• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Effect of total glucosides of paeony on serum cytokines in patients with psoriasis and its clinical efficacy: A meta-analysis

    2022-08-12 02:31:24WenTingChenYuHongYanJingJieYuXiaoYuChenChuanJianLu
    Journal of Hainan Medical College 2022年11期

    Wen-Ting Chen, Yu-Hong Yan, Jing-Jie Yu, Xiao-Yu Chen ,Chuan-Jian Lu,3,4?

    1. Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China

    2. Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China

    3. State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou 510120, China

    4. Key Laboratory of TCM Syndrome Clinical Research of Guangdong Province, Guangzhou 510120, China

    Keywords:Psoriasis Total glucosides of Paeony Cytokines Randomized controlled Meta-analysis

    ABSTRACT Objective: To evaluate the relationship between the changes of inflammatory cytokines and clinical efficacy in patients with psoriasis treated with Total glucosides of paeony by Meta analyses, and to explore the microcosmic mechanism of effective treatment of psoriasis with Total glucosides of paeony from the point of view of evidence-based medicine. Methods: The databases of CNKI, Wanfang, VIP, SinoMed, PuMed, Embase and Cochrane Library were searched by computer, and the time range was from the establishment of the database to May 2020. After screening, data extraction and bias risk assessment, Revman5.3 software was used for statistical analysis. Results: A total of 998 patients were included in 11 clinical studies,including 502 patients in the trial group and 496 patients in the control group. The results of Meta analysis showed that there was significant difference in the expression of cytokines between the two groups (MD=-10.97, 95%Cl[-15.56,-6.37]). The effective rate of treatment(OR=3.57, 95%Cl[2.58, 4.94]) and the decrease of PASI score (MD=-4.55, 95%Cl[-5.91,-3.20]) in the combined use of Total glucosides of paeony group were superior to those in the control group. Conclusion: Total glucosides of paeony can regulate immune and inflammatory response and improve skin lesions by inhibiting the expression of cytokines such as IL-2, IL-8,IL-23 and TNF-α in serum of patients with psoriasis. In view of the low overall quality of the included studies, larger samples and higher quality clinical trials are still needed to obtain more sufficient evidence.?Corresponding author: LU Chuan-jian, Professor, M.D., Doctoral Supervisor.

    1. Introduction

    Psoriasis as a chronic, inflammatory and recurrent skin disease caused by immunity or inflammation, psoriasis vulgaris is the most common, with red papules at the beginning, which can be expanded and fused into patches. White scales, shiny film and punctate bleeding are its typical characteristics, and finger (toe) nail spot depression can be seen, and most of the disease shows the seasonal change of severe winter and light summer. At present, it is believed that the pathogenesis of psoriasis is caused by the interaction of genetic, environmental and immune factors [1], in which cytokines play a key role in the pathophysiology of psoriasis [2]. Keratinocytes are easy to proliferate abnormally under the stimulation of inflammatory mediators [1]. Pharmacological studies show that total glucosides of paeony (TGP) can regulate immunity and inhibit inflammation, and can affect the expression of cytokines such as IL-8, IL-10, IL-17, IL-23, IFN-γ, TNF-α [3-4]. Therefore, it is rare to use total glucosides of paeony in the treatment of dermatosis,and it also has a certain curative effect on psoriasis. At present,the Meta analysis of the relationship between total glucosides of paeony and cytokines in patients with psoriasis has not been reported, so this study used Meta analysis to explore the effect of total glucosides of paeony on the expression of serum cytokines in patients with psoriasis.

    2. Data and methods

    2.1 Inclusion criteria

    (1) study types: randomized controlled trials; (2)subjects: patients diagnosed as psoriasis according to clinical criteria; (3) intervention measures: the control group was treated with other drugs or physiotherapy without total glucosides of paeony preparation, and the experimental group was treated with total glucosides of paeony preparation combined with control group.(4) outcome index: the main index was the test value of cytokines (IL-2, IL-4, IL-8, IL-10, IL-17, IL-18,IL-23, IFN-γ, TNF-α), and the secondary index was treatment effective rate or PASI score. Due to the differences in the definition of the total effective rate in each study, in order to facilitate statistics, the curative effect criteria of each study are unified as follows: total effective rate = (number of cured cases +number of markedly effective cases) / total number of cases×100%.

    2.2 Exclusion criteria

    Observational studies, animal experiments, in vitro cell experiments, conferences, reviews, empirical literature;the data are incomplete.

    2.3 Retrieval strategy

    Four Chinese databases (CNKI, SinoMed, Wanfang,VIP) and three English databases (PubMed, Cochrane Library, Embase) are searched by computer. The search time range is from the establishment of the database to May 2020. By using the combination of subject words and free words, the Chinese search words include"psoriasis", "Baibi", "total glucosides of paeony","cytokines", "randomized control", "clinical study" and so on, while the English words include "psoriasis","cytokine", "Total glucosides of paeony" and so on.

    2.4 Literature screening, data extraction and quality evaluation

    The work of literature screening and data extraction was completed by two independent researchers according to the established criteria, and checked and

    proofread each other. If there is any objection, it will be discussed and decided by two researchers, and the third party will be consulted when it is critical. After importing all the retrieved documents into Endnote X9 for preliminary checking, we read the title and abstract to delete the irrelevant literature. finally, we browsed the full text of the remaining literature and screened them to meet the requirements. The required data information was extracted and sorted into the Excel table, and the main information was the first author, the year of publication, the sample size of each group and intervention measures, course of treatment, outcome report.

    The biased risk assessment tool recommended by Cochrane Handbook 5.1.0 was used to evaluate the quality of the literature. High risk, low risk and unclear were evaluated in six areas: random sequence generation, allocation hiding, blind implementation,data integrity, selective reporting bias and other biases.

    2.5 Statistical methods

    Use RevMan 5.3 the software carries on the Meta analysis, the effect value of the measurement data is described by the mean difference (MD), and the effect value of the counting data is described by the ratio ratio(OR), both of which take 95% confidence interval(Cl).X2 qualitative and I2quantitative analysis were used to test the heterogeneity between studies. When I2<50%,P> 0.1, the heterogeneity was considered to be low,and the fixed effect model could be directly applied to merge. If I2> 50% and P<0.1, the heterogeneity was considered to be obvious. It is necessary to explore the source of heterogeneity and analyze the possible causes of heterogeneity by subgroup analysis. If heterogeneity still exists, random effect model is used for Meta analysis, and sensitivity analysis is used to test the stability of the results.

    3. Results

    3.1 Search results

    A total of 180 articles were retrieved from the above 7 databases, including 64 articles of Wanfang, 50 articles of CNKI, 34 articles of SinoMed, 27 articles of VIP, 3 articles of PuMed, 2 articles of Embase and 0 articles of Cochrane Library. After several times of screening,11 articles were included, with a total of 998 subjects,including 502 in the experimental group and 496 in the control group. The specific process is shown in figure 1.The baseline data of the subjects were included in each study, and the consistency between groups was good.The basic characteristics of the included literature are detailed in Table 1.

    Figure1 Document screening process

    3.2 Inclusion of research quality evaluation

    Although all the studies reported the specified outcome indicators and the data integrity was good, only 5 studies were grouped with random number tables, and the random allocation methods used in 4 studies were unknown. Hu Yin E's two studies were randomly assigned according to the order of treatment, so they were rated as"high risk". In terms of distribution concealment, except for two articles by Hu Yine, none of the other studies were mentioned;because all studies could not blind subjects and researchers and rated them as "high risk"; all studies did not say whether they were blind to outcome evaluators, so they were rated as "unclear"; taken together, the quality of the included study was low, and the specific evaluation was shown in figure 2.

    Figure2 summary map of bias risk assessment

    3.3 Meta analysis results

    3.3.1 CytokinesA total of 11 articles were included, and the results showed that the total effect of the two groups was MD=-10.97,95%Cl[-15.56,-6.37], P<0.00001, indicating that TGP could significantly affect the expression of cytokines in patients with psoriasis. The heterogeneity test was P<0.00001, which mainly came from the diversity and complexity of cytokines. The results of subgroup analysis showed that the values of the following four cytokines decreased significantly after taking TGP: IL-2 (MD=-11.42,95%Cl [-13.21,-9.63]), IL-8(MD=-15.67,95%Cl [-24.58,-6.76]), IL-23 (MD=-16.12,95%Cl[-25.04,-7.20]) and TNF-α (MD=-21.82). 95%Cl [-29.23,-14.41]).In the four subgroups of IL-4, IL-17, IL-18 and IFN-γ, the detectionvalue of the test group was lower than that of the control group, but the difference was not statistically significant (P>0.05). For the IL-10 subgroup, the value of the test group was higher than that of the control group, but the difference was not statistically significant. See figure 3 for details:

    Table 1 Basic characteristics of literature included

    Figure3 Forest map of Meta analysis of cytokines

    3.3.2 Effective rate of treatment

    Nine studies reported therapeutic efficacy, which was combined with a fixed-effect model and showed no significant heterogeneity among the studies (P=0.36 I2=10%). There was a significant difference in the effective rate between the two groups, and the effect of combined use of TGP was better than that of unused TGP(OR=3.57,95Cl% [2.58,4.94]). See figure 4.

    Figure4 Forest map of Meta analysis for effective treatment

    3.3.3 PASI score

    The outcome index of 7 articles reported the PASI score, and the results showed that there was significant difference between the two groups (P<0.00001), indicating that the effect of routine treatment alone (oral western medicine, topical ointment or NBUVB) on reducing PASI score was worse than that of combined use of TGP. The heterogeneity test was P<0.00001, and the source of heterogeneity was speculated to be related to different courses of treatment, so the random effect model was used for subgroup analysis, as shown in figure 5.

    Figure5 Forest map of PASI subgroup analysisFig. 5 Forest map of PASI subgroup analysis

    3.3.4 Sensitivity analysisMeta analysis of other studies after single study was excluded one by one. It can be seen from figure 6 that study 13 (Hu Yin E IL-10) has the greatest influence on the total combined effect. If it is removed, the combined effect will change from-1.60(-2.26, -0.94)to-1.99(-2.60, -1.37), while other studies have little effect on the total combined effect.

    4. Discussion

    At present, it is believed that the abnormal activation of T lymphocytes is the most important immune factor leading to psoriasis [16], and many kinds of interleukin, such as IL-2, IL-4, IL-17, IL-18, IL-22, IL-23 and so on, can stimulate the proliferation of activated T lymphocytes, thus induce the synthesis and release of inflammatory mediators and produce inflammatory response. IL-8 has a chemotactic effect on T lymphocytes and neutrophils, which can promote the proliferation of epidermal keratinocytes and new angiogenesis [17]. Moreover, there is also a cascade reaction between inflammatory mediators. IL-23 can promote Th17 cells to synthesize IL-17, IL-22 and act on keratinocytes, making them produce a large number of other inflammatory factors, chemokines and antimicrobial peptides to enhance immune response [18-19]. TNF-αcan induce and enhance the pathological state of inflammatory infiltration in psoriasis by activating neutrophils and vascular endothelial cells [20-21].

    The application of total glucosides of paeony to the treatment of psoriasis mainly shows the biological characteristics of negative immune regulation. It can not only inhibit the activation and proliferation of T lymphocytes, reduce the release of inflammatory factors, but also directly inhibit the cytokine secretion of HaCat cells[22], so as to reduce the level of inflammatory mediators in the serum of patients with psoriasis and stabilize the autoimmune system.Huang Aiping's study found that IL-8 and TNF-αare important pathological factors in the pathogenesis of psoriasis. TGP can treat psoriasis by inhibiting the abnormal expression of both. Zhang Yuhong's research conclusion shows that total glucosides of paeony can significantly control the abnormally high expression of IL-17 and IL-23 and maintain the balance of the immune system [24]. Wang Hongquan's research points out that TGP has a two-way regulating effect on IL-2 [25].

    A total of 11 clinical studies were included in this study. for the main outcome indicators, cytokines, TGP could alleviate the inflammatory response in patients with psoriasis (MD=-10.79,95Cl%[-15.47,-6.11]), and significantly inhibited the expression of IL-2, IL-8, IL-23 and TNF-α (P<0.05). It also affected the expression of IL-4, IL-17, IL-18, IFN-γ and IL-10,but there was no significant difference between the two groups. The effective rate of treatment and the decrease of PASI score in the experimental group treated with TGP were better than those without TGP (P<0.05). Therefore, from the perspective of evidence-based medicine, this study verified that TGP can improve the clinical effect of psoriatic lesions by reducing the pharmacological effects of IL-2,IL-8, IL-23 and TNF-α.

    This study also has some limitations: (1) the number of literatures is small, the sample size is insufficient, and the overall quality is not high; (2) there are clinical heterogeneity among different studies,such as the course of treatment and the severity of baseline skin lesions of the subjects. (3) the detection methods used in each study are different, and the sensitivity of the detection reagent is not clear,the above factors will affect the stability of the research conclusion.therefore, we look forward to more multi-center, large samples, highquality research to provide high-level evidence-based basis.

    母亲3免费完整高清在线观看| 日日干狠狠操夜夜爽| 在线观看免费日韩欧美大片| 亚洲天堂国产精品一区在线| 国产亚洲av高清不卡| 精品久久久久久,| 国产亚洲欧美在线一区二区| 精品熟女少妇八av免费久了| 国产激情欧美一区二区| 亚洲成人免费电影在线观看| 国产精品久久久久久精品电影 | 国产国语露脸激情在线看| 91大片在线观看| 亚洲最大成人中文| 欧美日本亚洲视频在线播放| 国产精品精品国产色婷婷| 麻豆国产av国片精品| 国产精品久久电影中文字幕| 成年版毛片免费区| 亚洲第一av免费看| 国产成人精品在线电影| 99香蕉大伊视频| 国产精品一区二区免费欧美| 久久久久久免费高清国产稀缺| 啦啦啦免费观看视频1| 他把我摸到了高潮在线观看| 亚洲欧美日韩无卡精品| 欧美中文综合在线视频| 中文字幕色久视频| 很黄的视频免费| 国产麻豆69| 久久久久久亚洲精品国产蜜桃av| 国产成人一区二区三区免费视频网站| 欧美中文日本在线观看视频| 国产激情久久老熟女| 精品第一国产精品| 免费观看精品视频网站| 亚洲情色 制服丝袜| 久久久久久久久中文| 91九色精品人成在线观看| 成年版毛片免费区| 精品电影一区二区在线| 美女大奶头视频| 少妇被粗大的猛进出69影院| 成人手机av| 欧美国产日韩亚洲一区| 午夜福利影视在线免费观看| 午夜福利高清视频| 国产一区二区激情短视频| tocl精华| 丁香六月欧美| 亚洲欧美日韩另类电影网站| 99热只有精品国产| 男人的好看免费观看在线视频 | 18禁裸乳无遮挡免费网站照片 | 成人欧美大片| 亚洲av成人不卡在线观看播放网| 亚洲狠狠婷婷综合久久图片| 久久草成人影院| 亚洲国产日韩欧美精品在线观看 | 天天添夜夜摸| 性欧美人与动物交配| 女人爽到高潮嗷嗷叫在线视频| 国产精品久久久久久亚洲av鲁大| 性色av乱码一区二区三区2| 夜夜夜夜夜久久久久| 国产亚洲精品综合一区在线观看 | 亚洲电影在线观看av| 黄色女人牲交| 欧美成狂野欧美在线观看| 国产成人av激情在线播放| 中文亚洲av片在线观看爽| 免费av毛片视频| 18美女黄网站色大片免费观看| 午夜成年电影在线免费观看| 夜夜看夜夜爽夜夜摸| 国产精品久久久人人做人人爽| 母亲3免费完整高清在线观看| 多毛熟女@视频| 午夜激情av网站| 日韩精品免费视频一区二区三区| 日韩大码丰满熟妇| 两个人看的免费小视频| 麻豆久久精品国产亚洲av| 99国产精品免费福利视频| 嫁个100分男人电影在线观看| 亚洲欧洲精品一区二区精品久久久| 欧美精品亚洲一区二区| 色综合亚洲欧美另类图片| 久久人妻熟女aⅴ| 亚洲免费av在线视频| av电影中文网址| 男女午夜视频在线观看| 天天添夜夜摸| 精品久久久久久成人av| 午夜激情av网站| 亚洲片人在线观看| 国产精品 国内视频| 日韩欧美国产在线观看| 日本黄色视频三级网站网址| 亚洲精品粉嫩美女一区| 国产国语露脸激情在线看| 国产亚洲精品av在线| 国产三级在线视频| 亚洲av第一区精品v没综合| 校园春色视频在线观看| 亚洲欧美日韩另类电影网站| 女性生殖器流出的白浆| 夜夜夜夜夜久久久久| 亚洲最大成人中文| 久久精品aⅴ一区二区三区四区| 久久天躁狠狠躁夜夜2o2o| 成人18禁在线播放| 国产一区二区三区视频了| 国产黄a三级三级三级人| bbb黄色大片| 9191精品国产免费久久| 欧美在线黄色| 成人手机av| 国产1区2区3区精品| 97碰自拍视频| 人成视频在线观看免费观看| 脱女人内裤的视频| 99国产极品粉嫩在线观看| 琪琪午夜伦伦电影理论片6080| 精品国产一区二区久久| 可以在线观看毛片的网站| 黑人巨大精品欧美一区二区蜜桃| 亚洲国产欧美一区二区综合| 精品国内亚洲2022精品成人| 精品人妻1区二区| 久久人妻熟女aⅴ| 成人18禁在线播放| 欧美亚洲日本最大视频资源| 免费观看人在逋| 91麻豆av在线| 黑人巨大精品欧美一区二区mp4| 99热只有精品国产| 99精品久久久久人妻精品| 看黄色毛片网站| 美女大奶头视频| 1024视频免费在线观看| 黄色a级毛片大全视频| 99久久久亚洲精品蜜臀av| 国产精品爽爽va在线观看网站 | 国产精品一区二区免费欧美| 国产成人系列免费观看| 国产精品 国内视频| 夜夜躁狠狠躁天天躁| 欧美+亚洲+日韩+国产| 免费观看人在逋| 正在播放国产对白刺激| 一区二区三区高清视频在线| 满18在线观看网站| 九色国产91popny在线| 国产欧美日韩一区二区三区在线| 久久中文字幕一级| 成人18禁在线播放| 女人被躁到高潮嗷嗷叫费观| 亚洲七黄色美女视频| 久久久久精品国产欧美久久久| 欧美亚洲日本最大视频资源| 大型av网站在线播放| 日韩欧美在线二视频| 精品国产亚洲在线| 啦啦啦 在线观看视频| 少妇的丰满在线观看| 久热爱精品视频在线9| 国产欧美日韩精品亚洲av| 国产麻豆69| 久久久久国产精品人妻aⅴ院| 国产蜜桃级精品一区二区三区| 又大又爽又粗| 亚洲自偷自拍图片 自拍| av视频免费观看在线观看| 亚洲一卡2卡3卡4卡5卡精品中文| 精品国产国语对白av| 男女下面进入的视频免费午夜 | 亚洲一卡2卡3卡4卡5卡精品中文| 国产乱人伦免费视频| 91精品三级在线观看| 首页视频小说图片口味搜索| 国产成人欧美| 叶爱在线成人免费视频播放| 午夜免费鲁丝| 亚洲片人在线观看| 国产欧美日韩综合在线一区二区| 亚洲人成网站在线播放欧美日韩| 性色av乱码一区二区三区2| 精品第一国产精品| 亚洲成人精品中文字幕电影| 国产欧美日韩一区二区精品| 国产精品免费视频内射| 久久久久久久午夜电影| 多毛熟女@视频| 91字幕亚洲| 国产成人精品无人区| 夜夜躁狠狠躁天天躁| 亚洲国产精品sss在线观看| 91国产中文字幕| 韩国av一区二区三区四区| 日韩欧美一区二区三区在线观看| 欧美黄色淫秽网站| 妹子高潮喷水视频| 亚洲七黄色美女视频| 免费观看精品视频网站| 国产又色又爽无遮挡免费看| 国产精品秋霞免费鲁丝片| 免费无遮挡裸体视频| 国产三级黄色录像| 熟女少妇亚洲综合色aaa.| 成人av一区二区三区在线看| 1024视频免费在线观看| 欧美乱码精品一区二区三区| 啦啦啦 在线观看视频| 美女扒开内裤让男人捅视频| 国产高清视频在线播放一区| 高清黄色对白视频在线免费看| 国产激情欧美一区二区| 久久精品国产亚洲av香蕉五月| 在线观看日韩欧美| 九色亚洲精品在线播放| 精品久久久久久久毛片微露脸| 正在播放国产对白刺激| 无遮挡黄片免费观看| 大香蕉久久成人网| 国产成+人综合+亚洲专区| 黄片小视频在线播放| 国产成人欧美在线观看| 丝袜在线中文字幕| 免费人成视频x8x8入口观看| 久久精品国产综合久久久| 欧美老熟妇乱子伦牲交| 首页视频小说图片口味搜索| www.自偷自拍.com| 午夜福利视频1000在线观看 | 丝袜人妻中文字幕| 美国免费a级毛片| 俄罗斯特黄特色一大片| 精品第一国产精品| 一a级毛片在线观看| 日韩有码中文字幕| 亚洲五月色婷婷综合| 国产精品爽爽va在线观看网站 | 咕卡用的链子| av有码第一页| 精品久久久久久久久久免费视频| 一区二区日韩欧美中文字幕| 欧美中文日本在线观看视频| 少妇粗大呻吟视频| 国产成人影院久久av| 国产亚洲精品一区二区www| 99热只有精品国产| 免费久久久久久久精品成人欧美视频| 嫩草影视91久久| 在线观看午夜福利视频| 两性午夜刺激爽爽歪歪视频在线观看 | 国产精品野战在线观看| 国产免费av片在线观看野外av| 久久这里只有精品19| 动漫黄色视频在线观看| cao死你这个sao货| 国产精品亚洲美女久久久| АⅤ资源中文在线天堂| 多毛熟女@视频| 久久久国产欧美日韩av| 亚洲一卡2卡3卡4卡5卡精品中文| 在线观看www视频免费| 大型av网站在线播放| 99久久99久久久精品蜜桃| 黄片小视频在线播放| 成人亚洲精品av一区二区| 男人舔女人的私密视频| 亚洲五月婷婷丁香| 手机成人av网站| 国产精品av久久久久免费| 中文字幕久久专区| 久久天堂一区二区三区四区| 大码成人一级视频| 久久欧美精品欧美久久欧美| 如日韩欧美国产精品一区二区三区| 成年版毛片免费区| 男女之事视频高清在线观看| 国产亚洲精品一区二区www| 在线天堂中文资源库| 成人18禁在线播放| 欧美在线黄色| av片东京热男人的天堂| 国产高清视频在线播放一区| 麻豆国产av国片精品| 精品不卡国产一区二区三区| 免费搜索国产男女视频| 久久精品亚洲精品国产色婷小说| 亚洲av电影在线进入| 精品久久久久久久久久免费视频| 精品人妻在线不人妻| 久久久久久亚洲精品国产蜜桃av| 波多野结衣高清无吗| 香蕉国产在线看| 老司机在亚洲福利影院| 午夜亚洲福利在线播放| 精品久久久精品久久久| 色综合站精品国产| 精品国内亚洲2022精品成人| 久久精品影院6| 成人18禁高潮啪啪吃奶动态图| 免费少妇av软件| 很黄的视频免费| 日韩免费av在线播放| 国产亚洲av嫩草精品影院| 色老头精品视频在线观看| 亚洲狠狠婷婷综合久久图片| 黑人操中国人逼视频| 变态另类丝袜制服| 国产成人av激情在线播放| 午夜免费观看网址| 日本三级黄在线观看| 国产成人系列免费观看| 国产单亲对白刺激| 男女午夜视频在线观看| 性少妇av在线| 村上凉子中文字幕在线| 精品无人区乱码1区二区| 不卡一级毛片| 如日韩欧美国产精品一区二区三区| 女同久久另类99精品国产91| 麻豆av在线久日| 成年版毛片免费区| 国产精品久久久久久人妻精品电影| 女人爽到高潮嗷嗷叫在线视频| 91成年电影在线观看| 看免费av毛片| 欧美老熟妇乱子伦牲交| 久久午夜综合久久蜜桃| 免费av毛片视频| 多毛熟女@视频| av欧美777| 老司机午夜福利在线观看视频| 午夜影院日韩av| 日本vs欧美在线观看视频| 好男人电影高清在线观看| 精品欧美国产一区二区三| 一区二区三区激情视频| 国产精华一区二区三区| 亚洲成人免费电影在线观看| 日韩大码丰满熟妇| 黄网站色视频无遮挡免费观看| 一级,二级,三级黄色视频| 日韩精品中文字幕看吧| 狠狠狠狠99中文字幕| 成人永久免费在线观看视频| 51午夜福利影视在线观看| 国产精品亚洲美女久久久| 俄罗斯特黄特色一大片| 亚洲专区字幕在线| 丝袜美腿诱惑在线| 久久精品亚洲精品国产色婷小说| 亚洲欧美一区二区三区黑人| 岛国在线观看网站| 大型av网站在线播放| 日韩精品中文字幕看吧| 免费搜索国产男女视频| 亚洲欧美精品综合一区二区三区| 国产精品久久久久久人妻精品电影| 岛国在线观看网站| 一级片免费观看大全| 老司机在亚洲福利影院| 麻豆av在线久日| 麻豆成人av在线观看| a级毛片在线看网站| 手机成人av网站| 免费搜索国产男女视频| 久热爱精品视频在线9| 中国美女看黄片| 国产视频一区二区在线看| 18美女黄网站色大片免费观看| 精品福利观看| 久久精品成人免费网站| 一级黄色大片毛片| 大香蕉久久成人网| 一区二区三区激情视频| 这个男人来自地球电影免费观看| 亚洲一区二区三区色噜噜| 好男人在线观看高清免费视频 | 午夜福利,免费看| 正在播放国产对白刺激| 国产精品,欧美在线| 国产亚洲欧美精品永久| 在线观看免费视频网站a站| 亚洲avbb在线观看| 亚洲视频免费观看视频| 久久热在线av| 亚洲av成人av| 麻豆一二三区av精品| or卡值多少钱| 国产免费男女视频| 国产成人精品无人区| 国产乱人伦免费视频| 中国美女看黄片| 日本黄色视频三级网站网址| 欧美日韩一级在线毛片| 午夜免费成人在线视频| 久久精品国产99精品国产亚洲性色 | 亚洲性夜色夜夜综合| 久久精品国产综合久久久| 精品国产乱码久久久久久男人| 亚洲专区字幕在线| 啪啪无遮挡十八禁网站| 亚洲欧美日韩另类电影网站| 久9热在线精品视频| 少妇粗大呻吟视频| 亚洲成a人片在线一区二区| 欧美av亚洲av综合av国产av| √禁漫天堂资源中文www| 日韩欧美一区二区三区在线观看| 黄色a级毛片大全视频| 女生性感内裤真人,穿戴方法视频| 中文字幕av电影在线播放| videosex国产| 久久精品亚洲熟妇少妇任你| 母亲3免费完整高清在线观看| 女同久久另类99精品国产91| 欧美人与性动交α欧美精品济南到| 12—13女人毛片做爰片一| 久久这里只有精品19| 搞女人的毛片| 午夜福利在线观看吧| 国产精品亚洲一级av第二区| 国产av又大| 嫩草影视91久久| 女人被狂操c到高潮| 欧美在线黄色| 多毛熟女@视频| 1024香蕉在线观看| 看免费av毛片| videosex国产| 99国产精品一区二区三区| a级毛片在线看网站| 在线观看www视频免费| 国产欧美日韩综合在线一区二区| 亚洲国产毛片av蜜桃av| 国产av一区在线观看免费| 亚洲成av片中文字幕在线观看| 日日夜夜操网爽| 国产精品爽爽va在线观看网站 | 亚洲三区欧美一区| 在线观看日韩欧美| 亚洲国产精品sss在线观看| 国产精品 欧美亚洲| 深夜精品福利| 咕卡用的链子| 一个人观看的视频www高清免费观看 | 亚洲欧美日韩无卡精品| 欧美日韩亚洲国产一区二区在线观看| 亚洲激情在线av| 黄片播放在线免费| 90打野战视频偷拍视频| 国产精品国产高清国产av| 1024视频免费在线观看| 欧美一区二区精品小视频在线| 非洲黑人性xxxx精品又粗又长| 国产成人系列免费观看| 最新美女视频免费是黄的| 女生性感内裤真人,穿戴方法视频| 国产亚洲精品一区二区www| 啪啪无遮挡十八禁网站| 免费在线观看影片大全网站| 十分钟在线观看高清视频www| 99re在线观看精品视频| 国产日韩一区二区三区精品不卡| 变态另类丝袜制服| 午夜福利影视在线免费观看| 又大又爽又粗| 18禁观看日本| 校园春色视频在线观看| 亚洲精品美女久久久久99蜜臀| 精品高清国产在线一区| 色播亚洲综合网| 亚洲三区欧美一区| 久99久视频精品免费| 久久人人精品亚洲av| 美女扒开内裤让男人捅视频| 精品乱码久久久久久99久播| 成人精品一区二区免费| 亚洲黑人精品在线| 中文亚洲av片在线观看爽| 无人区码免费观看不卡| 日韩 欧美 亚洲 中文字幕| 亚洲情色 制服丝袜| 久久久精品欧美日韩精品| 女性被躁到高潮视频| 国产精华一区二区三区| 涩涩av久久男人的天堂| 成人18禁在线播放| 色综合站精品国产| 精品福利观看| 国产极品粉嫩免费观看在线| 在线观看一区二区三区| 看免费av毛片| 国产高清有码在线观看视频 | 黄色丝袜av网址大全| 国产一区二区激情短视频| 欧美国产精品va在线观看不卡| 大香蕉久久成人网| 精品人妻1区二区| 国内久久婷婷六月综合欲色啪| АⅤ资源中文在线天堂| 国产成+人综合+亚洲专区| 丝袜人妻中文字幕| 国产男靠女视频免费网站| 国产av一区在线观看免费| 琪琪午夜伦伦电影理论片6080| 又黄又爽又免费观看的视频| 99riav亚洲国产免费| 97碰自拍视频| 黄色丝袜av网址大全| 90打野战视频偷拍视频| 一级a爱视频在线免费观看| 香蕉国产在线看| 午夜福利18| 日韩欧美在线二视频| 美女高潮到喷水免费观看| 欧美 亚洲 国产 日韩一| 嫁个100分男人电影在线观看| 国产av在哪里看| svipshipincom国产片| 久久久国产精品麻豆| 777久久人妻少妇嫩草av网站| 国产欧美日韩综合在线一区二区| 免费少妇av软件| 国产成人av激情在线播放| 性色av乱码一区二区三区2| 久久久久久免费高清国产稀缺| 国产精品亚洲av一区麻豆| 国产一卡二卡三卡精品| 午夜福利影视在线免费观看| 给我免费播放毛片高清在线观看| 男女午夜视频在线观看| 欧美久久黑人一区二区| 欧美日韩乱码在线| 欧美亚洲日本最大视频资源| 人妻久久中文字幕网| 亚洲熟妇中文字幕五十中出| 又黄又粗又硬又大视频| 青草久久国产| 国产xxxxx性猛交| 怎么达到女性高潮| 亚洲av熟女| 日韩免费av在线播放| 欧洲精品卡2卡3卡4卡5卡区| 国产成人精品在线电影| 亚洲熟女毛片儿| 国产单亲对白刺激| 老汉色av国产亚洲站长工具| 亚洲最大成人中文| 精品熟女少妇八av免费久了| 两个人免费观看高清视频| 精品卡一卡二卡四卡免费| a在线观看视频网站| 亚洲成人精品中文字幕电影| 啦啦啦观看免费观看视频高清 | 身体一侧抽搐| 熟女少妇亚洲综合色aaa.| 欧美日韩中文字幕国产精品一区二区三区 | 日韩精品免费视频一区二区三区| 久久 成人 亚洲| 18美女黄网站色大片免费观看| 女人高潮潮喷娇喘18禁视频| 91老司机精品| 狠狠狠狠99中文字幕| 日本免费一区二区三区高清不卡 | 变态另类丝袜制服| 九色亚洲精品在线播放| 97超级碰碰碰精品色视频在线观看| 国产一卡二卡三卡精品| 女人爽到高潮嗷嗷叫在线视频| 黄片大片在线免费观看| 天天躁狠狠躁夜夜躁狠狠躁| 亚洲 欧美一区二区三区| av超薄肉色丝袜交足视频| 日韩精品青青久久久久久| 国产片内射在线| 免费观看人在逋| 欧美一区二区精品小视频在线| 丰满人妻熟妇乱又伦精品不卡| 亚洲狠狠婷婷综合久久图片| 黄网站色视频无遮挡免费观看| 精品欧美一区二区三区在线| 国产黄a三级三级三级人| 久热爱精品视频在线9| 女人被狂操c到高潮| 99在线人妻在线中文字幕| 国产精品免费视频内射| 操出白浆在线播放| 亚洲视频免费观看视频| 在线观看舔阴道视频| 久久午夜亚洲精品久久| 久久亚洲精品不卡| 精品高清国产在线一区| 给我免费播放毛片高清在线观看| 一a级毛片在线观看| 黑人操中国人逼视频| 国产av又大| 久久婷婷人人爽人人干人人爱 | 亚洲五月天丁香| 天天躁夜夜躁狠狠躁躁| 色尼玛亚洲综合影院| 亚洲性夜色夜夜综合| 每晚都被弄得嗷嗷叫到高潮| 校园春色视频在线观看| 国产av精品麻豆| 动漫黄色视频在线观看| 国产精品久久电影中文字幕| 嫩草影院精品99| 亚洲专区国产一区二区|