Foreign body granuloma in the tongue differentiated from tongue cancer: A case report

lNTRODUCTlON

The introduction of a foreign body into the tongue can occasionally occur as food is being chewed. In most situations this can lead to pain, swelling and irritation[1]. Such foreign bodies can usually be identified and diagnosedvisual inspection, especially if they are not buried in the muscle layer[2]. A clear history of foreign body introduction into the mouth, as well as a timely visit to the physician, can be conducive to the diagnosis[3]. Penetration of the tongue by a foreign substance can cause an acute inflammatory response and foreign bodies that remain in place may elicit a granulomatous inflammatory response[4]. The cause of granuloma in the tongue can be difficult to ascertain, especially without a clear history of foreign body ingestion. In this paper, we describe the case of a foreign body granuloma in the tongue of a Chinese woman. The initial diagnosis was tongue cancer but further examination revealed a foreign body in the tongue which was removedsurgery.

艾莉沒(méi)有見(jiàn)到戴菲兒的合格證、發(fā)票、信譽(yù)卡、保修卡、使用說(shuō)明……但她相信戴菲兒所說(shuō)的每一句話。因?yàn)榘麩o(wú)法掩飾。因?yàn)樗吹酱鞣苾旱陌卮ǖ陌?。她?tīng)到連接在他們之間的那根看不見(jiàn)的細(xì)細(xì)的線繩的崩斷之音。一頓飯的時(shí)間，她成為主人，戴菲兒成為玩偶，世界就是這般離奇，充滿變數(shù)。

另外，進(jìn)口品最大的問(wèn)題在于受制于進(jìn)口備案等一系列手續(xù)。不過(guò)，隨著跨境電商的發(fā)展，韓妝也成為受惠者之一。例如，近日阿里巴巴宣布與浙江自貿(mào)區(qū)達(dá)成合作，加快非特殊化妝品備案流程，幫助進(jìn)口化妝品同步進(jìn)入中國(guó)市場(chǎng)。未來(lái)，通過(guò)阿里巴巴統(tǒng)一備案的普通進(jìn)口化妝品，從注冊(cè)備案到獲批周期大幅加快至3個(gè)月內(nèi)。

CASE PRESENTATlON

Chief complaints

The patient recovered well and there were no complications during the 2-mo follow-up period.

History of present illness

The patient sought out a general practitioner because of pain and noticeable swelling in the tongue that persisted for over 1 mo. She was given a short course of antibiotics which provided no symptom relief.The patient was referred to the Department of Stomatology, where an oral surgeon prescribed oral maxillofacial magnetic resonance imaging (MRI). The imaging revealed abnormal signal intensities, as shown in Figure 1, which are indicative of tongue cancer. The patient then visited the ENT Department for further consultation.

The results of routine tests of complete blood count, kidney function and liver function were normal.

History of past illness

本世紀(jì)以來(lái)，兒童參與武裝沖突的問(wèn)題引起國(guó)際社會(huì)越來(lái)越多的關(guān)注，市場(chǎng)和互聯(lián)網(wǎng)上涌現(xiàn)的大量自傳、新聞報(bào)道、紀(jì)錄片、小說(shuō)和電影表明媒體和藝術(shù)在共同努力讓世界了解此問(wèn)題。參與武裝沖突的兒童多是被綁架的兒童，年齡一般在5～18歲，他們被迫接受殘酷的訓(xùn)練，被迫參與殺人劫掠行動(dòng)，這些兒童被稱為娃娃兵（child soldier）。在哥倫比亞、斯里蘭卡、阿富汗、伊拉克以及非洲的一些國(guó)家，如幾內(nèi)亞、象牙海岸、利比里亞、塞拉利昂、烏干達(dá)等娃娃兵問(wèn)題非常嚴(yán)重。聯(lián)合國(guó)兒童基金會(huì)（UNICEF）等國(guó)際組織一直都在盡力解救娃娃兵，并努力幫助解救出的娃娃兵以健康的心理回歸社會(huì)。

2.圍繞提升專業(yè)能力素質(zhì)構(gòu)建專業(yè)支撐課程。支撐課程是對(duì)學(xué)員專業(yè)能力素質(zhì)起基礎(chǔ)和支撐作用的課程，對(duì)打牢學(xué)員的學(xué)科專業(yè)基礎(chǔ)、掌握扎實(shí)的專業(yè)理論知識(shí)，提高對(duì)部隊(duì)裝備和訓(xùn)練變換的適應(yīng)能力有著重要作用。對(duì)于這類(lèi)課程的定位，要充分考慮部隊(duì)任職崗位及未來(lái)崗位變化對(duì)學(xué)員專業(yè)能力的要求。既要注重讓學(xué)員掌握寬厚的專業(yè)基礎(chǔ)知識(shí)，又兼顧讓學(xué)員掌握專業(yè)技術(shù)學(xué)習(xí)和訓(xùn)練的基本方法，形成知識(shí)遷移和自主學(xué)習(xí)的能力，為學(xué)員的后續(xù)發(fā)展進(jìn)行知識(shí)儲(chǔ)備。

Personal and family history

There was no specific personal and family history.

Physical examination

Intraoral examination showed mild swelling in a longitudinal 2 cm × 1.5 cm area on the left lateral aspect of the tongue. A hardened nodule with an ill-defined margin was found on the tongue. The nodule was the same color as the surrounding tongue tissue (normal color) and no clearly identifiable foreign bodies were observed on the tongue as shown in Figure 2.

Laboratory examinations

在其2013年3月發(fā)表的“美國(guó)小學(xué)數(shù)學(xué)結(jié)構(gòu)之批評(píng)”一文中，馬立平博士用下圖比較了傳統(tǒng)數(shù)學(xué)(左)和發(fā)現(xiàn)式數(shù)學(xué)(右)在內(nèi)容和結(jié)構(gòu)上的差異[7]：

Imaging examinations

The oral maxillofacial MRI showed abnormal and ill-defined signal intensities on the left side of the tongue (size: 1.6 cm × 1.2 cm × 2.0 cm; Figure 1) and multiple swollen cervical lymph nodes (up to 0.7 cm in size, in the submaxillary region and carotid sheath). The primary diagnosis was tongue cancer as reported by the specialists in the Department of Radiology. However, the doctors in the ENT Department reviewed the MRI images and considered the possibility of foreign body granuloma for two reasons. First, granuloma and cancer can have similar imaging features; and second, the shadow seemed to indicate that the tongue tissue was protected from foreign bodies, as shown by images taken in the transverse plane. During the initial clinical interview the patient denied a history of foreign body ingestion. To differentiate between the two possibilities, further examinations were conducted.

Further diagnostic work-up

Informed written consent was obtained from the patient for publication of this report and any accompany images.

FlNAL DlAGNOSlS

Foreign body (fish bone) granuloma in the tongue.

TREATMENT

After the surgery, the patient received antibiotics (ceftriaxone) with systemic steroids and the postoperative recovery was uneventful. The patient was discharged on the third post-operative day.

OUTCOME AND FOLLOW-UP

A 61-year-old woman was admitted to the Ear Nose and Throat (ENT) Department of our hospital complaining of pain and noticeable swelling of the tongue.

DlSCUSSlON

A diagnosis of tongue cancer is often considered in older adults with an enlarged tongue nodule/mass and localized pain[5]. The many differential diagnoses of a tongue mass include an inflammatory lesion and schwannoma[1]. A diagnosis of a granuloma attributable to an embedded foreign body is rare when there is no clear history of foreign body ingestion or oral trauma[6]. In the present case, the differential diagnosis of an irregular nodule with a smooth surface included cavernous hemangioma, anaplastic large-cell lymphoma, endophytic squamous cell carcinoma and Kaposi sarcoma of the tongue[7-10].Differential diagnosis is important as cancer treatment and enucleation of a foreign body granuloma differ greatly in terms of surgical preparation, operation, tongue reconstruction and patient consultation[11-13].

The patient had no previous medical history.

MRI is the preferred diagnostic modality for evaluating tongue cancer because abnormal MRI signals have been strongly associated with pathological findings[14]. However, MRI is not an ideal modality for differentiating tongue cancer from embedded foreign body granuloma with foreign body[15]. The signals associated with tongue cancer are hyperintensity in a T2-weighted image (WI) and heterogeneous enhancement in an enhanced T1 WI, similar to granuloma[14,16]. In the present case, the fish bone (shown by hypointense signals in both the T1 and T2 WIs) was difficult to detect by MRI[17], and not surprisingly the primary diagnosis of tongue cancer was consistent with the abnormalities found in the tongue by MRI and with the swollen cervical lymph nodes. Besides this, shifting of metal fragments under the effects of MRI can result in potential damage of vital structures. If the doubt of a metal foreign body is present, the contraindications of MRI should be considered[18].

Several studies used ultrasound to detect a suspected embedded foreign body in the tongue[3,4,6].The foreign bodies, which included a pequi spine, metal wire, and fish bone were visualized and localized accurately, demonstrating the utility of ultrasound for guiding therapeutic interventions.Multislice computerized tomography (CT) and cone beam CT also seem useful for visualizing embedded foreign bodies, although CTs have poor performance in terms of detecting wood[15]. Thus,when an embedded foreign body is suspected in a patient with an enlarged tongue mass, ultrasonography and CT can play an important role in the differential diagnosis[19].

In our case, the lesion was “walled off” on transverse images (Figure 2). This might indicate that the mass was “delimited” by a capsule. A similar sign was observed in an early case report of a patient with foreign body granuloma[16]. Thus, this sign might be a useful indicator of the need for further examinations (other than MRI). However, this issue requires further investigation.

CONCLUSlON

We reported the case of a woman with an enlarged tongue mass initially diagnosed with tongue cancer.The ENT specialists reviewed the MRI data and corrected the diagnosis to ‘foreign body in the tongue’based on oral ultrasound examination. The granuloma containing the fish bone was completely removed during surgery and post-operative pathological examination confirmed that the lesion was a granuloma. In cases with an enlarged tongue mass, oral ultrasound and/or CT examinations are important for differential diagnosis, to facilitate selection of the appropriate treatment method.

ACKNOWLEDGEMENTS

the Research Start-up Grant for Talent of Mianyang Central Hospital of China, No. 2021YJRC-001; and the Applied Technique Research and Development Program of Mianyang City of China, No. 2019YFZJ022.

FOOTNOTES

Xu R was the patient’s doctor in charge, reviewed the literature and contributed to manuscript drafting; Jiang ZH operated on the patient and contributed to manuscript drafting; Xia L reviewed the literature and was responsible for the revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.

The authors acknowledge the colleagues for participating in this study. We are deeply indebted to the patient who participated in this study.

The patient was referred for ultrasound examination of the tongue. The ultrasound device used a linear probe with a 13-MHz transducer. The acoustic picture was consistent with a linear hyperechoic foreign body, specifically a piece of bone, as shown in Figure 3. When asked about the possibility of fish bone ingestion or another foreign body in the tongue, the patient could not recall whether she had recently eaten fish. However, her daughter recalled that a meal containing fish (with bones) might have been served to the patient 2 mo prior to seeking medical assistance. Complete surgical enucleation of the lesion was then conducted. The mass with the fish bone was completely removed without compromising the capsule (Figure 4A), and no hemorrhagic accident occurred. The fish bone was 1.5 cm in length (Figure 4B). Post-operative pathological examination showed that the lesion was a granuloma containing collagen fibers, macrophages and chronic inflammatory cells.

The authors declare that they have no conflict of interest.

丁苯酞聯(lián)合阿替普酶對(duì)急性腦梗死患者神經(jīng)功能、認(rèn)知功能和Hcy等血清學(xué)指標(biāo)的影響 ……………… 朱 燁等（8）：1095

The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

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阿東說(shuō)：“蠻好。我姆媽原先每天七點(diǎn)半叫阿里起來(lái)，現(xiàn)在叫他提前起。把錄音機(jī)帶著，到東湖邊去放哀樂(lè)。那里沒(méi)有什么人，放多大聲音都不怕?！?/p>

China

Zhen-Hua Jiang 0000-0001-5239-9154; Ran Xv 0000-0002-5381-111X; Li Xia 0000-0002-5529-884X.

以貫徹落實(shí)黨的十八大精神為起點(diǎn)，順應(yīng)時(shí)代發(fā)展，回應(yīng)民生訴求，在全市范圍全面實(shí)施“水更清”行動(dòng)計(jì)劃，水生態(tài)文明建設(shè)再譜新篇章。

Ma YJ

Filipodia

Ma YJ