液基薄層細(xì)胞學(xué)與活檢病理在早期宮頸癌及宮頸上皮內(nèi)病變中的臨床應(yīng)用價(jià)值

于文力

[摘要]目的 探討液基薄層細(xì)胞學(xué)以及活檢病理在早期宮頸癌及宮頸上皮內(nèi)病變篩查中的臨床應(yīng)用價(jià)值。方法 選取2008年1月～2014年12月在我院接受宮頸癌篩查的女性作為研究對(duì)象，其中9000例實(shí)施液基薄層細(xì)胞學(xué)檢查，891例實(shí)施術(shù)前活檢病理診斷，觀察兩種方法的診斷結(jié)果，并以最終臨床診斷結(jié)果為依據(jù)，分析兩種方法的診斷準(zhǔn)確率。結(jié)果 9000例接受液基薄層細(xì)胞學(xué)篩查的女性中，根據(jù)細(xì)胞學(xué)與組織學(xué)診斷可以相差一級(jí)的原則，低度鱗狀上皮內(nèi)病變（LSIL）、宮頸癌前病變（HSIL）以及鱗狀細(xì)胞癌（SCC）與最終病理診斷結(jié)果的符合率分別為31.9%（375/1174）、83.8%（155/185）、100.0%（65/65）；91例接受活檢病理診斷的女性中，CIN 1級(jí)、CIN 2級(jí)、CIN 3級(jí)、SCC與最終病理診斷結(jié)果的符合率分別為42.8%（80/187）、61.4%（285/464）、71.3%（132/185）、100.0%（65/65），隨著分級(jí)的升高，診斷符合率相應(yīng)升高，且各組結(jié)果比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 聯(lián)合應(yīng)用液基薄層細(xì)胞學(xué)和活檢病理的手段對(duì)早期宮頸癌及宮頸上皮內(nèi)病變進(jìn)行診斷，有利于提高患者的診斷效果，能夠?yàn)槠湓缙谥委熖峁┛煽恳罁?jù)。

[關(guān)鍵詞]液基薄層細(xì)胞學(xué)；活檢病理；早期宮頸癌；宮頸上皮內(nèi)病變；診斷

[中圖分類(lèi)號(hào)] R737.33 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2016）12（a）-0145-03

Clinical application value of liquid thin-layer cytology and biopsy pathology in early stage of cervical cancer and cervical intraepithelial lesions

YU Wen-li

Maternal and Child Health Care Hospital of Liaoning Province，Shenyang 110005，China

[Abstract]Objective To explore the clinical application value of liquid thin-layer cytology and biopsy pathology in early stage of cervical cancer and cervical intraepithelial lesions.Methods Women with cervical cancer screening from January 2008 to December 2014 in our hospital were selected as research subjects，9000 cases were given liquid based cytology test，891 cases were diagnosed by biopsy pathology before operation，and the diagnosis results of the two methods were observed，finally，based on the final clinical diagnosis results，the diagnostic accuracy of the two methods was analyzed.Results 9000 patients who underwent liquid thin-layer cytology screening of women，according to the principle of cytology and histology diagnosis could differ level，LSIL，HSIL and SCC and final pathological diagnosis coincidence rate was 31.9% （375/1174），83.8% （155/185），100.0% （65/65）.91 patients who underwent biopsy pathologic diagnosis of women，CIN 1，CIN 2，CIN 3 stage，SCC and final pathological diagnosis coincidence rate was 42.8% （80/187），61.4% （285/464），71.3% （132/185），100.0% （65/65），with the increase of classification，the diagnostic accuracy was increased，and there was significant difference in the results among each group （P<0.05）.Conclusion The combination of liquid based cytology and biopsy pathology is a method for the diagnosis of early stage of cervical cancer and cervical intraepithelial lesions，it is beneficial to improve the diagnostic efficiency and can provide a reliable basis for early treatment.

[Key words]Liquid thin-layer cytology；Biopsy pathology；Early cervical cancer；Cervical intraepithelial lesions；Diagnosis