Ebola virus infection, human Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p and predicted targets

Beuy Joob, Viroj Wiwanitkit

1Sanitation 1 Medical Academic Center, Bangkok, Thailand

2Hainan Medical University, China

3Faculty of Medicine, University of Nis, Serbia

4Joseph Ayobabalola University, Nigeria

5Dr DY Patil, Medical University, India

Ebola virus infection, human Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p and predicted targets

Beuy Joob1*, Viroj Wiwanitkit2,3,4,5

1Sanitation 1 Medical Academic Center, Bangkok, Thailand

2Hainan Medical University, China

3Faculty of Medicine, University of Nis, Serbia

4Joseph Ayobabalola University, Nigeria

5Dr DY Patil, Medical University, India

Article history:

Received 20 Sep 2014

Accepted 28 Sep 2014

Available online 10 Oct 2014

To the editor,

Sir, the present problematic Ebola virus (EBOV) infection in Africa is the global concern. The pathogenesis and host response to the EBOV infection is the interesting topic. Shenget al.recently published an interesting article on the observation of “human Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p in human umbilical vein endothelial cells following expression of EBOV glycoprotein[1].” Shenget al. mentioned that inhibiting those miRNA can result in protection against EBOV[1]. Shenget al. also mentioned for observation of some target pathways relating to those miRNAs. Here, the authors use standard bioinformatics technique, Target Scan Human (“searching for the presence of conserved 8mer and 7mer sites that match the seed region of each miRNA[2].”), to assess the predicted targets of those miRNAs. The predicted results are present in Table 1. Of interest, the predicted target here is discordant with the report by Shenget al[1]. (the adhesion-related molecules tissue factor pathway inhibitor, dystroglycan 1 and the caspase 8 and Fas-associated with death domain protein-like apoptosis regulator). The exact pathways and involved proteins in the inhibition of the three quote miRNAs should be further studied.

Table 1 Predicted target of Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p.

Conflict of interest statement

We declare that we have no conflict of interest.

[1] Sheng M, Zhong Y, Chen Y, Du J, Ju X, Zhao C, et al. Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoproteinin vitro.Sci China Life Sci2014; doi: 10.1007/s11427-014-4742-y.

[2] Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.Cell2005;120(1): 15-20.

10.12980/APJTB.4.2014APJTB-2014-0484

*Corresponding author: Beuy Joob, Sanitation 1 Medical Academic Center, Bangkok, Thailand.

E-mail: beuyjoob@hotmail.com