Clinical assessment indicators of postpartum hemorrhage:A systematic review☆

Ying Liu,Ying Shen,Wei Zhu,Jing-Bo Qiu,Qun Hung,*,Wen-Qin Ye

aThe International Peace Maternity&Child Health Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200030,China bNursing Department,Changhai Hospital Affiliated to the Second Military Medical University,Shanghai 200433,China

Clinical assessment indicators of postpartum hemorrhage:A systematic review☆

Ying Liua,b,Ying Shena,Wei Zhua,Jing-Bo Qiua,Qun Huanga,*,Wen-Qin Yeb,*

aThe International Peace Maternity&Child Health Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200030,ChinabNursing Department,Changhai Hospital Affiliated to the Second Military Medical University,Shanghai 200433,China

A R T I C L E I N F O

Article history:

3 July 2017

Available online 14 October 2017

Clinicalindicator

Postpartum assessment

Postpartum hemorrhage

Blood loss

Early warning

Systematic review

Objective:The assessment indicators of postpartum hemorrhage(PPH)were systematically reviewed to explore their relationship with blood loss as an early warning sign to identify potential PPH for prompt intervention.

Methods:A systematic literature search of 9 databases was conducted according to inclusion and exclusion criteria using a comprehensive strategy.Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)strategy was chosen as the tool for quality assessment of included studies,and data concerning the basic study characteristics and assessment indicators were extracted.

Results:Eleven studies were included in this review.The assessment indicators in different reports covered heart rate,blood pressure,placental and birth canal check,hemoglobin(Hb),hematocrit(HCT),coagulationfunction tests,hemodynamicparametersandarterialbloodgas,butnodata ontheassessment of postpartum uterine contraction were found.The relationship between indicators and blood loss varies.The overall quality of 9 manuscripts was comparatively high or moderate,and 2 were rated as low.

Conclusions:The association between blood loss and clinical symptoms is not conclusive based on the present studies,and specific cut-off points couldnot be formulated to determine the approximate amount of blood loss.However,some cut-off points can be considered warning signs for the need of advanced interventions,such as heart rate,prothrombin time,and placentalimplantation.Further research on comprehensive assessment and cut-off points should be performed such that birth attendants can distinguish PPH as early as possible.

?2017 Shanxi Medical Periodical Press.Publishing services by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).

1.Introduction

Postpartum hemorrhage(PPH)leads to prominent causes of maternal death.The WHO estimated that the total number of maternal deaths worldwide is over 3 million and that severe blood loss,infection,hypertension,complications of pregnancy and unsafe abortion account for 75%of such deaths.1Although the incidence of severe PPH is decreasing,it remains a huge threat to both the mother and the health care personnel.

PPH has been defined as“the amount of blood loss over 500 mlin natural vaginal delivery,or 1000 mL in cesarean section,within a period of 24 h postpartum”.2However,this definition tends to be retrospective.Thus,PPH can only be diagnosed if the parturient has lost more than 500 mL or 1000 mL of blood.Another limitation of diagnosing PPH is that no ideal method to precisely calculate how much blood has been lost has been reported to date.3Visual estimation,which is the most convenient method of blood loss estimation,underestimates blood loss by half the actual amount.4The Hb or HCT method has a delayed effect since intensive hemorrhage might cause the blood to concentrate in a short time,leading to a false impression that the value is within normal limits.Although the National Postpartum Hemorrhage Control Group in China has suggested that the gravimetrical method and volume method be combined as a routine measurement,the heavy workload in the delivery rooms makes this recommendation impractical on the basis of such a large population.Therefore,some professionals suggest that other clinicalindicators should be assessed to provide an early warning of the severity of the hemorrhage.Although guidelines5-7of PPH have been constantly updated,a detailed maternal assessment is never emphasized.Instead,these guidelines mainly presented recommendations on PPH prevention andintervention practices.Evidence demonstrates that timely assessment of vital signs can reduce the symptom-to-intervention period in those who experience PPH and significantly improve postintervention outcomes.8Early identification permits early intervention.

Clinical signs and symptoms are closely related tothe severity of blood loss irrespective of the normal or maternal population.It is commonly believed that vital signs are of great value for assessment,but they remain unchangeable until mild shock is present.In addition to vital signs,other indicators,such as the fundus position and the hardness of the uterus,are routinely assessed in the postpartum period.The main indicators,the time interval of assessment and the thresholds of differentseverityof blood loss are basically formulated with clinical experience from the obstetricians and midwives.A systematic review revealed the relationship between shock index and blood loss among 9 indicators,including heart rate,systolic blood pressure,shock index,prehospital systolic blood pressure,mean arterial pressure,diastolic blood pressure,pulse pressure,body temperature and respiratory rate.9Nevertheless,the included articles focus mainly on trauma patients or maternal patients with other complications,such as ectopic pregnancy.Two other reviews that focused on hemostatic monitoring suggested the lack of conclusive evidence for optimal hemostatic resuscitation but arrived at the notion that viscoelastic hemostatic assays were useful for rapid assessment in treating PPH,including thrombelastography-or thromboelastometry-based tests.10,11A reduction in f i brinogen played a major role in PPH and could be considered an early predictor of the worsening of a patient's condition.12To our knowledge,maternal hemodynamic features differ from the non-pregnant population,indicating the necessity of postpartum assessment for this population.Thus,due to the lack of consensus on what clinicalindicators should be assessed and the specific time point of each indicator signifying potential PPH,we conducted this review to identify clinical parameters that are essential for postpartum assessment to prompt health care providers of early warnings of PPH.

2.Materials and methods

The Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)statement13and the Meta-Analysis of Observational Studies in Epidemiology(MOOSE)guidelines14were adopted in this systematic review.

2.1.Inclusion and exclusion criteria

Focused on the PPH population,all studies included met the following criteria:relationship between the assessment indicators and loss of blood should be explored,both prospectively and retrospectively;types of studies were observational;both English and Chinese studies were included.Articles were omitted because the indicator results or the severity of blood loss were excluded.Studies exclusively focused on hemostasis exclusively were not considered given that similar reviews exist.

2.2.Searching strategies

Before systematic search of primary studies related to assessment indicators,the Cochrane Library was searched to ensure that no systematic review was reported for this particular topic.Then,a literature search was conducted to identify articles published in PubMed,EMBASE,ProQuest,Springer,Elsevier,CINAHL,CBM(China Biology Medicine),CNKI(China National Knowledge Infrastructure)and Wanfang Databases from the establishment of each database to December 2016.Terms used to retrieve articles included“(postpartum hemorrhage/postpartum hemorrhage)&assess*&(vital signs/heart rate/blood pressure/temperature/respiratory rate/consciousness/oxygen saturation/urine output/shock/uterine contraction/fundus/birth canalinjury/lower genital tract laceration/placenta completeness/placenta examination/laboratory test)”.In addition,important references of selected articles were considered for a complementary search.

2.3.Literature screening and critical appraisal

Two reviewers who were trained to conduct evidence-basednursing research independently read the title and abstract of each article.If inclusion criteria were met,we further reviewed the full article.Retained studieswerecrosschecked.Afterliterature screening,the quality of those selected studies was judged by the two reviewers based on the 22-item Strengthening the Reportingof Observational Studies in Epidemiology(STROBE)Statement.15A third reviewer was involved ifthere were any disputation throughout the critical appraisal.

2.4.Data extraction and analysis

A data extraction sheet was identified to transfer the data of eachselected study.The sheet contained the following information:author,year of publication,region of research,population,sample size,mode of delivery,treatment after delivery,severity of blood loss,indicators and its measurement,results of the relationship between assessment indicators and blood loss.The meta-analysis was not conducted given that most included studies didnot share a common format of quantitative analysis.For example,both Lin's16and Lin's17studies recorded the heart rate(HR),blood pressure(BP),hemoglobin(Hb)and hematocrit(HCT),but accurate HR and BP data were not reported,and the reported times of Hb and HCT differed.Therefore,only a descriptive discussion is provided.

3.Results

A total of 2319 citations were identified throughout the search process,and 39 articles were retrieved for full-text review.Finally,11 articles were selected.The details of literature screening are presented in Fig.1.

We separated the information extracted into two charts,including the characteristicsof studies(Table 1)and the assessment indicators explored in each study(Table 2).Of the 11 studies,4 were conducted in China,2 in France,and the remaining f i ve were from UK,Korea,Japan,Netherlands and Belgium,separately.The sample sizes ranged from 27 to 501,with a total of 1660 samples.The mode of delivery varies among each study,one of which was not specifically depicted given that the subjects weremostly transferredfrom primary or secondary hospitals.Treatment after delivery was basically administered according to institution rules,and the transferred patients were subjected to advanced interventional operations.Half of the studies(6 out of 11)described the method used to measure assessment indicators.The severity in 7 studies was represented as the amount of blood loss,and the patients in other four studies were previously suffering from PPH or severe PPH,which requires an immediate operation.

Both indicators and the assessment time of each indicator are summarized.The outcome of primary indicators included vital signs,lab tests,placenta completeness,birth canalinjury assessment,and other indicators,such as hemodynamic parameters,arterial blood gas and blood biochemistry.In all the 5 studies that included vital signs as indicators,only heart rate and blood pressure were recorded.Hb and HCT were the two lab tests most frequently performed.The associations of these indicators and the severity of blood loss were not consistent across the studies.The study conducted by Lee compared the bleeding locations of birth canal with computed tomography(CT)and angiography,which technically was a diagnostic accuracy experiment.However,no articles about the degree of postpartum uterus contraction were reported,which the authors intended to include as part of the searching strategies.

Table 3 presents the quality judgment results of 11 studies.As previously mentioned,Lee's research was evaluated with the QUADAS-2(Quality Assessment of Diagnostic Accuracy Studies)tool,18whereas the remaining studies were judged with STROBE.Most(9 out of 11)were considered to exhibit high or moderate quality.The remaining two were ranked as low due to the lack of information,such as research design and purpose,detailed information about collecting data,or accurate data for some indicators.

Fig.1.Flow diagram of literature selection.

4.Discussion

4.1.Literature screening

試驗(yàn)分別用平板和P6壓頭對圣女果進(jìn)行壓縮，加載速度為20mm/min。不同壓頭力——變形曲線如圖2所示。從圖2上可以看出，平板壓頭和P6壓頭的壓縮曲線有明顯的差異，平板壓頭和P6壓頭的壓縮曲線在初始階段趨勢相近，隨著變形量的增加P6壓頭壓縮曲線呈近似線性變化，而平板壓頭由于與壓縮物的接觸面積不斷增大，其壓縮曲線的斜率有明顯的增加過程。而且平板壓頭壓縮曲線中不會(huì)出現(xiàn)屈服極限點(diǎn)，P6壓頭壓縮的曲線中會(huì)出現(xiàn)明顯屈服極限點(diǎn)。平板壓頭壓縮的破裂極限點(diǎn)明顯高于P6壓頭壓縮的，對應(yīng)壓縮破裂的變形量也大于P6壓頭的。

Although a total of 2319 studies were initially identified,most of them were excluded because the study was not related to PPH or didnot focus on maternal assessment.Of those studies involving other diseases,gestational hypertension was a common disease.Other studies on PPH explored the effectiveness of prevention and intervention of PPHrather thanassessment indicators.Forinstance,active management of the third stage of labor as a prevention method was discussed in primary studies,systematic reviews and even guidelines.Regarding intervention results,some of the medical treatment studies were not selected because they focused on the dose and incidence of adverse effects.Most of the evidence was obtained from developed countries,whereas no datawere reported from Africa,where the prevalence of PPH is the highest.

4.2.Critical appraisal

Most of the articles were rated high or moderate.In these studies,potential bias was not mentioned or discussed as limitation in 5 studies.The data of HR and BP were not accurate in two Chinese studies;“not significantly different”was the only description provided,indicating a low reliability.

4.3.Assessment indicators

Assessing the clinical signs or symptoms of PPH in the parturient is necessary.As the condition worsens,more anomalous

indicators are noted.These findings are important as they not only implicate potential PPH but also direct the obstetricians and anesthesiologists how manage the treatment.

Table 1Characteristics of included studies.

Table 2Association between assessment indicators and blood loss.

p l a t e l e t;r l a l l y P L T=t r a v a s c u m e d i c a*;)2 9 2)a t o c r i t;d i n p=9(1-x):**t e T:2.0 6 u t e r u s r r e s s o f B l a d g r e e 0-d e(c m)f o 4 9 a l m i n a M g r o u D I C s c o r e:i n d e :1 v i t y (c m)e h i g h C r a r e n 5(0.4 2 l n t:C 1(-)?A n g i o g r a p h y:8(-)?1 7 l n t:(c m)*;d e=h;M t s c k e n e m(s h o o g 1)n a s s m e 4 8 1 7),),F i b r i n t a t i o n e c a P:R B w e e n u r e s r v e f e i r e m s i o n B i r t h c a C T i s s e 0-a s s e(+a s s e i c k n 4 5(7(+d i s t e n 3 8 t i o n e r t i o,0.9 0 T h l l P l a c e n s s m e w a p a U t e r i n r a s e T h n c e d t i o n p r o c e d S I F F=d t h r e a d q u v a t e i n ;H I C n s f u i n;D g l o b s e m o r a p r e t r a h e n s f e b=i n o t r a P r e=e;r g r e;H a m d p r e s s u n i n e d i s c h a l a=a o n b l o o L T D i s=P=s e;A n;;B t e m i n a r a s a r t=h e a m i s s i o=o A d H R r t a t e t r a n n a d e r y;c t i o n;a s p a s e a n A S s t-d T=e l i v r e e;p o s a i d D i s 9.7 c e S=d i o x D=;P;C o n r y r y c a r b l i v e d e r e f o l i v e o f d e r e P r e**6.9 i n a l=v a g l p r e s s u b e D=;B 7.5 5 V D s;l p a r t i a t i o n c a r t e r i a p l a s m a l o=a f r o z e n i c a t o m O 2 s h a n;P a C p.e r s o f=f r e F P:R m b b i n t i m e B C u r e g r o u t n u g r a p p r o t h r o m h y;F p r o c e d p r e s e n m o a l a t a r e T=d t o t i o n e n n t;?:d e n p u t e ;P t e r v i f i c a o f=c o m y g i n o x r e C T v a n c e d n s o f s f u s i o n w a t i m e r 2.2 h n p h o n *:d e C T 6 m i n a f t e i f i c a r t i a i n P r e-t r a n n d p=n t;*s i g n e(D i s)s f u s i o)a r g y:s s m e c k r M D m i s s i o r a r e g i o g(P l p r e s s u x;a d d i s c h a T r a n c i d e d a t n t d e a s s e :4 C T a d A n a f t e r t e r i a S I --s i g n l p a=s h o A I P g r o u p;a n 0 s m 1 0 2 5 2 6 2 4 1 0 b 2 u i e r:*:n n;0 7 s q 2 0 2 7-O 2 0 o t e 2 0 E r a 2 0 1 5 L i n 2 0 1 3=a d g r o u a g n a t e O 2 S o L e P a u l a t i o g e N o P a c o m a

Most of the 11 articles included HR,BP,Hb and HCT as primary indicators,whereas other indexes,such as placental assessment,birth canal assessment,and arterial blood gas(ABG)or blood biochemistry items,were less frequently mentioned.HR signif icantly differed in the studies by Robson,Gayat and Karpati but not in Lin's and Lin's.The latter two studies analyzed visual estimation between groups and precisely measured the method of blood loss.The authors didnot group all the subjects into a PPH group andnon-PPH group;thus,we couldnot determine whether the similarity of HR in patients with PPH or those without actually exists.Robson's study compared the HR of the PPH and control groups,reporting a different HR.However,only 9 patients were included in the PPH group,given its incidence.In Gayat's research,all the subjects all had severe PPH and were grouped in the medical treatment group or advanced interventional practice group.The values of both groups reached the borderline,and the AIP group exhibited worse values.The subgroups were formed because the author sought to identify indicators of AIP,which also included abnormal placentalimplantation,PT＜50%,f i brinogen＜2 g/L and detectable troponin I.This information helps the obstetricians to make a quicker decision on surgical treatment.The data on admission and discharge of Intensive Care Unit(ICU)were compared in Karpati's study,and the difference was found because patients'conditions were deteriorating when admitted to the ICU.A similar situation was noted for BP,except for the lack of a difference in BP reported in Gayat's study.In the systematic review of Pacagnella,shock index was conf i rmed as an accurate indicator of compensatory changes related to blood loss.9Shock index is the ratio of HR over Systolic Blood Pressure(SBP).Thus,our findings of HR and BP changes in PPH or severe PPH are to some degree consistent with the present review.It is generally recognized that bleeding less than 500 mL does not cause any clinical symptoms in the mother as the blood volume of full-term pregnant women increase by approximately half.The strong compensation ability allowed the vital signs to be maintained even when the amount of blood loss from hemorrhage reaches 1000 mL.HR and BP are typically two of the vital signs recommended for assessment,28but reports on respiratory rate or temperature changes if the patient starts to suffer severe PPH have not been published.

Hb also differed in Ping's research,wherein two methods of blood loss estimation served as the variables.The incongruity with Lins'results might be explained by the fact that all subjects underwent cesarean section,which typicallyinvolves moreblood loss.A combined effect of Hb and HCT was not examined given that the assessment time of each article was distinctive.The correlation between Hb or HCT and blood loss can be more complicated in the context of a prescribed blood transfusion.However,the results listed inTable 2 indicatethat mild hemorrhage wouldnotresult in a reduction of Hb and HCT,but the values became exacerbated as the hemorrhage worsens.Although Kodkany claimed that mothers who lost less than 500 mL of blood with minor clinical symptoms should be exempted from routine tests,4it would be too late to determine whether the values decrease.Therefore,identifying the best time to run the test can duly signify early interventions.

In Lee's research,the locations of bleeding were rapidly identifi ed with CT compared with traditional angiography or more commonly adopted inspection of the genital tract.This rarely used method of orientation was added to determine extrauterine bleeding with a higher sensitivity than the angiography method.This was the only article that we found regarding birth canal assessment through the search process,implying that either inspection was more prevalent or that genital assessment might be neglected by researchers,clinicians or midwives.

Placental assessment was noted in several studies,mostly using the ultrasound approach for retention.In Lin's research,the 95%con fi dence interval of the length of anteroposterior uterine walls(APD)was 5.8-6.4 cm.The larger the length,the more likely PPH will occur.Normal urinary retention is one cause of uterine atony;however,Lin found that the degree of bladder distention was not related to PPH.Detailed results and explanations werenot provided in the text;therefore,the reliability of the reported value seemed questionable.The authors concluded that clinicians should regularly use ultrasound as an approach to monitor the APD of the uterine to identify PPH as early as possible.It is recommended that the birth attendants regularly assess the completeness of the placenta.29The necessity of ultrasound in placental assessment needs to be con fi rmed given that the incidence of placenta accreta or retention is comparatively low,whereas the examination expenses are high.In addition,the effectiveness of ultrasound in identifying the residual tissue was limited;however,this fi nding is disputed.30Hence,cost-effectiveness analysis should be further performed for routine ultrasound application.

The coagulation function tests were mostly performed in cases of severe PPH,of which platelet and fi brinogen were the most frequently assessed parameters with signi fi cant changes.Other indicators that we assessed included ABG,blood biochemistry and hemodynamic parameters,but these parameters exhibited greater alterations in ICU patients and more rarely assessed.The patient's heart pumps more blood swiftly to provide suf fi cient blood to vital organs,resultinginanincreasedvelocityintegralandstrokevolume.Severe PPH could potentially lead to myocardialinjury with an elevatedTnI,whereastheliverandkidneyfunctionremainednormal.

Table 3Quality of included studies.

4.4.Limitations

Given that our literature search focused on English and Chinese studies,studies reported in other languages were not identified with the exception of 2 French and 1 Spanish articles,which were excluded through screening.Therefore,data from other countries might not be available.In addition,given the varied subjects of these studies,including both mild PPH and severe PPH patients,and different assessment time points for each indicator,the metaanalysis cannot be further implemented.The generality of the assessment should be deliberated accordingly.

5.Conclusions

According to our findings,assessment indicators and assessment time vary widely among institutions.Existing studies mainly focused on indicators of HR,BP,Hb,HCT,coagulations,blood biochemistry,arterial blood gas,hemodynamic parameters,uterine ultrasound for placental assessment and genitalinjury assessment,but the postpartum assessments of uterine contraction,level of consciousness,temperature,respiratory rate and bladder f i lling were not assessed.The association between blood loss and clinical symptoms is not conclusive based on the present studies,and specific cut-off points couldnot be formulated to determine the approximate amount of blood loss.However,some cut-off points can be regarded as a warning for the need for advanced interventions,such as heart rate,prothrombin time,and placentalimplantation.Further studies on comprehensive assessment and cut-off points should be performed such that birth attendants can distinguish PPH as early as possible.

Conf licts of interest

All authors have none to declare.

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9 May 2017

in revised form

17 August 2017

https://doi.org/10.1016/j.cnre.2017.10.003

2095-7718/?2017 Shanxi Medical Periodical Press.Publishing services by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).

☆This project was supported by Shanghai Nursing Association(No.2016SD-B03).

*Corresponding authors.

E-mail addresses:hqryrj@163.com(Q.Huang),wq1718@163.com(W.-Q.Ye).

Peer review under responsibility of Shanxi Medical Periodical Press.

How to cite this article:Liu Y,Shen Y,Zhu W,et al.Clinical assessment indicators of postpartum hemorrhage:A systematic review.Chin Nurs Res.2017;4:170-177.https://doi.org/10.1016/j.cnre.2017.10.003