海洋微生物次生代謝的生物合成機(jī)制

張長(zhǎng)生++朱義廣

摘 要：海洋微生物，日益成為新穎次級(jí)代謝產(chǎn)物發(fā)現(xiàn)的理想資源。該課題在前期研究基礎(chǔ)的基礎(chǔ)上，繼續(xù)進(jìn)行抗菌、抗腫瘤和抗污損等結(jié)構(gòu)新穎、活性獨(dú)特的次級(jí)代謝產(chǎn)物的挖掘，同時(shí)開展這些化合物的生物合成機(jī)制研究，揭示酶學(xué)機(jī)理，提出次級(jí)代謝產(chǎn)物生物合成途徑的分子和化學(xué)模型，進(jìn)而利用組合生物學(xué)技術(shù)擴(kuò)展其結(jié)構(gòu)多樣性，為獲得具有自主知識(shí)產(chǎn)權(quán)的創(chuàng)新藥物提供物質(zhì)基礎(chǔ)。

關(guān)鍵詞：海洋微生物 次級(jí)代謝產(chǎn)物 多樣性 功能分析

Study on Secondary Metabolites Biosynthesis of Marine Microbiology

Zhang Changsheng Zhu Yiguang

（South China Sea Institute of Oceanology， Chinese Academy of Sciences）

Abstract：Marine microorganisms，are emerging as ideal resources for discovering new taxa and new secondary metabolites. Encouraging from our solid research data accumulated previously， we aim in this project to continuously isolate and identify new metabolites and to demonstrate their functions， such as antimicrobial， anti-fouling and anti-tumor， etc. In addition， we aim to elucidate the biosynthetic gene clusters so as to reveal their biosynthetic mechanisms and pathways， to enhance their structural diversity via combinatorial biosynthesis. The ultimate goal of this project is to provide a basis for discovering lead compounds with pharmaceutical potential.

Key Words：Marine microbiology； Secondary metabolites； Diversity； Functional studies

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