not consistent.[18]

After comparing two groups’ data, we found that the patient group’s scores were significantly higher than those of the control group while they were watching the neutral pictures, and this could be because depressive patients were more sensitive and their emotions were evoked more easily. But while they were watching negative pictures and rating them with cognitive reappraisal and expression suppression, there was no significant difference between the two groups.Patients with depression showed the same emotional regulation ability as the healthy controls. Findings from some previous studies are consistent with this result,while others are not. For instance, in 2010, Ehring and colleagues suggested that rehabilitated depressive patients were able to utilize a cognitive reappraisal strategy to regulate negative emotions effectively under guidance. The results of this emotional regulation strategy were similar to those seen in the general population.[19]However the results of a study by Zhang and colleagues in 2016 were different than those reported by Ehring. They found that patients with mild to moderate depression could employ cognitive reappraisal strategy under guidance, but the effect was worse than that for non-depressed subjects.During cognitive reappraising, the amplitude of LPP wave generated by patients with depression reduced,but it was still greater than that seen in non-depressed subjects.[20] In the present study, the participants’ mean score on the HAMD-24 was 27.8, which is closer to the results of Zhang and colleagues’ study. The reason for this difference could be that nine subjects in the patient group in our study dropped out due to not being able to endure negative pictures, hence only patients with better emotion regulation ability completed this experiment.

This study is different from previous research done on this topic. It explored depressive patients’ two emotional regulation abilities: cognitive reappraisal and expression suppression. Cognitive reappraisal plays a role in the early stage of emotion generation;while expression suppression affects the late stage of emotion generation.[21]It was found that depressive patients’ scores in the emotion regulation experiment were irrelevant to their levels of depression and anxiety.In the present study, patients with depression showed the same emotional regulation ability as the normal controls did, even though not all subjects completed the experiment. But it can be interpreted that some patients with depression may have maintained relatively good emotional regulation ability. With some guidance and practice, this ability can be fully utilized. Moreover, this ability may not be influenced by patients’ alexithymia or depressive symptoms. This may help explain why psychological therapies that teach depressive patients to self-regulate emotions, such a cognitive behavioral therapy, are effective.

4.2 Limitations

There are several limitations of the present study. First of all, the sample size is relatively small, and most participants in the patient group were highly-educated female patients with depression. Therefore, we need to be cautious about explaining the results of this study and generalizing the findings. Secondly, nine of the participants (i.e. 25% of the total sample) did not finish the emotional regulation experiment. It has affected the results to a certain degree.

4.3 Implications

Depression is a common mental illness. As society develops, the economic and psychological impact of depression also appears to be growing. In China,psychological therapies to treat depression are becoming more widely used. Psychological therapies can be improved by further understanding the characteristics of alexithymia and emotional regulation strategies of patients with depression. Understanding these issues can also aid patients in gaining insight the way they perceive their emotions, which can be useful in the treatment and relapse prevention of depression.

Acknowledgement

Many thanks to Professor Chuqiao Chen, Professor Yi Wang, Dr. Lanlan Wang of the Shanghai Psychological Consultation and Treatment Center, Dr. Yanle Bai, Dr.Weijun Chen, Dr. Junhan Yu, Dr. Yanru Wu, Dr. Jingjing Huang, Dr. Lan Cao, Dr. Han Chen and Head-nurse Jin Dang for providing help on the present study.

Funding

Funding provided by the Shanghai Mental Illness Medical Center cultivation project; national clinical priority project– Shanghai Mental Health Center(Department of Health Administration 2011-873):Treatment effect of mindfulness on depressive patients with comorbid borderline personality disorder and fMRI before and after treatment comparison study.

Ethical approval

The present study was approved by the Shanghai Mental Health Center ethics committee. All participants provided written informed consent to participate in this study.

Conflict of interest statement

Authors declare no conflict of interest related to this manuscript.

Authors’ contribution

Hao Zhang: scales ratings, carrying out the experiments, data analysis, article writing and revision Jianyin Qiu: study design, screening, data analysis and article revision

Lisheng Song: screening, data analysis and article revision

Qing Fan: study design and screening

Yan Sun: screening

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50多個(gè)國(guó)家和地區(qū)，4000多名世界頂級(jí)舞者，齊聚美國(guó)鳳凰城，嘉琪是年紀(jì)最小的參賽選手。當(dāng)她出現(xiàn)在比賽現(xiàn)場(chǎng)時(shí)，人群中的高手們都一臉質(zhì)疑，甚至有人直接走過(guò)來(lái)，拿手在嘉琪的腦袋前比劃了兩下，“意思是說(shuō)我很矮?！奔午鳑](méi)有生氣，也絲毫不怯場(chǎng)，在場(chǎng)外的battle（對(duì)抗）環(huán)節(jié)中，跟著音樂(lè)來(lái)了一場(chǎng)freestyle（即興發(fā)揮），結(jié)果讓本來(lái)一臉輕視的圍觀舞者，心服口服地為這個(gè)中國(guó)小學(xué)生歡迎鼓掌；等到真正比賽時(shí)，她拿著一個(gè)粉色的保溫杯就上臺(tái)了，先是向臺(tái)下深深地鞠一躬，乖巧的樣子，絲毫沒(méi)有斗舞的氣勢(shì)。

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抑郁癥患者的述情障礙特征及情緒調(diào)節(jié)研究

張灝，范青，孫巖，仇劍崟，宋立升

抑郁癥；述情障礙；情緒調(diào)節(jié)；認(rèn)知重評(píng)；表達(dá)抑制

Background:Even though patients with depression often show significant alexithymia, the underlying mechanism of their alexithymia remains unclear. Furthermore, few experimental studies have explored their ability to regulate emotions.

Objective:To explore the characteristics of alexithymia in patients with depression, and the relationship of depressive symptoms, alexithymia and emotion regulation.

Methods:A total of 36 patients with depression and 31 healthy controls were enrolled. HAMD-24 and HAMA were used to evaluate depressive and anxious symptoms. Toronto Alexithymia Scale (TAS) was employed to assess alexithymia. A computer experiment was used to evaluate emotion regulation.

Results:66.67% of the patients with depression were considered as having alexithymia, but the rate in the control group was only 3.23%. The rates showed a significant difference (χ2=28.661, p<0.001).The score of TAS was higher in patients with depression than healthy controls (t=7.378, p<0.001).In a computerized emotional regulation experiment, under watch-neutral conditions, the emotion experience ratings of patients with depression were higher than those of controls (t=2.080, p=0.043);while under watch-negative, negative-reappraisal and negative-suppression conditions, the ratings of patients with depression showed no difference from those of the controls. The scores of TAS were correlated with the HAMD-24 scores and the HAMA scores significantly in patients with depression.However, the ratings on the emotional regulation experiment had no correlation with the HAMD-24 scores, the HAMA scores or the TAS scores.

Conclusion:The incidence of alexithymia is higher in patients with depression than the general population. The depressive symptoms may have interplay with alexithymia in patients with depression.Emotion regulation ability may be an independent trait and have nothing to do with the depressive state.

[Shanghai Arch Psychiatry. 2017;29(2): 95-103.

http://dx.doi.org/10.11919/j.issn.1002-0829.216098]

Mental Health Center of Shanghai Jiao Tong University School of Medicine, Shanghai, China

*Correspondence: Jianyin Qiu, Mailing address: No.600 South Wanping Road, Shanghai, China. Postcode: 200030. E-mail: jianyin_qiu@163.com; Lisheng Song. Mailing address: 600 South Wanping Road. Postcode: 200030. E-mail: slslulu@163.com

背景：抑郁癥患者表現(xiàn)出明顯的述情障礙，而關(guān)于其述情障礙的機(jī)制尚未明確，也較少有關(guān)于抑郁癥患者情緒調(diào)節(jié)能力的研究。

目的：探索抑郁癥患者的述情障礙特征，以及抑郁癥狀、述情障礙與個(gè)體情緒調(diào)節(jié)能力的關(guān)系。

方法：采用漢密爾頓抑郁量表（HAMD-24）、漢密爾頓焦慮量表（HAMA）、多倫多述情障礙量表（TAS）和計(jì)算機(jī)情緒調(diào)節(jié)實(shí)驗(yàn)，對(duì)36名抑郁癥患者和31名健康志愿者進(jìn)行評(píng)定分析。

結(jié)果：病例組中述情障礙發(fā)生率為66.67%，對(duì)照組為3.23%，兩組比例差異有顯著性（χ2=28.661，p＜0.001）。病例組的TAS得分顯著高于對(duì)照組（t=7.378，p＜0.001）。情緒調(diào)節(jié)實(shí)驗(yàn)中，病例組觀看中性圖片的評(píng)分顯著高于對(duì)照組（t=2.080，p=0.043）；而負(fù)性-觀看、負(fù)性-重評(píng)和負(fù)性-抑制三種實(shí)驗(yàn)條件下，兩組評(píng)分無(wú)顯著差異。在病例組中，HAMD-24、HAMA與TAS得分之間存在顯著相關(guān)，而情緒調(diào)節(jié)實(shí)驗(yàn)得分與HAMD-24、HAMA、TAS之間均未發(fā)現(xiàn)相關(guān)。

結(jié)論：抑郁癥患者中述情障礙的發(fā)生率可能高于一般人群，其抑郁癥狀與述情障礙之間可能存在相互影響。情緒調(diào)節(jié)能力可能是一種獨(dú)立的特質(zhì)，與抑郁狀態(tài)無(wú)關(guān)。

Hao Zhang is currently a master’s student at Shanghai Jiao Tong University Medical School. She has been working at the Shanghai Mental Health Center since 2014. Her main research interests are depression and using mindfulness in the treatment of depression.