難治性

善，通常被稱為難治性抑郁癥,難治性抑郁癥具有復(fù)發(fā)率高、致殘率高和生活質(zhì)量低等特點(diǎn)，給患者帶來痛苦，給社會(huì)和家屬帶來極大的負(fù)擔(dān)[1]。目前，難治性抑郁癥的病理機(jī)制尚不明確。研究發(fā)現(xiàn)抑郁癥患者下丘腦-垂體-腎上腺皮質(zhì)（hypothalamic-pituitary-adrenocortical，HPA）系統(tǒng)存在功能亢進(jìn)，而下丘腦-垂體-甲狀腺（hypothalamic-pituitary-thyroid–adrenocortical，HPT）系統(tǒng)功能低下，主要表

nner DL難治性抑郁癥; 抗抑郁藥替換; 抗抑郁藥聯(lián)合治療; 增效Summary:Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment