Mesh erosion into the colon following repair of parastomal hernia: A case report

Yu Zhang,Han Lin,Jia-Ming Liu,Xin Wang,Yi-Feng Cui,Zhao-Yang Lu

Yu Zhang,Han Lin,Jia-Ming Liu,Xin Wang,Yi-Feng Cui,Zhao-Yang Lu,Department of General Surgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China

Abstract BACKGROUND In recent years,mesh has become a standard repair method for parastomal hernia surgery due to its low recurrence rate and low postoperative pain.However,using mesh to repair parastomal hernias also carries potential dangers.One of these dangers is mesh erosion,a rare but serious complication following hernia surgery,particularly parastomal hernia surgery,and has attracted the attention of surgeons in recent years.CASE SUMMARY Herein,we report the case of a 67-year-old woman with mesh erosion after parastomal hernia surgery.The patient,who underwent parastomal hernia repair surgery 3 years prior,presented to the surgery clinic with a complaint of chronic abdominal pain upon resuming defecation through the anus.Three months later,a portion of the mesh was excreted from the patient’s anus and was removed by a doctor.Imaging revealed that the patient’s colon had formed a t-branch tube structure,which was formed by the mesh erosion.The surgery reconstructed the structure of the colon and eliminated potential bowel perforation.CONCLUSION Surgeons should consider mesh erosion since it has an insidious development and is difficult to diagnose at the early stage.

Key Words: Mesh erosion;Mesh migration;Parastomal hernia;Intestinal fistula;Intestinal internal fistula;Case report

lNTRODUCTlON

Although the incidence of parastomal hernias remains unknown,it is predicted to be ＞ 30% at 1 year,＞ 40% at 2 years,and ≥ 50% after many years thereafter[1].Suture repair is undoubtedly the simplest method for parastomal hernia repair,but its recurrence rate has been reported to be higher than that of mesh repair[2].Hence,mesh repair remains the mainstream method for treating parastomal hernias.Mesh repair can reduce the recurrence rate but may cause potential mesh-related complications.Currently,there is a lack of comparative evidence between the different mesh types for parastomal hernia repair.However,synthetic uncoated mesh types are generally not considered for intraperitoneal use because of the risk of adhesion,intestinal erosion,and stenosis[1].

Here,we present the case of a patient who underwent parastomal hernia repair with intraperitoneal onlay mesh repair mesh and developed a rare complication 3 years after the procedure.We reviewed 137 cases in 132 case reports of mesh erosion from 1973 to 2022 by searching the keywords,“Mesh Erosion” and “Mesh migration” in PubMed.

CASE PRESENTATlON

Chief complaints

In January 2021,a 67-year-old female who had undergone parastomal hernia repair surgery 3 years prior began experiencing chronic abdominal pain upon resuming defecation through the anus.

History of present illness

In January 2021,she underwent abdominal computed tomography (CT) for initial workup,which revealed a foreign material located in the distal colon (Figure 1A).Three months later,in April 2021,a portion of the foreign material was excreted from the patient’s anus.The patient consulted our center in an emergency and underwent CT examination again (Figure 1B).The foreign material was removed by a doctor who confirmed the foreign material as the mesh used in a parastomal hernia (Figure 1C and D).

Figure 1 The computed tomography images and the mesh.

History of past illness

The patient underwent anus-preserving radical resection (Dixon operation) for rectal cancer in November 2010.The pathological diagnosis revealed rectal villous tubular adenocarcinoma with negative margins and no lymph node metastasis.Four months later,she was admitted to the hospital because of difficulty with defecation and was diagnosed with postoperative anastomotic stenosis.The stenosis was removed using a colonoscope.Recurrent defecation difficulties for 3 years led to an emergency colostomy for intestinal obstruction.According to the surgical records,the distal colon was removed and closed from the peritoneal reflection.In January 2018,the patient was admitted to our center and underwent parastomal hernia mesh repair (keyhole,Shanshi,China) for an emerging parastomal hernia.

Personal and family history

The patient underwent anus-preserving radical resection (Dixon operation) for rectal cancer in November 2010.

Physical examination

A portion of the foreign material was excreted from the patient’s anus.The foreign material was removed by a doctor who confirmed the foreign material as the mesh used in a parastomal hernia.

Laboratory examinations

Laboratory tests were unremarkable.

Imaging examinations

We performed gastrointestinal contrast,where a contrast agent was injected through the stoma revealing a t-branch tube structure in the enterocoelia (Figure 2).Transanal colonoscopy was performed and revealed stenosis blocking the passage of the colonoscope.Severe inflammation triggered by the mesh of the parastomal hernia was observed.Due to severe stenosis at the anastomosis,the t-branch tube structure could not be seen in this direction (Figure 3).

FlNAL DlAGNOSlS

Mesh erosion into the colon secondary to bowel perforation.

TREATMENT

The patient was considered to have a potential intraperitoneal enteral leakage and consented to the elective operation.Midline abdominal incision was created,and the t-branch tube structure formed from the colon near the stoma,proximal and distal colons,and the lateral wall of the small intestine (Figure 4).The t-branch tube and unduly long colon was excised,and the original stoma was closed.A colostomy was reconstructed on the right side of the abdominal wall.

Figure 2 The contrast agent was injected through the drainage tube placed through the stoma.

Figure 4 The structure of the t-branch tube.

OUTCOME AND FOLLOW-UP

Pathological examination revealed granulomatous inflammation without tumor recurrence.The patient was discharged 10 d after the surgery.The patient showed no discomfort after discharge and continued receiving follow-up care on an outpatient basis.

DlSCUSSlON

According to the European Hernia Society guidelines on the prevention and treatment of parastomal hernias,the incidence of parastomal hernia is more than 30% 1 year after fistulization,more than 40% after 2 years,and can reach 50% or even higher over time[1].In China,the number of patients undergoing abdominal surgery has increased,and the number of patients with parastomal hernias has gradually increased[2].Due to the higher risk of recurrence after suture repair,mesh repair is still the best way to repair a parastomal hernia[1].Common complications of a parastomal hernia repair include seroma,intestinal injury,intraoperative and postoperative bleeding,bowel perforation,hernia recurrence,intestinal obstruction,mesh contamination or infection,and chronic pain.

Mesh erosion is commonly considered a rare complication[3].According to Jeanset al[4],the incidence of mesh erosion after inguinal hernia repair is less than 1%[4].However,Hamoudaet al[5] suggested that this percentage is significantly underestimated[5,6].Targaronaet al[7] reported that the incidence of graft erosion after hiatal hernia surgery was approximately 2.3%[7].Unlike hiatal hernia,diaphragm movement is the primary cause of mesh migration and erosion[8].Therefore,we hypothesized that the incidence of mesh erosion after parastomal hernia surgery would be lower than that after hiatal hernia surgery.

In our literature review,there was only one report of mesh erosion after parastomal hernia surgery[9].There were only a few cases of parastomal hernia and a low incidence of mesh erosion occurring after various hernia surgeries.Particularly,mesh erosions after parastomal hernia surgeries are even more scarce.In addition,the initial symptoms are usually hematochezia,intestinal obstruction,or other digestive system symptoms.Therefore,patients often seek treatment from gastroenterology or gastrointestinal surgery causing underreporting of mesh erosion.Moreover,the primary disease leading to a stoma can shorten the lifespan of patients,which may explain why parastomal hernias are uncommon.

We used “Mesh Erosion” and “Mesh migration” as the keywords to search in PubMed.The reference lists from the extracted studies were manually reviewed to identify additional potentially eligible studies.A total of 132 reports describing 137 cases of mesh erosion from 1973 to 2022 were reviewed (Table 1).All abdominal hernia types except hiatal hernia were included.Erosion caused by mesh placement due to pelvic floor prolapse and other diseases was excluded.The selected studies included 96 cases of mesh erosion of digestive organs,42 cases of urinary system erosion (including 8 cases of both digestive system and urinary system erosion),and 7 cases of other systems (including 1 case of the inguinal region,1 case of the testis,3 cases of migration of only non-eroded organs,1 case of a uterine adnexa,and 1 case of the heart).

Table 1 General information of the patients included in the review

Agrawal and Avill[10] believed that there are two main methods of mesh migration[10].The first is the mesh migration along the path of least resistance caused by inadequate fixation or external forces.The second is the slow and gradual migration across the anatomical plane.The mesh may be displaced initially and then eroded into adjacent tissues,which is the erosion and migration of the mesh caused by a foreign body reaction[10].Local tissue destruction from the inflammatory response,granulation tissue proliferation,and repetition of these two processes results in mesh erosion of the intestine.This process can take several years to occur.

Pathology and colonoscopy in the case reports of Millaset al[11],Celiket al[12],and Riazet al[13] confirmed granulomatous inflammation at the lesion site,which proves the existence of this process and is consistent with the present case.According to Losanoffet al[14] and Hamoudaet al[5],mesh erosion after inguinal hernia surgery is caused by direct contact between the rough mesh surface and organs such as the intestine.The parastomal hernia mesh includes a polyvinylidene difluoride and polyester layer and biological mesh.It is a basic requirement for a parastomal hernia mesh to contact the intestine;therefore,the effect of mesh material on intestinal erosion is irrelevant.

Riazet al[13] suggested that trimming the sharpened edges of the mesh could prevent damage to the surface of the organs and prevent an inflammatory response that could lead to weakness and mesh erosion[13].We agree with their opinion that an appropriate mesh should be selected to reduce the necessary trimming.Particularly in cases of parastomal hernia,the central pore should be trimmed to minimize mechanical damage caused by friction between the mesh and intestine.

Goswamiet al[15] reported a case of cecal erosion after transabdominal preperitoneal for a right inguinal hernia in a patient with a history of appendectomy before transabdominal preperitoneal[15].Goswamiet al[15] indicated that the adhesion caused by the patient’s previous appendectomy predisposed the patient to further adhesion between the mesh and organ,which eventually promoted mesh erosion.Abdominal adhesions caused by previous surgeries cause the intestine to lose its ability to avoid injury.Moreover,repeated friction between the fixed intestine and the foreign body causes local tissue damage,leading to mesh erosion.Patients with parastomal hernias have had at least one or several previous operations.For a parastomal hernia,more attention should be paid to adhesions caused by previous operations on mesh erosion.

According to Yang[16],titanium tackers used to fix mesh are more likely to adhere to the intestine,which Hollinskyet al[17] confirmed through animal experiments.In our experience,titanium tackers also cause serious adhesions.Persistent inflammation may increase the risk of postoperative hernia mesh erosion and migration[11].Parastomal hernias involve stomas;therefore,the surgical field is not as sterile as other hernia procedures,potentially leading to mesh erosion.Benedettet al[18] recommended that chemotherapy could lead to intestinal perforation and a difficult postoperative period[18].Patients with parastomal hernia commonly have intestinal tumors,and the state of immunological prostration induced by chemotherapy should not be disregarded.

In our case,another cause that should not be overlooked is the potential iatrogenic causes.The surgeon who performed the stoma may have intended to perform secondary intestinal anastomosis;therefore,the distal colon of the closed loop was over reserved.Preoperative examination before the parastomal hernia repair did not reveal the status of a closed loop intestine.Irregular operation and incomplete preliminary examination before parastomal hernia repair are also important reasons for tbranch tube formation.

It is difficult to diagnose mesh erosion because of the level of damage needed for a patient to feel symptoms,which can vary and take many years to develop.In our review,we observed 96 bowel mesh erosion cases (Table 2).The symptoms of mesh erosion include chronic abdominal pain,vomiting,digestive tract hemorrhage,bowel perforation,and intestinal obstruction.In patients who may have one or more of these symptoms,a negative fecal occult blood test may occur[12].Determining mesh status using radiography is also difficult[19].Among the 96 cases reviewed,the diagnosis was established during surgery in 74 cases,on the first endoscopy in 10 cases,on at least the second endoscopy in 7 cases,and by other means such as CT in 7 cases.A convenient and inexpensive objective assessment of mesh behavior after mesh placement is difficult because there are no routinely available mesh products with unique radiographic labels[20].

Table 2 Diagnostic methods of mesh erosion of the intestinal tract in literature review

Our literature review concluded that radiography,CT,and gastrointestinal angiography could only diagnose intestinal obstruction and leakage,although identifying the actual cause was still difficult.Doppler ultrasound is only performed after clinical judgment of a doctor to determine the mesh location.In our case,because the metal tackers moved into the intestine with the mesh,the CT scan alone could diagnose mesh erosion in the intestine.Early colonoscopy can only detect inflammation,intestinal polyps,or diverticulum;therefore,it may be wrongly interpreted and misdiagnosed as a malignant tumor[21-23].The actual cause can only be determined when patients undergo more than one colonoscopy or abdominal exploration after experiencing severe symptoms.The early diagnosis of mesh erosion is complex,and the history of hernia repair should not be ignored when a patient presents with abdominal symptoms.

In our literature review,only 9 patients did not receive surgical treatment,and the remaining patients with mesh erosions received surgical treatment.In the 9 cases opting for non-surgical treatment,some authors believed that surgery should still be performed[24-26].Previous studies discussed that patients usually refuse surgical treatment at the onset of their symptoms but finally receive surgical treatment once they worsen[27,28].Therefore,mesh erosion after parastomal hernia surgery should be actively treated.Due to the small number of cases,it was inconclusive if the mesh of a parastomal hernia erosion or the bowel loops should be removed and the stoma rebuilt.We believe that mesh erosion,especially penetration into the intestine,necessitates the removal of some or all of the mesh into the intestinal loops.The segment of the intestinal loop should be resected,and the stoma rebuilt.Owing to repeated operations at the original stoma,local skin scars cause difficulties in care of the stoma.Re-stoma reduces the possibility of postoperative intestinal leakage and improves the future nursing of patients.

CONCLUSlON

Mesh erosion is a rare complication,but its real incidence may be higher than the reported incidence.Previous studies have speculated on the etiology,many of which are more prominent in patients with parastomal hernia after surgery.Mesh erosion has no typical clinical manifestations,imaging,and endoscopy characteristics.With its insidious behavior,mesh erosion is difficult to diagnose at an early stage.Surgeons should be aware of the surgical history of hernia repair especially when the patient with mesh presents with abdominal symptoms.

FOOTNOTES

Author contributions:Zhang Y contributed to the conceptualization and methodology,wrote the original draft,reviewed,and edited;Lin H contributed to the conceptualization and methodology and collated the patient’s data;Liu JM and Wang X collated the patient’s data,reviewed,and edited;Cui YF reviewed,edited,and contributed to supervision;Lu ZY contributed to conceptualization,methodology,and supervision;All authors have read and approved the final manuscript.

lnformed consent statement:All study participants,or their legal guardian,provided informed written consent prior to study enrollment.

Conflict-of-interest statement:All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement:The authors have read CARE Checklist (2016),and the manuscript was prepared and revised according to CARE Checklist (2016).

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is noncommercial.See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:China

ORClD number:Yu Zhang 0000-0001-9004-8080;Han Lin 0000-0003-1507-3977;Jia-Ming Liu 0000-0003-1186-8932;Xin Wang 0000-0001-5441-2607;Yi-Feng Cui 0000-0003-4588-2521;Zhao-Yang Lu 0000-0003-2589-5560.

S-Editor:Li L

L-Editor:Filipodia

P-Editor:Li L