彭海洪 劉濟(jì)純
[摘要]目的 探討泮托拉唑聯(lián)合奧美拉唑治療消化性潰瘍出血的臨床效果。方法 收集2018年1~12月我院收治的80例消化性潰瘍出血患者,按照患者入院先后順序?qū)⑵浞譃閷?duì)照組和觀察組,每組各40例。對(duì)照組僅給予奧美拉唑進(jìn)行治療,觀察組給予泮托拉唑與奧美拉唑聯(lián)合治療。觀察兩組患者的臨床總有效率、治療后出血量、出血停止時(shí)間、嘔血次數(shù)、黑便次數(shù)、每日治療費(fèi)用及不良反應(yīng)發(fā)生情況。結(jié)果 觀察組的總有效率為90.00%,高于對(duì)照組的75.00%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。觀察組的治療后出血量、嘔血次數(shù)、黑便次數(shù)明顯少于對(duì)照組,出血停止時(shí)間明顯短于對(duì)照組,每日治療費(fèi)用明顯低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。觀察組的不良反應(yīng)總發(fā)生率為10.00%,明顯低于對(duì)照組的27.50%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 泮托拉唑聯(lián)合奧美拉唑治療消化性潰瘍出血的臨床效果顯著,能有效減少患者的出血量、嘔血次數(shù)及黑便次數(shù),縮短其恢的復(fù)時(shí)間,緩解其經(jīng)濟(jì)壓力。
[關(guān)鍵詞]奧美拉唑;泮托拉唑;消化性潰瘍出血;臨床療效
[中圖分類號(hào)] R573.1? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1674-4721(2019)8(a)-0147-03
[Abstract] Objective To investigate the clinical effect of Pantoprazole combined with Omeprazole in the treatment of peptic ulcer bleeding. Methods All of 80 patients with peptic ulcer hemorrhage admitted to our hospital from January to December 2018 were collected. The patients were divided into control group and observation group according to the order of hospital admission, 40 cases in each group. The control group was only treated with Omeprazole, while the observation group was treated with Pantoprazole combined with Omeprazole. The total clinical effective rate, the amount of bleeding after treatment, the stop time of bleeding, the number of hematemesis, the number of black stools, the daily cost of treatment and the incidence of adverse reactions were observed in patients of the two groups. Results The total effective rate of the observation group was 90.00%, which was higher than 75.00% of the control group, with statistical significance (P<0.05). The amount of bleeding after treatment, the number of hematemesis and the number of black stools in the observation group were significantly less than those in the control group, the stop time of bleeding was significantly shorter than that in the control group, and the daily treatment cost was significantly lower than that in the control group, and the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the observation group was 10.00%, which was significantly lower than that in the control group (27.50%). Conclusion Pantoprazole combined with omeprazole in the treatment of peptic ulcer hemorrhage has a significant clinical effect. It can effectively reduce the amount of bleeding, the number of hematemesis and the number of black stools, shorten the recovery time and alleviate the economic pressure of patients.
[Key words] Omeprazole; Pantoprazole; Peptic ulcer bleeding; Clinical efficacy
[參考文獻(xiàn)]
[1]陳光,徐小兵.奧美拉唑與泮托拉唑治療消化道潰瘍出血的成本-效果分析[J].現(xiàn)代醫(yī)藥衛(wèi)生,2016,32(19):2972-2973,2976.
[2]李薇,何書經(jīng).內(nèi)鏡下止血術(shù)聯(lián)合泮托拉唑或奧美拉唑治療消化性潰瘍出血療效觀察[J].中國(guó)煤炭工業(yè)醫(yī)學(xué)雜志,2018,21(2):130-133.
[3]萬曉林.泮托拉唑與奧美拉唑治療老年消化性潰瘍出血療效對(duì)比[J].基層醫(yī)學(xué)論壇,2016,20(32):4479-4481.
[4]潘大義.泮托拉唑與奧美拉唑治療消化性潰瘍出血的療效比較[J].航空航天醫(yī)學(xué)雜志,2016,27(6):751-752.
[5]趙欣心.消化性潰瘍出血治療中奧美拉唑與泮托拉唑的應(yīng)用效果對(duì)比分析[J].臨床醫(yī)藥文獻(xiàn)電子雜志,2017,4(84):16610-16611.
[6]董長(zhǎng)海.奧美拉唑與泮托拉唑治療消化性潰瘍出血的臨床療效[J].中國(guó)實(shí)用醫(yī)藥,2017,12(36):128-129.
[7]黃導(dǎo).奧美拉唑與泮托拉唑治療消化性潰瘍出血的臨床療效及安全性比較[J].中國(guó)藥物經(jīng)濟(jì)學(xué),2017,12(8):70-72.
[8]呂峰.泮托拉唑與奧美拉唑治療消化性潰瘍出血的效果對(duì)比研究[J].中外醫(yī)學(xué)研究,2017,15(27):173-174.
[9]祝芳亮.泮托拉唑與奧美拉唑治療消化性潰瘍出血治療對(duì)比研究[J].心理醫(yī)生,2018,24(23):155-156.
[10]高正強(qiáng).奧美拉唑、泮托拉唑治療消化性潰瘍出血的療效觀察[J].醫(yī)學(xué)信息,2017,30(10):90-91.
[11]張小燕.泮托拉唑與奧美拉唑治療消化性潰瘍出血療效對(duì)比評(píng)價(jià)[J].系統(tǒng)醫(yī)學(xué),2018,3(21):51-52,64.
[12]徐青.奧美拉唑與泮托拉唑治療消化性潰瘍出血的臨床療效對(duì)比[J].臨床醫(yī)藥文獻(xiàn)電子雜志,2018,5(15):169-170.
[13]龐雪花.泮托拉唑和奧美拉唑治療2型糖尿病并發(fā)消化性潰瘍出血的對(duì)比[J].醫(yī)學(xué)信息,2016,29(29):86-87.
[14]王曉東,馬阮昕.對(duì)比泮托拉唑和奧美拉唑治療消化性潰瘍出血的臨床療效[J].海峽藥學(xué),2017,29(12):178-179.
[15]徐寶琪.泮托拉唑治療消化性潰瘍的療效及安全性[J].包頭醫(yī)學(xué)院學(xué)報(bào),2016,32(1):57-58.
(收稿日期:2019-01-14? 本文編輯:許俊琴)