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    Health-related quality of life in living liver donors after transplantation

    2011-07-05 12:59:36PeiXianChenandLuNanYan

    Pei-Xian Chen and Lu-Nan Yan

    Chengdu, China

    Review Article

    Health-related quality of life in living liver donors after transplantation

    Pei-Xian Chen and Lu-Nan Yan

    Chengdu, China

    BACKGROUND:Living donor liver transplantation (LDLT) has recently emerged as an effective therapeutic alternative for patients with end-stage liver disease. In the meantime, the health-related quality of life (HRQoL) of the donors is becoming better appreciated. Here we aimed to review the current literature and summarize the effects of liver donation on the long-term HRQoL of living donors.

    DATA SOURCES:A literature search of PubMed using "donors", "living donor liver transplantation", "health-related quality of life", and "donation" was performed, and all the information was collected.

    RESULTS:The varied postoperative outcomes of liver donors are attributive to the different evaluation instruments used. On the whole, donors experienced good long-term physical and mental well-being with a few complaining of compromised quality of life due to mild symptoms or psychiatric problems. The psychosocial dimension has received increasing attention with the vocational, interpersonal and financial impact of liver donation on donors mostly studied.

    CONCLUSIONS:Generally, donors have a good HRQoL after LDLT. Nevertheless, to achieve an ideal donor outcome, further work is necessary to minimize the negative effects as well as to incorporate recent progress in regenerative medicine.

    (Hepatobiliary Pancreat Dis Int 2011; 10: 356-361)

    living donor; liver transplantation; donation; health-related quality of life

    Introduction

    Due to the disequilibrium between organ shortage and the mounting demand, living donor liver transplantation (LDLT) has emerged as a lifesaving alternative for those with end-stage liver disease[1]and has been given the green light in many countries throughout the world. An estimated number of over 12 000 LDLTs have been performed worldwide.[2]While the major focus has been directed towards the health-related quality of life (HRQoL) of the recipients, concerns over that of the donors are increasingly being voiced. According to some studies, up to 67% of donors suffer postoperative complications[3-7]with an overall reported mortality of 0.2% and a median morbidity of 16%.[8]In Japan, 8.4% of those who had donated grafts by the end of 2006 developed donation-related complications.[9]After donation, some donors may have to confront potentially life-threatening morbidity or even death, some may struggle with psychiatric problems or chronic symptoms for a long time after operation, while others feel fine and are willing to donate again. A nine-center adult-to-adult LDLT cohort study (A2ALL) disclosed that 62% of donors did not experience complications while 2% had life-threatening complications and 0.8% had lethal ones.[10]To some extent, such outcome variance implies that LDLT plays a role in alteration of the HRQoL of living donors after partial hepatectomy. HRQoL is a multi-faceted construct reflecting the overall physical, psychiatric and psychosocial well-being of a person.[11-15]Thus we reviewed the current literature and summarized the effect of LDLT on the physical, mental and psychosocial health of donors in the long run.

    HRQoL

    Physical health

    Considering the magnitude of LDLT surgery itself and the associated risks, some donors are likely to develop postoperative complications and persistent symptomslong after donation. Ran et al[16]reported that 14 out of 105 living donors had postoperative complications, with 11 undergoing invasive treatment or re-operation. Among these medical complications, biliary events appear to be pronounced. According to Adcock et al,[17]bile leak occurred in 3% of 202 donors surveyed. Moreover, a multicenter study[5]showed that 82 donors had biliary complications including cholestasis (7.3%), bile leakage (6.1%) and bile duct stricture (1.1%). Although most donors finally recover, some might unfortunately suffer from persistent symptoms possibly caused by surgical complications or the surgery itself. Ongoing symptoms such as abdominal discomfort, fatigue, chronic pain and scar itching,[18-21]albeit mild, might undermine donors' daily life. Irrespective of medical complications, most living liver donors remain in good physical condition postoperatively, if not as well as they were prior to surgery.[22-24]

    Mental health

    Regarding psychological health post-donation, psychiatric complications receive particular attention. Fukunishi et al[21]demonstrated that three cases without a psychiatric history exhibited paradoxical psychiatric syndrome post-donation. Trotter et al[3]also reported that 4.1% of 392 liver donors had one or multiple psychiatric complications. Other psychological problems such as low self-esteem,[25,26]enhanced stress and decreased confidence were also reported. These data remind us that the mental health of donors should not be neglected in long-term follow-up, which facilitates detecting and solving occult psychiatric problems before they get worse. However, only a small number of centers recognize the importance of prolonged post-donation monitoring and keep track of donor complications over time.[27]Equally as important as prolonged donor monitoring after operation, a well-designed pre-donation workup helps to identify those prone to compromised mental health after donation. Chan et al[28]published a workup scheme for donors undergoing urgent liver transplantation, which was shown to expedite initial evaluation, assure donor safety and allow timely operation. Regardless of psychiatric events, many donors claim that they have benefited from the process,[18-20]and even a great part of them are willing to donate again.[18,24,29-32]On the whole, living liver donors obtain improved mental well-being in the long-term follow-up period.[23,25,31,33]

    Psychosocial health

    The psychosocial aspect of the HRQoL of liver donors after operation is increasingly being recognized in addition to the physical and mental aspects, as recent evidence showed that some living liver donors experience psychosocial stress after donation.[34]Here, we concentrated on the interpersonal, vocational and financial impact.

    Interpersonal impact

    In LDLT, the relationship between the donor and the recipient is ethically mandated to be biological or legitimate in most countries. Therefore LDLT has a bearing on the intimacy between the donors and the recipients or between the donors and their families. Fortunately, a majority of donors reported an improved or stable relationship compared with the preoperative situation.[18,19,25,31,35]In contrast, those who feel coerced preoperatively either by medical teams, families, recipients or themselves might end up with unfavorable interpersonal outcomes. They may complain of suffering more than anticipated or having a worse relationship with the recipients and their families due to interference by voluntarism during the decision-making process. Fujita et al[36]established a five-stage decision-making model to help professionals to understand the donors' feelings and offer sufficient support. In this way, donors are more likely to face up to negative outcomes that might be generated.

    Vocational impact

    Due to the operation and postoperative recuperation, donor performance in school or workplace is inevitably affected. Some donors are able to return to pre-donation employment, and some may have to turn to lightduty jobs or are laid-off due to compromised physical and mental status, while others may have to resume working probably due to financial burdens. Although impaired ability may render donors unfit for their predonation occupation, Holtzman et al[37]showed that 96% of donors received encouragement from school or workplace for their decision, which implies that the donation experience promotes the donors' identity in their workplace or school and their intimacy with coworkers (Table 1).

    Financial impact

    LDLT is slightly more costly than cadaveric transplantation, presumably due to the higher incidence of complications with LDLT.[24,41]Though donationrelated expenses are covered by the recipients' insurance and inpatient costs are covered by a universal healthcare system, donors still have to pay most of the outpatient costs. In addition, it was pointed out that employers and insurance companies are reluctant to pay the incomethat employees lose due to donation.[42]As a result, the costs of transportation, loss of work hours, medications, babysitters and phone calls are usually not reimbursed. In this case, donors, especially those in poor economic condition or without insurance, might end up living on a budget or finding it hard to make ends meet (Table 2).

    Evaluation tools

    Multiple studies have examined the physical, mental and psychosocial HRQoL in living liver donors using a wide variety of surveys, which are generally categorized into generic and disease-specific measurements (Table 3). One of the advantages of applying generic instrumentssuch as 36-item short-form survery (SF-36) is that they make comparison among different diseases possible and monitor overall health conditions. In contrast, disease-specific instruments such as the chronic liver disease questionnaire can identify disease-specific changes that might be overlooked by generic tools.[48]Jay et al[49]concluded that the development of targeted instruments improves HRQoL assessment in recipients and helps identify factors that influence their wellbeing. Therefore, we need an integrated instrument or an appropriate combination of both generic and liver transplant-specific characteristics to improve the accuracy of long-term evaluation of donor HRQoL.

    Table 1. Post-donation employment among living liver donors

    Table 2. Financial problems experienced by living liver donors after donation

    Conclusion and perspectives

    In conclusion, living liver donors generally experience good physical and mental quality of life after transplantation, whereas quite a number suffer from financial burdens, unfavorable changes in employment, or interpersonal relationship changes with regard to psychosocial aspects. In a bid to achieve satisfactory outcomes in HRQoL at both the physical and psychosocial levels, steps should be taken to advocate standard follow-up protocols in every liver transplantation center, better guaranteeing the process of informed consent and promoting multidisciplinary cooperation.

    Only with a multidisciplinary perioperative modality can an LDLT be accomplished in favor of both the donor and the recipient.[50]It is imperative for health care professionals to cooperate throughout liver transplantation from donor selection to postoperative follow-up. Preoperatively, radiologists, hepatologists and psychiatrists need to work together to assess the suitability of potential donors and the selection of those eligible as well as providing support and assistance in thedecision-making process, which occasionally involves social workers familiar with liver transplantation. During the operation and the period immediately after operation, cooperation between surgeons, anesthetists and nurses is indispensable throughout the surgery and monitoring. Long after the operation, support may be needed from local governments, philanthropic organizations and even the media to help disadvantaged donors and families to overcome financial difficulties, and resume a normal life as before donation.

    Table 3. Collected series: long-term quality of life assessment in living liver donors

    Finally, although great efforts have been made to overcome the liver source challenge by expanding the donor pool,[51,52]in order to cure terminally ill people and sustain intact the well-being of a healthy individual, we should take advantage of the emerging techniques of regenerative medicine to produce livers in vitro to optimize organ sources.

    Funding:None.

    Ethical approval:Not needed.

    Contributors:CPX wrote the main body of the article under the supervision of YLN. YLN provided advice on medical aspects. YLN is the guarantor.

    Competing interest:No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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    Received November 26, 2010

    Accepted after revision April 14, 2011

    Author Affiliations: Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, China (Chen PX and Yan LN)

    Lu-Nan Yan, MD, PhD, Division of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, China (Tel: 86-28-81812453; Fax: 86-28-85423724; Email: yanlunan688@ 163.com)

    ? 2011, Hepatobiliary Pancreat Dis Int. All rights reserved.

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