Variant of Wellen’s syndrome in type 1 diabetic patient: A case report

Mukosolu Florence Obi,Manjari Sharma,Vikhyath Namireddy,Paul Gargiulo,Chelsea Noel,Cho Hyun,Blossom De Gale

Abstract BACKGROUND Wellen’s syndrome is a form of acute coronary syndrome associated with proximal left anterior descending artery (LAD) stenosis and characteristic electrocardiograph (ECG) patterns in pain free state. The abnormal ECG pattern is classified into type A (biphasic T waves) and type B (deeply inverted T waves), based on the T wave pattern seen in the pericodial chest leads.CASE SUMMARY We present the case of a 37-year-old male with history of type 1 diabetes mellitus (T1DM), gastroparesis, mild peripheral artery disease and right toe cellulitis on IV antibiotics who presented to the emergency department with nausea, vomiting and abdominal pain for 3 d and as a result couldn’t take his insulin. Noted to have fasting blood sugar 392 mg/dL. Admitted for diabetic gastroparesis. During the hospital course, the patient was asymptomatic and denied any chest pain. On admission, No ECG and troponin draws were performed. On day 2, the patient became hypoxic with oxygen saturation 80% on room air, intermittent mild rightsided chest pain which he attributed to vomiting from his gastroparesis. Initial ECG done was significant for Biphasic T wave changes in leads V2 and V3 and elevated high sensitivity troponin. Patient was transitioned to cardiac intensive care unit and cardiac catheterization performed with result significant for extensive coronary artery disease.CONCLUSION This case highlights an exceptional manifestation of Wellen's syndrome, wherein the right coronary artery and circumflex artery display a remarkable 100% constriction, alongside a proximal LAD stenosis of 90%-95%. Notably, this occurrence transpired in a patient grappling with extensive complications arising from T1DM. Moreover, it underscores the utmost significance of promptly recognizing the presence of Wellen's syndrome and swiftly initiating appropriate medical intervention.

Key Words: Wellens’s syndrome;Biphasic T waves;Deeply inverted T waves;Precordial leads;Left anterior descending artery;Pseudo-normalization;Right coronary artery;Left circumflex artery;Case report

INTRODUCTION

Wellen's syndrome is a distinctive condition characterized by distinct alterations in the ST-T waves in the precordial leads, indicating an obstruction in the proximal left anterior descending coronary artery[1]. This syndrome has been observed in individuals experiencing unstable angina, as well as those with atypical presentations devoid of acute chest pain. If left untreated, Wellen's syndrome can cause myocardial infarction and necrosis in the anterior wall of the heart. The hallmark features of Wellen's syndrome are biphasic T waves (type A in 25% of cases) or deeply inverted T waves (type B in 75% of cases) in V2-V3, which can extend to V1-V6 and often involve the proximal anterior left anterior descending artery (LAD). Nevertheless, research has demonstrated that this syndrome is not confined solely to the proximal anterior LAD, as similar changes have been reported in the right coronary artery (RCA) and circumflex artery[2]. The correlation between T wave changes in precordial leads and the heightened risk of developing anterior wall myocardial infarction, despite medical intervention, was first elucidated by de Zwaanet al[3] in 1982. The diagnostic criteria for Wellen's syndrome encompass a history of angina, deeply inverted or biphasic T waves in the precordial leads, normal or slightly elevated serum cardiac enzymes, absence of precordial Q waves, minimal or isoelectric ST segment elevation (less than 1 mm), and the presence of the specific electrocardiograph (ECG) pattern during pain-free states[4]. Risk factors associated with Wellen's syndrome include diabetes mellitus, arterial hypertension, metabolic syndrome, hypercholesterolemia, smoking, and a family history of premature heart disease, all of which are present in our patient. This case report, accompanied by a review of the existing literature, emphasizes the critical importance of early recognition of Wellen's syndrome, not only in relation to the proximal LAD, but also its involvement in both the RCA and circumflex artery.

CASE PRESENTATION

Chief complaints

A 37-year-old man with chief complaint of nausea, vomiting, abdominal pain for 3-day duration associated with diarrhea.

History of present illness

The patient arrived at the emergency department with complaints of abdominal pain, characterized as burning, nonradiating and constant, 7/10 in severity, which he attributed to his gastroparesis as he has had multiple admissions with gastroparesis flares. Patient has a past medical history of type 1 diabetes, diabetic gastroparesis, major depression, anxiety, smoking (1 pack per week), 1 g of marijuana consumption and right 4thtoe cellulitis recently treated with IV antibiotics. Admits to intermittent depressive episode; during which he stops taking his medication including insulin but denied suicidal ideation and intent.

History of past illness

Diabetic gastroparesis, type 1 diabetes mellitus, peripheral artery disease, and right toe cellulitis on antibiotics.

Figure 1 Chest X Ray consistent with acute pulmonary Edema. Indicating bat wing opacities,interstitial edema,increased cardiothoracic ration and cephalization of pulmonary vessesl.

Figure 2 Electrocardiogram indicative of ejection fraction less 20%. Moderately dilated left ventricle and left atrium.

Personal and family history

A noteworthy familial background of cardiovascular disease is documented, encompassing the father, parental uncle, and grandfather, each of whom underwent double bypass surgeries. The father's bypass operation was performed at the relatively young age of 40.

Physical examination

In the physical exam the abdomen was non-distended, tenderness on palpation of the 4 quadrants, positive bowel sounds, no organomegaly appreciated. The blood pressure on admission was 129/99 with heart rate of 124 bpm. Chest symmetry with respiration, no crackles or wheezing noted and normal vesicular breath sounds. Normal S1, S2 and no pathological murmur heard. The patient was euvolemic, and no bilateral lower extremity edema was noted.

Laboratory examinations

Urine toxicology is positive for marijuana. Given the atypical presentation, high sensitivity troponin was not ordered. Uncontrolled diabetes, Hyperlipidemia and hypoxia noted (Table 1).

Imaging examinations

Patient was admitted for diabetic gastroparesis, bedside point of care ultrasound; was significant for inferior vena cava (IVC) dilation and Kerley B lines. A chest X ray was ordered, which shows acute pulmonary edema (Figure 1). Given acute and sudden onset of hypoxia, echocardiogram (ECHO) was ordered (Figure 2), after notable elevation in cardiac enzyme (elevated high sensitivity troponin). The first electrocardiogram (EKG) was then ordered (Figure 3).

FURTHER DIAGNOSTIC WORK-UP

The patient underwent a treatment regimen that involved the administration of 3 L of normal saline, along with medications such as Benadryl, famotidine, Zofran, and IV fluids at a rate of 125 mL/h. Additionally, the patient received Reglan 10 mg every 8 h and pantoprazole. On the second day at 6:00 pm, the patient experienced a drop in oxygensaturation, reaching the mid-80s while breathing room air. To address this, the patient was placed on a venti-mask at 50% oxygen concentration. During the examination, the patient acknowledged experiencing mild and intermittent right-sided chest pain, attributing it to vomiting and noting a history of similar pain during gastroparesis flares over the past 5 years. The patient denied any previous history of heart disease. A point-of-care ultrasound at the bedside revealed notable dilation of the IVC and the presence of Kerley B lines. Chest X-ray was ordered, which confirmed the diagnosis of acute pulmonary edema (Figure 1). Given the sudden onset of hypoxia, further investigations were initiated, including laboratory tests and an EKG (Figure 2). The patient received a 40 mg dose of furosemide and was subsequently continued on furosemide 40 mg every 12 h. To alleviate anxiety, the patient was given a STAT dose of alprazolam 0.25 mg orally. Following these measures, an initial EKG was ordered, along with a high sensitivity troponin test (Figure 3). Later that day, a cardiology consultation was sought, and an ECHO was performed. The ECHO revealed a moderately dilated left ventricle with a severely reduced ejection fraction of less than 20%. The left atrium was also found to be moderately dilated (Figure 2). The cardiologist was informed about the clinical findings and the elevated troponin levels. As a result, the acute coronary syndrome (ACS) protocol was initiated. The patient received a heparin drip following a loading dose of aspirin 81mg and a statin 80 mg, both given immediately. The patient was transferred to the cardiac center for coronary angiographic catheterization and right heart catheterization. The results of these procedures indicated the presence of extensive disease in the LAD, with stenosis extending to both the RCA and circumflex artery (Figure 4).

Table 1 Consistent with hypoxia from arterial blood gas,elevated troponin and uncontrolled diabetes

FINAL DIAGNOSIS

Conclusion of the cardiac coronary angiogram report indicated the following: Dominance: Right dominant; left main: Mild luminal irregularities less than 30%; left another decending artery: Min lad: 90% stenosis; distal lad: 95% stenosis; diagonal 1: 90% stenosis; circumflex artery: Ostial circ: 100 % stenosis; and RCA: Prox rca: 100% stenosis.

Figure 3 Electrocardiogram showing Biphasic T wave inversion on V2-V3. T wave inversion in V4-V5.

TREATMENT

Following the placement of an intra-aortic balloon pump in the cardiac laboratory center, the patient was promptly transferred to the intensive care unit. In this setting, the patient's treatment regimen included the immediate initiation of aspirin 81 mg, ticagrelor 180 mg given STAT, followed by 90 mg every 12 h. Additionally, a nitroglycerin drip and 80 mg of atorvastatin were administered. The cardiologist recommended transferring the patient to a tertiary center for urgent coronary artery bypass graft (CABG) surgery given significant coronary artery lesions. On January 23, 2023, the patient underwent quadruple CABG, and a subsequent bedside ECHO revealed no evidence of pericardial effusion. Upon improvement, the patient was discharged with a medication regimen consisting of spironolactone 25 mg, metoprolol succinate 25 mg, aspirin 81 mg, atorvastatin 80 mg, valsartan 40 mg, and dapagliflozin 5 mg once a day.

OUTCOME AND FOLLOW-UP

Follow up in Cardiology clinic 1 wk post discharge from the tertiary center after contrary bypass graft. Notable significant improvement of symptoms with improved functional capacity and activities of daily living.

DISCUSSION

Wellen’s syndrome was first described in 1982 by de Zwaanet al[3] as proximal LAD T- wave syndrome in the process of evaluating subgroup of patients with unstable angina during a stable and pain-free period[5]. Our patient presents with no chest pain, but abdominal pain, which he attributed to his recurrent gastroparesis. Wellen’s syndrome was then discovered to be associated with significant critical occlusion of the LAD with a characteristic presentation distinctive to abnormal T wave changes in precordial leads in patients with suspected ACS. The electrocardiographic manifestation of Wellen’s syndrome is characterized by 2 patterns; pattern A has biphasic T waves in V2-V3 (25%), and pattern B has symmetric and deeply inverted T waves in precordial chest leads (75%)[5,6]. In this case report, the patient presented on EKG with biphasic T wave in V2-V3 (Figure 2). These T wave changes signifies severe myocardial dysfunction or ischemia, although patients have been known to exhibit this syndrome during a pain free period at the time EKG is taken and have normal or minimally elevated cardiac enzymes, the prognosis of its event represents high risk of extensive anterior wall myocardial infarction within time of presentation[7]. Wellen’s syndrome can also be a pre-coronary infarction stage that can lead to detrimental ACS. The concept of occlusion and reperfusion in the EKG sequence of Wellen’s syndrome likely involves sudden complete occlusion of the LAD causing transient anterior ST segment elevation myocardia injury, leading to chest pain and diaphoresis stage not captured on EKG. Second stage then involves re-perfusion of the LAD likely secondary to spontaneous clot lysis leading to resolution of the chest pain with improvement in ST elevation and the appearance of biphasic or inverted T wave morphology[8]. Although Wellen’s syndrome is known to involve mostly the LAD the syndrome is not limited to the anterior leads. The precordial T wave changes can be seen in the inferior or lateral leads with RCA or circumflex artery occlusion as noted in many studies and events in our case presentation. Diagnostic criteria of Wellen’s syndrome includes[9]: Isoelectric or minimally elevated (＜ 1 mm) ST segment elevation; no precordial Q waves; deeply inverted or biphasic T waves in V2-V3 but may extend to V1-6; ECG pattern present in pain free state; preserved precordial R wave progression; recent history of angina; and normal or elevated serum cardiac markers.

Figure 4 Coronary angiography report. A to C: Coronary angiogram report consistent with severe triple vessel disease with stenosis in left anterior descending artery (A),left circumflex artery (B) and right coronary artery (C).

Wellen’s syndrome is often not an acute process as it can develop over days or weeks especially seen in people with risk factors (smoking, hypertension, diabetes and metabolic syndromeetc.). Although the syndrome is a temporary obstruction of the culprit coronary artery (pre-infarction state), LAD or artery involved can re-occlude at any time and the first EKG seen is normalization of the T wave called pseudo-normalization after which the T wave becomes upright and prominent; thus sign of hyper acute ST-elevation myocardial infarction during which the patient complains of chest pain that is associated with other symptoms of ACS[10]. Sometimes Wellen’s syndrome can manifest in normal coronaries following an episode of vasospasm seen in cases of cocaine abuse, however, it is still appropriate to rule out thrombus formation or coronary thrombosis with angiogram during presentation given the syndromes risk of leading to sever and extensive anterior wall myocardial infarction and possible death. The phenomenon of re-occulsion and re-perfusion was likely experienced by our patient, however given the history of uncontrolled diabetes with complications, his presentation prior to hospital admission maybe masked during occlusion stage given the result of extensive coronary stenosis found on cardiac angiogram (Figure 4).

It is well known fact that uncontrolled diabetes can lead to cardiovascular disease. Its pathophysiology is linked to hyperglycemic state leading to an increase in oxidative stress, which results in micro and macrovascular complications. Persistent elevation in blood sugar can cause an overproduction of superoxide by the mitochondrial electron transport chain leading to complications seen in diabetic patients. The activation of superoxide overproduction pathway leads to increase generation of nitric oxide due to uncoupled state of endothelial nitric oxide synthase (NOS) and inducible NOS. All which leads to deoxyribonucleic acid (DNA) damage due to the formation of the strong oxidant peroxynitrite[11]. DNA damage causes rapid activation of poly (adenosine diphosphate-ribose) polymerase, depleting the intracellular concentration of its substrate nicotinamide adenine dinucleotide, and slowing the rate of glycolysis, electron transport, and adenosine-triphosphate formation and thus causing acute endothelial dysfunction[12]. Hyperglycemic state is an inflammatory state as it induces surge of inflammatory cytokines (such as C reactive protein, interleukin interleukin (IL)-6, IL-8 tumor necrosis factor-α, and endothelin-1and as result contribute to plaque instability. Accumulation of these inflammatory cytokines leads to endothelial injury and hypercoagulability increasing the risk for cardiovascular event. In clotting cascade, the quantity of clotting factors, including glycation and oxidation is affected during hyperglycemic state increasing the risk of thrombosis[13]. Patients with type 1 diabetes are on insulin regimen for glycemic control. Hyperinsulinemia can lead to an increase in hepatic synthesis on prothrombic factors leading to thrombotic state.

Cardiac autonomic neuropathy (CAN) is the most common complication seen in type I diabetic patients. Poor glycemic control is the risk factor of CAN with prevalence approximately 20%, increases with age and a known predictor of cardiovascular morbidity and mortality in type 1 diabetes[14]. Type 1 diabetes is thought to be caused by an autoimmune reaction that destroys the beta cells of the pancreas. The same immunological factors are seen affecting the sympathetic ganglia leading to cardiac sympathetic dysfunction[15]. All these pathologies can also be seen in patients with type 2 diabetes. In correlation to our patient, who presented with uncontrolled and complicated diabetes as such has increased risk of CAN and arthrosclerosis. Our patient presented with Wellen’s syndrome, but the diagnosis was late given that patient delayed medical evaluation for cardiac disease, as he believed that all his symptoms of intermittent chest discomfort were due to prolonged vomiting and gastroparesis flares.

CONCLUSION

Wellen's syndrome emphasizes the need for serial EKGs in patients with cardiovascular risk factors, as critical stenosis may be detected and require invasive interventions. This case report highlights the extensive nature of Wellen's syndrome, involving occlusion in the LAD, RCA, and circumflex arteries. It demonstrates that Wellen's syndrome extends beyond proximal LAD disease and presents distinct EKG changes. Clinicians face diagnostic challenges due to atypical presentations, delaying ACS identification. Thus, it is vital for clinicians to identify Wellen's syndrome on EKGs and evaluate high-risk patients regardless of atypical symptoms.

FOOTNOTES

Author contributions:Obi MF contributed to manuscript writing, editing and data analysis; Namireddy V contributed to editing; Gale DB and Noel C contributed to data collection; Gargiulo P, Sharma M and Hyun C contributed to conceptualization and supervision; all authors have read and approved the final manuscript.

Informed consent statement:Informed verbal consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement:The authors declare that they have no conflict of interest to disclose.

CARE Checklist (2016) statement:The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:United States

ORCID number:Mukosolu Florence Obi 0009-0002-4977-0076;Vikhyath Namireddy 0009-0003-2664-4883.

S-Editor:Lin C

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P-Editor:Xu ZH