• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for the treatment of undifferentiated embryonal sarcoma of the liver in children

    2022-12-19 08:06:58MinHeJiaBinCaiCanLaiJunQingMaoJieNiXiongZhongHaiGuanLinJieLiQiangShuMeiDanYingJinHuWang
    World Journal of Clinical Cases 2022年19期
    關(guān)鍵詞:島津離子化質(zhì)譜儀

    Min He, Jia-Bin Cai, Can Lai,Jun-Qing Mao, Jie-Ni Xiong, Zhong-Hai Guan, Lin-Jie Li, Qiang Shu Mei-Dan Ying,Jin-Hu Wang

    Abstract

    Key Words: Undifferentiated embryonal sarcoma of the liver; Unresectable; Neoadjuvant therapy; Transcatheter arterial chemoembolization; Systemic chemotherapy

    lNTRODUCTlON

    Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive mesenchymal tumor that occurs mainly between the ages of 6 and 10 years, without gender predominance[1]. The prognosis of UESL has previously been considered poor[2]. Modern multimodal treatment and supportive therapy have improved survival[3]. Complete tumor excision plays the central role in the treatment of UESL[4]. Transcatheter arterial chemoembolization (TACE) is an effective therapeutic method and has been widely used in the treatment of patients with hepatic malignancy[5,6]. In an attempt to increase resection rate and improve the outcome of UESL, we performed preoperative TACE combined with systematic chemotherapy for the treatment of unresectable UESL in children and evaluated its feasibility and effectiveness.

    MATERlALS AND METHODS

    Patient characteristics

    All the procedures in this study conformed to the ethical requirements of the Ethics Committee of the Children’s Hospital, Zhejiang University School of Medicine and have been approved. The children’s families provided signed informed consent. Six patients with UESL received neoadjuvant therapy (NAT) at our hospital between January 2004 and December 2019. The patients were 4 boys and 2 girls with a mean age of 7 years (range, 3-11 years). The symptoms at admission included abdominal pain, abdominal mass and jaundice. The longest tumor ranged from 8.6 to 14.8 cm (mean, 12 cm). One patient presented with pulmonary metastasis and another with retroperitoneal lymph node metastases. The details of the six patients are summarized in Table 1.

    NAT

    Pathological diagnosis was obtained by percutaneous needle biopsy before treatment in all patients. NAT included preoperative TACE and systemic chemotherapy. TACE was performed under general and sacral block anesthesia. With continuous monitoring, including electrocardiography, blood pressure and oxygen saturation measurements, the femoral artery was catheterized using the Seldinger technique. A 5-F Pigtail catheter was introduced into the abdominal aorta to perform aortography and define the main feeding artery of the tumor, and then a 4-F or 5-F Cobra catheter was advanced toward the tumor-feeding arteries for chemoembolization. The chemoembolic emulsion consisted of pirarubicin 40 mg/m2, vindesine 3 mg/m2, cisplatin 90 mg/m2and iodized oil 0.5 mLpermaximum tumor diameter (cm), which has been proved to have good efficacy and safety in the treatment of UESL and other tumors in our center[5,7]. The drugs were mixed and diluted in 120-180 mL of normal saline, and infused into the feeding artery at a rate of 120 mL/h. After perfusion, the outline of the entire tumor was revealed (Figure 1).

    Intravenous chemotherapy was administered 3 wk after TACE if the blood parameters were at normal levels. The chemotherapy regimen consisted of vindesine 3 mg/m2on day 1, carboplatin 150 mg/m2and pirarubicin 20 mg/m2on days 2 and 3. Vindesine was injected every 7 d.

    Tumor response was evaluated by enhanced computed tomography (CT) scan or magnetic resonance imaging after every cycle of NAT according to the revised Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1[8]. Surgical resection was carried out after one or two cycles depending on the patient’s response. Postoperative intravenous chemotherapy was given every 3 wk, and the drugs administered were those listed above.

    Toxicity evaluation

    Toxicity was evaluated after each session of NAT. Cardiac function was monitored by echocardiography and ECG; renal function by serum electrolytes, urea, creatinine, and creatinine clearance; and liver function by aspartate aminotransferase and alanine aminotransferase (ALT). Complete blood cell count was repeated weekly to assess bone marrow suppression.

    Follow-up

    All patients were followed every 2 mo during the first year after comprehensive treatment, every 3 mo during the second and third years, every 6 mo during the fourth and fifth years and annually after 5 years. Follow-up examinations included physical check-up, imaging (abdominal ultrasound and CT, chest X-ray or CT), and laboratory testing (blood and urine analysis, and liver and renal function tests).

    RESULTS

    TACE was successfully performed in all patients. The tumor volumes decreased by 18.2%-68.7%, with a mean decrease of 36% after 1 cycle of NAT (t= 3.524,P= 0.017). According to the RECIST criteria, 4 patients had a partial response (PR) and underwent surgery, while 2 had stable disease (SD) and received another cycle of NAT before surgery. Retroperitoneal lymph node metastasis and pulmonary metastasis observed in one patient, respectively, were slightly reduced after TACE, and no regrow or other lesions appeared before surgery. Total tumor resection was performed in all patients without positive surgical margins and major postoperative complications. Retroperitoneal lymph node dissection was performed in the patient with lymph node metastasis. The patient with lung metastasis was not treated surgically as the lesions were no longer obvious after chemotherapy. Massive tumor necrosis was seen on pathological examination of the surgical specimen: > 90% necrosis in 2, > 50% necrosis in 3, and 25% necrosis in 1, with an average of 71.8%. Six to 10 courses of regular venous chemotherapy were administered after surgery in patients without metastasis, and 12 courses in the 2 patients with metastases.

    The toxic side effects included fever (37.8-39.9 °C) in 5 cases, nausea and vomiting in 3, and mild bone marrow suppression in 3, all these symptoms recovered within 1-2 wk following symptomatic treatment. All patients showed varying degrees of ALT elevation, which returned to normal within 7-10 d after treatment with hepatoprotective drugs. No cardiac or renal toxicity, bleeding or nontarget embolization occurred.

    Table 1 Clinicpathological data, treatment, follow-up and outcome of 6 patients with undifferentiated embryonal sarcoma of the liver

    Figure 1 Transcatheter arterial chemoembolization procedure of case 6. A: The catheter was introduced into the tumor-feeding artery and performed angiography, showing the stereoscopic configuration of "holding ball"; B: After injection of anticarcinogen and lipiodol, the outline of the entire tumor was revealed.

    The follow-up duration ranged from 2 to 15 years (median 8 years), and the follow-up rate was 100%. At the last follow-up on February 1, 2021, all patients were alive and disease-free.

    DlSCUSSlON

    Early detection of UESL is difficult, and it is usually found when the tumor becomes larger or metastasizes. It metastasizes in up to 15% of children, usually to the lungs, pleura and peritoneum[9]. Preoperative chemotherapy is currently recommended if a huge unresectable tumor or metastases are present. Although intravenous chemotherapy, as the mainstay of adjuvant treatment for UESL, has improved survival rates, the toxicity induced by systemic chemotherapy may result in early death or potential long-term and late effects[10,11]. In addition, the therapeutic effects in UESL with incomplete resection or distant metastases are still unsatisfactory[12].

    TACE was first introduced in the treatment of adult liver tumor in the late 1970s and yielded good results[13]. Since then, reports of TACE in pediatric cases of hepatoblastoma have gradually increased[6,14,15]. In previous studies at our center, preoperative TACE was effective in the treatment of UESL in two cases[5]. Also, neoadjuvant TACE and systemic chemotherapy have been administered in patients with Wilms tumor and clear cell sarcoma of the kidney and achieved satisfactory results[7,16].

    Complete tumor excision plays a central role in the treatment of UESL[4]. TACE can increase the total resection rate in several ways. TACE can deliver a higher concentration of anticancer drugs into the tumorviadirect perfusion through the tumor-feeding artery, which reduces the dose of drugs and systemic toxicity[5,6,16]. Lipiodol embolization can reduce the blood supply of tumor and accelerate necrosis. High concentrations of chemotherapeutic drugs and internal ischemia cause the tumor to gradually shrink. After TACE, a pseudo-capsule can be seen around the tumor and a boundary exists between the tumor and normal liver tissue during the operation (Figure 2). These are conducive to complete resection, reducing the rate of positive surgical margins, and diminishing intraoperative bleeding (Figure 3). In this study, all the patients achieved total resection without positive surgical margins and severe bleeding.

    TACE plays an important role in the primary lesion but has little effect on distal metastasis[15,17]. In this series, two patients had pulmonary and retroperitoneal lymph node metastasis on admission, respectively. Fortunately, after TACE and before systemic chemotherapy, we found that the metastasis was slightly reduced and no other lesions appeared. Following infusion into the hepatic artery, chemotherapy drugs will still flow through the hepatic vein to the heart and the entire body; thus, the extrahepatic lesions can also be suppressed. However, intravenous chemotherapy is still essential, as the dose of chemotherapy drugs flowing into the body following TACE is limited, and do not achieve an effective concentration. Preoperative intravenous chemotherapy can effectively inhibit primary hepatic and extrahepatic lesions, while postoperative intravenous chemotherapy can reduce the risk of recurrence and improve the survival rate[18,19]. Therefore, systemic chemotherapy can complement TACE. In our series, prolonged postoperative chemotherapy was performed in the two patients who are presently recurrence-free. However, the prognosis is poor, even if the patient receives intravenous chemotherapy, when complete excision of the tumor cannot be achieved[4]. The patient with lung metastases who is currently event-free still requires long-term follow-up.

    In recent years drug-eluting beads (DEBs) have been introduced as novel drug-delivery agents for TACE, which can deliver higher concentrations of drugs to the tumor and lower systemic concentrations[20]. Studies have shown a lower incidence of systemic toxicity and improved tolerance with DEBTACE, but overall survival did not differ from conventional lipiodol-TACE[21,22]. DEB-TACE has been widely used for the treatment of hepatocellular carcinoma in adults, but has not been reported in pediatric liver malignancies, and its clinical safety needs to be confirmed by further clinical trials in children. In addition, DEB-TACE reduces systemic complications by lowering extrahepatic drug concentrations, but it also decreases the inhibition of extrahepatic lesions. Therefore, DEB-TACE was not used in this study. In the near future, DEB-TACE is expected to be applied in the treatment of unresectable intrahepatic malignancy in pediatric patients.

    No technical complications including bleeding, vascular injury, or nontarget embolization were noted in this study. Nontarget embolization must be viewed as a critical situation during the TACE procedure, as its appearance may lead to serious consequences[23]. The incidence of nontargeted organ embolization, such as pulmonary embolism, splenic infarction, and gallbladder infarction, was found to be approximately 5%[23,24]. The main risk factors for the development of these complications include: (1) Non-selective placement of the catheter; (2) High doses of cytostatics and iodized oil used in TACE; and (3) Use of small-diameter embolic agents[24]. A case of paraplegia after TACE in a patient with clear cell sarcoma of the kidney was reported in our center, which was caused by injection of chemotherapeutic drugs and lipiodol into the spinal cord through the lumbar artery. Hence, angiography must be performed repeatedly to confirm the location of the catheter during the TACE procedure especially before injection of the embolic agent.

    Postembolization syndrome and drug toxicity mainly include fever, abdominal pain, gastrointestinal reaction (nausea and vomiting), myelosuppression and organ damage (cardiotoxicity, renal insufficiency, and hepatic dysfunction)[25]. In our cases, fever was the most common symptom after TACE, possibly due to massive necrosis of the large tumor, which lasted a long time and did not respond to antibiotics. Under such circumstances, short-term small doses of hormones can be used to suppress inflammation and lower prolonged fever. Elevated ALT levels occurred in all of our patients, which returned to normal within 7-10 d after treatment without affecting follow-up treatment. Renal failure, cardiac damage, and severe myelosuppression did not occur. Hence, NAT may be considered a safe preoperative treatment for UESL.

    Figure 2 The imaging manifestation of case 6. A and B: Computed tomography scans showed a giant mass of the right liver (diameter 14.8 cm); C and D: One month after neoadjuvant therapy: The tumor volumes shrunk by 48.8%, lipiodol deposits in the tumor with a clear boundary; E and F: One month after tumor resection.

    Figure 3 These are conducive to complete resection, reducing the rate of positive surgical margins, and diminishing intraoperative bleeding. A: The gross of tumor appears as border clear with about 10 cm in diameter; B: The cut surface is red, brown or yellow and has soft qualitative with focal necrosis.

    It is noteworthy that two of our patients underwent 2 cycles of NAT before surgery. They achieved SD (tumor shrinkage was approximately 20%) after one cycle of NAT, and still had large tumors with PRETEXT stage III on radiography[26]. After another cycle of NAT, PRs (tumor shrinkage of approximately 35%) were achieved. Therefore, it is suggested that patients who are insensitive to the initial response should be considered for a second round of NAT, which can yield better results. However, unlimited chemotherapy is not desirable. Generally, surgery should be performed after two cycles of NAT, and liver transplantation should be considered if a limited response occurs in a patient with an unresectable tumor.

    There were some limitations in this study. Firstly, the data were from a single institution and based on a retrospective analysis. In addition, there was no control group due to the small number of cases, and the assessment of disease response cannot definitely be attributed to TACE or systemic chemotherapy. Further prospective and controlled studies with a larger cohort are needed to compare the efficacy of TACE, systemic chemotherapy and NAT for UESL, respectively.

    CONCLUSlON

    The present study indicated that the use of NAT effectively reduced tumor volume, cleared tumor margins, and caused massive tumor necrosis. This chemotherapy regimen may be a promising choice for successful surgery of UESL in children.

    ARTlCLE HlGHLlGHTS

    FOOTNOTES

    Author contributions:All authors contributed equally to this work; Wang JH was the guarantor and designed the study; He M drafted the initial manuscript; Wang JH and Ying MD helped to review the literature; Lai C and Wang JH conducted the TACE process; Mao JQ and Li LJ were the oncologists who treated the patient; Wang JH, He M, Cai JB, Xiong JN, Guan ZH and Shu Q were the surgeons who treated the patient; all authors issued final approval for the version to submitted.

    Supported byYouth Program of Natural Science Foundation of Zhejiang Province, No. LQ20H160027; and National Natural Science Foundation of China, No. U20A20137.

    lnstitutional review board statement:The study was reviewed and approved by the Children’s Hospital, Zhejiang University School of Medicine Institutional Review Board, No. 2021-IRB-252.

    lnformed consent statement:All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

    美國Waters公司MICROMASS Quattro Micro API型質(zhì)譜儀,配有電噴霧離子化源(ESI),數(shù)據(jù)采集:MassLynx 4.1軟件(美國Waters公司)。島津LC‐20 10CHT高效液相色譜儀,恒溫水浴箱(Heto Holten Denmark),匹配紫外檢測器、熒光檢測器。

    Conflict-of-interest statement:All the authors report no relevant conflicts of interest for this article.

    Data sharing statement:No additional data are available.

    Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

    Country/Territory of origin:China

    ORClD number:Min He 0000-0003-0178-097X; Jia-Bin Cai 0000-0002-2233-0022; Can Lai 0000-0002-4474-3987; Jun-Qing Mao 0000-0002-3162-9106; Jie-Ni Xiong 0000-0003-1603-1728; Zhong-Hai Guan 0000-0002-8397-4585; Lin-Jie Li 0000-0001-7311-7283; Qiang Shu 0000-0002-4106-6255; Mei-Dan Ying 0000-0003-0039-9683; Jin-Hu Wang 0000-0002-7749-2475.

    S-Editor:Fan JR

    L-Editor:A

    P-Editor:Fan JR

    猜你喜歡
    島津離子化質(zhì)譜儀
    Impaired eye tracking is associated with symptom severity but not dynamic postural control in adolescents following concussion
    單細(xì)胞質(zhì)譜分析方法研究進(jìn)展
    廣告索引
    水利信息化(2020年1期)2020-01-04 07:07:11
    使用尖玻片、毛細(xì)管和尖滴管三種玻璃尖端電噴霧離子化質(zhì)譜分析方法
    納米金輔助介質(zhì)阻擋放電離子化質(zhì)譜分析法在獸藥飼料快檢中的應(yīng)用
    讓科技還原真實,以熱情回報社會—訪島津企業(yè)管理(中國)有限公司市場部部長胡家祥
    構(gòu)建模型,解決質(zhì)譜儀問題
    基于質(zhì)譜儀爐氣分析的VOD精煉過程模型開發(fā)
    上海金屬(2015年3期)2015-11-29 01:10:04
    熱電離飛行時間質(zhì)譜儀性能評價
    氦離子化檢測器氣相色譜法分析氦中微量氖①
    低溫與特氣(2012年4期)2012-01-10 01:52:58
    久久99蜜桃精品久久| 午夜福利,免费看| 亚洲av电影在线观看一区二区三区| 亚洲久久久国产精品| 一本久久精品| 只有这里有精品99| 国产乱人偷精品视频| 91aial.com中文字幕在线观看| 韩国高清视频一区二区三区| 精品国产乱码久久久久久小说| 国产日韩欧美亚洲二区| 2021少妇久久久久久久久久久| 日日撸夜夜添| 国产午夜精品一二区理论片| av在线播放精品| 搡女人真爽免费视频火全软件| 人体艺术视频欧美日本| 亚洲精品一区蜜桃| 18禁在线无遮挡免费观看视频| 三级国产精品欧美在线观看| 亚洲成人一二三区av| 综合色丁香网| 交换朋友夫妻互换小说| 亚洲av在线观看美女高潮| 国产日韩一区二区三区精品不卡 | 五月伊人婷婷丁香| 成人综合一区亚洲| 久久99热6这里只有精品| 久久精品夜色国产| 日韩精品免费视频一区二区三区 | 丰满迷人的少妇在线观看| 亚洲av男天堂| 99久久精品一区二区三区| 嫩草影院入口| 26uuu在线亚洲综合色| 久久久国产欧美日韩av| 好男人视频免费观看在线| 亚洲伊人久久精品综合| 九草在线视频观看| 亚洲国产欧美日韩在线播放 | 老司机影院成人| 最新中文字幕久久久久| 97精品久久久久久久久久精品| 在线观看美女被高潮喷水网站| 一边亲一边摸免费视频| 亚洲怡红院男人天堂| 精品久久久久久久久亚洲| 久久精品国产自在天天线| 日本与韩国留学比较| 免费观看a级毛片全部| 搡女人真爽免费视频火全软件| 69精品国产乱码久久久| 如日韩欧美国产精品一区二区三区 | 黄片无遮挡物在线观看| a级片在线免费高清观看视频| 国产淫语在线视频| 国产免费又黄又爽又色| 亚洲人成网站在线观看播放| 国产视频内射| 好男人视频免费观看在线| 精品午夜福利在线看| 两个人的视频大全免费| kizo精华| 另类精品久久| 日韩亚洲欧美综合| 极品人妻少妇av视频| 午夜日本视频在线| 岛国毛片在线播放| 亚洲精品乱码久久久v下载方式| 日本爱情动作片www.在线观看| 亚洲欧洲国产日韩| 人体艺术视频欧美日本| 国产日韩欧美亚洲二区| 少妇熟女欧美另类| 熟女人妻精品中文字幕| 亚洲,一卡二卡三卡| 精品一区二区免费观看| 欧美区成人在线视频| 永久免费av网站大全| 午夜av观看不卡| 欧美精品一区二区大全| 国产精品国产av在线观看| 妹子高潮喷水视频| 久久综合国产亚洲精品| 亚洲av男天堂| 日韩人妻高清精品专区| 亚洲不卡免费看| 亚洲,一卡二卡三卡| 一本—道久久a久久精品蜜桃钙片| 男女边摸边吃奶| 成人毛片a级毛片在线播放| 99热这里只有精品一区| 亚洲精品成人av观看孕妇| 午夜福利影视在线免费观看| 亚洲婷婷狠狠爱综合网| 亚洲国产最新在线播放| 日韩欧美精品免费久久| 婷婷色av中文字幕| 欧美 日韩 精品 国产| 啦啦啦啦在线视频资源| 中文字幕亚洲精品专区| 99热这里只有精品一区| 一区二区三区乱码不卡18| 黑人猛操日本美女一级片| 99九九线精品视频在线观看视频| 成人影院久久| 精品久久久精品久久久| 老司机影院成人| 日本欧美国产在线视频| 青春草国产在线视频| 亚洲av在线观看美女高潮| 亚洲国产毛片av蜜桃av| 人妻 亚洲 视频| 亚州av有码| 日韩不卡一区二区三区视频在线| 日韩中字成人| 99久久中文字幕三级久久日本| 国产成人精品婷婷| 国产免费视频播放在线视频| 韩国高清视频一区二区三区| 国产日韩欧美亚洲二区| 欧美激情国产日韩精品一区| 精品人妻熟女毛片av久久网站| 午夜福利,免费看| 亚洲激情五月婷婷啪啪| 久久免费观看电影| 国内揄拍国产精品人妻在线| 亚洲av成人精品一二三区| 国产男女内射视频| 成人影院久久| 精品卡一卡二卡四卡免费| 麻豆成人午夜福利视频| 丝袜在线中文字幕| 久久久国产欧美日韩av| 午夜精品国产一区二区电影| 99热这里只有精品一区| 一个人免费看片子| 欧美丝袜亚洲另类| 久久人人爽人人片av| 久久久久久人妻| 免费黄网站久久成人精品| 亚洲精品国产av蜜桃| 观看免费一级毛片| 人妻系列 视频| 黄色视频在线播放观看不卡| av天堂久久9| 久久久精品94久久精品| 国产一区二区在线观看av| 久久热精品热| 男的添女的下面高潮视频| 亚洲经典国产精华液单| 人人妻人人爽人人添夜夜欢视频 | 一区二区三区乱码不卡18| 一区二区三区四区激情视频| 午夜福利视频精品| 麻豆成人午夜福利视频| 水蜜桃什么品种好| 2021少妇久久久久久久久久久| 好男人视频免费观看在线| 下体分泌物呈黄色| 国产 精品1| 建设人人有责人人尽责人人享有的| 国产黄色视频一区二区在线观看| 免费黄色在线免费观看| 国产精品熟女久久久久浪| 国产美女午夜福利| 日本猛色少妇xxxxx猛交久久| 日韩人妻高清精品专区| 精品人妻偷拍中文字幕| 麻豆成人av视频| 欧美激情国产日韩精品一区| 国产日韩欧美在线精品| 亚洲国产最新在线播放| 国产精品欧美亚洲77777| 一区二区av电影网| 国产欧美日韩综合在线一区二区 | av专区在线播放| 亚洲国产精品国产精品| 国产一级毛片在线| 超碰97精品在线观看| 国产日韩欧美亚洲二区| 男人添女人高潮全过程视频| 日韩成人伦理影院| av福利片在线观看| 人人妻人人看人人澡| 亚洲在久久综合| 人妻制服诱惑在线中文字幕| h日本视频在线播放| 亚洲成人av在线免费| 99精国产麻豆久久婷婷| 亚洲欧美精品自产自拍| 汤姆久久久久久久影院中文字幕| 成人毛片a级毛片在线播放| 中文欧美无线码| 国产精品偷伦视频观看了| 纵有疾风起免费观看全集完整版| 国产精品久久久久久久电影| 黄色配什么色好看| 免费看不卡的av| 一个人免费看片子| 一级爰片在线观看| 80岁老熟妇乱子伦牲交| 美女中出高潮动态图| 18+在线观看网站| 亚洲国产欧美日韩在线播放 | 久久狼人影院| 久久亚洲国产成人精品v| 免费av不卡在线播放| 中文天堂在线官网| av播播在线观看一区| 欧美一级a爱片免费观看看| 亚洲久久久国产精品| 国产午夜精品久久久久久一区二区三区| 日本与韩国留学比较| 伊人亚洲综合成人网| av播播在线观看一区| 色吧在线观看| 中国三级夫妇交换| 丰满迷人的少妇在线观看| 我要看黄色一级片免费的| 99热这里只有是精品在线观看| 三级国产精品片| 伊人久久国产一区二区| 久久久欧美国产精品| 欧美人与善性xxx| 99re6热这里在线精品视频| 插逼视频在线观看| 久久久午夜欧美精品| 色婷婷av一区二区三区视频| 亚洲精品国产色婷婷电影| 99九九在线精品视频 | 久久精品久久久久久久性| 乱人伦中国视频| 亚洲第一av免费看| 内射极品少妇av片p| 色网站视频免费| 久久99精品国语久久久| av播播在线观看一区| 免费av中文字幕在线| 精品少妇内射三级| 亚洲欧美日韩另类电影网站| 国产亚洲精品久久久com| 国产综合精华液| 亚洲伊人久久精品综合| 精品久久久久久久久亚洲| 欧美xxⅹ黑人| 蜜桃在线观看..| 男女免费视频国产| 噜噜噜噜噜久久久久久91| 国产成人91sexporn| 国语对白做爰xxxⅹ性视频网站| 丰满饥渴人妻一区二区三| 国产精品久久久久久久久免| 国产精品.久久久| 日韩大片免费观看网站| 中国美白少妇内射xxxbb| 亚洲国产精品成人久久小说| 亚洲国产欧美在线一区| 国产av码专区亚洲av| 乱人伦中国视频| 国产高清有码在线观看视频| 两个人的视频大全免费| 极品教师在线视频| 成人影院久久| 国产黄色免费在线视频| 久久久精品免费免费高清| 日本欧美国产在线视频| 国产精品国产三级国产av玫瑰| 99re6热这里在线精品视频| 国产成人aa在线观看| 免费播放大片免费观看视频在线观看| 少妇的逼水好多| 国产精品久久久久成人av| 亚洲av.av天堂| 三级经典国产精品| 精品人妻一区二区三区麻豆| 性色avwww在线观看| 国产伦精品一区二区三区视频9| 人妻一区二区av| 狠狠精品人妻久久久久久综合| 亚洲情色 制服丝袜| 哪个播放器可以免费观看大片| 国产在线男女| 91在线精品国自产拍蜜月| 免费高清在线观看视频在线观看| 大又大粗又爽又黄少妇毛片口| 一本大道久久a久久精品| 美女国产视频在线观看| 人体艺术视频欧美日本| 新久久久久国产一级毛片| 中文精品一卡2卡3卡4更新| 大话2 男鬼变身卡| 亚洲欧美日韩另类电影网站| 国产精品秋霞免费鲁丝片| 国产午夜精品一二区理论片| 成人二区视频| 国产高清有码在线观看视频| 观看av在线不卡| 久久女婷五月综合色啪小说| 人人妻人人澡人人爽人人夜夜| 少妇高潮的动态图| 久久久久久久久久久免费av| 高清午夜精品一区二区三区| 欧美精品一区二区大全| 亚洲真实伦在线观看| 26uuu在线亚洲综合色| 亚洲av男天堂| 有码 亚洲区| 午夜激情久久久久久久| 美女xxoo啪啪120秒动态图| 国产成人免费无遮挡视频| 亚洲av免费高清在线观看| 水蜜桃什么品种好| 男人狂女人下面高潮的视频| 欧美日韩av久久| 18禁动态无遮挡网站| 精品亚洲成国产av| 日韩一区二区视频免费看| 人妻一区二区av| 欧美三级亚洲精品| 国产午夜精品久久久久久一区二区三区| 久久免费观看电影| 五月伊人婷婷丁香| 七月丁香在线播放| 久久午夜综合久久蜜桃| 午夜福利视频精品| 亚洲欧美清纯卡通| 亚洲高清免费不卡视频| 简卡轻食公司| 亚洲精品456在线播放app| 丝袜喷水一区| 99re6热这里在线精品视频| 久久人妻熟女aⅴ| 日本av免费视频播放| 97超视频在线观看视频| 大片电影免费在线观看免费| 免费观看无遮挡的男女| 最近的中文字幕免费完整| 久久久久久人妻| 午夜视频国产福利| 国产探花极品一区二区| 黄色日韩在线| 美女大奶头黄色视频| 国产一区二区在线观看日韩| 欧美精品国产亚洲| 亚洲精品久久午夜乱码| 女性被躁到高潮视频| 欧美成人午夜免费资源| 91精品一卡2卡3卡4卡| 全区人妻精品视频| 国产黄色免费在线视频| 久久久久视频综合| 日本av手机在线免费观看| 五月天丁香电影| 99久久人妻综合| 欧美激情国产日韩精品一区| 性高湖久久久久久久久免费观看| 男女免费视频国产| 菩萨蛮人人尽说江南好唐韦庄| 少妇的逼好多水| 亚洲,一卡二卡三卡| 狂野欧美白嫩少妇大欣赏| 国产深夜福利视频在线观看| 在线播放无遮挡| 国产精品久久久久久久电影| 久久99蜜桃精品久久| 国产男人的电影天堂91| 男男h啪啪无遮挡| 天堂俺去俺来也www色官网| 国产日韩欧美在线精品| 成人亚洲欧美一区二区av| 精品久久久久久久久亚洲| 成人漫画全彩无遮挡| 精品人妻熟女av久视频| 精品99又大又爽又粗少妇毛片| 精品一品国产午夜福利视频| 欧美日韩综合久久久久久| 亚洲精品日韩av片在线观看| 各种免费的搞黄视频| 王馨瑶露胸无遮挡在线观看| 超碰97精品在线观看| 成人午夜精彩视频在线观看| 国产av码专区亚洲av| 一区二区av电影网| 久久97久久精品| 久久99热6这里只有精品| 免费看日本二区| 深夜a级毛片| 男女边吃奶边做爰视频| 插阴视频在线观看视频| 国产欧美日韩一区二区三区在线 | 人妻系列 视频| 美女中出高潮动态图| 精品国产一区二区三区久久久樱花| 中文欧美无线码| a级毛片免费高清观看在线播放| 午夜福利影视在线免费观看| 亚洲av在线观看美女高潮| 亚洲欧美日韩东京热| 久久久久久久久久久久大奶| 欧美精品国产亚洲| 99九九在线精品视频 | 黑丝袜美女国产一区| 看非洲黑人一级黄片| av国产精品久久久久影院| 婷婷色av中文字幕| 高清视频免费观看一区二区| 久久99精品国语久久久| 成人特级av手机在线观看| 大香蕉97超碰在线| 国产精品麻豆人妻色哟哟久久| 日本黄色日本黄色录像| 欧美精品一区二区免费开放| 国产亚洲最大av| 99热6这里只有精品| 人人妻人人看人人澡| 免费高清在线观看视频在线观看| 国产亚洲欧美精品永久| 中文乱码字字幕精品一区二区三区| 97在线人人人人妻| 精品国产一区二区三区久久久樱花| 婷婷色综合大香蕉| 亚洲国产精品一区三区| 99热全是精品| 国产伦理片在线播放av一区| 欧美亚洲 丝袜 人妻 在线| 亚洲av电影在线观看一区二区三区| 国产 精品1| 久久这里有精品视频免费| 交换朋友夫妻互换小说| 国产国拍精品亚洲av在线观看| 最近中文字幕高清免费大全6| av免费观看日本| 一级片'在线观看视频| 亚洲欧美日韩卡通动漫| av国产久精品久网站免费入址| 丝袜脚勾引网站| 中文在线观看免费www的网站| 久久久精品免费免费高清| 国产有黄有色有爽视频| 久久国产乱子免费精品| 十分钟在线观看高清视频www | 激情五月婷婷亚洲| 精品久久久精品久久久| 日韩免费高清中文字幕av| 人妻少妇偷人精品九色| 国产一区有黄有色的免费视频| 亚洲性久久影院| 男女啪啪激烈高潮av片| 成人国产av品久久久| 高清av免费在线| 性色av一级| 欧美日韩综合久久久久久| 夫妻午夜视频| 晚上一个人看的免费电影| 久久久久久久久久人人人人人人| 最近最新中文字幕免费大全7| 国产亚洲精品久久久com| 亚洲丝袜综合中文字幕| 日本av免费视频播放| 能在线免费看毛片的网站| 国产伦精品一区二区三区四那| 大香蕉97超碰在线| 国产亚洲av片在线观看秒播厂| av有码第一页| 久久人人爽人人爽人人片va| 啦啦啦啦在线视频资源| 色94色欧美一区二区| 久久久国产一区二区| 久久精品久久久久久久性| 亚洲中文av在线| 一级毛片 在线播放| 国产精品久久久久成人av| 熟女av电影| 色吧在线观看| 麻豆成人午夜福利视频| 91精品国产国语对白视频| 亚洲国产毛片av蜜桃av| 日本与韩国留学比较| 啦啦啦中文免费视频观看日本| 成年av动漫网址| 两个人的视频大全免费| 一级二级三级毛片免费看| av黄色大香蕉| 22中文网久久字幕| 国产免费视频播放在线视频| 免费人成在线观看视频色| 99热网站在线观看| 亚洲国产精品国产精品| 国产成人91sexporn| 伊人久久国产一区二区| 视频区图区小说| 晚上一个人看的免费电影| 国产熟女欧美一区二区| 一二三四中文在线观看免费高清| 极品教师在线视频| 成人免费观看视频高清| 国产精品一区二区在线不卡| 亚洲丝袜综合中文字幕| 一边亲一边摸免费视频| 99热这里只有精品一区| 97超碰精品成人国产| 少妇人妻 视频| av卡一久久| 成年女人在线观看亚洲视频| 自拍欧美九色日韩亚洲蝌蚪91 | 日日摸夜夜添夜夜添av毛片| 91久久精品国产一区二区三区| 成年女人在线观看亚洲视频| 少妇的逼好多水| 中文在线观看免费www的网站| 午夜av观看不卡| 99久国产av精品国产电影| 全区人妻精品视频| 精品少妇内射三级| 久久毛片免费看一区二区三区| 男女边吃奶边做爰视频| 免费人成在线观看视频色| 中国三级夫妇交换| 国产日韩欧美亚洲二区| 桃花免费在线播放| 一个人免费看片子| av又黄又爽大尺度在线免费看| 又黄又爽又刺激的免费视频.| 色吧在线观看| 少妇精品久久久久久久| xxx大片免费视频| 日韩一区二区视频免费看| 高清av免费在线| 国产午夜精品一二区理论片| 日韩av免费高清视频| 亚洲人成网站在线播| 免费看光身美女| 日日摸夜夜添夜夜爱| 久久亚洲国产成人精品v| 日本爱情动作片www.在线观看| 国产成人午夜福利电影在线观看| www.色视频.com| 欧美成人精品欧美一级黄| 婷婷色综合大香蕉| 狂野欧美激情性bbbbbb| 永久免费av网站大全| 久久久久精品性色| 在线观看av片永久免费下载| 亚洲综合精品二区| 免费av不卡在线播放| 国精品久久久久久国模美| 久久久久久久久久成人| 亚州av有码| 精品亚洲成a人片在线观看| 一本—道久久a久久精品蜜桃钙片| 三级国产精品片| 亚洲第一区二区三区不卡| 久久人人爽av亚洲精品天堂| 久久狼人影院| 在线观看三级黄色| 久久久国产欧美日韩av| 少妇人妻 视频| 国产精品一二三区在线看| 两个人的视频大全免费| 免费观看无遮挡的男女| 伊人久久精品亚洲午夜| 亚洲av福利一区| 国产在线一区二区三区精| 少妇丰满av| 老司机影院成人| 国产精品一区二区三区四区免费观看| 国产亚洲欧美精品永久| 简卡轻食公司| 亚洲欧美成人精品一区二区| 人人妻人人澡人人看| 亚洲人与动物交配视频| 十八禁网站网址无遮挡 | 亚洲精品456在线播放app| 欧美精品一区二区免费开放| 热re99久久精品国产66热6| 亚洲欧美精品专区久久| 男人狂女人下面高潮的视频| 最新的欧美精品一区二区| 麻豆精品久久久久久蜜桃| 在线观看免费日韩欧美大片 | 男人和女人高潮做爰伦理| 精品国产露脸久久av麻豆| 午夜福利影视在线免费观看| av.在线天堂| 春色校园在线视频观看| 永久网站在线| 久久午夜福利片| 国产成人精品福利久久| 日韩强制内射视频| 国产成人精品一,二区| 国内揄拍国产精品人妻在线| 久久久久久久大尺度免费视频| 国产一区二区三区av在线| 极品教师在线视频| 免费观看a级毛片全部| 三上悠亚av全集在线观看 | 国产亚洲精品久久久com| 国产av码专区亚洲av| 最后的刺客免费高清国语| 看十八女毛片水多多多| 国产免费视频播放在线视频| 黑丝袜美女国产一区| 久久国内精品自在自线图片| 亚洲精品aⅴ在线观看| 国产精品99久久99久久久不卡 | 亚洲av综合色区一区| 久久精品国产自在天天线| 中文字幕亚洲精品专区| 亚洲美女视频黄频| 久久精品国产a三级三级三级| 亚洲国产av新网站| 乱码一卡2卡4卡精品| www.色视频.com| videos熟女内射|