Day case vs inpatient total shoulder arthroplasty: A retrospective cohort study and cost-effectiveness analysis

Aditya Borakati, Division of Surgery and Interventional Science, Royal Free Hospital and University College London, London NW3 2QG, United Kingdom

Asad Ali, Srinivas Gadikoppula, Michael Kurer, Department of Trauma and Orthopaedics, North Middlesex University Hospital, London N18 1QX, United Kingdom

Chetana Nagaraj, Department of Anaesthesia, North Middlesex University Hospital, London N18 1QX, United Kingdom

Abstract

BACKGROUND

Day case total shoulder arthroplasty (TSA) is a novel approach, not widely practiced in Europe. We conducted a retrospective cohort study of patients comparing elective day case and inpatient TSAs in our United Kingdom centre.

AIM

To evaluate the efficacy and cost-effectiveness of day case TSA compared to standard inpatient total shoulder arthroplasty.

METHODS

All patients undergoing TSA between January 2017 and July 2018 were included.Outcome measures were: Change in abduction and extension 3 mo postoperatively; 30-d postoperative adverse events and re-admissions in day case and inpatient groups. We also conducted an economic evaluation of outpatient arthroplasty. Multivariate linear and logistic regression were used to adjust for demographic and operative covariates.

RESULTS

Fifty nine patients were included, 18 d cases and 41 inpatients. There were no adverse events or re-admissions at 30 d postoperatively in either group. There were no significant differences in adjusted flexion (mean difference 16.4, 95%CI:17.6-50.5, P = 0.337) or abduction (mean difference: 13.2, 95%CI: 18.4-44.9, P =0.405) postoperatively between groups. Median savings with outpatient arthroplasty were ￡529 (interquartile range: 247.33-789, P ＜ 0.0001).

CONCLUSION

Day case TSA is a safe, effective procedure, with significant cost benefit. Wider use may be warranted in the United Kingdom and beyond, with potential for significant cost savings and improved efficiency.

Key words: Orthopedics; Shoulder; Arthroplasty; Ambulatory care; Day case; Cohort studies

INTRODUCTION

Total shoulder arthroplasty is well established as a safe, effective treatment for multiple pathologies, including osteoarthritis, rotator cuff arthropathy and complex fractures of the humerus[1,2].

Typically, it is performed under general anaesthesia with an overnight stay for administration of analgesia intravenously. Increasingly, however, the procedure is performed on an outpatient (or day case) basis. This has been facilitated through the use of continuous nerve blockade with portable infusion devices for ambulatory analgesia outside of the hospital setting[3].

The latter approach has been widely adopted across the United States[4,5], although uptake has been slow elsewhere, notably in the United Kingdom and Europe, with limited literature available. There is a significant potential for improved cost effectiveness and throughput efficiency with an outpatient approach. We have therefore conducted this retrospective cohort study in our United Kingdom centre with the aim of comparing the clinical and cost efficacy of traditional inpatient total shoulder arthroplasty with outpatient regimens in this setting. We hypothesised that our outpatient protocol would have equivalent efficacy to inpatient protocols with a significantly lower cost.

MATERIALS AND METHODS

Inclusion criteria

All adult (18+) patients undergoing elective total shoulder arthroplasty at North Middlesex University Hospital, London, United Kingdom between January 2017 and July 2018 were included. Both anatomical and reverse arthroplasties were included.

Exclusion criteria

Patients undergoing arthroplasty for an acute traumatic indication, such as fracture,were excluded.

Perioperative procedure

Prior to selection for surgery all patients underwent clinical assessment of mobility with range of motion recorded. All patients selected for surgery underwent anaesthetic pre-assessment and were identified based on pre-morbid status (no severe cardiorespiratory co-morbidities) for suitability for an outpatient procedure. Patients must have had a friend or family member staying with them for 24 h postoperatively,speak English, be contactable by telephone and have the family member willing to be trained to remove the analgesic catheter. Patients eligible for outpatient arthroplasty only underwent day case analgesic procedure and same day discharge dependent on staffing availability.

All patients were admitted on the day of surgery and operated on under general anaesthesia. Patients selected for a day case procedure were given a continuous intrascalene analgesic infusion following the surgery and discharged the same day,with the infusion pumpin situ. This was then removed at day 3 postoperatively in the community by family members or friends of the patient who were given written instructions on removal. Patients were followed up daily over telephone by specialist pain nurses until removal of the infusion catheter. Those with planned inpatient stays were given strong opiate analgesia and were admitted until this could be weaned off with appropriate mobilisation as assessed by physiotherapy. Patients were followed up at 3 mo postoperatively to assess mobility and to assess imaging to ensure appropriate prosthesis placement.

Data collection

Data was collected re trospectively, with patients identified from prospectively recorded theatre logs and case note retrieval. Data collected included demographic information such as age and gender, co-morbidities and indication for procedure,operative information and postoperative complications and range of motion at 3 mo as assessed in clinic. Patients were stratified into day case and inpatient groups depending on the preoperative plan for admission or not.

Outcomes

Primary outcome measures were mean increase in active flexion and abduction at 3 mo postoperatively. Secondary outcomes were postoperative complication and readmission rates at 30 d.

Economic analysis

The difference in costs between day case and inpatient procedures was calculated using the cost of catheter insertion, analgesic infusion costs and removal of the catheter for the outpatient group. For the inpatient group the median length of stay was used to calculate cost of inpatient nursing care. All other costs of care were assumed equal in both groups.

The median cost difference between inpatient and outpatient groups was calculated and statistical significance assessed using the Mann WhitneyUtest.

Statistical analysis

Descriptive data are presented as means with standard deviation or medians with interquartile ranges (IQR) dependent on the normality of the data as appropriate.Normality was assessed by visual inspection of histograms and quantile-quantile plots and subsequent statistical testing was directed by this assessment. Statistical significance in terms of demographic and operative differences between day case and inpatient groups was calculated using Fisher’s exact or Student’s two-tailedt-tests as appropriate.

Difference in mean abduction and flexion between inpatient and outpatient groups was assessed using Student’s two-tailedt-test. The threshold for statistical significance was set withP＜ 0.05.

Multivariate linear and logistic regression analysis was used to adjust for demographic and operative covariates (including age, gender, side, anatomicvsreverse and indication of procedure) in the primary outcomes, following univariate analysis.

Statistical analysis was conducted using Microsoft R Open 3.5.1[6](Microsoft Corp.,Redmond, WA, United States) with tidyverse[7], desctools[8], finalfit[9], tableone[10]and lubridate[11]packages.

Following the main analysis we later decided (post-hoc) to conduct an analysis of the power of our sample to detect a clinically significant difference (agreed by consensus of the study team) of 30 degrees of abduction between outpatient and inpatient groups. This analysis used the variance in abduction following total shoulder arthroplasty at 6 mo as reported by Ramzjouet al[12].

Reporting guidelines

This study is reported according to the STROBE guidelines for observational studies[13].

RESULTS

Fifty nine eligible patients were identified in the study period, of these, 18 were planned day cases and 41 planned inpatient stays. The characteristics of the study population are summarised in Table 1, note- all the planned day case patients were discharged on the day of surgery as expected and all inpatients were admitted overnight as planned. Inpatients had a median stay of 2 d and 6 h (IQR: 28-78 h).There were no significant differences in day case and inpatient groups at baseline.

Unadjusted analysis (Table 2) showed no significant difference between groups for the increase in range of motion postoperatively. Univariate analysis of the demographic and operative covariates, alongside admission status is displayed in Table 3, there were no significant associations between the primary outcomes and the explanatory variables.

Following adjustment for all covariates (Table 3 and Figure 1), there was no significant difference between day case and inpatient groups for change in flexion(mean difference: 16.4, 95%CI: 17.6-50.5,P= 0.337) and abduction postoperatively(mean difference: 13.2, 95%CI: 18.4-44.9,P= 0.405).

There were no adverse events related to surgery in both groups and no readmissions following discharge in either group.

Economic analysis

Mean cost of admission was ￡260 per day. This gave a median cost of admission for the inpatient group of ￡585 (IQR: 303.33-845). Cost of catheter insertion, infusion and removal was ￡56. Cost of the analgesia catheter was the same for all outpatients. It is assumed all other variables are the same between inpatient and outpatient groups.

The median savings of outpatient arthroplasty were therefore ￡529 (IQR: 247.33-789.00,P＜ 0.0001).

Power calculation

Post-hoc power calculations showed with this sample size, there was a 0.861 power to detect a 30 degree difference in abduction using the variance reported by Razmjouet al[12]at 6 mo.

DISCUSSION

This study is the only published experience of outpatient total shoulder arthroplasty in the United Kingdom. We show the non-inferiority of day case total shoulder replacement with inpatient total shoulder arthroplasty in terms of range of motion and adverse events postoperatively, at lower cost.

Our results mirror those reported elsewhere. Ilfieldet al[3]showed similar range of motion outcomes in inpatient and outpatient groups in their initial pilot study with a single intrascalene block postoperatively in 2005. In their follow up randomised trial they further showed patients who did not have the block, had a lower range of motion initially after the operation as would be expected, despite high doses of intravenous opioids[14].

Recently, Beanet al[15]in their similarly sized retrospective study in the United States, showed reduced 90-d complication rates with outpatient arthroplasty and fewer visits to emergency departments following discharge compared to their inpatient comparator. In this study, patients were excluded from receiving outpatient surgery if they had a number of comorbidities, such as cardiopulmonary disease.Lerouxet al[4]and Basqueset al[5]in their population level studies in the United States also confirmed no increased adverse events or re-admissions in those undergoing outpatient surgery, even after adjusting for pre-existing co-morbidities and demographic factors such as age.

The cost benefit of outpatient shoulder arthroplasty has already been modelled in the United States, where savings were estimated between 747 and $15507 per patient,with a base case of $5594[16]. Our findings match the lower end of these estimates,however, we have only evaluated two key variables for cost differential in our analysis. Additional analgesics, blood tests and physiotherapy costs are likely to increase the relative cost of standard inpatient arthroplasty and we have not accounted for these. Further, admission costs in the United States are known to be markedly higher than the United Kingdom[17].

In addition to direct costs, the potential for increased throughput and reduction of bed use is significant, particularly in the context of the National Health Service where there are significant waiting times and targets to be met.

Our study is also relatively unique in having solely remote follow up of patients with the infusion catheter. Many centers have specialist community nursing teams to facilitate the care and monitoring of the analgesic infusion whilst in the community.Our study shows that it is safe to monitor these patients remotely, while alleviating the need for specialist community nursing resources and training.

In the United Kingdom the only published experience of nerve block infusions for ambulatory shoulder surgery was a successful pilot of 10 patients, which showedgood analgesia[18].

Table 1 Summary characteristics of study population

Strengths

Our study is relatively unique outside of the United States and has a comparator group of inpatients unlike many similar studies. We have further looked at functional outcomes in terms of range of motion in comparison to inpatient surgery unlike much of the previous literature. This study also contains the only cost analysis of outpatient shoulder arthroplasty outside the United States. We believe our study has greater applicability to the publicly provided health systems found in the United Kingdom and Europe, both in terms of demographic similarity and patient pathways.

Further, the statistical analysis we have conducted is robust and the multivariate analysis we have conducted includes several covariates which have been adjusted for.Finally, we have conducted a power calculation, which whilst post-hoc, shows that this study may be appropriately powered and can be used to inform future studies.

Limitations

We have not been able to collect data on co-morbidities to adjust for this as a covariate for postoperative results. Further we have not collected data on pain scores or satisfaction in the long term, which are key factors in the success of the operation.Further, although we have collected data on the two key movements (extension and abduction) ideally a formalised functional assessment such as the Oxford shoulder score[19]should be used. However, in theory, as the operative procedure is identical in both inpatient and outpatient groups, there should be no long term differences in pain or function with the outpatient method, which only alters the postoperative analgesia modality.

For the cost analysis we did not look at all possible costs associated with each procedure and their respective pathways but only the key differentiators, the cost of the catheter and infusion for outpatients and the cost of admission of inpatients (the latter only includes nursing costs). Preferably, alternative costs such as anaesthetic and recovery times, pain nurse telephone follow up, inpatient physiotherapy, pain nurse and medication costs should be included.

Ideally, an appropriately powered, randomized controlled trial with long term follow up comparing patients undergoing outpatient arthroplasty with a continuous nerve blockvsthe traditional inpatient group is needed, as yet, no such trial has been conducted. This trial should randomise patients regardless of pre-existing comorbidities and assess postoperative complication rates, re-admission rates as well as postoperative function and overall service discharge rate. A comprehensive cost analysis using National Health Service tariff prices is essential following this to ensure translation in our setting.

The criterion regarding appropriate selection of patients is important, as there is much debate around this, in shoulder but also hip and knee arthroplasty, where outpatient surgery has been more extensively studied[20]. Meneghiniet al[21]have recommended a scoring system to facilitate selection of suitable patients for day case arthroplasty, however, this only considered hip and knee arthroplasties. Ideally, asimilar scoring system or set of criteria to identify eligible patients for day case shoulder arthroplasties is needed.

Table 2 Unadjusted changes in flexion, abduction and discharge rates at 3 mo postoperatively in day case and inpatient groups

Further, it may be advantageous to use regional anaesthesia only as opposed to a general anaesthetic to further reduce recovery times and potentially to extend surgery to those unfit for general anaesthesia. This has been employed in arthroscopic procedures and some more minor shoulder surgeries such as rotator cuff repair, but is rarely used for total shoulder arthroplasty due to inadequate analgesia. Development of newer techniques such as continuous intrascalene blocks and alternative blocks such as supraclavicular blocks may ameliorate this[22].

It must be noted that the peripheral nerve block techniques that facilitate day case shoulder arthroplasty are not without their disadvantages. The process of achieving regional nerve blockade takes significantly more time than induction of general anaesthesia[23]. With intrascalene blockades, complications include pneumothoraces,phrenic nerve palsies, transient or permanent neurological deficits including hoarseness of voice and Horner’s syndrome due to incorrect nerve blockade and,rarely, systemic toxicity such as myocardial depression. Overall, the risks of regional anaesthesia for surgery are still far lower and less severe than with general anaesthesia[24]. In conclusion, elective total shoulder arthroplasty appears to be safe and effective when performed as a day case procedure in the United Kingdom, with lower costs, mirroring similar results reported in the United States. This suggests that these procedures should be performed more widely as a day case procedure in the United Kingdom and other countries with similar publicly funded health systems, in carefully selected patients, to reduce bed occupancy, improve efficiency and reduce costs. However, larger, more rigorous randomised controlled trials comparing the day case procedure with traditional inpatient regimes including robust cost-effectiveness analyses are needed.

Table 3 Uni- and multi-variate analysis of postoperative range of motion differences

Figure 1 Adjusted mean difference in postoperative flexion and extension between day case and inpatient groups at 3 mo. Bars represent 95% confidence intervals.

ARTICLE HIGHLIGHTS

procedures such as total shoulder arthroplasty as outpatient procedures may reduce bed occupancy while obtaining significant cost benefits. The study was registered with our local clinical governance department as a service evaluation, no explicit patient consent was required for this study of anonymised retrospective data.

Research objectives

We aimed to compare standard inpatient total shoulder arthroplasty with outpatient total shoulder arthroplasty. The primary outcomes were change in flexion and extension at 3 mo postoperatively in each group. Adverse events, re-admission rates and cost analyses were also obtained.

Research methods

We conducted a retrospective cohort study of all patients who underwent total shoulder arthroplasty at North Middlesex University Hospital, London, United Kingdom between January 2017 and July 2018. Both inpatient and outpatient surgical groups underwent general anaesthesia and the same operative procedures. The outpatient group had continuous intrascalene analgesic infusion catheters which were retained postoperatively and they were discharged on the day of surgery. These patients were followed up by telephone by specialist community pain nurses for 3 d postoperatively and the catheter removed by the patient in their home on day 3. Costs were calculated with median length of stay and admission costs in the inpatient group and catheter, infusion and community nursing costs in the outpatient group.Between group differences were assessed using Student’st-test orχ2tests as appropriate.Multivariate linear and logistic regression was conducted to adjust for confounding variables.

Research results

Fifty nine patients were included, 18 d cases and 41 inpatients. There were no adverse events or re-admissions at 30 d postoperatively in either group. There were no significant differences in adjusted flexion (mean difference: 16.4, 95%CI: 17.6-50.5,P= 0.337) or abduction (mean difference: 13.2, 95%CI: 18.4-44.9,P= 0.405) postoperatively between groups. Median savings with outpatient arthroplasty were ￡529 (interquartile range: 247.33-789,P＜ 0.0001).

Research conclusions

This study shows that outpatient total shoulder arthroplasty is a safe procedure with similar efficacy to traditional inpatient arthroplasty. We demonstrate significant cost savings with the outpatient procedure in our publicly funded, United Kingdom setting. These findings suggest that outpatient total shoulder arthroplasty should replace traditional inpatient arthroplasty in suitable patients, in the United Kingdom and beyond, to save costs and relieve capacity.

Research perspectives

Ideally an appropriately powered, randomised control trial comparing outpatient and inpatient procedures is required to evaluate the technique. Formal functional assessment with tools such as the Oxford shoulder score is also needed to accurately assess efficacy. New methods of anaesthesia such as total regional anaesthesia with brachial plexus blockade need further study and may obviate the need for general anaesthesia and extend availability of surgery to those unfit for general anaesthesia. Novel minimally invasive surgical techniques such as arthroscopic and robotic shoulder arthroplasty may also reduce pain and the need for inpatient admission.