□ 文/本刊記者 胡睿
通過血清、唾液可快速診斷肝炎中英聯(lián)合啟動(dòng)研發(fā)獲得英國牛頓基金支持的重大項(xiàng)目
□ 文/本刊記者 胡睿
嘉賓合影,英國駐重慶總領(lǐng)事館總領(lǐng)事艾佩詩(前排左四)出席會(huì)議。
4月12日,中英聯(lián)合研發(fā)項(xiàng)目“一種肝炎診斷檢測(cè)集成試劑盒的聯(lián)合研發(fā)與產(chǎn)業(yè)化”國家重點(diǎn)研發(fā)計(jì)劃重點(diǎn)專項(xiàng)在重慶大學(xué)啟動(dòng)。出席會(huì)議的有英國駐重慶總領(lǐng)事館總領(lǐng)事艾佩詩女士,英國Biovici公司、英國斯旺西大學(xué)Owen Guy教授團(tuán)隊(duì)、英國國家物理實(shí)驗(yàn)室Olga Kazakova教授團(tuán)隊(duì),重慶大學(xué)副校長王時(shí)龍教授、重慶大學(xué)科技處副處長劉敢新教授、重慶大學(xué)光電工程學(xué)院常務(wù)副院長郭永彩教授等相關(guān)領(lǐng)導(dǎo),以及重慶大學(xué)劉玉菲教授團(tuán)隊(duì)和常州碳維納米科技有限公司等項(xiàng)目科研團(tuán)隊(duì)。作為國家重點(diǎn)研發(fā)計(jì)劃“政府間國際科技創(chuàng)新合作”重點(diǎn)專項(xiàng)—中英研究與創(chuàng)新橋計(jì)劃首個(gè)啟動(dòng)項(xiàng)目,該項(xiàng)目還得到英國牛頓基金支持。項(xiàng)目總投資約為1600萬元人民幣(約186萬英鎊)。
據(jù)了解,這個(gè)由青年千人計(jì)劃專家、重慶大學(xué)劉玉菲教授團(tuán)隊(duì)、英國Biovici公司、英國斯旺西大學(xué)Owen Guy教授團(tuán)隊(duì)、英國國家物理實(shí)驗(yàn)室Olga Kazakova教授團(tuán)隊(duì)和常州碳維納米科技有限公司等5方組成的科研團(tuán)隊(duì)聯(lián)合申請(qǐng)的項(xiàng)目,將開發(fā)用于肝炎診斷的新型即時(shí)診斷設(shè)備,為監(jiān)控血清、唾液肝炎標(biāo)志物開發(fā)一種具商業(yè)用途的快速傳感器,并探索其商業(yè)化,為病患提供幫助。該項(xiàng)目為中英研究與創(chuàng)新橋計(jì)劃中英聯(lián)合資助的15個(gè)項(xiàng)目之一。
在啟動(dòng)會(huì)上,重慶大學(xué)光電工程學(xué)院教授、該項(xiàng)目高校技術(shù)負(fù)責(zé)人劉玉菲教授介紹:“全球有近20億人感染了病毒性肝炎,其中25%遭受慢性或長期感染,每年有100萬人死于肝硬化和肝癌。以我國為例,大約有1.3億人感染乙型肝炎,4000萬人感染丙型肝炎,病患死亡率高達(dá)40%?!彼岢?,如果能實(shí)現(xiàn)早期診斷,就能有效提升患者的診療效果,預(yù)防肝炎傳染。
據(jù)介紹,五方聯(lián)合開發(fā)的肝炎診斷檢測(cè)集成試劑盒,其技術(shù)核心是在一種微流控芯片與特異性檢測(cè)上?!案鶕?jù)我們的初步設(shè)計(jì),微流控芯片上劃分有甲肝、乙肝、丙肝3個(gè)檢測(cè)區(qū),每個(gè)檢測(cè)區(qū)有多個(gè)檢測(cè)單元。”劉玉菲舉例說,比如在乙肝檢測(cè)區(qū),如果3個(gè)檢測(cè)單元都呈陽性或陰性,這是很好得出診斷結(jié)果的,如果呈現(xiàn)一個(gè)或兩個(gè)陽性,那經(jīng)過進(jìn)一步數(shù)據(jù)分析,再得出診斷結(jié)果。這也避免了假陽性或陰性的情況,讓肝炎診斷更加精準(zhǔn)。微流控芯片上有幾十甚至上百個(gè)微流控通道,集成了許多石墨烯傳感器,當(dāng)血液或唾液樣本進(jìn)入微流控芯片后,在運(yùn)輸、混合、篩選之后,石墨烯傳感器就能快速找到血清或唾液肝炎標(biāo)志物,分析診斷出樣本是否受到肝炎感染。
簡單來說,只需要檢測(cè)患者的一滴血清或唾液,便能使用這項(xiàng)科研產(chǎn)品在幾分鐘的時(shí)間內(nèi)快速診斷出是否感染肝炎,“該類產(chǎn)品的年市場(chǎng)需求超過4.25億英鎊,研發(fā)的產(chǎn)品預(yù)計(jì)2019年推向市場(chǎng)。”劉玉菲表示。
此次合作的五方將分別負(fù)責(zé)石墨烯材料制備、材料表征與測(cè)試、傳感器加工與集成、石墨烯表面修飾、檢測(cè)電路與分裝,并準(zhǔn)備在華設(shè)立合資公司,共同推動(dòng)石墨烯材料及試劑盒產(chǎn)品的全球銷售。另外,在項(xiàng)目啟動(dòng)會(huì)上,重慶大學(xué)、英國斯旺西大學(xué)、英國國家物理實(shí)驗(yàn)室聯(lián)合設(shè)立的“智能感知技術(shù)協(xié)同創(chuàng)新中心”也正式揭牌,未來,三方將在人工智能、智能傳感、腦科學(xué)與神經(jīng)科學(xué)等領(lǐng)域展開全方位的合作與探索。
(圖片由重慶大學(xué)光電工程學(xué)院教授劉玉菲提供)
On April 12, a key project of national key R&D plan—“Joint R&D and industrialization of an integrated kit for hepatitis diagnosis and detection”—which is operated by China and UK, was launched in Chongqing University. Participants included Ms. Cecille El Beleidi,Consul General of British Consulate-General in Chongqing, Biovici Company in British, Professor Owen Guy and his teams from Swansea University, Professor Olga Kazakova and his teams from National Physics Laboratory, Professor Wang Shilong,vice-principal of Chongqing University, Professor Liu Ganxin,deputy director general of department of science and technology,Chongqing University, Professor Liu Yufei and his teams from Chongqing University and Changzhou Tanwei Nanometer Science and Technology Co., Ltd. As a major project of national key R&D plan in the “Intergovernmental cooperation in international scienti fi c and technological innovation”, the fi rst startup project of China-UK Research and Innovation Bridge Program, this project also has gained the support of British Newton Fund. The total investment of the project is about ¥16 million RMB (£1.86 million).
It is understood that this project was jointly applied by fi ve research groups: Professor Liu Yufei, expert of the Recruitment Program of Global Experts, and his teams; Biovici Company; Professor Owen Guy and his teams from Swansea University; Professor Olga Kazakova and his teams from National Physics Laboratory;Chongqing University and Changzhou Tanwei Nanometer Science and Technology Co., Ltd. This research group will develop a new diagnostic device for hepatitis diagnosis and develop a fast sensor for commercial use to monitor serum, saliva and hepatitis markers. After putting this sensor into market, patients can bene fi t from it. This project also represents one of the fifteen projects jointly supported by China and UK in the China-UK Research and Innovation Bridge Program.
Professor Liu Yuqing: Hepatitis can be quickly diagnosed by serum and saliva
As the university technical leader and the professor of school of optical engineering in Chongqing University, Liu Yufei made an introduction on the launching ceremony. He said nearly 2 billion people worldwide are infected with viral hepatitis, among which 25% infected person are subjected to chronic infection. Every year, one million people die from cirrhosis and liver cancer. Taking China as an example, about 130 million people are infected with hepatitis B, 40 million are infected with hepatitis C, and the death rate is as high as 40%. Liu also provided that the diagnosis and treatment effect of infected person can be effectively improved by the realization of early diagnosis to prevent hepatitis infection.
According to the presentation, the technical core of this integrated kit for the purpose of hepatitis diagnosis developed jointly by fi ve parties lies on micro fl uidic chip and its speci fi c detection. According to our preliminary design, there are 3 detection areas of hepatitis A, hepatitis B and hepatitis C on the microfluidic chip and each detection area has a plurality of detection units, explained by Liu. For example, in the area of hepatitis C, if the 3 test units are positive or negative, this will be easy for the diagnosis; if one or two are positive, further data analysis should be done to obtain the diagnosis. It also avoids false positives or negative cases,making hepatitis diagnosis more accurate. Microfluidic chips are equipped with dozens of, or even hundreds of microfluidic channels, integrated with many graphene sensors. When the blood or saliva samples come into the microfluidic chip, after mixing,transportation, filtering, graphene sensors will be able to quickly fi nd the saliva or serum markers of hepatitis to analyze whether the sample is infected with hepatitis or not.
Research products are expected to be available in 2019
In simple terms, with only one drop of serum or saliva from the patient, the research product can be used to quickly diagnose hepatitis infection in a few minutes. The market demand of this kind of products exceeds 425 million pounds, and the products are expected to be put into the market in 2019, said by Professor Liu.Five parties in this cooperation are responsible for the preparation of graphene material, material characterization and testing, sensor processing and integration, the surface modi fi cation of graphene,and detection circuit and packaging respectively. They also prepared to set up joint venture in China to jointly promote the global sales of graphene materials and reagent kits. In addition,“Collaborative Innovation Center of Intelligent Sensing Technology”jointly established by Chongqing University, Swansea University,National Physics Laboratory also was of fi cially inaugurated. In the future, those three parties will carry out all-round cooperation and exploration in the areas of arti fi cial intelligence, intelligent sensing,brain science and neuroscience.
A Major Project Supported by British Newton Fund Was Launched by Both China and UK in Chongqing:Hepatitis can be quickly diagnosed by serum and saliva
□ Article / journalist Hu Rui