Radiologic features of Castleman’s disease involving the renal sinus: A case report and review of the literature

Xiao-Wan Guo, Xu-Dong Jia, Shan-Shan Shen, Hong Ji, Ying-Min Chen, Qian Du, Shu-Qian Zhang

Abstract

Key words: Duplex collecting system; Castleman’s disease; Plasma cell type; Renal sinus;Image; Case report

INTRODUCTION

Castleman’s disease (CD) is a rare benign lymphoproliferative disease, and its pathogenesis is still unclear. CD usually involves mediastinal lymph nodes.Extrathoracic presentations have rarely been described, with even fewer presentations in the kidneys. CD can be histologically classified into three types as follows: Hyaline vascular type, plasma cell type, and mixed type. Preoperative diagnosis by imaging examination is very difficult to differentiate the plasma cell type of CD from malignant lymphoma. Here, we report a case of plasma cell type CD with only renal sinuses involved. We hope to identify the imaging features that can help the preoperative qualitative diagnosis of this disease through a literature review. Our case is unique because it is the first report of CD presenting as sinus tumors in a patient with a duplex collecting system (DCS)

CASE PRESENTATION

Chief complaints

A 65-year-old woman showed right renal sinus lesions on renal ultrasonography performed as part of a healthy physical examination. Medical history was negative for symptoms of discomfort.

對(duì)社會(huì)治理研究狀況做了一次時(shí)間不長(zhǎng)的階段性調(diào)查，說(shuō)明研究取得了進(jìn)展。這一研究領(lǐng)域也受到了行政系統(tǒng)的關(guān)注與支持。為了使研究持續(xù)開(kāi)展，宜倡導(dǎo)反思、切磋，拓寬研究領(lǐng)域，在弘揚(yáng)傳統(tǒng)文化精華的同時(shí)，注意把握尺度、防止沉渣泛起。僅陳以上管見(jiàn)就正于方家，尚祈同行不吝指正。

History of present illness

Her history was unremarkable.

Laboratory examinations

Laboratory findings showed mild liver dysfunction. Urinalysis findings were within normal limits, and urine cytology showed no evidence of malignancy. No obvious abnormality was found in other laboratory examinations. Normal blood flow to the left kidney and slightly decreased blood flow to the right kidney were noted on nephro-dynamic images.

Imaging examinations

DCS and a soft tissue mass with mild enhancement at the lower right renal sinus were detected after subsequent abdominal computed tomography (CT). Magnetic resonance imaging (MRI) revealed a homogeneous mass that was isointense on M3D Lava in-phase images and hypointense on T2-weighted images (T2WI). Diffusionweighted images (DWI) showed a hyperintense mass (Figure 1).

FINAL DIAGNOSIS

The final diagnosis was CD of plasma cell type (Figure 2).

Figure 1 Plasma cell type of Castleman’s disease involving the renal sinus and adjacent parenchyma in a 65-year-old woman. A: Coronal contrast-enhanced computed tomography (CT) image showing bilateral renal pelvis duplication; B: Axial contrast-enhanced CT image obtained at the renal hilum level shows mildly homogenous enhancement of a soft tissue mass in the right lower renal sinus; C: T2-weighted images (TR/TE, 10000/82.6)showing a soft tissue mass in the right renal sinus with slightly hypointense signals compared to that of the renal cortex; D: Diffusion-weighted images (b = 800 s/mm2) showing that the mass (open arrow) is mildly hyperintense, and a hyperintensity lesion is in the renal parenchyma (solid arrow).

TREATMENT

The patient underwent a right radical nephrectomy. Histological examination revealed hyperplastic lymphoid follicles in the renal sinus and adjacent parenchyma.Immunohistochemical staining showed the following results: CD38 (+), CD138 (+),Kappa (+), Lambda (+), and CD21 (FDC+).

OUTCOME AND FOLLOW-UP

After treatment, thoracic and abdominal CT scans were used to determine whether the disease was multicentric. However, no enlarged lymph node or other lesions were found.

DISCUSSION

CD remains a rare and poorly understood disease characterized by massive growth of the lymphoid tissue. The renal sinus is an extremely unusual location for the manifestation of CD. The exact mechanism of CD in the renal sinus has not been reported thus far. Chronic low-grade inflammation, an immunodeficiency state, and autoimmunity have been proposed as probable mechanisms[1]. Patients with DCS are more susceptible to chronic inflammation, which is the probable cause of CD[2]. Our case supports chronic low-grade inflammation as a possible mechanism, although the exact cause of formation requires further study.

Figure 2 Histological examination of the right kidney in a 65-year-old woman. A: Photomicrograph (original magnification, 40×; hematoxylin-eosin staining)showing hyperplastic lymphoid follicles (asterisks) in renal sinus fat tissue below the normal renal pelvis (open arrow) in the lower right renal sinus; B: Interfollicular areas showing heavy staining.

As far as we know, six articles on CD involving the renal sinus have been reported[3-8]. All lesions were confined to the renal sinus except in one case with a large range of lesions and retroperitoneal involvement. Six lesions in five cases were diagnosed as CD of plasma cell type, all of which were reported as case reports. Their imaging findings and pathological features are summarized in Table 1. In this table,the total number of patients with CD involvement of renal sinuses is six (seven lesions), including four males and two females, with an average age of 66 years. All of these patients presented homogeneous soft tissue density masses with mild enhancement, and the longest diameter less than 5 cm on CT image. Although the specific longest diameter of lesions was not given in some articles[4,5], the imaging data of lesions were given. Therefore, their size could be roughly obtained by comparison with the imaging data, in which the exact size of the lesions had been given. Four of these patients underwent MRI scans[4-6], showing isointense lesions on T1WI and hypointense lesions on T2WI, and two of these patients showed hyperintense lesions on DWI[4,5]. We believe that hypointensity on T2WI, hyperintensity on DWI manifestations, and mild enhancement can help us to distinguish the plasma cell type of CD from many renal sinus lesions, such as transitional cell carcinoma and renal sinus lymphoma. In most cases, the lesions of transitional cell carcinoma show high signal on T2WI, with unsmooth edges and hematuria as the most common clinical symptoms. However, it is still impossible to differentiate CD from renal sinus lymphoma by imaging alone. It also has lower signal intensity than a normal cortex with T1WI, and it is relatively iso- or hypointense in T2WI and hyperintense on DWI.

In Table 1, only one of the seven lesions showed complete occlusion of the collecting system[5], and the rest of the lesions showed slight dilatation of renal pelvis and calyces. Therefore, compensatory dilatation of the collecting duct system was considered to be caused by subcutaneous lymphocyte hyperplasia in the urinary tract.The pathology of three cases clearly indicated that the pelvic tumor was a benign lymphoproliferative lesion with widely scattered, hyperplastic lymphoid follicles,while the pelvic urothelium was intact, which was consistent with the smooth and nonfilling defect on the inner surface of the collection system from CT and MRI imaging[3,4]. Shethet al[9]reported that the imaging findings of renal lymphoma are related to the tumor growth pattern. If malignant lymphocytes proliferate focally,single or multiple well-defined masses can be formed and adjacent urinary tract systems destroyed. However, if it follows an infiltrative growth pattern, then the size of the kidney may increase without damage to the basic structure, and the lesions may be quite small with ill-defined borders. Similar well-defined renal sinus masses have been found in reported cases. If they are considered renal sinus lymphoma, then their growth mode should be focal growth, which is bound to be accompanied by adjacent urinary tract destruction. In fact, three cases showed complete urinary tract epithelium under an electron microscope. Although the remaining four cases failed to provide pathological evidence, these cases all shared similar imaging features, which show smooth intrarenal pelvic lateral surfaces. Therefore, we speculated that the plasma cell type of CD, due to its benign hyperplasia of lymphoid pathological, may not show epithelial invasion like lymphoma. We believe the imaging findings of the plasma cell type of CD, showing peripelvic soft tissue masses and a smooth internal surface of the renal pelvis, suggest that the urinary tract epithelial system is invulnerable. It can be used to differentiate the plasma cell type of CD from malignant lymphoma with a focal growth pattern. However, it is just a speculation and more cases are needed to verify it. Since the treatment of CD is different from that of lymphoma, the preoperative diagnosis of CD involving renal sinus will affect the choice of clinical treatment.

Table 1 Clinicopathological and imaging characteristics of previously reported cases of plasma cell type of Castleman’s disease with renal sinus involvement

CONCLUSION

In conclusion, our case suggests that a patient with a DCS may have a risk of suffering CD due to his or her susceptibility to chronic inflammation, and imaging findings of the plasma cell type of CD, showing hypointensity on T2WI, hyperintensity on DWI,peripelvic soft tissue masses, and a smooth internal surface of the renal pelvis, are important to the preoperative diagnosis of CD of plasma cell type involving only the renal sinus.