• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Meta-analysis of the impact of hyperuricemia on contrast agent-related acute kidney injury after percutaneous coronary intervention

    2023-03-06 09:56:30YAOZhiSHIYuexinSUNLuying
    Journal of Hainan Medical College 2023年24期

    YAO Zhi, SHI Yue-xin, SUN Lu-ying

    Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China

    Keywords:

    ABSTRACT Objective: To evaluate the impact of hyperuricemia on the occurrence of contrast agentrelated acute kidney injury after percutaneous coronary intervention.Methods: Retrieve PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases,and publish articles on the correlation between hyperuricemia and contrast agent-related acute kidney damage after percutaneous coronary intervention from the establishment of the database to August 16 2023.Two researchers independently conducted literature screening and data extraction to evaluate the bias risk of inclusion in the study, and conducted metaanalysis using Review Manager 5.4 software.Results: A total of 12 articles were included,including 11 676 patients.The meta-analysis results showed that compared with patients without hyperuricemia, patients with hyperuricemia had a higher risk of developing PC-AKI,with an incidence rate of 22.3%.Hyperuricemia was a risk factor for the occurrence of PCAKI (OR=2.03, 95%CI: 1.58-2.61); Patients with hyperuricemia have a higher risk of death after PC-AKI, with a mortality rate of 7.5%.Hyperuricemia is a risk factor for early death in PC-AKI patients (OR=2.33, 95%CI: 1.81-3.00); The probability of CRRT treatment after PCAKI in patients with hyperuricemia is higher, at 3.14%.Hyperuricemia is an influencing factor for CRRT treatment in PC-AKI patients (OR=7, 95%CI: 2.83-17.30).Conclusion: Existing research evidence suggests that the presence of hyperuricemia is an independent risk factor for the occurrence of PC-AKI, and it significantly increases the hospital mortality rate and the risk of renal replacement therapy in PC-AKI patients.

    1.Introduction

    Contrast agent induced acute kidney injury (PC-AKI) is one of the common complications of percutaneous coronary intervention(PCI)/coronary angiography (CAG).The latest definition of PCAKI by the Contrast Agent Safety Committee of the European Society of Urology and Reproductive Radiology is that within 48-72 h of exposure to contrast agents, serum creatinine increases by 0.3 mg/dL (26.5 μ Mol/L, or 1.5 times the basal serum creatinine value [2].PC-AKI is the third leading cause of hospital acquired AKI, accounting for 12% of all cases.In the general population receiving PCI/CAG, the incidence of PC-AKI is less than 3%, but in the high-risk population, the incidence is as high as 40%[4].The mortality rate of PC-AKI patients during hospitalization is 7.1%,and the mortality rate of PC-AKI patients who require hemodialysis is as high as 35.7%, with a mortality rate of 81.2% within 2 years[5].The incidence rate and mortality of chronic kidney diseases caused by PC-AKI are increasing year by year.

    PC-AKI is an important adverse reaction that occurs after various radiological surgeries, and its pathogenesis is not fully understood.The epidemiological status, diagnosis, and treatment are not yet unified.The occurrence of PC-AKI may be significantly related to some known risk factors, such as age, basic renal insufficiency,diabetes and unreasonable use of contrast media[7].Although prevention is the key to PC-AKI treatment, accurate early predictive indicators cannot be found at present, and timely risk assessment can only be relied on to strengthen the prevention of PC-AKI.

    In recent years, the relationship between hyperuricemia and PCAKI has attracted the attention of scholars.Multiple studies have shown a correlation between hyperuricemia and PC-AKI, and serum uric acid levels may be a new independent predictor of PC-AKI[8].The relationship between preoperative hyperuricemia and the prognosis of PC-AKI in patients is currently unclear.Therefore, our aim is to conduct a meta-analysis to demonstrate the correlation and prognosis between serum uric acid levels and PC-AKI, and further compare the impact of serum uric acid levels on postoperative AKI in patients with different baseline serum creatinine levels, and provide scientific basis for clinical prevention of PC-AKI in PCI/CAG.

    2.Materials and Methods

    2.1 Literature retrieval strategy

    This study strictly referred to the systematic review and metaanalysis entries in the PRISMA statement[9].Retrieve China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP Database, PubMed, Embase, Cochrane Library, and Web of Science databases.The search method adopts a combination of subject words and free words.Chinese search terms include:serum uric acid, hyperuricemia, uric acid, percutaneous coronary intervention, PCI, coronary intervention, coronary stent placement,coronary angiography, coronary angiography, contrast agent nephropathy, contrast agent nephropathy, acute kidney injury, acute renal failure, acute renal insufficiency, and acute renal dysfunction.The English search terms include: Serum uric acid, hyperuricemia,uric acid, chronic coronary intervention, PCI, coronary intervention,coronary stent placement, coronary angiography, coronary angiography, contrast-enhanced neuropathy, contrast-enhanced neuropathy, acute renal injury, acute renal failure, acute renal insufficiency, and acute renal dysfunction The search deadline is from the establishment of each database until August 16 2023.

    2.2 Criteria for inclusion and exclusion of literature

    Inclusion criteria: (1) Study design type: cohort study or casecontrol study; (2) Chinese and English literature that has been publicly published both domestically and internationally and can be accessed in databases; (3) Research subjects: Adult patients with PC-AKI who meet the 2012 KDIGO diagnostic criteria for AKI[10];(4) Research content: Clinical research on the relationship between preoperative high uric acid levels and PC-AKI can be obtained; (5)Require complete information, comparable data, and clear outcome indicators.

    Exclusion criteria: (1) Relevant literature on serum uric acid level as a continuous variable for research; (2) Repeated indexed literature(including 1 identical literature); (3) Literature with missing data or inability to obtain full text; (4) Literature with a score of<6 on the Newcastle Ottawa Scale (NOS); (5) Review, conference abstract,systematic review, animal experiments, and other non clinical studies.

    2.3 Literature screening and data extraction

    Two reviewers independently screen literature and examine data.Differences will be resolved through discussion or consultation with a third party.Extract raw data from relevant studies, including information from researchers, basic clinical characteristics of the study population, NOS scores, diagnostic criteria for hyperuricemia and AKI.Learn and master the Newcastle Ottawa Scale (NOS),which includes three dimensions: sample selection, comparability,and reliability of results, with a total of 8 items and a maximum score of 9.Two researchers independently evaluated the quality of the selected study, and the higher the score, the better the quality of the study.Exclude articles with scores below 6.

    2.4 Statistical processing

    Perform meta-analysis on the included literature using Review Manager 5.4 software.Using software default Q-test method(α= 0.05), calculate the I2 statistic and test to determine if there is heterogeneity between the studies.When I2<50% and P 0.1,it indicates that the statistical heterogeneity between the studies is small, and a fixed effects model is chosen; WhenI250% andP<0.1, it indicates significant statistical heterogeneity between studies.After verifying the input data, subgroup analysis is used to analyze the sources of heterogeneity.When merging the data, a random effects model is used; If P<0.1 and the source of heterogeneity cannot be determined, descriptive analysis will be used.Draw a funnel plot to test publication bias.The difference is statistically significant withP<0.05.

    3.Results

    3.1 Literature search results

    After searching the literature database, 322 studies were obtained,and 241 studies were included after deleting 81 duplicate articles.After reading the literature titles and abstracts 194 studies were excluded.After reading the full text of the remaining 47 studies, 35 studies were again excluded.Among them, 15 studies were unable to obtain data, 10 were unrelated to this study, and 10 were low-quality literature.12 studies were ultimately included in the meta-analysis(Figure 1).

    3.2 Basic characteristics of included literature

    A total of 12 articles were included, including 3 Chinese articles [19 20,22] and 9 English articles[11-18,21], with a total of 11676 research subjects.The basic characteristics of the included research and the results of literature quality evaluation are shown in Table 1.

    3.3 Meta analysis results

    3.3.1 The incidence of PC-AKI in patients with hyperuricemia

    Twelve studies[11-22] reported the occurrence of PC-AKI in patients with hyperuricemia.Due to high heterogeneity between studies(I2=74%,P<0.01), a random effects model was used.The results showed that compared with patients without hyperuricemia, patients with hyperuricemia had a higher risk of developing PC-AKI, with an incidence rate of 22.3%.Hyperuricemia is a risk factor for the occurrence of PC-AKI (OR=2.03, 95%CI: 1.58-2.61), as shown in Figure 2.

    3.3.2 Risk of death in patients with hyperuricemia after PCAKI

    Fig 2 Forest map of the impact of hyperuricemia on the incidence of PC-AKI

    Seven studies[12,16-18 20-22] investigated the impact of hyperuricemia on early mortality in PC-AKI patients.Due to low heterogeneity between studies (I2=0%, P<0.01), a fixed effects model was used.The results showed that compared with patients without hyperuricemia, patients with hyperuricemia had a higher risk of death after PC-AKI, with a mortality rate of 7.5%.Hyperuricemia is a risk factor for early mortality in PC-AKI patients (OR=2.33,95%CI: 1.81-3.00), as shown in Figure 3.

    3.3.3 Impact of hyperuricemia on CRRT treatment in PCAKI patients

    There are 5 studies[12,16,18,19,22] exploring the impact of hyperuricemia on CRRT treatment in PC-AKI patients.Due to low heterogeneity between studies (I2=0%, P<0.01), a fixed effects model was used.The results showed that compared with patients without hyperuricemia, patients with hyperuricemia had a higher probability of undergoing CRRT treatment after PC-AKI, at 3.14%.Hyperuricemia is an influencing factor for CRRT treatment in PCAKI patients (OR=7, 95% CI: 2.83-17.30), as shown in Figure 4.

    Fig 4 Forest map of the impact of hyperuricemia on CRRT treatment in PC-AKI patients

    3.3.4 Subgroup analysis of the incidence of PC-AKI in patients with hyperuricemia

    The meta-analysis of the effect of hyperuricemia on the incidence of PC-AKI showed high heterogeneity among the 12 studies included.In order to identify the sources of heterogeneity, a sensitivity analysis was performed by deleting each study once.The results showed that there was no significant change in the combined statistics after excluding each study, indicating that the research results were robust and reliable.Based on the inclusion of similar characteristics in the study, we conducted subgroup analysis and found that the relationship between elevated uric acid levels and the occurrence of PC-AKI was not influenced by the study design and experimental population (see Figures 5 and 7).According to the grouping results based on basic renal function, the incidence rates of PC-AKI in patients with hyperuricemia in the normal renal function group, basic renal insufficiency group, and mixed group were 20.1%,28%, and 6.4%, respectively, with statistical significance (P<0.05).Patients with basic renal insufficiency who have hyperuricemia have a higher risk after PC-AKI (see Figure 6).According to the study area and racial grouping, the incidence of PC-AKI in patients with hyperuricemia in the European and Asian groups was 31.2% and 15.5%, respectively.The meta-analysis results showed a statistically significant difference (P<0.05).

    3.3.5 Publication bias analysis

    Fig 5 Subgroup analysis of the impact of hyperuricemia on the incidence of PC-AKI by study design type

    Fig 6 Subgroup analysis of the incidence of PC-AKI in hyperuricemia by basic renal function level

    This study used the OR value as the x-axis and the logarithmic standard error SE (log OR) of the OR value as the y-axis to detect publication bias using a funnel plot.We conducted a bias analysis on the incidence and risk of death of PC-AKI in patients with hyperuricemia, and the funnel plots showed relatively symmetrical trends (see Figures 8 and 10).We used Begg rank correlation tests(Figures 9A and 11A), and the results showed P>0.05.The Egger linear regression method (Figures 9B and 11B) obtainedP>0.05,and both qualitative and quantitative tests indicated that there was no significant publication bias in this study.

    Fig 7 Subgroup analysis of the impact of hyperuricemia on the incidence of PC-AKI by population ethnicity

    Fig 8 Publication bias funnel plot of the incidence of PC-AKI in patients with hyperuricemia

    Fig 9 Publication bias funnel plot of PC-AKI mortality risk in patients with hyperuricemia

    Fig 9 Evaluation of publication bias in the incidence of PC-AKI in patients with hyperuricemia

    4.Discussion

    A meta-analysis of 12 related studies involving 11676 participants currently indicates that hyperuricemia is a risk factor for the occurrence of PC-AKI (OR=2.03, 95%CI: 1.58-2.61).Compared with patients without hyperuricemia, patients with hyperuricemia have a higher risk of developing PC-AKI, with an incidence rate of 22.3%, which is consistent with most previously reported results[22-24].In addition, our study also suggests that patients with hyperuricemia have a higher hospitalization mortality rate and risk of receiving renal replacement therapy after PC-AKI.Compared with the traditional grouping method based on the occurrence of PCAKI events (PC-AKI group and non PC-AKI group), the studies included in this meta-analysis are grouped according to the serum uric acid level (non hyperuricemic group and hyperuricemic group).This grouping method can better reflect the independent correlation between the serum uric acid level and the incidence rate of PCAKI.So far, few studies focus on the relationship between serum uric acid level and PC-AKI incidence rate based on this grouping method.This is the first meta-analysis that fully considers the impact of basic renal function when exploring the relationship between hyperuricemia and PC-AKI incidence rate.

    In subgroup analysis, it was found that the relationship between hyperuricemia and the occurrence of PC-AKI was not influenced by study design and racial population, but rather by basal renal function.The incidence of PC-AKI in patients with basic renal insufficiency accompanied by hyperuricemia is 28%, which is much higher than that in the population with normal basic renal function.Research has shown that CKD plays a central role in the pathophysiology of PC-AKI[25].As serum creatinine levels increased from 1.5 mg/dL to 6.8 mg/dL, the incidence of PC-AKI increased from 8% to 92% [26].The root cause analysis is as follows: Firstly, 70% of the uric acid in the body is excreted through the kidneys, and about 90% to 95% of the uric acid filtered by the glomeruli is absorbed,mainly by the proximal tubules.The uric acid secreted by the renal tubules themselves is very low[27].Therefore, uric acid concentration depends on glomerular filtration and subsequent tubular reabsorption function[28].Serum uric acid is a clear biomarker of chronic kidney disease and an independent risk factor for the development of chronic kidney disease[29].Preexisting chronic kidney disease increases the risk of AKI.Ishani et al.[30] reported that the AKI incidence rate of patients with chronic kidney disease was 8.8%,while the incidence rate of patients with non chronic kidney disease was 2.3%.Pannu N et al.[31] found that patients with eGFR less than 30 mL/min/1.73 m2had an 18 times higher risk of developing AKI compared to patients with eGFR greater than 60 mL/min/1.75 m2.Therefore, patients with hyperuricemia who already have subclinical chronic renal dysfunction are at an increased risk of developing AKI.Many studies support that hyperuricemia is an independent risk factor for cardiovascular disease, and the incidence rate of cardiovascular disease in hyperuricemia patients is higher than that in normal people[32].PC-AKI is a complex multifactorial disease, which is related to CKD, diabetes, old age, congestive heart failure, anemia and high-dose contrast media[33].Although the risk factors of PC-AKI are known, its clear mechanism is still not fully understood.The general mechanism of PC-AKI occurrence may include two aspects: the cytotoxic effect of contrast agents on renal tissue and changes in renal hemodynamics[34].Some studies suggest that inflammation, oxidative stress, cell apoptosis, and endothelial dysfunction may also have some impact on the development process of PC-AKI[35].Serum uric acid is a degradation product of human purine metabolism, and its potential pathogenic role in renal dysfunction may help understand the relationship between hyperuricemia and the development of PC-AKI.Firstly, contrast agents can increase the excretion of serum uric acid.Elevated uric acid in urine may lead to crystallization, especially when exposed to contrast agents.These urate crystals, combined with the direct toxic effects of contrast agents, may damage renal tubules and cause kidney damage[36].Secondly, an increase in uric acid levels can also activate the renin angiotensin aldosterone system (RAAS), which leads to strong vasoconstriction and further reduces renal blood flow,increasing renal vascular resistance[37].In a previous study, uric acid was found to be associated with an increase in the production of many inflammatory factors, such as interleukin-6 (IL-6), C-reactive protein, etc.These factors can stimulate the inflammatory response and further induce renal tubular injury[38].In addition, hyperuricemia can reduce the bioavailability of nitric oxide (NO), enhance oxidative stress, and these pathological and physiological mechanisms can lead to damage to glomerular endothelial cells, thereby inducing endothelial dysfunction and ultimately affecting renal perfusion[39].All these factors can interact with each other and lead to the development of PC-AKI.

    Limitations of this meta-analysis.(1) Most of the included studies were adjusted for multiple variables, but there may be confounding effects of other unadjusted risk factors on the final results.(2)The relevant studies only provided rough OR values for inpatient mortality and renal replacement therapy, which may affect the accuracy of the final results.(3) This meta-analysis is mainly aimed at patients who receive iodine contrast agents administered within the coronary artery.Therefore, the results of the meta-analysis may not be applicable to AKI outcomes caused by enhanced computed tomography (CT), CT angiography, and non coronary angiography.(4) The included studies come from observational studies conducted at centers in different countries and regions, so differences in method evaluation, patient selection, serum uric acid definition, contrast agent use, and PC-AKI definition may have an impact on their final results.There are differences in the definition of hyperuricemia in meta-analyses, which may to some extent affect the quality evaluation and reliability of the results, leading to heterogeneity among studies included in the meta-analysis and confusion in the understanding of the final conclusion.(5) The study only involved Asians and Europeans, making it difficult to accurately assess the association between serum uric acid and PC-AKI among different ethnic groups worldwide.

    In summary, through meta-analysis of the large sample data collected from 12 literature, it was found that the presence of hyperuricemia is independently associated with the occurrence of PC-AKI, and it significantly increases the in-hospital mortality rate and the risk of renal replacement therapy in PC-AKI patients.Due to the fact that serum uric acid is a preventable and treatable clinical symptom, measuring its level before coronary angiography may be an effective method for assessing the risk of PC-AKI occurrence and improving clinical prognostic outcomes.Future research, especially high-quality randomized controlled trials, needs to repeatedly verify whether uric acid lowering therapy is beneficial for the prevention and treatment of CI-AKI.

    Authors’ contribution

    Yao Zhi: Responsible for the research topic selection, literature search and screening, data extraction, statistical analysis, and article writing; Shi Yuexin: Responsible for literature screening and data extraction; Sun Luying: Responsible for feasibility evaluation of topic selection and article revision.

    All authors declare that there is no conflict of interest.

    真人做人爱边吃奶动态| 免费不卡黄色视频| 中文字幕人妻丝袜一区二区| 自线自在国产av| 咕卡用的链子| 欧美最黄视频在线播放免费 | 国产高清国产精品国产三级| 在线看a的网站| 亚洲精品粉嫩美女一区| 亚洲片人在线观看| 国产高清激情床上av| 午夜视频精品福利| 欧美日韩精品网址| 9色porny在线观看| 久久性视频一级片| 香蕉丝袜av| 久热这里只有精品99| 身体一侧抽搐| 老司机福利观看| 桃红色精品国产亚洲av| 国产欧美日韩精品亚洲av| 日本黄色视频三级网站网址| 丁香六月欧美| 亚洲国产欧美网| 日本一区二区免费在线视频| 18美女黄网站色大片免费观看| 欧美激情极品国产一区二区三区| 一a级毛片在线观看| 韩国精品一区二区三区| 男人舔女人的私密视频| 嫩草影视91久久| 免费在线观看影片大全网站| 不卡一级毛片| 999精品在线视频| 黑人巨大精品欧美一区二区mp4| 又黄又爽又免费观看的视频| 激情在线观看视频在线高清| 看片在线看免费视频| 免费av中文字幕在线| 婷婷丁香在线五月| 交换朋友夫妻互换小说| 久久中文字幕人妻熟女| 欧美日韩亚洲综合一区二区三区_| 欧美激情极品国产一区二区三区| 91麻豆精品激情在线观看国产 | 两性夫妻黄色片| 一个人观看的视频www高清免费观看 | 精品国产美女av久久久久小说| 新久久久久国产一级毛片| 亚洲av成人不卡在线观看播放网| 亚洲专区中文字幕在线| 亚洲 欧美 日韩 在线 免费| 精品一区二区三区视频在线观看免费 | 一级毛片精品| 50天的宝宝边吃奶边哭怎么回事| 美女福利国产在线| 亚洲av五月六月丁香网| 看黄色毛片网站| 最近最新中文字幕大全电影3 | 一级毛片女人18水好多| 国内久久婷婷六月综合欲色啪| 午夜久久久在线观看| 性欧美人与动物交配| 在线av久久热| 国产区一区二久久| 中文字幕色久视频| 婷婷丁香在线五月| 精品第一国产精品| 可以免费在线观看a视频的电影网站| 久久天躁狠狠躁夜夜2o2o| 国产亚洲精品久久久久5区| 日韩欧美三级三区| 美女午夜性视频免费| 少妇粗大呻吟视频| 国产亚洲av高清不卡| 欧美不卡视频在线免费观看 | 国产精品 欧美亚洲| 少妇的丰满在线观看| 亚洲欧美激情综合另类| 真人一进一出gif抽搐免费| 久久99一区二区三区| 少妇裸体淫交视频免费看高清 | 妹子高潮喷水视频| 在线观看66精品国产| 欧美性长视频在线观看| 国产99久久九九免费精品| 色尼玛亚洲综合影院| 多毛熟女@视频| 亚洲avbb在线观看| 久久草成人影院| 久久精品国产99精品国产亚洲性色 | 国产精品98久久久久久宅男小说| 亚洲一区二区三区不卡视频| 在线观看免费高清a一片| 精品一区二区三区av网在线观看| 搡老乐熟女国产| 精品欧美一区二区三区在线| 97超级碰碰碰精品色视频在线观看| 欧美日韩福利视频一区二区| 久久九九热精品免费| 18禁裸乳无遮挡免费网站照片 | 欧美丝袜亚洲另类 | 99久久综合精品五月天人人| 国产精品秋霞免费鲁丝片| 日本精品一区二区三区蜜桃| 午夜影院日韩av| 国产男靠女视频免费网站| 波多野结衣高清无吗| 少妇粗大呻吟视频| 久久婷婷成人综合色麻豆| 精品少妇一区二区三区视频日本电影| 91九色精品人成在线观看| 欧美大码av| 精品日产1卡2卡| 美女扒开内裤让男人捅视频| 99久久综合精品五月天人人| 国产精品国产av在线观看| 日韩中文字幕欧美一区二区| 国产亚洲精品久久久久久毛片| 黄色成人免费大全| 色老头精品视频在线观看| 国产精品乱码一区二三区的特点 | 精品久久久久久久久久免费视频 | 美女国产高潮福利片在线看| 欧美不卡视频在线免费观看 | 国产精品免费视频内射| 一级a爱视频在线免费观看| 黄色成人免费大全| 亚洲精品一卡2卡三卡4卡5卡| 曰老女人黄片| 日韩精品青青久久久久久| 亚洲欧美日韩无卡精品| 大型黄色视频在线免费观看| 日韩欧美国产一区二区入口| 久久欧美精品欧美久久欧美| 亚洲三区欧美一区| 夜夜看夜夜爽夜夜摸 | 99re在线观看精品视频| 国产xxxxx性猛交| 亚洲av片天天在线观看| 国产亚洲精品综合一区在线观看 | 日日爽夜夜爽网站| 美女扒开内裤让男人捅视频| 精品久久久久久电影网| 日韩一卡2卡3卡4卡2021年| 这个男人来自地球电影免费观看| 国产精品久久久久久人妻精品电影| 国产精品自产拍在线观看55亚洲| 亚洲久久久国产精品| 午夜免费观看网址| 99热只有精品国产| 91麻豆精品激情在线观看国产 | 夜夜夜夜夜久久久久| 午夜老司机福利片| 成人黄色视频免费在线看| 视频区图区小说| 精品一区二区三区四区五区乱码| 中文字幕色久视频| 国产精品久久电影中文字幕| 国产日韩一区二区三区精品不卡| 9色porny在线观看| 国产99久久九九免费精品| 久久国产亚洲av麻豆专区| 欧美乱码精品一区二区三区| 欧美精品啪啪一区二区三区| 在线国产一区二区在线| 日韩国内少妇激情av| www日本在线高清视频| 日韩免费高清中文字幕av| 99国产精品一区二区三区| 在线十欧美十亚洲十日本专区| 女人爽到高潮嗷嗷叫在线视频| 女人爽到高潮嗷嗷叫在线视频| 欧美乱色亚洲激情| 一级a爱视频在线免费观看| 超碰97精品在线观看| 亚洲伊人色综图| 午夜福利欧美成人| av欧美777| 亚洲熟妇中文字幕五十中出 | 中文字幕最新亚洲高清| 人妻久久中文字幕网| 午夜久久久在线观看| 国产在线精品亚洲第一网站| 亚洲色图综合在线观看| 高清在线国产一区| 国产国语露脸激情在线看| 三级毛片av免费| 国产精品 欧美亚洲| 国产成人av激情在线播放| 又黄又爽又免费观看的视频| 老熟妇仑乱视频hdxx| av欧美777| 国产三级黄色录像| www.www免费av| 亚洲欧美激情综合另类| 国产片内射在线| 午夜日韩欧美国产| 在线观看免费视频日本深夜| 亚洲 国产 在线| 一区二区日韩欧美中文字幕| videosex国产| 日韩高清综合在线| 热99re8久久精品国产| 国产精品 欧美亚洲| 国产成人精品久久二区二区免费| 国产精品国产高清国产av| 亚洲全国av大片| 搡老岳熟女国产| 免费高清视频大片| 日本a在线网址| 久久午夜亚洲精品久久| 欧美丝袜亚洲另类 | 制服诱惑二区| 18禁黄网站禁片午夜丰满| 熟女少妇亚洲综合色aaa.| 两个人看的免费小视频| 国产亚洲精品一区二区www| 亚洲精品成人av观看孕妇| 妹子高潮喷水视频| 亚洲国产精品999在线| 国产精品一区二区三区四区久久 | 两人在一起打扑克的视频| 国产高清videossex| 国产精品国产高清国产av| 男人舔女人的私密视频| 一进一出好大好爽视频| 日韩av在线大香蕉| 三级毛片av免费| 一级片'在线观看视频| www.熟女人妻精品国产| 99久久99久久久精品蜜桃| 午夜激情av网站| 激情在线观看视频在线高清| 国产亚洲精品久久久久久毛片| ponron亚洲| 精品一品国产午夜福利视频| 国产亚洲欧美在线一区二区| 人成视频在线观看免费观看| 国产精品美女特级片免费视频播放器 | 久久人人爽av亚洲精品天堂| 日韩国内少妇激情av| 超碰97精品在线观看| 亚洲国产精品999在线| 一二三四社区在线视频社区8| 亚洲欧美一区二区三区黑人| 国产成人av教育| 91老司机精品| 色婷婷久久久亚洲欧美| 午夜精品国产一区二区电影| 国产真人三级小视频在线观看| 国产精品爽爽va在线观看网站 | 人妻久久中文字幕网| av电影中文网址| 不卡一级毛片| 他把我摸到了高潮在线观看| 亚洲人成77777在线视频| 香蕉国产在线看| 国产精品 欧美亚洲| 久久精品亚洲精品国产色婷小说| 亚洲三区欧美一区| 欧美黄色片欧美黄色片| 叶爱在线成人免费视频播放| 久久久久九九精品影院| 法律面前人人平等表现在哪些方面| 脱女人内裤的视频| 国产精品免费视频内射| 一a级毛片在线观看| 久久久国产精品麻豆| 日韩有码中文字幕| 免费av中文字幕在线| 欧美国产精品va在线观看不卡| 亚洲成人久久性| 亚洲激情在线av| 精品福利永久在线观看| 日韩一卡2卡3卡4卡2021年| 人妻丰满熟妇av一区二区三区| 黄色成人免费大全| 在线观看一区二区三区激情| 亚洲人成77777在线视频| 欧美成狂野欧美在线观看| 免费不卡黄色视频| 国产成人精品久久二区二区免费| 午夜影院日韩av| 一级片免费观看大全| 精品一区二区三区av网在线观看| 男女午夜视频在线观看| 黄片大片在线免费观看| 国产伦一二天堂av在线观看| 美女高潮喷水抽搐中文字幕| e午夜精品久久久久久久| 亚洲五月色婷婷综合| 亚洲狠狠婷婷综合久久图片| 国内久久婷婷六月综合欲色啪| 国产欧美日韩一区二区三区在线| 国产av精品麻豆| 在线播放国产精品三级| 国产深夜福利视频在线观看| 亚洲av熟女| 色尼玛亚洲综合影院| 亚洲精品在线观看二区| 99riav亚洲国产免费| 亚洲国产欧美网| av视频免费观看在线观看| 波多野结衣一区麻豆| 一本大道久久a久久精品| 日韩欧美三级三区| 成年女人毛片免费观看观看9| av免费在线观看网站| 久久香蕉国产精品| 在线播放国产精品三级| 亚洲成人免费av在线播放| 国产色视频综合| 欧美性长视频在线观看| 一进一出好大好爽视频| 夜夜夜夜夜久久久久| 精品少妇一区二区三区视频日本电影| 视频区欧美日本亚洲| 99久久国产精品久久久| 午夜日韩欧美国产| 亚洲第一av免费看| 1024视频免费在线观看| 我的亚洲天堂| 伊人久久大香线蕉亚洲五| 亚洲狠狠婷婷综合久久图片| 91麻豆av在线| 国产精品一区二区精品视频观看| 久久精品国产清高在天天线| 香蕉国产在线看| 热re99久久国产66热| 最好的美女福利视频网| 国产成人精品无人区| 中文字幕最新亚洲高清| 老汉色∧v一级毛片| 国产一区二区激情短视频| 精品无人区乱码1区二区| 亚洲欧美一区二区三区久久| 亚洲少妇的诱惑av| 久久人妻熟女aⅴ| www.精华液| 日本黄色视频三级网站网址| 长腿黑丝高跟| 18禁黄网站禁片午夜丰满| 欧美乱码精品一区二区三区| 日本欧美视频一区| 日韩人妻精品一区2区三区| 色尼玛亚洲综合影院| 亚洲欧美激情在线| 日韩视频一区二区在线观看| 久久伊人香网站| 丝袜在线中文字幕| av视频免费观看在线观看| 18美女黄网站色大片免费观看| 久久人人爽av亚洲精品天堂| 麻豆久久精品国产亚洲av | 无人区码免费观看不卡| 香蕉久久夜色| 在线永久观看黄色视频| 两性夫妻黄色片| 国产精品电影一区二区三区| 在线十欧美十亚洲十日本专区| 一a级毛片在线观看| 国产黄色免费在线视频| 黄色a级毛片大全视频| 少妇粗大呻吟视频| 久久久精品欧美日韩精品| 在线av久久热| av免费在线观看网站| 日韩欧美三级三区| 在线观看免费午夜福利视频| 亚洲欧美一区二区三区久久| 免费少妇av软件| 免费看十八禁软件| 欧美最黄视频在线播放免费 | 亚洲熟妇熟女久久| 两人在一起打扑克的视频| 热99国产精品久久久久久7| 国产真人三级小视频在线观看| 男人操女人黄网站| 一级毛片精品| 一区福利在线观看| 日本vs欧美在线观看视频| 中文亚洲av片在线观看爽| 19禁男女啪啪无遮挡网站| 欧美人与性动交α欧美精品济南到| 一级毛片女人18水好多| 一区福利在线观看| 中文欧美无线码| 一级毛片高清免费大全| 精品久久久久久,| 久久久久国内视频| 日日夜夜操网爽| 免费看a级黄色片| 母亲3免费完整高清在线观看| 午夜久久久在线观看| 亚洲人成网站在线播放欧美日韩| 国产一区二区三区综合在线观看| 女人精品久久久久毛片| 亚洲av五月六月丁香网| 宅男免费午夜| 国产精品美女特级片免费视频播放器 | 18禁观看日本| 成人亚洲精品一区在线观看| 性欧美人与动物交配| 国产乱人伦免费视频| 91麻豆精品激情在线观看国产 | 一级a爱视频在线免费观看| 欧美黄色片欧美黄色片| 人人妻人人澡人人看| 一级a爱视频在线免费观看| 亚洲成av片中文字幕在线观看| 一区在线观看完整版| 欧美日韩国产mv在线观看视频| 亚洲国产看品久久| 国产av又大| 热99国产精品久久久久久7| 日韩欧美三级三区| 欧美中文日本在线观看视频| 久久精品亚洲熟妇少妇任你| 国产精品免费一区二区三区在线| 日韩人妻精品一区2区三区| 脱女人内裤的视频| 亚洲美女黄片视频| 99riav亚洲国产免费| 久久国产亚洲av麻豆专区| 精品人妻在线不人妻| bbb黄色大片| 一级黄色大片毛片| 黑丝袜美女国产一区| 精品第一国产精品| 无遮挡黄片免费观看| 一区二区三区精品91| 亚洲欧美一区二区三区久久| 男人舔女人下体高潮全视频| 青草久久国产| 老司机亚洲免费影院| 久久久水蜜桃国产精品网| 国产亚洲欧美精品永久| 激情视频va一区二区三区| 99精国产麻豆久久婷婷| 成人18禁高潮啪啪吃奶动态图| 神马国产精品三级电影在线观看 | 欧美在线一区亚洲| 国产精品一区二区免费欧美| 波多野结衣av一区二区av| 一级作爱视频免费观看| 又黄又爽又免费观看的视频| 日本精品一区二区三区蜜桃| 最新在线观看一区二区三区| 亚洲欧美激情在线| 日日干狠狠操夜夜爽| 两个人看的免费小视频| 波多野结衣高清无吗| 又大又爽又粗| 亚洲中文日韩欧美视频| 80岁老熟妇乱子伦牲交| 亚洲午夜理论影院| 国产精品影院久久| 亚洲国产欧美一区二区综合| 美国免费a级毛片| 国产一区二区三区在线臀色熟女 | 丁香欧美五月| 一区在线观看完整版| 色婷婷久久久亚洲欧美| 国产黄a三级三级三级人| 人妻久久中文字幕网| 女人被躁到高潮嗷嗷叫费观| 最近最新中文字幕大全免费视频| 亚洲精品久久午夜乱码| 免费少妇av软件| 99香蕉大伊视频| 9热在线视频观看99| 欧美日韩中文字幕国产精品一区二区三区 | 午夜影院日韩av| 国产极品粉嫩免费观看在线| 亚洲欧美激情在线| 一级,二级,三级黄色视频| 在线国产一区二区在线| 宅男免费午夜| 久久精品国产99精品国产亚洲性色 | 少妇裸体淫交视频免费看高清 | 香蕉国产在线看| 高清av免费在线| 久久人人97超碰香蕉20202| 久久天躁狠狠躁夜夜2o2o| 真人做人爱边吃奶动态| 两个人免费观看高清视频| 极品人妻少妇av视频| 一级a爱视频在线免费观看| 天天添夜夜摸| 黄片播放在线免费| 欧美在线黄色| 精品熟女少妇八av免费久了| 亚洲一区二区三区不卡视频| 1024香蕉在线观看| av片东京热男人的天堂| 一区二区三区激情视频| 国产精品av久久久久免费| 婷婷丁香在线五月| 天天躁夜夜躁狠狠躁躁| www.www免费av| 亚洲色图av天堂| 欧美日韩中文字幕国产精品一区二区三区 | 亚洲av成人不卡在线观看播放网| 18美女黄网站色大片免费观看| 国产亚洲精品一区二区www| 天堂√8在线中文| 黑人猛操日本美女一级片| 久久人人精品亚洲av| 欧美日韩福利视频一区二区| 一级黄色大片毛片| 精品免费久久久久久久清纯| 看片在线看免费视频| 88av欧美| www.熟女人妻精品国产| 波多野结衣av一区二区av| 精品一区二区三区四区五区乱码| 激情视频va一区二区三区| 国产精品久久久久久人妻精品电影| 亚洲欧美一区二区三区久久| 免费高清视频大片| 在线播放国产精品三级| 一级a爱片免费观看的视频| 无人区码免费观看不卡| 999久久久精品免费观看国产| 69av精品久久久久久| 国产亚洲精品一区二区www| 欧美激情极品国产一区二区三区| 天堂影院成人在线观看| 国产不卡一卡二| 桃色一区二区三区在线观看| 欧美日韩亚洲高清精品| 99riav亚洲国产免费| 老熟妇乱子伦视频在线观看| 欧美激情高清一区二区三区| 91在线观看av| 国产三级黄色录像| 看免费av毛片| 人人妻人人爽人人添夜夜欢视频| 法律面前人人平等表现在哪些方面| 无遮挡黄片免费观看| 精品久久久久久电影网| 欧美一区二区精品小视频在线| 久久性视频一级片| 又紧又爽又黄一区二区| 免费人成视频x8x8入口观看| 不卡av一区二区三区| 国产精品爽爽va在线观看网站 | 12—13女人毛片做爰片一| 桃红色精品国产亚洲av| 亚洲精品一卡2卡三卡4卡5卡| 夜夜爽天天搞| www日本在线高清视频| 久久人妻福利社区极品人妻图片| 丝袜美足系列| 女性生殖器流出的白浆| 免费观看精品视频网站| 一二三四社区在线视频社区8| 两个人看的免费小视频| 久久精品国产清高在天天线| 久久伊人香网站| 欧美黑人精品巨大| 高清av免费在线| 巨乳人妻的诱惑在线观看| 欧美丝袜亚洲另类 | 精品一区二区三卡| 成年女人毛片免费观看观看9| 久久人人精品亚洲av| 性少妇av在线| 女人高潮潮喷娇喘18禁视频| 国产精品美女特级片免费视频播放器 | 欧美黑人欧美精品刺激| 9色porny在线观看| 中文字幕人妻丝袜一区二区| 国产日韩一区二区三区精品不卡| 丰满的人妻完整版| 正在播放国产对白刺激| 国产精品国产av在线观看| 国产精品 欧美亚洲| 一进一出好大好爽视频| 国内久久婷婷六月综合欲色啪| 两个人免费观看高清视频| 久久伊人香网站| 两个人免费观看高清视频| 亚洲精品国产色婷婷电影| 深夜精品福利| 欧美久久黑人一区二区| 99热只有精品国产| 亚洲精品久久午夜乱码| 19禁男女啪啪无遮挡网站| 久久 成人 亚洲| 90打野战视频偷拍视频| 在线观看舔阴道视频| 欧美激情高清一区二区三区| 免费在线观看视频国产中文字幕亚洲| а√天堂www在线а√下载| 岛国在线观看网站| 亚洲aⅴ乱码一区二区在线播放 | 亚洲国产精品合色在线| 亚洲黑人精品在线| 一二三四在线观看免费中文在| 视频在线观看一区二区三区| 又紧又爽又黄一区二区| 亚洲五月婷婷丁香| 老司机靠b影院| 国产欧美日韩综合在线一区二区| 18禁观看日本| 免费不卡黄色视频| 亚洲欧美日韩无卡精品| 精品日产1卡2卡| 天堂动漫精品| 不卡av一区二区三区| 精品免费久久久久久久清纯| 欧美激情久久久久久爽电影 | 亚洲aⅴ乱码一区二区在线播放 |