他克莫司治療原發(fā)性腎病綜合征的臨床分析

魏建波+寧芳芳+盧勤燕

[摘要]目的 探討他克莫司治療原發(fā)性腎病綜合征的臨床療效情況。方法 選取2011年2月～2015年3月我院腎內科收治原發(fā)性腎病綜合征患者30例臨床資料，依據(jù)治療措施不同進行分組，對照組（環(huán)磷酰胺聯(lián)合醋酸潑尼松治療）15例和他克莫司組（他克莫司聯(lián)合醋酸潑尼松治療）15例。比較兩組原發(fā)性腎病綜合征患者治療前和治療6個月后血清白蛋白、肌酐、膽固醇、三酰甘油、尿蛋白定量情況以及兩組患者臨床療效情況。結果 兩組原發(fā)性腎病綜合征患者治療前血清白蛋白、肌酐、膽固醇、三酰甘油、尿蛋白定量比較，差異無統(tǒng)計學意義（P>0.05），對照組和他克莫司組治療6個月后血清白蛋白均高于治療前，肌酐、膽固醇、三酰甘油、尿蛋白定量均低于治療前，他克莫司組治療6個月后血清白蛋白均高于對照組，肌酐、膽固醇、三酰甘油、尿蛋白定量均低于對照組，他克莫司組原發(fā)性腎病綜合征患者治療緩解率高于對照組，差異有統(tǒng)計學意義（χ2=7.65，P<0.05）。結論 他克莫司治療原發(fā)性腎病綜合征患者臨床癥狀改善明顯，緩解率高，值得臨床推廣應用。

[關鍵詞]他克莫司；原發(fā)性腎病綜合征；白蛋白；肌酐；尿蛋白定量

[中圖分類號] R692 [文獻標識碼] A [文章編號] 1674-4721（2016）12（b）-0129-03

The clinical analyzing of treatment primary nephrotic syndrome by tacrolimus

WEI Jian-bo NING Fang-fang LU Qin-yan

Department of Nephrology，the Sixth Affiliated Hospital of Guangzhou Medical University，Qingyuan 511518，China

[Abstract]Objective To explore the clinical effects of treatment primary nephrotic syndrome by tacrolimus.Methods 30 cases clinical data of primary nephrotic syndrome patients in our hospital department of nephrology from February 2011 to March 2015 were selected，and divided into two groups by different treatment methods，the control group （cytoxan compared with prednisone acetate treatment）15 cases and the Tacrolimus group （prednisone acetate compared with tacrolimus treatment）15 cases.The serum albumin，creatinine，cholesterol，triglyceride，urine protein quantitation of two groups primary nephrotic syndrome patients before treatment and after treatment 6 moths were compared，clinical curative effect of two groups primary nephrotic syndrome patients were compared.Results The serum albumin，creatinine，cholesterol，triglyceride，urine protein quantitation of two groups primary nephrotic syndrome patients before treatment were no significant difference（P>0.05），the serum albumin of control group and Tacrolimus group after treatment 6 moths were higher than before treatment；the creatinine，cholesterol，triglyceride，urine protein quantitation were lower than before treatment；the serum albumin of Tacrolimus group after treatment 6 moths was higher than that of control group；the creatinine，cholesterol，triglyceride，urine protein quantitation were lower than that of control group；the remission rate of treatment group was higher than that of control group，the differences were significant（χ2=7.65，P<0.05）.Conclusion The clinical symptoms of treatment primary nephrotic syndrome by tacrolimus is obviously，remission rate is high，it is worth to be used.

[Key words]Tacrolimus；Primary nephrotic syndrome；Albumin；Creatinine；Urine protein quantitation