lntestinal erosion caused by meshoma displacement:A case report

Jin-Feng Wu,Jian Chen,Fang Hong

Jin-Feng Wu,Jian Chen,Department of General Surgery,Tongde Hospital of Zhejiang Province,Hangzhou 310012,Zhejiang Province,China

Fang Hong,Department of Gynaecology and Obstetrics,Zhejiang University School of Medicine Sir Run Run Shaw Hospital,Hangzhou 310016,Zhejiang Province,China

Abstract BACKGROUND A meshoma formation and erosion to the small intestine is rare.Herein,we report one case of a meshoma that was not treated early;causing it to displace and erode the small intestine,with infection,complete control of symptoms was achieved after removal of the infected patch mass,no recurrence of hernia after 2 years of follow-up.CASE SUMMARY A 62-year-old male patient presented with recurrent abdominal pain repeatedly for 1 wk,which has worsened 2 d before admition,accompanied by fever.Five years before presentation he underwent right inguinal hernia Plug and patch repair approach.Two years ago,a computed tomography scan revealed a right lower abdominal mass with soft tissue density,measuring approximately 30 mm × 17 mm,which was diagnosed as meshoma that was not treated.The patient had poorly controlled diabetes in the past year.CONCLUSIONThe formation of meshoma is rare,and that if not treated in time it might erode and require resection of the involved organ.

Key Words:Tension-Free mesh repair;Polypropylene mesh;Meshoma;Mesh infection;Bowel resection;Case report

lNTRODUCTlON

Tension-free repair with mesh has become a standard surgical modality in adult inguinal hernia repair[1,2],significantly reducing the recurrence rate after inguinal hernia repair.As the use of polypropylene mesh in tension-free hernia repair has become more widespread,the clinical problems associated with it have also received increasing attention.At present,it has been proved that the foreign body reaction caused by implanted prosthetic materials can cause a series of complications,such as mesh displacement,adhesion and erosion,meshoma,chronic pain and even mesh infection.

Most mesh infections are acute,which usually occur during postoperative hospitalization or within 1-2 wk of discharge.The infection is mainly superficial and rarely involves the mesh.If not treated promptly,it can develop into a chronic mesh infection,which often ends up involving the mesh,forming a chronic infected sinus tract and causing delayed wound healing.Clinical manifestations of mesh infection include fever,painful local swelling,scleroma,erythema and even purulent discharge and fistula formation with the skin,the rate of mesh infection in open hernia repair is higher than that in laparoscopic hernia repair[3].

Conservative treatment including intravenous antibiotics,percutaneous puncture drainage or negative pressure suction to the wound has a high failure rate as the mesh is already infected and persists as a foreign body deep as a source of infection[4,5].If the wound is not healed after repeated debridement and dressing change,the infected mesh should be removed as soon as possible[6].It is still the most commonly used method to treat infection in clinic practice.

CASE PRESENTATlON

Chief complaints

A 62-year-old male patient was admitted to the hospital with right lower abdominal pain for 1 wk,which has worsened in the last 2 d.

History of present illness

The patient’s diabetes found in the past year and poor control of blood glucose level.

History of past illness

He had a history of multiple inguinal hernia repairs and had undergone a non-mesh repair of a left inguinal hernia at the age of 40 years.At the age of 57,he was diagnosed with a right inguinal hernia and underwent a plug and patch approach.At the age of 60,he underwent a transabdominal preperitoneal patch procedure for a recurrent left inguinal hernia.

Personal and family history

The patient had no family history of inguinal hernia disease.

Physical examination

Temperature 38.2 °C,heart rate 118 bpm,a hard mass was palpated in the right lower abdomen,about 4 cm × 3 cm in extent,poorly defined,with localized skin pressure and rebound pain,no myalgias,bowel sounds 4 bpm.

Laboratory examinations

Complete blood count:White blood count(WBC)12.5,reference 3.5-9.5 with units of 109/L;neutrophils 11.4,reference 1.8-6.3 with units of 109/L;C-reactive protein(CRP)146.56,reference 0-8 with units of mg/L;fecal occult blood test(+);fasting blood sugar 14.73,reference 3.89-6.11 with units of mmol/L;hemoglobin A1c 12.2%,reference 3.6-6.5.

Imaging examinations

A computed tomography(CT)scan 2 years ago revealed a sigmoid herniation into the left scrotum and a right lower abdominal mass with soft tissue density,measuring approximately 30 mm × 17 mm,with a clear surrounding fatty space.This preoperative contrast-enhanced CT scan of abdomen:a mass soft tissue density shadow with a size of about 32 mm × 26 mm can be seen in the lower right abdomen,with lower density in the center of the lesion,poorly defined borders and blurred surrounding fatty spaces,with enhanced edges and no enhancement in the central region(Figure 1).

FlNAL DlAGNOSlS

Mesh infection,meshoma,gastrointestinal bleeding,and type 2 diabetes.

TREATMENT

Comparing abdominal CT in 2018 and 2020,it was found that the right lower abdominal mass was not significantly enlarged,the center of the mass was not enhanced,and the surrounding fatty spaces were blurred.Combined with the patient’s diabetes found in the past year and poor control of blood sugar level,the right inguinal hernia was treated with mesh plug plain patch 5 years ago.This right lower abdominal mass was initially considered as meshoma with infection.After intravenous antibiotic treatment for about 10 d before operation,the patient’s body temperature,WBC and CRP were normal,and the blood sugar levels were well controlled after standardized hypoglycemic treatment(Figure 2),but the mass did not shrink.It was discussed and the decision was made to perform a laparoscopic exploration.Intraoperatively,a portion of the right lower abdominal ileal canal was found to be congested and oedematous,with dense adhesions forming to the abdominal wall(Figure 3).The central texture was firm,and sharp dissection with scissors revealed a mesh-like structure with outflow of pus(Figure 3B).The mass was completely separated from the abdominal wall,but not from the small bowel,so it was converted to open surgery.It was found that the mesh had eroded the ileal canal,so part of the ileum was resected along with the mass.Postoperative autopsy revealed a central mesh structure and a cavity in the mass(Figure 3E).

Figure 1 Computed tomography.A:Abdominal computed tomography(CT)in 2018 reveals a left indirect inguinal hernia,and a hypodense focus(short arrow)in the right lower abdomen;B:The contents of the left indirect inguinal hernia are the sigmoid colon;C:Abdominal CT in 2020 shows a mass on the lateral side of the right umbilical artery(long arrow),with no obvious enhancement in the arterial phase;D:The central part of the mass is found to be more hypointense in the venous phase(long arrow),with circumferential enhancement around the edges of the mass.

Figure 2 Blood glucose control levels.Continuous fold is fasting,intermittent line is bedtime.

Figure 3 lntraoperative findings.A:Surgical scar after multiple inguinal hernia repairs;B:Greyish white,purulent,viscous fluid from the mass found intraoperatively;C:Examination of the vas deferens and spermatic vessels after debridement of the mass with no damage and no defective weak areas in the internal ring opening or abdominal wall;D:Partial exfoliation of the ileal canal pulpy muscle layer(arrow)with tortuous intestinal ducts in a mass,closely related to the meshoma;E:Postoperative autopsy reveals a central non-resorbable mesh structure and a cavity in the mass.

OUTCOME AND FOLLOW-UP

Gastrointestinal endoscopy 1 mo after surgery did not reveal abnormal lesions.There was no recurrence of the inguinal hernia during the 2-year follow-up.

DlSCUSSlON

The incidence of mesh infections ranges from 0.11% to 5.00%[7,8]and 0.7%-2.0% after laparoscopic inguinal hernia repair and up to 6%-10% in open-mesh techniques[9].Risk factors for mesh infection include the patient’s underlying disease such as diabetes,coronary artery disease,chronic obstructive pulmonary disease,smoking,morbid obesity,malnutrition and immune deficiency[7,10].But also,the type of mesh,the timing of the procedure,the surgical approach,whether the mesh was placed flat,the management of early postoperative complications such as haematoma or seroma requiring surgical management,the surgeon’s experience,and the use of improperly sterilized instruments,etc.The most common pathogens areStaphylococcus aureusandStaphylococcus epidermidis,in addition to several anaerobic bacteria of the genusStreptococcusandEnterobacteriaceaethat play a key role in the pathogenesis of hernia repair mesh infections[11,12].The bacterial culture of this patient yieldedStreptococcus agalactiae(Group B Streptococcus,group B strep,GBS),which is a Gram-positive conditional pathogenic bacterium that is commensal in the human intestine and vagina.It causes severe and potentially fatal infections mainly in neonates and the elderly,while carriers have no obvious symptoms[13],the drug sensitivity of this patient was sensitive to penicillin,moxifloxacin,vancomycin and tegacyclin,except for tetracycline and clindamycin.

When the patch becomes infected,bacteria attach to the surface of the mesh and can form a microenvironment called “biofilm”[3,4,14].Through its three-dimensional structure,the biofilm provides mechanical stability for bacteria and physical protection against external stressors(immune cells and therapeutic compounds,including antibiotics),rendering any conservative therapeutic measures ineffective[4].As a result,this infection is usually persistent,with poor response to antibiotics and often requiring surgical treatment.It has been suggested that removal of partial mesh is associated with a 50% incidence of persistent prosthetic infection and a significant increase in the incidence of surgical site occurrence and reoperation.In the case of clean contaminated wounds and mesh-associated infection or fistula,the previous mesh should be completely removed whenever safe and feasible[15].Open debridement can be very extensive and complex,and complete resection is often not achieved,especially when internal organs,especially hollow organs such as the bladder,colon or small bowel,are heavily attached to the abdominal wall or eroded by the mesh[16].In such cases,the laparoscopic technique demonstrates its advantages.This technique allows a thorough exploration of the abdominal cavity,locating the focus of infection,determining whether there are adhesions and whether internal organs are involved and guiding further treatment,thus allowing unnecessary destruction of the healthy layers of the abdominal wall and nearby organs to be avoided.

Mesh infections can lead to catastrophic consequences,severely affecting the lives of patients and increasing the cost of healthcare to society[17].This makes preventing patch infections far better than treating them.According to the literature conclusion,the following suggestions are made for the placement of the patch[18,19].Firstly,choose the right type of mesh.Although patches are widely used in inguinal hernia repair,guidelines do not recommend the use of mesh plugs[1].Mesh plugs are more likely to enter the abdominal cavity due to their conical shape and heavier weight,but are equally more likely to cause friction and even erosion of the organs.Among the various types of mesh,polypropylene is the preferred material because it is chemically inert,stable,non-immunogenic,non-toxic,flexible,and lightweight,has high tensile strength and is relatively resistant to infection.Secondly,attention needs to be paid to the details of the surgical procedure.It is necessary to keep the surgical field clean when placing the mesh,pay attention to the flatness of the mesh,avoid curling and folding,and avoid any direct contact with the viscera(vital),which can greatly reduce complications.When not fixed,inadequately fixed or inadequately dissected so that there is insufficient space for the mesh,this can lead to folding and curling of the mesh and eventually to the formation of a bulbous mass called a meshoma,a phenomenon first identified and named by Amid[20]in 2004.Thirdly,we must also not neglect the importance of surgical documentation.The size of the original hernia defect,the type of repair,the mesh material,the exact anatomical position of the mesh placement and the fixation technique must be accurately documented to provide as much information as possible for possible reoperation in the future.Finally,improving the patient’s own physical state.For example,quitting smoking,controlling diabetes and reducing the patient’s weight can greatly reduce the risk of wound complications[5].

CONCLUSlON

The incidence of mesh infection is rare and,when it does occur,it has serious consequences for the patient and poses therapeutic difficulties for the surgeon,while treatment outcomes are often unsatisfactory.The formation of meshoma can not only cause mesh infection,but may even erode and require removal of the affected organ if left untreated.Therefore,after the formation of the meshoma,surgery to remove the meshoma as early as possible is recommended.

ACKNOWLEDGEMENTS

We thank the patient and all the rest doctors and nurses in our department.

FOOTNOTES

Author contributions:Chen J provided a lot of help in the operation;Hong F provided help in the polishing of language;Wu JF contributed to manuscript writing and editing;all authors have read and approved the final manuscript.

lnformed consent statement:Informed written consent was obtained from the patients for the publication of this report and any accompanying images.

Conflict-of-interest statement:The authors declare that they have no conflict of interest.

CARE Checklist(2016)statement:The authors have read the CARE Checklist(2016),and the manuscript was prepared and revised according to the CARE Checklist(2016).

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial(CC BYNC 4.0)license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is noncommercial.See:https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:China

ORClD number:Jin-Feng Wu 0000-0001-8295-1771;Fang Hong 0000-0003-3236-1727.

S-Editor:Chen YL

L-Editor:A

P-Editor:Chen YL