• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Deep learning based radiomics for gastrointestinal cancer diagnosis and treatment: A minireview

    2022-12-09 02:52:12PakKinWongInNengChanHaoMingYanShanGaoChiHongWongTaoYanLiangYaoYingHuZhongRenWangHonHoYu
    World Journal of Gastroenterology 2022年45期

    Pak Kin Wong, In Neng Chan, Hao-Ming Yan, Shan Gao, Chi Hong Wong, Tao Yan, Liang Yao, Ying Hu,Zhong-Ren Wang, Hon Ho Yu

    Abstract Gastrointestinal (GI) cancers are the major cause of cancer-related mortality globally. Medical imaging is an important auxiliary means for the diagnosis,assessment and prognostic prediction of GI cancers. Radiomics is an emerging and effective technology to decipher the encoded information within medical images, and traditional machine learning is the most commonly used tool. Recent advances in deep learning technology have further promoted the development of radiomics. In the field of GI cancer, although there are several surveys on radiomics, there is no specific review on the application of deep-learning-based radiomics (DLR). In this review, a search was conducted on Web of Science,PubMed, and Google Scholar with an emphasis on the application of DLR for GI cancers, including esophageal, gastric, liver, pancreatic, and colorectal cancers.Besides, the challenges and recommendations based on the findings of the review are comprehensively analyzed to advance DLR.

    Key Words: Radiomics; Deep learning; Gastrointestinal cancer; Medical imaging

    INTRODUCTION

    Gastrointestinal (GI) cancers, mainly include colorectal, gastric, liver, esophageal, and pancreatic cancers, and are the leading cause of cancer-related mortality globally[1]. According to CANCER TOMORROW[2], a forecast of the global burden of cancer mortality and incidence, by 2040, new cases of GI cancer and deaths will increase significantly. In recent years, computed tomography (CT),magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound (US) and other medical imaging techniques have been widely used in GI cancer diagnosis and treatment[3,4]. It is foreseeable that with the increase in GI cancer, the amount of medical imaging data will continue to grow. However, manual reading cannot cope with this growth, and the disparity in expertise among radiologists causes a high rate of missed diagnosis and misdiagnosis. In addition, traditional CT, MRI,PET, US, and other imaging examinations cannot observe changes in tumor heterogeneity, which can provide a better understanding of the causes and progression of cancer[5]. The development of radiomics technology provides new opportunities and methods to solve these dilemmas.

    Radiomics is an emerging method for quantitative analysis and prediction of tumor phenotypes using machine learning or statistical models, and was proposed by Lambinet al[6] in 2012. In recent years,radiomics has been widely used in GI cancer and showed notable outcomes in tumor characterization,therapy response assessment, and prediction of survival rate after surgery[7-11]. Compared with the conventional method of using only manual inspection, radiomics can extract high-dimensional features that are difficult to be quantitatively described by the doctors from massive radiological images, and to correlate them with clinical and pathological data of patients in order to improve diagnosis and prognostication[12]. The fundamental premise of radiomics is that the developed descriptive models may produce useful prognostic, predictive and diagnostic information. Radiomics can be divided into two main categories: conventional radiomics, also referred to handcrafted radiomics (HCR) and deeplearning-based radiomics (DLR), also referred to as discovery radiomics[13]. Given the benefits of these two approaches, hybrid solutions that mix HCR and DLR also exist.

    The HCR workflow is divided into multiple steps: (1) Image acquisition and reconstruction; (2) image segmentation and delineation of region of interest (automatic, semi-automatic, or manual delineation);(3) feature extraction and quantification. This is the core step of HCRs. The extracted features are mainly handcrafted features (also referred as pre-designed features), including shape, texture and intensity features. Some features may be highly correlated or redundant, so feature dimensionality reduction is an important step in feature analysis; and (4) Clinical target-oriented model building and validation. At this step, classic machine learning algorithms are usually used to develop high-precision and highefficiency prediction models, and the models are trained and validated with sufficient data. The workflow of HCR is depicted in Figure 1.

    Although HCR has been widely adopted in GI cancer and has achieved significant results, it has some deficiencies, such as low degree of automation and standardization, cumbersome and time-consuming feature extraction steps, and insufficient robustness and accuracy. Recently, deep learning, a promising technique in characterization of medical images, has gained much attention[14-17]. Many researchers have adopted DLR to overcome the limitations of conventional radiomics[18-22]. DL refers to a broad class of algorithms rather than a specific model. As long as a deep neural network structure is used to represent features at a deeper level, it can be called DL model. One of the most popular DL models used in medical imaging is convolutional neural networks (CNNs), which can automatically learn representative features from medical images. The use of CNNs in radiomics makes it easy to build an end-toend feature extraction process, thereby avoiding the tedious and handcrafted feature extraction process.CNNs can also be used in image reconstruction and segmentation to improve the automation level of HCR, and the accuracy and reliability of diagnosis and prediction (Figure 1).

    Figure 1 Overview of steps in handcrafted radiomics workflow and steps that can be done with deep learning models. ROI: Region of interest.

    DL techniques are revolutionizing radiomics. In the field of GI cancer diagnosis and treatment, while there are several surveys on HCR[9-11], there is no specific review on the application of DLR. To provide a comprehensive overview of DLR in GI cancer, the performance of DLR in gastroenterology is summarized in this review, with an emphasis on the diagnosis and treatment of GI cancers, including esophageal, gastric, liver, pancreatic, and colorectal cancers. The original contributions to knowledge of this review are: (1) A unique interdisciplinary viewpoint on radiomics by discussing state-of-the-art DLR solutions; and (2) the challenges and recommendations based on the findings of the review are thoroughly analyzed to advance the field.

    DLR FOR ESOPHAGEAL CANCER

    Esophageal cancer is the seventh most prevalent form of cancer and the sixth most lethal cancer globally[1], and it is classified into esophageal squamous cell carcinoma (ESCC) or esophageal adenocarcinoma according to the type of cells. In consideration of the low overall 5-year survival rate of patients and the variation in responsiveness of patients to the current treatments such as neoadjuvant chemotherapy(NAC) and neoadjuvant chemoradiotherapy (NCRT) due to tumor heterogeneity, it is vital to have accurate diagnosis, pretreatment evaluation and survival rate prediction. The number of DLR studies regarding esophageal cancer has been growing, with most of the studies exploring treatment response,and the others investigating disease classification and survival rate prediction.

    An important preoperative topic of esophageal cancer is diagnosis, yet the number of relevant DLR studies for diagnosis is minimal. Takeuchiet al[23] fine-tuned VGG16 to develop a DLR model for the diagnosis of esophageal cancer from CT scans, and its performance was comparable to that of the radiologists during testing, with a higher accuracy of 84.2% and specificity of 90.0%.

    Response to treatment, especially NAC and NCRT, is one of the most popular research interests in the field of esophageal cancer. Huet al[24] designed a CT-based model to predict the pathological complete response to NCRT of patients with ESCC using DL features, in which the support vector machine (SVM)classifier executed the classification action. The DL features were extracted using pretrained models,and the optimal one used ResNet50 that achieved an area under the receiver operating characteristic curve (AUC) of 0.805 and accuracy of 77.1% for the testing cohort, which achieved better results than using handcrafted features. Ypsilantiset al[25] designed a 3S-CNN model that extracted DL features from PET scans and predicted whether the patient with esophageal cancer was non-responsive to NAC.This model was also compared with other competitive machine learning algorithms and results showed that it surpassed the other models with an average specificity, sensitivity and accuracy of 80.7%, 81.6%,and 73.4% respectively. Amyaret al[26] presented a novel 3D CNN model named 3D RPET-NET that predicted the response to CRT using esophageal cancer images of FDG-PET scans, and a comparative analysis with other approaches in the literature was also carried out. Three-dimensional RPET-NET obtained the best results with an accuracy of around 72% and even reached 75% when using tumor volume with an isotropic margin of 2 cm. Liet al[27] proposed a CT-based 3D DLR model (3D-DLRM),which was modified from ResNet34. Its aim was to predict whether patients with locally advanced thoracic ESCC had an objective or nonobjective response to concurrent CRT, achieving a validation AUC and positive predictive value of 0.833 and 100%, respectively. They also evaluated a model integrating the 3D-DLRM with clinical selected factors that even outperformed the individual 3DDLRM, reaching a validation AUC of 0.861.

    Other research interests of esophageal cancer include patient survival rate prediction. Wanget al[28]compared the use of an HCR model, DLR model and DLR nomogram for the prediction of the survival rate of esophageal cancer patients after 3 years of CRT, in which DL features were extracted and selected by DenseNet-169 to build the DLR model. This DLR nomogram attained the highest validation AUC of 0.942 and Harrell’s concordance index (C-index) of 0.784, surpassing the results produced by the sole use of HCR and DLR models. Yanget al[29] proposed a 3D-CNN model based on ResNet18 to predict esophageal cancer patient survival rate using PET scans. The model was initially pretrained to classify abnormal and healthy esophagus, and then trained to classify whether patients survived or expired within a year after diagnosis in the second stage, and the model obtained an AUC of 0.738. Gonget al[30] developed a hybrid radiomics nomogram to predict local recurrence-free survival (LRFS) of locally advanced ESCC patients who received definitive CRT from contrast-enhanced CT (CECT) scans, and it was combined with radiomic features, features extracted by 3D-DenseNet and prognostic clinical risk factors. The final model achieved a C-index of 0.76 for its external validation set, indicating the effectiveness of the addition of DL features for better prediction performances.

    Some studies also discuss the application of DLR to prediction of lymph node (LN) metastasis, which is an effective prognosis factor of ESCC. Wuet al[31] built a model involving HCR, computer vision and DLR to predict the LN status of ESCC patients, and they also constructed two simpler models for efficacy comparison, and they exploited Convolution Neural Network-Fast (CNN-F) to extract DL features from CT images. The model with all signatures involved performed the best with C-statistic of 0.875, 0.874, and 0.840 for training, internal validation, and external validation cohorts, and those demonstrate its satisfactory discriminative ability.

    The studies about the application of DLR for esophageal cancer are summarized in Table 1.

    DLR FOR GASTRIC CANCER

    Gastric cancer (GC) is the fifth most prevalent form of cancer and the fourth most lethal cancer globally[1]. To ameliorate the low survival rate of patients, early diagnosis of disease and systematic treatment methods are necessary. The application of DLR in GC has been a promising area for research with a rising number of relevant studies published every year, that aim to tackle or refine the existing concerns regarding GC.

    Many studies focused on prediction of treatment response of patients. Cuiet al[32] constructed a pretreatment venous-phase CT-based DLR nomogram that combined handcrafted features, DL features and remarkable clinicopathological factors to identify locally advanced GC patients with good response to NAC. The nomogram achieved better than the clinical model and the separate use of two features that were built for comparison, attaining C-index values of 0.829, 0.804, and 0.827 in its internal validation cohort and two external validation cohorts, respectively. Liet al[33] developed a combined artificial intelligence (AI) model that incorporated feature outputs from HCR and DLR models, which aimed to determine whether the patients had signet ring cell carcinoma (SRCC) of GC and predict survival and treatment response to postoperative chemotherapy from CECT images. They also compared its efficacy with the clinical, HCR and DLR models, and the AI model obtained the bestresults with an AUC of 0.786 and accuracy of 71.6% for diagnosing SRCC for the test cohort. The AI model also evaluated that SRCC patients with higher risks had shorter median overall survival (OS) and insignificant improvements in median OS after receiving adjuvant chemotherapy than those of lower risk, indicating its good capability to predict survival and response to treatment. Tanet al[34] built a dual-energy CT delta radiomics model to predict the treatment response to chemotherapy of patients with far-advanced GC. They developed a V-Net segmentation model, and the application of this semiautomatic segmentation model to the delta radiomics model shortened the diagnostic time and achieved better results in terms of mean AUC (0.728vs0.687 in the testing cohort, 0.828vs0.749 in the independent validation cohort) than using manual segmentation.

    Table 1 Summary of studies using deep-learning-based radiomics for esophageal cancer

    Survival rate prediction is also a popular topic for DLR of GC. Haoet al[35] combined clinical variables, radiomic features and DL features to build a CT-based prediction Cox proportional-hazard model, which served to predict the OS and progression-free survival (PFS) of patients with GC. The model acquired the highest C-index of 0.783 and 0.770 for OS and PFS when using postoperative clinical variables, and the most dominant variables for survival prediction were identified as important prognostic factors in the subsequent survival analysis. Some studies only made use of DL techniques to build predictive models for similar purposes. Zhanget al[36] proposed a multi-focus and multi-level fusion feature pyramid network (MMF-FPN) to predict OS risks of GC patients from CT images, and other models using existing methods in the literature were used for comparison. The experimental results showed that MMF-FPN was the finest model that attained the highest C-indexes (validation:0.74, testing: 0.76) and hazard ratios (validation: 3.50, testing: 9.46).

    To do a preoperative prediction of early recurrence of patients with advanced GC from CT images,Zhanget al[37] designed a radiomics nomogram that utilized clinical characteristics and radiomics signature containing handcrafted and DL features as input. The radiomics nomogram reached an AUC and accuracy of 0.806 and 0.723, respectively, while having considerable k values of 0.932 for both intraand inter-reader agreement, exceeding the results obtained by the radiomics signature and clinical modal built for comparison.

    Accurate prediction of LN status of GC, which is a remarkable prognostic factor, is of importance to determine the appropriate treatment. Guanet al[38] explored the efficacy of using different DL models to extract features and machine learning classifiers (i.e., SVM and random forest) to build a CT-based predictive model for the evaluation of LN status. Other models using radiomic features and integrated features were built for comparison, and the best model was ResNet50-RF with an AUC and accuracy of 0.9803 and 98.10%, respectively. A nomogram based on DL feature scores and clinical risk factors was also developed and a higher AUC of 0.9914 was achieved in the testing cohort. Donget al[39] proposed a similar DLR nomogram to evaluate the number of LN metastases of locally advanced GC patients before surgery, in which radiomics signatures that contained handcrafted and DL features and clinical characteristics were used. The performance of the model was evaluated with four validations sets; three of which were collected from China and one from Italy. The model showed its good discriminative capability to identify N-staging of GC with higher C-indexes of 0.797 in the validation sets from China and 0.822 in the set from Italy, and it outperformed other predictors such as clinical models and single signatures. To predict the LN status and prognosis of patients, the dual-energy CT-based DLR nomogram created by Liet al[40] incorporated CT-reported LN and two radiomics signatures for arterial-phase and venous-phase CT images, in which DL features were extractedviaCNN. The nomogram performed better and gained a higher AUC of 0.82 than the clinical model built alongside for comparative analysis, and the associated prognosis prediction was satisfactory in terms of PFS (C-index:0.64) and OS (C-index: 0.67). Jinet al[41] developed a DLR model that adopted ResNet-18 to evaluate the LN status in nodal stations using CECT, and the high value of the median AUC of the 11 stations (0.876)proved the excellent prediction ability of the model. The authors attempted to build a nomogram combining the DL features with clinical features, but no significant improvements in the results were observed.

    Other prognostic factors of GC have also been investigated in previous studies. Sunet al[42] exploited DL techniques to build a CT-based radiomics nomogram for evaluating the status of serosal invasion of advanced GC patients. Three radiomics signatures were generated based on the three phases of CT images with their DL features extracted using CNNs, and they were integrated with clinical characteristics to form the nomogram. The final model outperformed other models, such as clinical and phenotypic models, and its AUC for test sets I and II was 0.87 and 0.90, respectively. Liet al[43]compared the use of DL features and radiomic features to create a CECT-based GC risk (GRISK) model using similar procedures for the prediction of the status of lymphovascular invasion in patients with localized GC. The team explored the use of deep transfer learning models to build a gastric imaging marker, in which five pretrained models and an auto-encoder were utilized for feature extraction and reduction, respectively. Then, it was integrated with patient clinical and radiological characteristics to construct its own GRISK model. The GRISK model with deep transfer learning gastric imaging marker obtained comparable AUC (0.722vs0.725) and accuracy (0.671vs0.710) with the other model with the radiomics gastric imaging marker but did not surpass the latter model.

    The studies investigating the usage of DLR for GC are summarized in Table 2.

    DLRs FOR LIVER CANCER

    Primary liver cancer is the sixth most prevalent form of cancer and the third most lethal cancer globally,and some of its common phenotypes are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma[1]. Taking the high mortality caused by this disease into account, the clinical application of early diagnosis, individualized evaluation and prognosis prediction are valued. The exploitation of DLR technology in liver cancer has been rapidly developing, and various solutions for the issues in different phases of diagnosis and treatment are emerging.

    Computer-aided diagnosis does not only aid radiologists such as shortening the diagnosis time, but also allow them to evaluate appropriate treatments at earlier stages of liver cancer. Dinget al[44]constructed a CT-based DLR model that fused a radiomics signature and a DL model, to differentiate HCC into low or high grade. The DL model was an alteration of VGG19 and it performed better than the radiomics signature, with better AUC (0.7513vs0.7475) and accuracy (66.31%vs65.78%). The fused DLR model was the optimal model with observable improvements in the results, achieving an AUC of 0.8042 and accuracy of 72.73%.

    Accurate prediction of patient response to different therapies is critical to realize personalized treatment at different stages of HCC. Penget al[45] developed a multi-class DL model from ResNet50 to predict four treatment responses to transarterial chemoembolization (TACE) therapy of HCC patients using CECT scans. Its performance was assessed using confusion matrices and receiver operating characteristic curves, and the model attained an AUC over 0.90 for all four classes in both validation sets, and accuracies of 85.1% and 82.8% for validation sets 1 and 2, respectively. In the next year, they combined conventional radiomics and DL to build a new CECT-based DLR model that served to predict the initial treatment response to TACE of HCC patients preoperatively[46]. Different from their priorwork, they designed their own CNN for feature extraction and prediction, and the DL model was integrated with five radiomics models built with different classic machine learning algorithms or tumor size feature to build integrated models for efficacy comparison. The DL model outperformed all individual radiomics models with an AUC of 0.972, while all integrated models yielded higher values of AUC than merely using DL model. The combination of DL with random forest classifier obtained the highest AUC of 0.994.

    Table 2 Summary of studies using deep-learning-based radiomics for gastric cancer

    Survival prediction is also an important research area to facilitate individualized HCC treatment. To predict the OS of HCC patients who were treated with stereotactic body radiation therapy, Weiet al[47]established a CECT-based DL network model that comprised two variational-autoencoder-based survival models and one CNN-based model for extracting radiomic features, clinical features and CT features. The performance of the separate models and the integrated radiomics model using either DL network or Cox hazard model was compared by C-index, in which the integrated model produced the highest C-index of 0.650 in repeated cross-validation among all models. Liuet al[48] developed two separate DLR models to differentiate HCC patients who received radiofrequency ablation (RFA) or surgical resection into high or low risks using CEUS images, and the corresponding radiomics signatures were built. Afterwards, two radiomics nomograms were constructed by combining the signatures with clinical variables to predict the 2-year PFS of patients and both models. Both DLR models achieved satisfactory values of C-index (0.726 for RFA, 0.741 for surgical resection). The good agreement of the survival predictions of the nomograms was demonstrated from the calibration curves.

    Postoperative recurrence of cancer is one of the primary causes of death, which extends to the increase in recurrence risk assessment using DLR. To predict the early recurrence of HCC patients using multi-phase CECT scans, Wanget al[49] explored the predictive ability of various kinds of models, and they included a DLR model based on ResNet, a clinical model extracting features from clinical data and three combined CNN-based models of different structures. Experimental results demonstrated that the integration of DL features and clinical features improved the prediction accuracy, and one combined model obtained the highest AUC of 0.825. The team improved their study by comparing the DL model with a conventional radiomics model, and one more combined model of another structure was added to the comparative analysis of their previous work[50]. The DL model performed better than the radiomics model with an average AUC of 0.7233 and accuracy of 69.52%, while one of the combined models surpassed the rest in the comparative analysis and reached 0.8248 and 78.66% in its average AUC and accuracy, respectively. They also investigated the effect of attaching a joint loss function to the best model on the average AUC and accuracy, and the two metrics were improved to 0.8331 and 80.49%. Heet al[51] presented an intelligent-augmented DL model for Risk Assessment of Post LIver Transplantation (i-RAPIT) model in their study, which was a multi-network model that estimated the recurrence risk of HCC patients after liver transplantation. The i-RAPIT model was composed of two deep CapsNet networks for feature extraction from MR and pathological images, and a naturallanguage-processing-based radial basis function (NLP-based RBF) for extracting clinical features. Before the MR images were entered into the model, U-Net was also exploited for tumor and liver detection in the images. The model achieved a total accuracy of 82%, and AUC of 0.87 and F-1 score of 84% when comparing with other network combinations.

    Early detection of microvascular and macrovascular invasion is another practical approach to select the proper therapy for HCC patients and reduce mortality. Jianget al[52] adopted 3D-CNN to build a CT-based DL model for predicting the status of microvascular invasion of HCC patients, and three models based on radiomics features, radiologic features, and integration of the two kinds of features and clinical characteristics was also used for comparison. The results produced by the four models were excellent, with the DL model achieving better results for a few metrics such as AUC (0.906), and sensitivity (93.2%) in the validation set. Wanget al[53] devised a new DL model named MVI-Mind that consisted of a light-weight transformer for segmentation and a CNN for prediction of microvascular invasion, and several DL techniques were used to compare the proposed methods. The MVI-Mind attained highest mean intersection over union of 0.9006 and accuracy of 99.47% as compared with other DL segmentation algorithms, and it maintained its superiority in prediction and obtained AUC values of 0.9223, 0.8962, and 0.9100 for arterial phase, portal venous phase and delayed period CT images,respectively. For estimating the status of macrovascular invasion using CT scans, Fuet al[54] utilized the concept of multi-task DL neural network (MTnet) to build predictive models. Radiomic features from CT images, clinical and radiological factors were fused to construct the proposed model, and it was modified from U-Net that contained modules engaged in tumor segmentation, feature extraction and prediction. It exhibited the most outstanding performance with an AUC of 0.836 among all models built for comparison.

    The studies investigating the implementation of DLR for liver cancer are summarized in Table 3.

    DLR FOR PANCREATIC CANCER

    Pancreatic cancer is the seventh most deadly cancer worldwide, in which pancreatic adenocarcinoma or pancreatic ductal adenocarcinoma (PDAC) are the most prevalent, accounting for the high mortality rate[1]. The number of deaths caused by this disease is almost equivalent to the number of cases due to the overall poor prognosis, so the introduction of advanced AI technologies is essential and urgent to rectify the situation. In these few years, the field of DLR in pancreatic cancer has flourished and more critical issues such as disease differentiation and survival prediction have been discussed.

    Achieving an accurate diagnosis of PDAC gives a great contribution to avoiding false predictions and improving the survival outcomes of patients. For distinguishing between PDAC and autoimmune pancreatitis using CT scans, Ziegelmayeret al[55] developed a DLR model that utilized VGG19 to extract DL features, and its efficacy was compared with a model trained on handcrafted radiomic features. The former model performed better with higher mean values in AUC, sensitivity, and specificity (0.90, 89% and 83%) over the cross-validation procedure. Liaoet al[56] used a DL model based on the coarse-to-fine network architecture search (C2FNAS) to perform segmentation of CECT images for radiomic feature extraction, and they were used for training the machine learning model forprediction. The DL segmentation model obtained a mean Dice score of 0.773 for segmentation while the prediction model yielded an AUC of 0.960 when distinguishing between PDAC and the control group(non-cancerous diseases and normal pancreas). Tonget al[57] constructed a ResNet-50-based DLRs model to classify PDAC and chronic pancreatitis patients from CEUS images, and the outputs were the probability of being PDAC or chronic pancreatitis, and heatmaps with highlighted regions that displayed the detected lesions. A two-round reader study was conducted to test the effectiveness of the model. The model achieved an AUC of 0.967 and 0.953 in two validation sets and outperformed the radiologists in the first round, while radiologists could obtain higher accuracies in determining the disease with the aid of the model in the second round.

    Table 3 Summary of studies using deep-learning-based radiomics for liver cancer

    Prediction of treatment response is also a critical aspect in the field of DLR in pancreatic cancer.Watsonet al[58] built a CNN model based on LeNet to classify, using CT scans, whether PDAC patients had a pathological response or no response to NAC. It was compared with two models: a hybrid DL model that had the same architecture as the pure DL model but captured both CT image features and one clinical feature [≥ to 10% decrease in carbohydrate antigen (CA)-19], and a CA-19 model only taking in the feature regarding CA-19 decrease. Both DL models could produce superior results than the CA-19 model, and the hybrid DL model obtained a slightly higher AUC than the pure DL model (0.784vs0.738).

    Survival prediction is another vital feature of PDAC that occupies a substantial portion of the existing DLR studies. Muhammadet al[59] designed a CNN architecture modified from AlexNet to evaluate the survival risk of PDAC patients that received radiomic features extracted from CECT images, and the model reached a C-index of 0.85, indicating itself as a good survival model. Zhanget al[60] also made use of a CNN that was pretrained with non-small cell lung cancer images to construct their CT-based survival model for patients with resectable PDAC, in which a modified loss function was used. The proposed model accomplished finer prognostic predictions than the conventional radiomic model with an index of prediction accuracy of 11.81% and C-index of 0.651. They released another paper in the same year and compared the efficacy of DL and radiomic features from CECT images by feeding them separately to a random forest classifier to build a DLR model for predicting OS[61]. Similar to their prior work, the DL features were extracted by a pretrained CNN model but with a different structure. The model that used DL features attained an AUC of 0.81, which was higher than the other model based on radiomic features and gained a hazard ratio of 1.38 when the respective risk scores (predicted probabilities of deaths) were tested in survival analyses. Later, they further modified their previous DLR model to a risk score-based feature fusion model to predict 2-year OS[62]. Two small models based on DL and radiomic features separately were embodied in the framework to generate their corresponding risk scores, and these risk scores were used to train the main prediction model. The performance of the proposed model was later assessed with other models using different feature reduction techniques, and the risk score model achieved the highest AUC of 0.84. Yaoet al[63] devised a new multi-task network model to perform both survival and tumor surgical margin prediction of resectable PDAC patients simultaneously using multi-phase CECT scans. Inside the model, a 3D-CNN model incorporated with a nnUNet for pancreas segmentation was exploited for the margin prediction part, while the combination of 3D-ResNet18 and Contrast-Enhanced 3D Convolutional Long Short-Term Memory (CE-ConvLSTM)network was responsible for survival prediction. The model achieved the results exceeding all other deep models in the comparative analysis, which yielded a C-index of 0.705 in predicting survival outcome and a balanced accuracy of 73.6% in determining the resection margin. They revised their preliminary work by incorporating pancreatic anatomical features into the model and switching to implement an automatically self-learning segmentation method that used 3D UNet as the network architecture and nnUNet as the backbone model for training[63]. The new model attained the highest survival C-index of 0.667 and balanced accuracy of 67.1% for resection margin prediction among all the models including their previous model and other DL and radiomics models.

    LN metastasis also possesses a high prognostic value in pancreatic cancer and it is noteworthy to have an early and accurate prediction of its status. Anet al[64] developed a DLR model with different radiomics signatures extracted from dual-energy CT scans for the prediction of LN metastasis by a pretrained ResNet-18 model. Experiments of adding key clinical features were conducted to compare the effectiveness of using different approaches. The combined model integrated DL features and key clinical features yielded the highest AUC of 0.92 and accuracy of 86%.

    The expression of various genes is an influential factor for patient prognosis and preoperative prediction of these prognostic factors can assist the diagnosis and treatment evaluation process. To predict the status ofHMGA2andC-MYCgene expression of PDAC patients, Liet al[65] compared the use of radiomic features, DL features (extracted by pretrained CNN) and integration of both features in a CT-based model using an SVM classifier. Region of interest segmentation was conducted by two experienced radiologists individually, and the model was tested with different segmented images for improving the validity of the study. A model using DL features and all features achieved similar values in all evaluation metrics for bothC-MYCandHMGA2tests, while DL features selected by Doctor B obtained outstanding average AUC scores (C-MYC: 0.90,HMGA2: 0.91) and accuracies (C-MYC: 95%,HMGA2: 88%) in the two gene tests.

    The studies investigating the application of DLR for pancreatic cancer are summarized in Table 4.

    DLR FOR COLORECTAL CANCER

    Colorectal cancer (CRC) is the third most common kind of cancer and the second leading cause of cancer-related fatalities worldwide[1]. It is crucial to carry out research on the diagnosis, treatment response prediction, and survival prediction of CRC, which can improve the prognosis of patients and significantly reduce the social and medical burden. In recent years, promising research results have emerged in the preoperative, intraoperative and postoperative stages of CRC using DLRs technology,covering the entire process of CRC diagnosis and treatment.

    DLR is revolutionizing the treatment options for CRC. When making treatment decisions for CRC patients, identifyingKRASmutations, which may contribute to the continued proliferation of tumors,can help personalize treatment and care for CRC patients[66]. For preoperative prediction ofKRASmutations in patients with CRC, HCR and DLR were merged into a noninvasive model created by Wuet al[67]. The model, which mixed the handcrafted and DLR radiomics features, produced a C-index for the original cohort of 0.815 and the validation cohort of 0.832, which was higher than using HCR or DLR alone. For the individualized treatment decision-making in colorectal liver metastases (CRLM)management, the prediction of chemotherapeutic response is crucial. To predict the response to chemotherapy in CRLM, Weiet al[68] developed a ResNet10-based DLR model that used contrastenhanced multidetector CT images as inputs. They also developed an HCR model for comparison. TheDLR model achieved a higher AUC than the HCR model when predicting the response to chemotherapy in CRLM (training: 0.903vs0.745; validation: 0.820vs0.598). Microsatellite instability(MSI) function is a predictive biomarker for clinical outcomes and predicts responses to adjuvant 5-fluorouracil and immunotherapy in CRC. A DL model that was created using the MobileNetV2 architecture by Zhanget al[69] was adopted to predict the MSI status of CRC based on MR images. With AUC values of 0.868, the best model successfully identified 85.4% of the MSI status, indicating that the suggested model may aid in locating individuals who might benefit from chemotherapy or immunotherapy.

    Table 4 Summary of studies using deep-learning-based radiomics for pancreatic cancer

    DLR in CRC also emphasizes the need to predict treatment response. For improving NCRT response prediction in locally advanced rectal cancer, Fuet al[70] compared the handcrafted and DL features extracted from pre-treatment diffusion-weighted MR images. The DLR approach produced a mean AUC of 0.73, while the HCR method yielded a mean AUC of 0.64, which demonstrated that DLR may achieve higher classification performance compared with HCRs. To predict the distant metastasis in locally advanced rectal cancer patients receiving NCRT, Liuet al[71] exploited the use of a DLR model based on MR images. DLR achieved a C-index of 0.747 and AUC of 0.894 at 3 years. In order to define tumor morphological change for response evaluation in patients with metastatic CRC, Luet al[72]offered a DLR study using CNN and recurrent neural network. They discovered that the DL network performed better than the size-based equivalent with C-index (0.649vs0.627), and was capable of predicting the early on-treatment response in metastatic CRC. The predictive performance could be improved by the integration of DL network with size-based methodology.

    LN metastasis, which is a key prognostic factor for CRC, is among the other study topics of CRC.Dinget al[73] adopted a DLR nomogram based on faster region-based CNN (Faster R-CNN) to predict LN metastasis in patients with CRC. Patient age, Faster R-CNN-detected LN metastasis, and tumor differentiation were predictors in the Faster R-CNN nomogram for predicting LN metastasis, with AUCs in the training and validation sets of 0.862 and 0.920, respectively. Zhaoet al[74] applied a DLR model related with genomics phenotypes for predicting LN metastasis in CRC and showed good performance with AUCs of 0.81, 0.77, and 0.73 in the training, testing and validation sets, respectively.Liet al[75] examined the performance of the three most popular classification techniques-DL, conventional machine learning, and deep transfer learning-to determine the most efficient way for automatic classification of CRC LN metastases. Deep transfer learning was the most successful, with an accuracy of 0.7583 and AUC of 0.7941. All of these studies have shown that DLR technology has good performance in the prediction and classification of LN metastasis.

    The studies exploring the creation of DLR for CRC are summarized in Table 5.

    CHALLENGES AND RECOMMENDATIONS

    In the past several years, with the development of DL technology, the research and application of DLR in tumor diagnosis, treatment and prognosis have been increasing. To perform a systematic evaluation of the status of DLRs for GI cancer, we conducted an extensive review on all original publications between January 1, 2015, and August 30, 2022. Even though several published articles have confirmed the exceptional performance of DLR, there are still many issues that algorithm designers and doctors must address. Below is a list of the challenges and recommendations for DLR in future research summarized by our team.

    Prospective and multi-center studies

    According to the most recent research, most studies on DLR were retrospective and single center.Retrospective studies may have sample selection bias and cannot truly reflect the distribution of clinical cases, which could jeopardize the precision of DLR models. As different centers have different machine parameters, scanning settings, and diagnostic rules, single-center studies limit the generalization of the DLR models. Prospective and multi-center studies can evaluate the reliability and accuracy of the DLR models, enhance their generalization, and bridge the gap between academic studies and clinical applications. Thus, carrying out prospective and multi-center studies is the key to accelerating the clinical application of DLRs models.

    Development of user-friendly DL models

    We found that many physicians do not really want to use DLR methods for related research because the models usually have complex structures, large parameters, poor interpretability, non-existence of gradients, overfitting, and other problems, which limit the promotion and use of DLR technology.Therefore, it is necessary to develop simple and user-friendly models and training schemes for nonprofessional users. Publication of more source codes and pre-training weights are ways to reduce the development and training difficulty of DL models. For overfitting problems, development of automatic data augmentation schemes and image synthesis schemes can increase the amount of training data. For the black box nature of DL models, attention maps and network dissection schemes can be integrated into the model to improve interpretability.

    Establishment of accessible datasets

    For DLR, the dataset is the new oil. DLR analysis requires a large amount of data to train and validate models; however, most studies are based on private datasets and do not use uniform construction standards, which will hinder the reproducibility of the studies and deployment of DLR models. Thus, a professional data development organization that combines multi-center data should be established. The organization should also standardize the development process of multiple kinds of datasets and make the datasets publicly accessible. Additionally, to reward data contributors, researchers who use these datasets could charge appropriate fees.

    Efficient fusion of multiple features

    DLR is a new technology in the field of AI for medical image analysis. Although its performance is satisfactory, it is not a panacea, especially in the case of extreme shortage of data. Numerous studieshave demonstrated that combining HCR and DLR, can result in better performance. Thus, we suggest integrating other clinical features, genomics, handcrafted features, and DL features to build an optimal solution. Moreover, a suitable feature dimensionality reduction scheme should also be adopted to reduce the redundancy of the integrated features. In addition to imaging features, features extracted from clinical data sources, such as gene expression, clinical characteristics, and blood biomarkers, can also be combined to enhance radiomic features.

    Table 5 Summary of studies using deep-learning-based radiomics for colorectal cancer

    CONCLUSION

    Globally, GI cancers account for a large portion of cancer-related fatalities. For the diagnosis and treatment of GI cancer, DLR can offer a simpler, quicker and more reliable approach. This article is the first comprehensive review on DLR in the GI tract. The status, difficulties, and suggestions discussed in this review can help engineers create optimal radiomics products to support clinical decision-making and offer guidance for diagnosis and treatment of other tumors. Despite the success of DLR in GI cancer, prospective and multi-center studies are still needed. Development of user-friendly DL models,the creation of large public databases, and the fusion of multiple features are also necessary to encourage the clinical application of radiomics.

    FOOTNOTES

    Author contributions:Wong PK, Chan IN, Yan HM, Gao S, Wong CH, and Yan T collected the literature and wrote the initial manuscript, conceptualized the table and figures, and contributed equally to this work; Yao L, Hu Y, Wang ZR, and Yu HH conceptualized the structure of the text and critically revised the manuscript for important intellectual content; all authors read and approved the final version of the manuscript.

    Supported bythe Guangdong Basic and Applied Basic Research Fund, Shenzhen Joint Fund (Guangdong-Shenzhen Joint Fund) Guangdong-Hong Kong-Macau Research Team Project, No. 2021B1515130003; Science and Technology Development Fund of Macau, No. 0026/2022/A; and Project of Xiangyang Science and Technology on Medical and Health Field, No. 2022YL05A.

    Conflict-of-interest statement:All authors declare no conflict of interest.

    Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

    Country/Territory of origin:China

    ORCID number:Pak Kin Wong 0000-0002-7623-6904; In Neng Chan 0000-0002-7015-4510; Hao-Ming Yan 0000-0002-2223-4671; Shan Gao 0000-0002-8232-4134; Chi Hong Wong 0000-0003-2183-4525; Tao Yan 0000-0002-8929-015X; Liang Yao 0000-0003-3377-1509; Ying Hu 0000-0002-3807-3649; Zhong-Ren Wang 0000-0002-3488-7119; Hon Ho Yu 0000-0002-9580-345X.

    S-Editor:Chen YL

    L-Editor:A

    P-Editor:Chen YL

    久久久久网色| 国产黄色免费在线视频| 人人妻人人爽人人添夜夜欢视频| 99热这里只有是精品在线观看| 精品久久久精品久久久| 亚洲国产精品一区三区| av福利片在线| 91午夜精品亚洲一区二区三区| 五月开心婷婷网| 精品视频人人做人人爽| 狠狠精品人妻久久久久久综合| 久久久久网色| 精品卡一卡二卡四卡免费| 一边亲一边摸免费视频| 亚洲美女视频黄频| 国产免费一级a男人的天堂| 午夜福利,免费看| 国产色婷婷99| 亚洲av免费高清在线观看| 久久影院123| 亚洲第一区二区三区不卡| 国产成人午夜福利电影在线观看| 又黄又爽又刺激的免费视频.| 性色av一级| 91在线精品国自产拍蜜月| 久久精品国产自在天天线| 两个人的视频大全免费| 九草在线视频观看| 久久久久久久久久久丰满| 成人无遮挡网站| 国产亚洲午夜精品一区二区久久| 美女主播在线视频| 精品熟女少妇av免费看| 高清视频免费观看一区二区| 久久久久久久亚洲中文字幕| 国产69精品久久久久777片| 国模一区二区三区四区视频| 99九九线精品视频在线观看视频| 亚洲国产精品专区欧美| 日本与韩国留学比较| 亚洲成色77777| 久久国产精品男人的天堂亚洲 | av免费在线看不卡| 欧美日韩精品成人综合77777| 大香蕉久久网| 国产淫语在线视频| 亚洲精品成人av观看孕妇| 成人影院久久| 日韩大片免费观看网站| 午夜av观看不卡| 日韩人妻高清精品专区| 亚洲成人av在线免费| 麻豆成人av视频| 国产一区有黄有色的免费视频| 超碰97精品在线观看| 国产精品久久久久成人av| 亚洲精品av麻豆狂野| 男女国产视频网站| 一本色道久久久久久精品综合| 大香蕉久久成人网| 交换朋友夫妻互换小说| 欧美最新免费一区二区三区| 人人妻人人爽人人添夜夜欢视频| 成人综合一区亚洲| 亚洲精品乱码久久久v下载方式| 天堂俺去俺来也www色官网| 麻豆精品久久久久久蜜桃| 亚洲天堂av无毛| 夫妻性生交免费视频一级片| 欧美97在线视频| 丰满饥渴人妻一区二区三| 国产成人免费无遮挡视频| 日韩制服骚丝袜av| 三级国产精品欧美在线观看| 久久久欧美国产精品| 欧美最新免费一区二区三区| 亚洲,欧美,日韩| 午夜精品国产一区二区电影| 国产免费视频播放在线视频| 十分钟在线观看高清视频www| 成人毛片a级毛片在线播放| 国产伦理片在线播放av一区| a级片在线免费高清观看视频| 久久毛片免费看一区二区三区| xxx大片免费视频| 久久久久久伊人网av| 久久久久精品久久久久真实原创| 观看av在线不卡| 制服诱惑二区| 婷婷色综合大香蕉| 国产欧美日韩综合在线一区二区| 制服诱惑二区| 欧美日韩精品成人综合77777| 久久99蜜桃精品久久| 高清黄色对白视频在线免费看| 亚洲人成77777在线视频| 国产精品.久久久| 精品酒店卫生间| 赤兔流量卡办理| 亚洲三级黄色毛片| 成人综合一区亚洲| 成人综合一区亚洲| 国产淫语在线视频| 免费人成在线观看视频色| 又黄又爽又刺激的免费视频.| 老女人水多毛片| 亚洲图色成人| 国产亚洲精品第一综合不卡 | 99久国产av精品国产电影| 成人无遮挡网站| 97超视频在线观看视频| 菩萨蛮人人尽说江南好唐韦庄| 国产一区亚洲一区在线观看| 一区二区av电影网| 街头女战士在线观看网站| 国产永久视频网站| 永久免费av网站大全| 美女脱内裤让男人舔精品视频| 国产成人freesex在线| 18+在线观看网站| 一级爰片在线观看| 精品人妻一区二区三区麻豆| 18禁动态无遮挡网站| a级毛色黄片| 99久久精品国产国产毛片| 99久久综合免费| 午夜免费鲁丝| 国产精品人妻久久久影院| 精品国产一区二区久久| 91国产中文字幕| 亚洲欧美精品自产自拍| 欧美人与善性xxx| 在线观看免费视频网站a站| tube8黄色片| 国产日韩欧美亚洲二区| 日韩一区二区三区影片| 热99国产精品久久久久久7| 黄色怎么调成土黄色| 视频中文字幕在线观看| 久久久精品94久久精品| 国产亚洲欧美精品永久| 亚洲精品乱久久久久久| 亚洲国产av影院在线观看| 欧美日韩视频精品一区| 日本与韩国留学比较| 黄片无遮挡物在线观看| 男女边摸边吃奶| 美女大奶头黄色视频| 母亲3免费完整高清在线观看 | 日韩精品免费视频一区二区三区 | 亚洲精品乱久久久久久| 日本色播在线视频| 久久久久久久久久久久大奶| 亚洲成色77777| 麻豆成人av视频| 久久婷婷青草| 日本欧美视频一区| 热99久久久久精品小说推荐| 欧美+日韩+精品| 黄色一级大片看看| 成人亚洲精品一区在线观看| 国产av码专区亚洲av| 亚洲第一区二区三区不卡| 国产女主播在线喷水免费视频网站| 伊人亚洲综合成人网| 汤姆久久久久久久影院中文字幕| 最近最新中文字幕免费大全7| 亚洲av.av天堂| 黑人高潮一二区| 国产亚洲欧美精品永久| 久久ye,这里只有精品| 国产成人av激情在线播放 | 五月天丁香电影| 国产黄色视频一区二区在线观看| 亚洲精品成人av观看孕妇| 丝袜在线中文字幕| 国产老妇伦熟女老妇高清| 狂野欧美白嫩少妇大欣赏| 成人二区视频| 亚洲av在线观看美女高潮| 免费黄频网站在线观看国产| 精品久久久噜噜| 久热这里只有精品99| 国产伦理片在线播放av一区| 国产在线免费精品| 国产精品一区二区三区四区免费观看| 亚洲人成77777在线视频| 日韩人妻高清精品专区| 一级毛片黄色毛片免费观看视频| 两个人的视频大全免费| 亚洲色图 男人天堂 中文字幕 | 精品久久久噜噜| 男女无遮挡免费网站观看| 亚洲精品久久成人aⅴ小说 | 久久人妻熟女aⅴ| 午夜福利网站1000一区二区三区| 在线天堂最新版资源| 亚洲av日韩在线播放| 精品人妻偷拍中文字幕| 街头女战士在线观看网站| 免费播放大片免费观看视频在线观看| 亚洲怡红院男人天堂| 99久久中文字幕三级久久日本| 一本色道久久久久久精品综合| 午夜激情久久久久久久| 精品一区在线观看国产| 黑人欧美特级aaaaaa片| 卡戴珊不雅视频在线播放| 亚洲精品国产av成人精品| 亚洲欧美中文字幕日韩二区| 午夜激情av网站| 青春草国产在线视频| 女的被弄到高潮叫床怎么办| 十八禁高潮呻吟视频| 亚洲三级黄色毛片| 国产又色又爽无遮挡免| 欧美激情国产日韩精品一区| 成人免费观看视频高清| 欧美xxⅹ黑人| 在线观看免费日韩欧美大片 | 久久精品夜色国产| 91精品国产九色| 国产在线一区二区三区精| 夜夜爽夜夜爽视频| 久久亚洲国产成人精品v| 欧美激情极品国产一区二区三区 | 精品人妻熟女毛片av久久网站| 久久女婷五月综合色啪小说| 三级国产精品欧美在线观看| 亚洲av国产av综合av卡| 免费播放大片免费观看视频在线观看| 免费不卡的大黄色大毛片视频在线观看| 日韩av免费高清视频| 天堂8中文在线网| 国产精品久久久久久av不卡| 国产精品熟女久久久久浪| 青春草国产在线视频| 国产深夜福利视频在线观看| 美女中出高潮动态图| 婷婷色av中文字幕| 人妻系列 视频| 91精品国产九色| 熟妇人妻不卡中文字幕| 蜜桃久久精品国产亚洲av| 欧美日韩亚洲高清精品| 老熟女久久久| 日本91视频免费播放| 少妇精品久久久久久久| 精品久久久噜噜| 男女无遮挡免费网站观看| 考比视频在线观看| 亚洲欧美成人精品一区二区| 在线精品无人区一区二区三| 欧美+日韩+精品| 免费大片黄手机在线观看| 久久女婷五月综合色啪小说| 国产黄色免费在线视频| 国产成人精品婷婷| 久久国产亚洲av麻豆专区| 熟女人妻精品中文字幕| 狠狠精品人妻久久久久久综合| 日韩欧美一区视频在线观看| 色94色欧美一区二区| 国产黄色免费在线视频| 亚洲av.av天堂| 天堂8中文在线网| 亚洲国产色片| 自线自在国产av| 免费看不卡的av| 日韩av在线免费看完整版不卡| 欧美精品国产亚洲| 午夜福利视频精品| 国产精品国产三级国产专区5o| 精品一区二区三卡| 99精国产麻豆久久婷婷| 免费观看a级毛片全部| av一本久久久久| 亚洲精品日本国产第一区| 97在线人人人人妻| 久久久久国产网址| 91国产中文字幕| 久久久精品94久久精品| 在线观看一区二区三区激情| h视频一区二区三区| 全区人妻精品视频| 人人妻人人澡人人看| 久久久久久久精品精品| 亚洲欧美中文字幕日韩二区| 亚洲图色成人| 亚洲在久久综合| 免费人妻精品一区二区三区视频| 多毛熟女@视频| 一本一本综合久久| 大又大粗又爽又黄少妇毛片口| .国产精品久久| 亚洲av欧美aⅴ国产| 精品一区二区免费观看| 观看美女的网站| 狂野欧美激情性bbbbbb| 国产一区有黄有色的免费视频| 黄色配什么色好看| 视频在线观看一区二区三区| 国产欧美另类精品又又久久亚洲欧美| 亚洲色图综合在线观看| 亚洲人与动物交配视频| 老熟女久久久| 一个人看视频在线观看www免费| 国产成人精品无人区| 色婷婷av一区二区三区视频| 视频中文字幕在线观看| 国产精品99久久99久久久不卡 | 一区二区三区免费毛片| 青春草国产在线视频| 成人综合一区亚洲| 国产精品一区二区在线观看99| 男女啪啪激烈高潮av片| 爱豆传媒免费全集在线观看| 91精品伊人久久大香线蕉| 性色av一级| 久久久精品免费免费高清| 国产精品久久久久久久电影| 精品国产一区二区久久| 天美传媒精品一区二区| 在线免费观看不下载黄p国产| 亚洲av成人精品一区久久| 女人久久www免费人成看片| 国产精品偷伦视频观看了| 午夜激情久久久久久久| 性色avwww在线观看| 91精品国产九色| 国产精品国产av在线观看| 国产免费福利视频在线观看| 极品人妻少妇av视频| 在线观看美女被高潮喷水网站| 亚洲欧美一区二区三区国产| 国产高清三级在线| 成人亚洲精品一区在线观看| 永久免费av网站大全| 又大又黄又爽视频免费| 久久久精品94久久精品| 午夜91福利影院| 少妇熟女欧美另类| 嘟嘟电影网在线观看| 男人添女人高潮全过程视频| 看免费成人av毛片| 男女免费视频国产| 一区在线观看完整版| 在线观看三级黄色| 久久97久久精品| 最近的中文字幕免费完整| 国产色婷婷99| 久久久久久久久久久久大奶| 男女边吃奶边做爰视频| 简卡轻食公司| 精品一品国产午夜福利视频| 寂寞人妻少妇视频99o| 97超视频在线观看视频| 成人无遮挡网站| 精品人妻一区二区三区麻豆| .国产精品久久| 久久久久精品久久久久真实原创| 中文字幕av电影在线播放| 晚上一个人看的免费电影| 在线精品无人区一区二区三| 成人手机av| 18禁在线播放成人免费| 久久精品久久久久久久性| 午夜福利,免费看| 免费人妻精品一区二区三区视频| 一级二级三级毛片免费看| 久久99热6这里只有精品| 久久亚洲国产成人精品v| 久久99精品国语久久久| 成人18禁高潮啪啪吃奶动态图 | 久久精品国产鲁丝片午夜精品| 欧美日韩综合久久久久久| 亚洲国产av新网站| 毛片一级片免费看久久久久| 九九爱精品视频在线观看| 大香蕉久久网| 亚洲怡红院男人天堂| 日韩欧美精品免费久久| 十八禁高潮呻吟视频| 久久久久久久久久久免费av| 少妇丰满av| 美女内射精品一级片tv| 中文字幕久久专区| 全区人妻精品视频| 国产一区亚洲一区在线观看| a 毛片基地| 99久久人妻综合| 亚洲成色77777| 一级片'在线观看视频| 另类精品久久| 久久久久久久久久久免费av| 搡女人真爽免费视频火全软件| 一本久久精品| 一级爰片在线观看| 一级毛片黄色毛片免费观看视频| 18禁裸乳无遮挡动漫免费视频| 亚洲精品美女久久av网站| 国产 一区精品| 久久97久久精品| 亚洲美女搞黄在线观看| 久久国产精品大桥未久av| 日韩制服骚丝袜av| 亚洲成人手机| 国产深夜福利视频在线观看| 成人亚洲精品一区在线观看| 亚洲av男天堂| 最近手机中文字幕大全| 伊人久久国产一区二区| 狠狠婷婷综合久久久久久88av| 亚洲综合色网址| a 毛片基地| av黄色大香蕉| 人体艺术视频欧美日本| 一本色道久久久久久精品综合| 欧美日韩av久久| 国产毛片在线视频| 欧美精品一区二区免费开放| 免费大片18禁| 久久久久久人妻| 人体艺术视频欧美日本| 又粗又硬又长又爽又黄的视频| 日韩 亚洲 欧美在线| 欧美老熟妇乱子伦牲交| 精品久久久久久久久亚洲| 男男h啪啪无遮挡| 精品亚洲成国产av| 边亲边吃奶的免费视频| 久久久久人妻精品一区果冻| 如何舔出高潮| 亚洲成人av在线免费| 2018国产大陆天天弄谢| 韩国高清视频一区二区三区| 黄色配什么色好看| 日日撸夜夜添| 国产老妇伦熟女老妇高清| 日韩在线高清观看一区二区三区| 最新的欧美精品一区二区| 久久青草综合色| 高清毛片免费看| 亚洲第一区二区三区不卡| 国国产精品蜜臀av免费| 婷婷色av中文字幕| 久久久久久久久久人人人人人人| 啦啦啦在线观看免费高清www| 久久精品国产亚洲网站| 伦理电影大哥的女人| 各种免费的搞黄视频| 精品人妻熟女av久视频| 国产在线视频一区二区| av免费在线看不卡| 久久久久国产精品人妻一区二区| 久久鲁丝午夜福利片| 最近最新中文字幕免费大全7| 黄色怎么调成土黄色| 亚洲av福利一区| 人妻系列 视频| 国产免费现黄频在线看| 一级片'在线观看视频| 欧美3d第一页| 黑丝袜美女国产一区| 国产成人精品婷婷| 啦啦啦啦在线视频资源| 夫妻性生交免费视频一级片| 日韩av免费高清视频| 国产精品久久久久久精品古装| av有码第一页| 亚洲av男天堂| a级毛片黄视频| 午夜福利,免费看| 又大又黄又爽视频免费| 午夜福利影视在线免费观看| 亚洲精品久久成人aⅴ小说 | 婷婷色综合大香蕉| 精品久久久精品久久久| 午夜免费观看性视频| av福利片在线| 老司机影院成人| 麻豆成人av视频| 中国三级夫妇交换| 青春草国产在线视频| 成人亚洲欧美一区二区av| 丰满乱子伦码专区| 国产深夜福利视频在线观看| 亚洲av欧美aⅴ国产| 久久韩国三级中文字幕| 精品一品国产午夜福利视频| 精品久久久久久久久亚洲| 色婷婷久久久亚洲欧美| 久久精品国产亚洲av涩爱| 免费不卡的大黄色大毛片视频在线观看| 久久人人爽人人片av| 欧美最新免费一区二区三区| 中国三级夫妇交换| 亚洲成人一二三区av| 国产免费福利视频在线观看| 大片免费播放器 马上看| 看免费成人av毛片| 久久人人爽av亚洲精品天堂| 80岁老熟妇乱子伦牲交| 极品人妻少妇av视频| 热re99久久精品国产66热6| 边亲边吃奶的免费视频| 亚洲高清免费不卡视频| 人人妻人人爽人人添夜夜欢视频| 一本—道久久a久久精品蜜桃钙片| 国产一级毛片在线| 亚洲av欧美aⅴ国产| 亚洲国产最新在线播放| 十八禁网站网址无遮挡| 一级a做视频免费观看| 91成人精品电影| 少妇丰满av| 亚洲人与动物交配视频| 精品熟女少妇av免费看| 一二三四中文在线观看免费高清| 国产日韩欧美亚洲二区| 中文乱码字字幕精品一区二区三区| 日韩免费高清中文字幕av| 大又大粗又爽又黄少妇毛片口| 国产极品粉嫩免费观看在线 | 国国产精品蜜臀av免费| 水蜜桃什么品种好| av有码第一页| 精品久久久久久电影网| 王馨瑶露胸无遮挡在线观看| 一级二级三级毛片免费看| 国产亚洲一区二区精品| 亚洲精品aⅴ在线观看| xxx大片免费视频| 国产黄色视频一区二区在线观看| 亚洲欧美成人精品一区二区| 亚洲一区二区三区欧美精品| 男女边吃奶边做爰视频| 免费黄色在线免费观看| 国产成人freesex在线| 在线看a的网站| 一区二区三区四区激情视频| 中文字幕亚洲精品专区| 美女脱内裤让男人舔精品视频| 国产精品三级大全| 国产日韩欧美在线精品| 美女大奶头黄色视频| 黄片播放在线免费| 午夜激情av网站| 午夜福利,免费看| 亚洲欧洲国产日韩| 大香蕉97超碰在线| 国产免费现黄频在线看| 色吧在线观看| 美女国产高潮福利片在线看| 午夜免费男女啪啪视频观看| 成人国产麻豆网| 青春草国产在线视频| 欧美日本中文国产一区发布| 最新中文字幕久久久久| av在线播放精品| 中国美白少妇内射xxxbb| 亚洲色图 男人天堂 中文字幕 | 曰老女人黄片| 国产av码专区亚洲av| 一级a做视频免费观看| 免费黄色在线免费观看| 日韩,欧美,国产一区二区三区| 亚洲av男天堂| 久久久久国产精品人妻一区二区| 国产免费福利视频在线观看| 中国国产av一级| 成年av动漫网址| 欧美三级亚洲精品| 丰满少妇做爰视频| 赤兔流量卡办理| 欧美bdsm另类| 久热久热在线精品观看| 插逼视频在线观看| 精品久久久久久电影网| 女性被躁到高潮视频| 国产淫语在线视频| 亚洲天堂av无毛| 99久久精品国产国产毛片| 久久久久久久大尺度免费视频| 欧美日韩成人在线一区二区| 18禁在线无遮挡免费观看视频| 国产成人午夜福利电影在线观看| 一级a做视频免费观看| 亚洲国产欧美日韩在线播放| 国产熟女欧美一区二区| 成人18禁高潮啪啪吃奶动态图 | 国产精品99久久99久久久不卡 | 热re99久久国产66热| 精品亚洲成国产av| 视频在线观看一区二区三区| 亚洲精品国产色婷婷电影| 亚洲三级黄色毛片| 国产黄频视频在线观看| 午夜福利影视在线免费观看| 久久久国产精品麻豆| 色哟哟·www| 欧美亚洲日本最大视频资源| 免费av不卡在线播放| 男女国产视频网站| 一级毛片aaaaaa免费看小| 久久99蜜桃精品久久| 成人无遮挡网站| 18禁动态无遮挡网站| 亚洲天堂av无毛| 国产精品嫩草影院av在线观看| 成人免费观看视频高清| 99九九在线精品视频| 一本一本久久a久久精品综合妖精 国产伦在线观看视频一区 | 91成人精品电影| 汤姆久久久久久久影院中文字幕|