• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Efficacy and effect on serum VEGF-C of mild moxibustion plus functional exercise for upper-limb lymphedema after breast cancer surgery

    2021-08-26 10:47:22HuXiangli胡向麗ChenFang陳芳
    關(guān)鍵詞:陳芳

    Hu Xiang-li (胡向麗), Chen Fang (陳芳)

    The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, China

    Abstract

    Keywords: Moxibustion Therapy; Moxa Stick Moxibustion; Exercise Therapy; Breast Neoplasms; Postoperative Complications; Breast Cancer Lymphedema; Vascular Endothelial Growth Factor C

    Breast cancer is one of the most common types of female malignant tumor and its incidence continues to exhibit an upward trend year-by-year that seriously threatens female’s health[1]. Surgery is the preferred treatment for breast cancer. Post-operative complications include subcutaneous effusion, flap necrosis, lymphedema of the affected upper limb,incision infection and so on[2]. Upper-limb lymphedema is one of the most common complications after breast cancer surgery, clinically manifested by swelling, pain,numbness, and limited lifting of the affected limb. It seriously affects the patients’ quality of life, and results in negative emotional states such as anxiety and depression, thereby delaying radiotherapy,chemotherapy and other necessary treatments[3-4].Current treatments of upper-extremity lymphedema mainly include pharmacotherapy (e.g. diosmin and batroxobin) and physical therapy (e.g. upper-extremity exercise, manual lymphatic drainage and compression bandages), which can relieve symptoms to some extents,but with unstable efficacy, and symptoms are prone to relapse after withdrawal of these treatments[5].Moxibustion is an important component of traditional Chinese medicine (TCM), which can tonify qi to warm yang and expel blood stasis to dredge collaterals. It shows remarkable curative effects in the treatment of edematous diseases[6]. Thus, this study aims to observe the clinical efficacy of mild moxibustion plus functional exercise against upper extremity lymphedema after breast cancer surgery and its effect on serum vascular endothelial growth factor C (VEGF-C). The report is described as follows.

    1 Clinical Materials

    1.1 Diagnostic criteria

    1.1.1 Diagnostic criteria in Western medicine

    The diagnostic criteria of upper-limb lymphedema after breast cancer surgery referred theSurgery[7]:diagnosed with breast cancer via pathological examination; circumference of the affected upper limb exceeds that of the healthy upper limb by at least 2 cm.

    1.1.2 Diagnostic criteria in TCM

    Adopting the syndrome differentiation criteria of qi deficiency and blood stasis in theGuiding Principles for Clinical Study of New Chinese Medicines[8]. Primary symptoms: swelling, numbness of the affected limb, a fixed local stabbing pain, shortage of qi, no desire to speak and fatigue; secondary symptoms: pale complexion, symptom exacerbation due to physical activity, spontaneous sweating, scaly skin, a purple or ecchymotic tongue with white coating, and sunken,unsmooth and weak pulse.

    1.2 Inclusion criteria

    Those who met the diagnostic criteria of upper-limb lymphedema after breast cancer surgery and the syndrome differentiation criteria of qi deficiency and blood stasis; aged 20-60 years old; had an estimated survival time of more than 6 months; informed and consented to participate in this study.

    1.3 Exclusion criteria

    Those who had breast tumor recurrence or metastases; with cardiac, hepatic, renal disease or other serious diseases; with upper-limb lymphedema caused by deep vein thrombosis or tumor thrombus; were pregnant or during lactation.

    1.4 Criteria for elimination and dropout

    Those who did not receive treatment as prescribed or used other treatments due to poor compliance;condition deteriorated or severe adverse reactions occurred; proposed to withdraw from the study.

    1.5 Statistical analysis

    The data were analyzed by SPSS 22.0 software. The measurement data conforming to normal distribution and homogeneity of variance were expressed as mean ±standard deviation (±s) and analyzed witht-test. Nonparametric tests were used for measurement data that did not conform to normal distribution or homogeneity of variance.P<0.05 was taken as statistically significant.

    1.6 General data

    A total of 78 patients were enrolled from our hospital between January 2018 and March 2020. The patients were divided into a control group and an observation group by the random number table method, with 39 cases in each group. No dropout occurred during the trial.The youngest and oldest were 34 and 58 years old in the patients in the observation group, and 32 and 60 years old in the control group, respectively. There were no statistically significant differences between the two groups in baseline age, tumor site and pathological type(allP>0.05), confirming that the two groups were appropriately comparable (Table 1).

    Table 1. Baseline characteristics in the two groups

    2 Treatment Methods

    2.1 Control group

    The control group received functional exercise, mainly including shoulder rotation movement, rope pulling movement, finger climbing movement and upper-limb extension movement. The functional exercise lasted for 20 min each time. The patient performed twice per day,once in the morning and the other at night, for a total of 4 weeks.

    2.2 Observation group

    The observation group was treated with the same functional exercise plus mild moxibustion.

    Acupoints: Quchi (LI 11), Jianyu (LI 15) on the affected side, and bilateral Xuehai (SP 10), Zusanli (ST 36) and Yinlingquan (SP 9).

    Methods:The patient took a supine position and exposed the local skin. After igniting the moxa stick, the doctor aimed the moxa stick at the selected acupoints and conducted mild moxibustion approximately 3 cm away from the skin. Moxibustion was applied at each acupoint for 5-10 min. Slight redness of the local skin and warm feeling without burning pain was preferable. The patient received treatment once every other day for 4 weeks.

    3 Results Observation

    3.1 Observation items

    3.1.1 Difference in circumference of the two upper limbs

    The circumferences of the two upper limbs were measured at 15 cm above the cubital crease, and the difference between the two sides was compared before and after treatment.

    3.1.2 Lymphatic flow of the affected upper limb

    Lymphatic flow of the affected upper limb was measured before and after treatment by radionuclide method.

    3.1.3 Disability of arm, shoulder and hand (DASH)

    DASH questionnaire was used to evaluate patient’s affected limb function before and after treatment, with a score ranging from 0 to 100 points (the higher the score,the more severe the disability)[9].

    3.1.4 Functional assessment of cancer therapy-breast(FACT-B)

    FACT-B questionnaire was used to evaluate patient’s quality of life before and after treatment, with a score ranging from 0 to 144 points and the higher the score,the better the post-mastectomy quality of life[10].

    3.1.5 Serum VEGF-C level

    Fasting venous blood of the patient was drawn before and after treatment, and then the serum VEGF-C level was determined by the enzyme immunoassay method.

    3.2 Efficacy evaluation

    The efficacy index was calculated by the change of difference in circumference between the two upper limbs, and the clinical efficacy was evaluated according to the efficacy index[11]. The efficacy index = (Beforetreatment circumference of the affected upper limb -After-treatment circumference of the affected upper limb) ÷ Difference in circumference between the two upper limbs × 100%.Markedly effective: The efficacy index was >90%.Effective: The efficacy index was ≥10%, but ≤90%.Invalid: The efficacy index was <10%.

    3.3 Results

    3.3.1 Comparison of the therapeutic efficacy

    After treatment, the total effective rate was 94.9% in the observation group, and it was significantly higher than 71.8% in the control group (P<0.05), (Table 2).

    3.3.2 Comparisons of the difference in circumference between the two upper limbs and lymphatic flow of the affected upper limb

    Before treatment, there was no significant difference in the difference in circumference between the two upper limbs or lymphatic flow of the affected upper limb between the two groups (bothP>0.05). The difference in circumference between the two upper limbs of the two groups decreased significantly after treatment (bothP<0.05), but it was significantly lower in the observation group than in the control group (P<0.05). The lymphatic flow of the affected upper limb of the two groups increased significantly after treatment (bothP<0.05), but it was significantly greater in the observation group than in the control group (P<0.05), (Table 3).

    3.3.3 Comparisons of the DASH and FACT-B scores

    Before treatment, there were no significant differences in the DASH and FACT-B scores between the two groups (bothP>0.05). The DASH scores of the two groups decreased significantly after treatment (bothP<0.05), but it was significantly lower in the observation group than in the control group (P<0.05). The FACT-B scores of the two groups increased significantly after treatment (bothP<0.05), but it was significantly higher in the observation group than in the control group (P<0.05),(Table 4).

    3.3.4 Comparison of the serum VEGF-C level

    Before treatment, there was no significant difference in the serum VEGF-C level between the two groups(P>0.05). After treatment, the serum VEGF-C level increased significantly in the observation group (P<0.05),whereas the control group did not show significant change (P>0.05). The post-treatment serum VEGF-C level in the observation group was significantly higher than that in the control group (P<0.05), (Table 5).

    Table 2. Comparison of the total effective rate between the two groups (case)

    Table 3. Comparisons of the difference in circumference between the two upper limbs and lymphatic flow of the affected upper limb between the two groups

    Table 4. Comparisons of the DASH and FACT-B scores between the two groups ( x ±s, point)

    Table 5. Comparison of the serum VEGF-C level between the two groups ( x ±s, pg/mL)

    4 Discussion

    Upper-limb lymphedema is a common complication after breast cancer surgery, mainly caused by axillary lymph node dissection. This surgery usually disrupts plenty of lymphatic vessels, leading to lymphatic obstruction. If the compensatory capacity of lymphatic circulation is diminished or the lymphoid load increases,lymphedema of the affected upper limb can occur[12].Radiotherapy can cause local tissue fibrosis, radiationinduced skin damage and muscular contractures,thereby compressing the reflux pathway of lymph.Radiotherapy can also induce lymphangitis and inhibit lymphangiogenesis, which may increase the risk of lymphedema[13]. Further, age, body mass index and the size of the breast mass also appear to be risk factors of upper-limb lymphedema after breast cancer surgery[14].

    VEGF-C is a cell-specific growth factor. It has a high affinity for vascular endothelial growth factor receptor 3(VEGFR-3), which is expressed on endothelial lymphatic cells. The binding of VEGF-C to VEGFR-3 can influence the differentiation of lymphatic endothelial cells, inhibit their apoptosis and promote lymphangiogenesis[15]. In study of Visuri MT,et al[16], VEGF-C was injected into the hind limbs of sows. The results showed that the growth of new lymphatic vessels in the area of excision was induced, and no signs of sprouting angiogenesis or increased blood vascular permeability were observed. In study of Hou CQ,et al[17], VEGF-C was injected into lymphedema limbs of rabbits. The results suggested that the swelling of the limbs was reduced and the microlymphatic vessel number declined. The efficacy increased gradually with time. It can be seen that sufficient VEGF-C concentration can promote lymphangiogenesis and alleviate lymphedema.Therefore, modulation of the serum VEGF-C level may be a potential therapeutic target in upper-limb lymphedema after breast cancer surgery.

    Functional exercise is a widely used physical therapy.It can increase muscle strength, prevent muscle atrophy and joint stiffness in order to avoid venous compression by scar tissue and reduce the obstruction of venous return. It can also promote lymphatic reflux to relieve edema through the stress of muscles contraction and relaxation on lymphatic vessel[18]. Functional exercise should be gradual and stepwise because lymphedema can be induced or aggravated by excessive exercise.

    Upper-limb lymphedema after breast cancer surgery belongs to the category of ‘edema’ and ‘vessel Bi-Impediment’, characterized by deficiency in root and excess in branch[19]. The qi of patients with breast cancer is already deficient. Surgery can further damage the qi and blood, leading to more severe deficiency of healthy qi. Deficient qi will fail to promote blood flow and result in blood stasis. Blood stasis can also result from vessel damages during surgery. Prolonged blood stasis leads to stagnation of body fluids which later on causes retention of fluid under the skin, resulting in the disease. Thus, qi deficiency and blood stasis is a common pathogenesis of upper-limb lymphedema after breast cancer surgery, and treatment should focus on tonifying qi, expelling blood stasis, dredging collaterals and eliminating dampness[20].

    Mild moxibustion is characterized by warm stimulation, through which the effect of warming yang for tonifying qi, warming and dredging meridians and collaterals, and expelling blood stasis for regulating qi can be exerted. This therapy holds particularly true for the patients with qi deficiency and blood stasis. Quchi (LI 11),Jianyu (LI 15), Xuehai (SP 10), Zusanli (ST 36) and Yinlingquan (SP 9) were selected for mild moxibustion in this study. Quchi (LI 11) and Jianyu (LI 15), locate in the affected areas, can stimulate Yangming meridians,dredge collaterals and regulate qi and blood for improving the stagnation of qi, blood and water of the upper limb. Xuehai (SP 10) is good at treating various disorders of blood. It can invigorate spleen to eliminate dampness, nourish blood and expel blood stasis. Zusanli(ST 36), the He-Sea point of the Stomach Meridian of Foot Yangming, has the function of invigorating spleen and stomach and tonifying qi and blood. Yinlingquan(SP 9), the He-Sea point of the Spleen Meridian of Foot Taiyin, can strength spleen for regulating qi, dredge collaterals and induce diuresis for alleviating edema,which is an important acupoint for treating edema. The compatibility of these acupoints can achieve the purpose of tonifying qi for strengthening the vital, removing stasis for dredging collaterals, inducing diuresis for alleviating edema.

    The results of this study showed that the total effective rate was significantly higher in the observation group than in the control group (P<0.05). The difference in circumference between the two upper limbs of the two groups decreased significantly after treatment (bothP<0.05), but it was significantly lower in the observation group than in the control group (P<0.05). The lymphatic flow of the affected upper limb of the two groups increased significantly after treatment (bothP<0.05), but it was significantly greater in the observation group than in the control group (P<0.05). The DASH scores of the two groups decreased significantly after treatment (bothP<0.05), but it was significantly lower in the observation group than in the control group (P<0.05). The FACT-B scores of the two groups increased significantly after treatment (bothP<0.05), but it was significantly higher in the observation group than in the control group (P<0.05).The results indicate that mild moxibustion combined with functional exercise for upper-limb lymphedema after breast cancer surgery is effective, as it can reduce the difference in circumference between the two upper limbs, increase the lymphatic flow of the affected upper limb, and improve the limb function and the quality of life. After treatment, the serum VEGF-C level increased significantly in the observation group (P<0.05), whereas the control group did not show significant change(P>0.05). The post-treatment serum VEGF-C level was significantly higher in the observation group than in the control group (P<0.05). The results indicate that the efficacy of mild moxibustion combined with functional exercise for upper-limb lymphedema after breast cancer surgery is certain, which might be associated with the regulation of serum VEGF-C level.

    In conclusion, the efficacy of mild moxibustion combined with functional exercise for upper-limb lymphedema after breast cancer surgery is certain,which can reduce the difference in circumference between the two upper limbs, increase the lymphatic flow of the affected upper limb, improve the limb function and the quality of life, and regulate serum VEGFC level. Therefore, this combination therapy is worthy of clinical promotion.

    Conflict of Interest

    The authors declare that there is no potential conflict of interest in this article.

    Acknowledgments

    There was no project-fund supporting for this study.

    Statement of Informed Consent

    All participants were informed and consented to participate in this study.

    Received: 10 July 2020/Accepted: 9 October 2020

    猜你喜歡
    陳芳
    三只小黃鴨
    文學(xué)港(2024年4期)2024-06-07 07:56:30
    同學(xué)情永不變
    上海故事(2023年9期)2023-11-01 02:45:48
    保潔阿姨自學(xué)十年英語(yǔ):水平超六級(jí)以上
    過(guò)時(shí)的暗號(hào)
    “第一次”主題寫(xiě)作指導(dǎo)及習(xí)作展評(píng)
    韓永剛 陳芳 李忱 莫秀秀 作品
    大眾文藝(2020年5期)2020-03-11 07:56:50
    韓永剛 陳芳 邢艷群 李忱 莫秀秀 作品
    大眾文藝(2020年4期)2020-03-06 11:45:00
    哲理漫畫(huà)
    舞伴
    東方劍(2016年6期)2016-08-27 06:16:09
    只想和你活下去
    国产aⅴ精品一区二区三区波| 12—13女人毛片做爰片一| 亚洲精品乱码久久久v下载方式 | 色综合亚洲欧美另类图片| 国产亚洲av高清不卡| 国语自产精品视频在线第100页| 久久久精品大字幕| 国产v大片淫在线免费观看| 色精品久久人妻99蜜桃| 国产成人福利小说| 亚洲欧美日韩无卡精品| 夜夜看夜夜爽夜夜摸| 成人国产综合亚洲| 亚洲在线观看片| 狂野欧美激情性xxxx| 美女cb高潮喷水在线观看 | 国产亚洲精品一区二区www| 欧美大码av| 国产97色在线日韩免费| 香蕉国产在线看| 香蕉丝袜av| 亚洲av免费在线观看| 人人妻,人人澡人人爽秒播| 老司机在亚洲福利影院| 国产精品电影一区二区三区| 99久国产av精品| 又爽又黄无遮挡网站| 久久性视频一级片| 国产黄色小视频在线观看| 久久午夜综合久久蜜桃| 两人在一起打扑克的视频| 久久久久九九精品影院| 国产精品av久久久久免费| 久久精品综合一区二区三区| 国产一区二区在线观看日韩 | 国产 一区 欧美 日韩| 老司机午夜福利在线观看视频| 午夜精品在线福利| 99国产精品一区二区蜜桃av| 狠狠狠狠99中文字幕| 亚洲av日韩精品久久久久久密| 国产精品久久久人人做人人爽| 日韩免费av在线播放| 黄色成人免费大全| 午夜日韩欧美国产| 国产又黄又爽又无遮挡在线| 国产亚洲欧美98| 国产美女午夜福利| 欧美xxxx黑人xx丫x性爽| 视频区欧美日本亚洲| 亚洲激情在线av| 丁香欧美五月| 国内少妇人妻偷人精品xxx网站 | 黄片大片在线免费观看| 99riav亚洲国产免费| 欧美日韩乱码在线| 麻豆国产97在线/欧美| 国产91精品成人一区二区三区| 色在线成人网| 91字幕亚洲| 女同久久另类99精品国产91| 亚洲午夜精品一区,二区,三区| 国产午夜精品论理片| 中文字幕久久专区| 99久久成人亚洲精品观看| 在线看三级毛片| 午夜免费激情av| 国产成人精品久久二区二区91| 日韩欧美免费精品| 99在线人妻在线中文字幕| 九九久久精品国产亚洲av麻豆 | 亚洲精品美女久久久久99蜜臀| 国内揄拍国产精品人妻在线| 午夜影院日韩av| www.自偷自拍.com| 人人妻,人人澡人人爽秒播| 亚洲精品在线美女| 一个人看的www免费观看视频| 中文资源天堂在线| 成年版毛片免费区| av天堂中文字幕网| 真人做人爱边吃奶动态| 亚洲天堂国产精品一区在线| 色综合欧美亚洲国产小说| 国产视频内射| 在线免费观看不下载黄p国产 | 青草久久国产| a级毛片在线看网站| 国产精品久久视频播放| 色播亚洲综合网| 国产成人精品无人区| 我要搜黄色片| 最近视频中文字幕2019在线8| 视频区欧美日本亚洲| 久久香蕉国产精品| 国产成年人精品一区二区| av欧美777| 日本与韩国留学比较| 男人舔女人的私密视频| 12—13女人毛片做爰片一| 国产99白浆流出| 99视频精品全部免费 在线 | 51午夜福利影视在线观看| or卡值多少钱| 19禁男女啪啪无遮挡网站| 美女黄网站色视频| 97超视频在线观看视频| 久久这里只有精品中国| 日韩 欧美 亚洲 中文字幕| 国产三级在线视频| 日韩精品青青久久久久久| 成人av一区二区三区在线看| 亚洲成人久久性| 欧美三级亚洲精品| 午夜福利高清视频| 每晚都被弄得嗷嗷叫到高潮| 欧美日韩黄片免| 欧美三级亚洲精品| 亚洲国产精品合色在线| 国产精品1区2区在线观看.| 免费在线观看视频国产中文字幕亚洲| netflix在线观看网站| 日韩欧美在线乱码| 91九色精品人成在线观看| 亚洲一区二区三区不卡视频| 国产精品亚洲美女久久久| 成人永久免费在线观看视频| 日韩欧美在线乱码| 色综合婷婷激情| 91在线观看av| 9191精品国产免费久久| 少妇的逼水好多| 韩国av一区二区三区四区| 天堂av国产一区二区熟女人妻| 真人做人爱边吃奶动态| 午夜日韩欧美国产| 91在线观看av| 国产精品亚洲美女久久久| 又黄又粗又硬又大视频| 日本熟妇午夜| 国产精品98久久久久久宅男小说| 又紧又爽又黄一区二区| 国产高清视频在线播放一区| 日韩人妻高清精品专区| 成人国产一区最新在线观看| 久久久国产欧美日韩av| 无遮挡黄片免费观看| 国产一区二区在线观看日韩 | 超碰成人久久| 亚洲欧美日韩东京热| 国产黄片美女视频| 小说图片视频综合网站| 夜夜看夜夜爽夜夜摸| 亚洲中文字幕一区二区三区有码在线看 | 韩国av一区二区三区四区| 亚洲专区字幕在线| 又黄又爽又免费观看的视频| 国产黄片美女视频| 中文亚洲av片在线观看爽| 欧美日韩黄片免| 91字幕亚洲| 亚洲成人精品中文字幕电影| 亚洲国产精品999在线| 日韩欧美一区二区三区在线观看| 久久天堂一区二区三区四区| 欧美黄色片欧美黄色片| 天堂动漫精品| 亚洲无线在线观看| 91av网站免费观看| 岛国在线免费视频观看| a级毛片在线看网站| 香蕉国产在线看| 色av中文字幕| 在线播放国产精品三级| 亚洲在线观看片| 色综合婷婷激情| 欧美三级亚洲精品| 757午夜福利合集在线观看| 黄色成人免费大全| 亚洲成人久久性| 久久人人精品亚洲av| 久久精品夜夜夜夜夜久久蜜豆| 色吧在线观看| 成在线人永久免费视频| 日韩av在线大香蕉| 两性夫妻黄色片| 女警被强在线播放| 久久久国产成人精品二区| 欧美中文综合在线视频| 99热这里只有是精品50| 日日摸夜夜添夜夜添小说| 免费无遮挡裸体视频| 两个人的视频大全免费| 久久人人精品亚洲av| 男女做爰动态图高潮gif福利片| 97超视频在线观看视频| 90打野战视频偷拍视频| 男女之事视频高清在线观看| 麻豆av在线久日| 可以在线观看的亚洲视频| 国产精品 欧美亚洲| 久久国产精品人妻蜜桃| 波多野结衣巨乳人妻| 亚洲国产精品合色在线| 一区二区三区激情视频| 国产精品久久久久久亚洲av鲁大| 亚洲自拍偷在线| 婷婷六月久久综合丁香| 一个人免费在线观看的高清视频| 日韩av在线大香蕉| 精品欧美国产一区二区三| 老司机午夜十八禁免费视频| 美女扒开内裤让男人捅视频| 国内精品久久久久精免费| 欧美日韩国产亚洲二区| 麻豆成人av在线观看| 国产乱人视频| 在线免费观看的www视频| 成在线人永久免费视频| 国产精品久久视频播放| 黄色片一级片一级黄色片| 成人三级做爰电影| 国产精品久久久久久亚洲av鲁大| 国产不卡一卡二| 欧美日韩中文字幕国产精品一区二区三区| 午夜亚洲福利在线播放| 亚洲欧美日韩高清专用| 最新在线观看一区二区三区| 午夜久久久久精精品| 在线国产一区二区在线| 亚洲午夜精品一区,二区,三区| 日本黄大片高清| 久久人人精品亚洲av| 在线免费观看的www视频| 俄罗斯特黄特色一大片| 国产欧美日韩一区二区精品| 色av中文字幕| 国产欧美日韩精品一区二区| 欧美精品啪啪一区二区三区| 午夜视频精品福利| 日韩 欧美 亚洲 中文字幕| 一二三四社区在线视频社区8| 黄频高清免费视频| 亚洲色图 男人天堂 中文字幕| 国产成人啪精品午夜网站| 99久久精品一区二区三区| 免费看光身美女| 久久久久久人人人人人| 在线观看一区二区三区| 欧美日韩中文字幕国产精品一区二区三区| 夜夜爽天天搞| 熟女人妻精品中文字幕| 亚洲av电影不卡..在线观看| 久久人妻av系列| 又黄又粗又硬又大视频| 亚洲 欧美一区二区三区| 久久精品亚洲精品国产色婷小说| 亚洲欧美日韩高清在线视频| 亚洲自偷自拍图片 自拍| 日本免费一区二区三区高清不卡| avwww免费| 国产一区二区三区在线臀色熟女| 亚洲精品久久国产高清桃花| 亚洲欧美精品综合久久99| 亚洲欧美日韩高清在线视频| 岛国在线观看网站| 999久久久国产精品视频| 国产高清激情床上av| 亚洲狠狠婷婷综合久久图片| 嫁个100分男人电影在线观看| 免费看日本二区| 国产精品野战在线观看| 999精品在线视频| 一a级毛片在线观看| 亚洲精品粉嫩美女一区| 一个人观看的视频www高清免费观看 | 成人午夜高清在线视频| 久久久久性生活片| 亚洲在线观看片| 国产精品98久久久久久宅男小说| 欧美av亚洲av综合av国产av| 国产一区二区在线av高清观看| 18禁裸乳无遮挡免费网站照片| 精品午夜福利视频在线观看一区| 亚洲av中文字字幕乱码综合| 国内精品美女久久久久久| 精品国产三级普通话版| 亚洲精华国产精华精| 亚洲精品乱码久久久v下载方式 | 精品久久久久久久久久免费视频| av天堂中文字幕网| 男女做爰动态图高潮gif福利片| 亚洲av第一区精品v没综合| 欧美日韩福利视频一区二区| 日韩大尺度精品在线看网址| 国产乱人伦免费视频| 日韩成人在线观看一区二区三区| 十八禁网站免费在线| 亚洲精品久久国产高清桃花| 最新在线观看一区二区三区| 一级毛片精品| 午夜两性在线视频| 香蕉av资源在线| 搡老妇女老女人老熟妇| 一进一出抽搐动态| 观看免费一级毛片| 网址你懂的国产日韩在线| 亚洲欧美日韩无卡精品| 99国产综合亚洲精品| bbb黄色大片| 午夜精品一区二区三区免费看| 动漫黄色视频在线观看| 99久久精品热视频| 桃红色精品国产亚洲av| 最新美女视频免费是黄的| 黑人巨大精品欧美一区二区mp4| 99久久精品热视频| 国产成人影院久久av| 国产成人啪精品午夜网站| 日韩国内少妇激情av| 婷婷精品国产亚洲av在线| 最近视频中文字幕2019在线8| 欧美日韩福利视频一区二区| 一级毛片女人18水好多| 三级国产精品欧美在线观看 | 日韩欧美在线二视频| 亚洲欧美日韩东京热| 亚洲自拍偷在线| 俄罗斯特黄特色一大片| 免费在线观看亚洲国产| 少妇的逼水好多| 日韩精品青青久久久久久| 久久久精品欧美日韩精品| 无人区码免费观看不卡| 好看av亚洲va欧美ⅴa在| 久久精品国产亚洲av香蕉五月| 色播亚洲综合网| 一卡2卡三卡四卡精品乱码亚洲| 99国产精品一区二区三区| 男女之事视频高清在线观看| 久99久视频精品免费| 亚洲成av人片在线播放无| 老熟妇仑乱视频hdxx| 长腿黑丝高跟| 精品一区二区三区视频在线 | 国内精品久久久久精免费| 身体一侧抽搐| 国产黄a三级三级三级人| 麻豆国产av国片精品| 日韩大尺度精品在线看网址| 成年女人看的毛片在线观看| 中文字幕人妻丝袜一区二区| 禁无遮挡网站| 国产激情偷乱视频一区二区| 91字幕亚洲| 久久久久久大精品| 国产单亲对白刺激| 熟女少妇亚洲综合色aaa.| 成人国产综合亚洲| avwww免费| 色精品久久人妻99蜜桃| 国内久久婷婷六月综合欲色啪| 黄色成人免费大全| 他把我摸到了高潮在线观看| 亚洲精品久久国产高清桃花| 中文在线观看免费www的网站| 久久久久久九九精品二区国产| 欧美黄色片欧美黄色片| 国产亚洲精品久久久com| 怎么达到女性高潮| 国产高清视频在线播放一区| 久久久精品欧美日韩精品| 成人亚洲精品av一区二区| h日本视频在线播放| 久久久成人免费电影| 18禁裸乳无遮挡免费网站照片| 久久人妻av系列| 久久久久久人人人人人| 最近视频中文字幕2019在线8| 色视频www国产| 久久精品亚洲精品国产色婷小说| 91av网一区二区| 一个人观看的视频www高清免费观看 | 亚洲欧美日韩高清专用| 看片在线看免费视频| 午夜免费成人在线视频| 男女之事视频高清在线观看| 99久久成人亚洲精品观看| 欧美三级亚洲精品| 亚洲精品粉嫩美女一区| 99热6这里只有精品| 国产免费男女视频| 国内揄拍国产精品人妻在线| 一边摸一边抽搐一进一小说| 国产精品一区二区免费欧美| 999久久久国产精品视频| 俄罗斯特黄特色一大片| 婷婷丁香在线五月| 免费av不卡在线播放| 97超视频在线观看视频| 欧美日韩福利视频一区二区| 亚洲国产欧美网| www日本黄色视频网| 国产亚洲av嫩草精品影院| 中文字幕av在线有码专区| 亚洲美女黄片视频| 国产精品久久视频播放| 高潮久久久久久久久久久不卡| 人人妻人人澡欧美一区二区| 国产成人精品久久二区二区91| 黄色丝袜av网址大全| 身体一侧抽搐| 亚洲av第一区精品v没综合| 国产综合懂色| 国产爱豆传媒在线观看| 国产精品精品国产色婷婷| 99热这里只有精品一区 | 国产欧美日韩精品亚洲av| av女优亚洲男人天堂 | 麻豆国产97在线/欧美| 校园春色视频在线观看| 免费在线观看影片大全网站| 亚洲狠狠婷婷综合久久图片| 亚洲第一电影网av| 波多野结衣高清无吗| a级毛片在线看网站| 一级毛片女人18水好多| 国产一区在线观看成人免费| 国产亚洲av嫩草精品影院| 国产成人精品久久二区二区免费| 亚洲美女视频黄频| 精品熟女少妇八av免费久了| 少妇熟女aⅴ在线视频| 久久久久久久久久黄片| 成人鲁丝片一二三区免费| 黄色成人免费大全| 国产黄a三级三级三级人| 国产单亲对白刺激| 九九在线视频观看精品| 亚洲国产欧美人成| 精品日产1卡2卡| 亚洲av成人不卡在线观看播放网| 91在线精品国自产拍蜜月 | 国内久久婷婷六月综合欲色啪| 12—13女人毛片做爰片一| 精品国产乱码久久久久久男人| 99久久成人亚洲精品观看| 国产乱人视频| 欧美在线一区亚洲| 99精品在免费线老司机午夜| 国产一区二区在线观看日韩 | 97超视频在线观看视频| 99热6这里只有精品| 精品福利观看| 成年女人永久免费观看视频| 亚洲av电影不卡..在线观看| 日本黄大片高清| 母亲3免费完整高清在线观看| 一级毛片女人18水好多| 亚洲国产看品久久| 黄色片一级片一级黄色片| 日本成人三级电影网站| 欧美性猛交╳xxx乱大交人| www.熟女人妻精品国产| 午夜成年电影在线免费观看| 两性午夜刺激爽爽歪歪视频在线观看| 久久这里只有精品中国| 女警被强在线播放| 亚洲专区国产一区二区| 亚洲狠狠婷婷综合久久图片| 级片在线观看| 最好的美女福利视频网| 男人的好看免费观看在线视频| 亚洲va日本ⅴa欧美va伊人久久| 欧美黑人欧美精品刺激| 性欧美人与动物交配| 久久精品91蜜桃| 欧美在线一区亚洲| 国产精品野战在线观看| 国产主播在线观看一区二区| 亚洲人与动物交配视频| 国产精品1区2区在线观看.| a级毛片a级免费在线| 99久久成人亚洲精品观看| 欧美日本亚洲视频在线播放| 两性夫妻黄色片| www日本在线高清视频| 九色成人免费人妻av| 国产av一区在线观看免费| 日本五十路高清| 给我免费播放毛片高清在线观看| 成年版毛片免费区| 亚洲狠狠婷婷综合久久图片| 久久国产精品人妻蜜桃| 美女大奶头视频| 日韩有码中文字幕| 变态另类成人亚洲欧美熟女| 久久中文字幕人妻熟女| 午夜精品一区二区三区免费看| av国产免费在线观看| 国产成人aa在线观看| 国产视频一区二区在线看| 最近最新中文字幕大全免费视频| 国产伦精品一区二区三区四那| 九九久久精品国产亚洲av麻豆 | 国产精品野战在线观看| 久久精品国产亚洲av香蕉五月| 在线看三级毛片| 黄色 视频免费看| 久久精品91无色码中文字幕| 国产免费男女视频| 淫秽高清视频在线观看| 国产精品一区二区免费欧美| 啦啦啦免费观看视频1| 无人区码免费观看不卡| 国产午夜福利久久久久久| av视频在线观看入口| 亚洲av片天天在线观看| 国产精品,欧美在线| 91麻豆av在线| 婷婷精品国产亚洲av在线| 欧美成狂野欧美在线观看| 一个人看的www免费观看视频| 制服丝袜大香蕉在线| 99国产精品99久久久久| 日本精品一区二区三区蜜桃| 欧洲精品卡2卡3卡4卡5卡区| 久久人人精品亚洲av| 久99久视频精品免费| 午夜两性在线视频| 99久久无色码亚洲精品果冻| 国产午夜精品论理片| 琪琪午夜伦伦电影理论片6080| 亚洲欧美日韩高清在线视频| 18禁国产床啪视频网站| 亚洲男人的天堂狠狠| 精品久久久久久,| 老司机午夜十八禁免费视频| 1000部很黄的大片| 午夜免费激情av| 在线a可以看的网站| 亚洲五月天丁香| 在线十欧美十亚洲十日本专区| 一个人免费在线观看的高清视频| 国产探花在线观看一区二区| 黄片小视频在线播放| 国产av一区在线观看免费| 国产一区在线观看成人免费| 成人鲁丝片一二三区免费| 亚洲美女黄片视频| 欧美黄色淫秽网站| 欧美又色又爽又黄视频| 欧美色视频一区免费| 精品电影一区二区在线| 国产成人影院久久av| 曰老女人黄片| 免费大片18禁| 国产亚洲精品一区二区www| av在线天堂中文字幕| 91在线观看av| 99国产综合亚洲精品| 国产精品亚洲美女久久久| 俄罗斯特黄特色一大片| 在线国产一区二区在线| 琪琪午夜伦伦电影理论片6080| 中文字幕久久专区| 男女床上黄色一级片免费看| 久久热在线av| 免费av毛片视频| 天堂影院成人在线观看| 丰满人妻一区二区三区视频av | 欧美在线一区亚洲| 国产精品一区二区精品视频观看| 岛国在线免费视频观看| 99国产精品一区二区三区| 我要搜黄色片| 国产成+人综合+亚洲专区| 俄罗斯特黄特色一大片| 91在线观看av| 欧美性猛交╳xxx乱大交人| 99久久99久久久精品蜜桃| 淫秽高清视频在线观看| 中文字幕高清在线视频| 视频区欧美日本亚洲| 亚洲中文日韩欧美视频| 天天添夜夜摸| 亚洲一区二区三区不卡视频| 午夜亚洲福利在线播放| 日本熟妇午夜| 久久久久久久精品吃奶| 亚洲午夜精品一区,二区,三区| 欧美激情在线99| 国产精品一区二区三区四区免费观看 | 国产单亲对白刺激| 欧美在线黄色| 日本三级黄在线观看| 一区福利在线观看| 亚洲第一电影网av| 男女床上黄色一级片免费看| 一级毛片女人18水好多| 亚洲精品国产精品久久久不卡| 天堂av国产一区二区熟女人妻| 久久久久久久午夜电影| 一本综合久久免费| 两个人视频免费观看高清| 少妇熟女aⅴ在线视频| 日韩av在线大香蕉| av福利片在线观看| 国模一区二区三区四区视频 | 国产精品久久久久久人妻精品电影| 亚洲av五月六月丁香网| 久久久久国内视频| 99久久久亚洲精品蜜臀av| 黄色片一级片一级黄色片| 久久久久亚洲av毛片大全|