• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Clinical features and treatment of near-work-related acquired esotropia

    2022-08-10 01:39:44RuiLinGuoLiKunAiShiQiangZhao
    關鍵詞:鬼子應用型院校

    INTRODUCTION

    大部分應用型本科院校已根據自身的專業(yè)特色,建立了相對成熟的校企合作機制。而電子商務實踐的教學改革,正好可以利用這一優(yōu)勢,搭建適合電子商務課程的實踐平臺,以企業(yè)的實踐工作和社會發(fā)展趨勢為導向,為學生提供更接地氣的學習環(huán)境。應用型本科院校還可以聘請創(chuàng)新創(chuàng)業(yè)培訓團隊的企業(yè)講師做學生的“場外指導”,將工作實踐第一線的內容搬到教學實踐中,幫助學生制訂工作計劃,擬訂工作任務,以小組為單位展開競賽,能夠極大地提高教學效果。

    With the development of society and the widespread popularity of portable electronic devices, the number of ACE patients has increased. Most of these patients suffer from distant diplopia, with mild or asymptomatic near symptoms that can be relieved after rest. They spend long periods using mobile devices, which eventually results in constant diplopia. This kind of ACE is temporarily being called near-work-related esotropia

    . There have been few reported studies on esotropia,and its mechanism remains unknown, including its relation with the duration of near vision, dioptre, accommodation and convergence as well as the difference in binocular visual function, accommodation and convergence amplitude between patients and normal people. This study intends to explore the causes of the occurrence and development of this kind of esotropia and evaluate the therapeutic efficacy of botulinum toxin extraocular muscle injections by analysing the differences in accommodation and convergence, binocular vision and other functions between these patients and normal people.

    SUBJECTS AND METHODS

    To assess the effect of the treatment from the standpoint of the patients, each participant needed to subjectively assess the severity of their symptoms at each visit before and after treatment on a scale from zero to four. With higher scores,the patients experienced more diplopia: 0 meant no diplopia,neither distant nor near; 1 indicated occasional diplopia only at a distance; 2 meant occasional diplopia, both distant and near;3 suggested diplopia most of the time; and 4 indicated diplopia in the distance and near all the time (diplopia score 0:4).

    In this study, from April 2015 to November 2018,107 patients with near-work-related esotropia who were treated in Beijing Tongren Hospital affiliated with Capital Medical University were recruited as participants in the experimental group. Another 30 peers without near-work-related esotropia were included in the control group

    A total of 107 patients were included in the experimental group: 52 males (48.6%) and 55 females (51.4%). The average age was 31.06±10.64 (range 15-57)y. There were 30 participants in the control group:17 females (56.67%) and 13 males (43.33%). The average age was 32.1±7.97 (range 16-53)y. There was no significant difference in age (

    =0.825) or sex (

    =0.61) between the two groups (Table 1).

    重慶市家庭過期藥品居民處置行為調查及回收建議…………………………………………………… 付曉娟等(7):999

    The general ophthalmological testing included refraction, best-corrected visual acuity, slit-lamp and fundus exams. The patients’ primary characteristics were collected,such as their age, sex, time of onset, main symptoms and occupation. At the same time, the patients’ medical history,daily duration of close distance (≤30 cm) eye use and habit of taking off glasses to see near objects.

    This study was conducted following the Declaration of Helsinki and was approved by the Ethics Committee of Beijing Tongren Hospital affiliated with Capital Medical University. All participants signed their informed consent.

    For the patients and normal participants over 18 years of age, manifest refraction was performed; for those under 18,cycloplegic refraction with 1% tropicamide was performed first, followed by post-cycloplegic refraction the next day to get the final endpoint. The following data were measured after completing the refractive correction: adjustment amplitude(negative lens method), positive and negative relative accommodation (PRA and NRA, respectively), accommodative convergence to accommodation ratio (AC/A; gradient method),distant and near-horizontal squint angle (prism alternating cover test and Von Graefe method), distant and near-horizontal imaging function, binocular vision function and stereopsis(Worth four-point lamp, Synoptophore and Titmus near stereopsis).

    Acute acquired comitant esotropia (ACE) has a large impact on binocular visual functions of patients. It is common among juveniles and adults

    . Diplopia develops suddenly in most patients who also show esotropia without symptoms of ophthalmoplegia or organic lesions. This kind of esotropia usually has a certain binocular visual function

    .Diplopia refers to the abnormal phenomenon of two images appearing when two eyes look at one object, which is caused by deviation of the visual axis and projection of the object image onto the macular fovea of one eye and the area outside the fovea of the other eye

    .

    Botulinum toxin type A (BTXA; Hengli, Lanzhou Institute of Biological Products) injection is a freeze-dried crystalline product; there are 100 units per bottle, where one unit is a 50% lethal dose in a mouse, which is equivalent to 0.04 ng

    .All patients were injected with BTXA in the medial rectus of both eyes. Alcaine surface anaesthetic (0.5%) was used before injection. Under the guidance of an EMG magnifier, a monopole needle-like electrode was used for the medial rectus of both eye injections. The dose of each injection was recorded.All patients were reexamined ten months after treatment.

    The software program SPSS 22.0(IBM, Chicago, USA) was used to conduct the statistical analysis. The continuous variables of normal distribution were expressed as the mean±standard deviation, the continuous variables of non-normal distribution were expressed as the median (interquartile range), and the categorical variables were expressed as the frequency (%). For two comparisons,each value was compared by a

    -test when the data conformed to the normal distribution, while the non-normally distributed continuous data were compared using non-parametric tests.The counting data were tested by the Chi-square test. A value of

    <0.05 was considered statistically significant.

    Normally, accommodation of 1 D could cause a set of 3-5 prism dioptors of convergence (AC/A: 3-5)

    . The data of the two groups were in the normal range. There was no significant difference between the two groups, but the AC/A of the experimental group was slightly higher than that of the control group. Although some studies have shown that the AC/A is constant over one’s lifetime

    , it is still worthy of long-term observation.

    RESULTS

    Inclusion criteria: 1) bestcorrected visual acuity ≥1.0; 2) no history of prior esotropia or systemic disease; 3) seeing distant complexes was the first symptom, diplopia is horizontal ipsilateral, and the distance between objects in all directions is equal; and 4) near vision≥4h per day (distance between the eyes and the object ≤30 cm).Exclusion criteria: 1) patients with other systemic diseases; 2)patients with incomplete data.

    According to the measurements, the recruited patients did not have presbyopia, and the influence of refractive error was excluded in the patients with glasses. So,both factors could be excluded. After the examination, only 2 of the 107 patients in the experimental group had remarkable overcorrection of myopia, while no remarkable overcorrection of myopia was observed in the control group.

    The results of this study showed that the refraction of the two groups conformed to a normal distribution. In the experimental group, the refractive error was -3.63±2.56 D in the right eye and -3.61±2.39 D in the left eye. There was no significant difference in the refraction between the left and right eyes.In the control group, the refractive error was -2.80±2.56 D in the right eye and -2.61±2.39 D in the left eye. There was no significant difference between the two eyes. There was also no significant difference in the refraction between the two groups(Table 2).

    In this study, 79.5% of the patients in the experimental group had a habit of taking off their glasses to see near objects, and 3.2% of the patients in the control group had the same habit. The rate of this habit in the experimental group was significantly higher than that in the control group (

    =0.00; Table 3).

    The results exhibited that the AC/A was (3.97±1.66)

    /D in the experimental group and (3.20±1.15)

    /D in the control group(

    =0.089; Table 4). In the experimental group, the NRA was 2.18±0.61 D in the right eye and 2.25±0.64 D in the left eye;the NRA of both eyes was 2.37±0.73 D. In the control group,the NRA was 2.21±0.44 D in the right eye and 2.18±0.43 D in the left eye; the NRA of both eyes was 2.28±0.40 D (Table 5). It is worth noting that there was a significant difference in the PRA between the two groups (Table 6). In the experimental group,the PRA was -2.59±2.15 D in the right eye and -2.53±2.19 D in the left eye; the PRA of both eyes was -2.27±2.17 D. In the control group, the PRA was -4.21±1.93 D in the right eye and -4.37±1.87 D in the left eye; the PRA of binoculus was-3.73±1.45 D.

    In the near-work-related esotropia group, 84.9% of the patients had far stereoscopic vision, 15.1% had no distant stereoscopic vision, 77.5% had near stereoscopic vision, and 22.5% had no near stereoscopic vision. In the control group, the number of people with far and near stereopsis was 100%, and there was a significant difference. Distant stereopsis was found in 84.9% of patients in the experimental group; 15.1% of the patients had no distant stereopsis. Additionally, 77.5% of patients had near stereopsis and 22.5% had no near stereopsis in the experimental group. In the control group, all patients had distant and near stereopsis. Based on the above data, the difference between the two groups was statistically significant.

    The range of ex-fusion was (-6.49±4.22)° in the experimental group and (-6.77±1.81)° in the control group (

    >0.05). The infusion range was (9.84±5.72)° in the experimental group and(22.04±8.71)° in the control group (

    =0.000). The fusion range in the experimental group was smaller than that in the control group (Figure 1).

    The follow-up results showed that in the near-work-related esotropia group, the duration of looking closely was (9.26±2.97)h, the onset time was (21.13±20.68)mo,the near esotropia angle was (17.08±11.98)

    , and the distant esotropia angle was (19.07±11.68)

    , demonstrating the significant difference between the distant and near squint angles (

    <0.05).Twenty-seven patients received the BTXA injection treatment.The diplopia score was 3.57±0.39 before treatment and 0.47±0.64 after treatment, which evidenced that the diplopia symptoms of most patients improved. Ten months after treatment, the squint angles of distant and near vision were(4.07±3.86)

    and (1.93±2.86)

    , respectively. The difference between the pre-treatment and post-treatment values was statistically significant (

    <0.05).

    研究學問為什么要勇敢???做一個學者,你每有一個新的發(fā)現(xiàn)或新的突破,必然會使很多傳統(tǒng)勢力不悅,學術上每邁一個臺階,必然有很多人不滿意,如果沒有一種勇敢的精神,突破這些傳統(tǒng)的觀念,大概就不大容易做成事情。

    After 10mo of treatment, the diplopia and esotropia of most patients had improved after treatment (

    <0.05).

    DISCUSSION

    In the clinical trial, we noticed that the patients were able to describe their symptoms very clearly and precisely; some even listed the specific dates when they were or were not symptomatic. They were well educated and generally anxious.Additionally, convergence spasm, which is often provoked by fixation at near, is associated with certain psychiatric conditions

    . This made us believe that there might be some predisposing psychological factors to near-work-related esotropia. We then attempted to qualify the personality trait of perfectionism in this group using a scale from 0 to 4, with higher scores tending toward perfectionism (self-serious level score 0:4).

    The results of this study revealed that 84.9% of patients in the experimental group had distant stereopsis. Additionally,77.5% of patients had near stereopsis in the experimental group. In the control group, all patients had distant and near stereopsis. The results showed that there were significant differences. Of the patients with near-work-related esotropia,89.72% had ametropia of more than -1.0 D. These patients needed little or no accommodation when looking closely at something, but more convergence was still needed to achieve better proximal binocular vision that led to the occurrence of tonic convergence, visual proximity convergence and fusional convergence

    . This made the patients unable to relax when adjusting their vision, resulting in distant-look diplopia. In this study, 79.5% of the patients with near-work-related esotropia had a habit of taking off their glasses to see nearby objects, as did 3.2% of the participants in the control group. There was a significant difference between the two groups. Therefore, it was speculated that taking off glasses to see nearby objects is one of the determinants inducing the onset of this kind of esotropia

    . Most of the patients with ACE suffered acute onset, especially young people and adults

    . Most patients had good binocular vision before the onset of esotropia and abnormal binocular retinas after the esotropia affected their stereoscopic vision

    . Therefore, this examination demonstrated that the visual function of the patients was affected by esotropia. However, several studies have shown that there is no significant correlation between the time of onset and the prognosis of stereoscopic function.

    近年來,在“健康中國”戰(zhàn)略下,受益技術驅動,響應分級診療政策,各大型公立醫(yī)院紛紛加大智慧醫(yī)療與全民健康事業(yè)的深度融合力度,旨在進一步改善患者就醫(yī)體驗,促進服務效率提升的智慧化項目相繼落地。

    在教師對學生的評價方面,要采用平時性評價及終結性評價各占一定比例的方式。對于平時性評價,教師要根據學生的課堂表現(xiàn)、在線學習的登錄次數、在線學習時間及閱讀量、在線提交的作業(yè)完成情況、討論發(fā)言的總體表現(xiàn)、網絡無紙化測試成績等方面進行綜合評估。學生在課堂上完成任務之后,教師還應該組織學生開展評價活動,評價的內容要針對學生在完成語言任務的過程進行及時。中肯的評價,這種教師評價、學生互評、自我評價相結合的評價方式能讓學生在展示自身任務、觀看其他同學的任務并參與評價的過程中對教師及同學的評價進行反思,并從中獲得進步。

    The PRA and NRA can indirectly evaluate the ability of image sets. The NRA refers to the ability to adjust and relax when a set is fixed, while the PRA refers to the ability to increase the adjustment reserve when a set remains unchanged. If the relative adjustment ability is strong, then the imaging set is large; if the relative adjustment ability is weak, then the imaging set is small. In this study, the PRA of the experimental group was significantly lower than that of the control group,but there was no significant difference in the NRA. According to Yekta

    mean NRA and PRA is +2.08±0.33 and-2.92±0.76 D in an Iranian young adult population. The maximum expectable normal NRA could be up to +2.5 D,but the maximum PRA depends on different factors. The PRA is usually stopped at -2.5 D by the examining physician to balance the PRA and NRA values, though the true value of the PRA could be even higher

    . The NRA of our results was in the same range, while the PRA was higher; this might depend on age, dioptre, gender and other factors

    . The PRA in the experimental group was significantly lower than that in the control group. When the binocular set was fixed, the accommodation of the eye increased or decreased separately,and the imaging set was used instead of the accommodative set to maintain the binocular vision, which was called relative adjustment. Combining these results for the NRA and PRA values, it was speculated that patients with a low regulatory reserve for a lengthy period of using near vision experienced a retinal defocus phenomenon, induced regulation and regulatory collection, resulting in esotropia. At the same time, the smaller PRA indirectly reflected the poor imaging aggregation ability of the patients, which was consistent with the symptoms of diplopia

    .

    The range of in-fusion in the experimental group was significantly smaller than that in the control group, but the ex-fusion results showed no significant difference between the two groups. Previous studies have proven that the scope of convergence is negatively related to the encouragement,examination sequence, distance and focal length. This study’s results discovered that the fusion range of the experimental group became smaller and that the esotropia angle became larger. The fusion range of the patients with near-work-related esotropia was reduced, and the imaging set was insufficient.Therefore, it was necessary to mobilise other fusion functions,such as tension collection, which resulted in poor eye position control and esotropia, and the binocular visual function of some patients was damaged. The follow-up results of this study showed that there was a significant difference between the distant esotropia angle and the near esotropia angle in the experimental group. This feature was similar to ‘divergence insufficient esotropia’

    . It has been speculated that long-term close vision may lead to medial rectus spasm, which causes the eye position to change when looking far away, bringing about changes in the farsighted eye position, abnormal location of the retina and diplopia

    .

    In this study, all patients suffered from long-distance diplopia,initially long-term close vision after long-term diplopia,which can be relieved after rest and eventually developed into continuous hypermetropia and even diplopia with the aggravation of the course of the disease. Twenty-seven patients received a BTXA extraocular muscle injection. Ten months after treatment, most patients had ameliorated diplopia symptoms. There was also a significant difference in the esotropia angle between ten months before and after treatment,which indicated that the BTXA played an important role in treating the esotropia and reducing the diplopia symptoms. It was confirmed that this kind of esotropia is associated with medial rectus spasm

    . Ten months after surgery, the diplopia and esotropia of most patients presented an improvement after treatment. The remission of symptoms after the extraocular injection of BTXA could certify this conclusion.

    我操。我也重復了一遍李耕田的倆字,確實有問題了,而且問題就像禿子頭上的虱子一樣明顯。我掏出李老黑給我的標語內容對照了一下,問題不是出在我這里。

    天亮了。這是一個難得的好天氣,湛藍的天空中,飄著幾縷淡薄的白云。一輪紅日從東邊噴薄而出,朝霞把群山染得一片血紅。從山頂望出去,群山逶迤,林莽葳蕤。在高家?guī)X山腳下,鬼子像螞蟻一樣密密麻麻地往這邊涌過來。看來,這至少是一個近千人的鬼子大隊。

    However, this study was a retrospective study. According to the data, we found that there were differences in the aspect of the accommodation function between the patients and the general population. The differences could explain some of the symptoms of the patients, such as esotropia and diplopia, but were insufficient to prove that the accommodation function defect provoked the esotropia or that the esotropia led to the anomaly of the accommodation function. These specific conclusions need further confirmation by prospective cohort studies.

    There were still several limitations in this study. First, this study was a case-control study, not a randomised controlled trial.Second, this study was a single-centre clinical study with a small sample size. It is necessary to enlarge the sample size across multiple centres. Third, the clinical follow-up was of short duration. Longer follow-up observation is still needed.In conclusion, this study evidenced that the regulation function and the habit of taking off one’s glasses when looking closely are related to near-work-related esotropia; however, the length of time spent looking closely at something and the onset time have nothing to do with it. Therefore, near-work-related esotropia may be inhibited by regulation function training in the early stage of this disease. Additionally, BTXA injections play a significant role in relieving diplopia and restoring eye position.

    ACKNOWLEDGEMENTS

    Guo RL conceived of the study;Ai LK participated in its design and coordination; Zhao SQ helped to draft the manuscript. All authors read and approved the final manuscript.

    None;

    None;

    None.

    1 Li B, Sharan S. Evaluation and surgical outcome of acquired nonaccommodative esotropia among older children.

    2018;53(1):45-48.

    2 Buch H, Vinding T. Acute acquired comitant esotropia of childhood: a classification based on 48 children.

    2015;93(6):568-574.

    3 Fu T, Wang J, Levin M, Xi P, Li DG, Li JF. Clinical features of acute acquired comitant esotropia in the Chinese populations.

    2017;96(46):e8528.

    4 Erkan Turan K, Kansu T. Acute acquired comitant esotropia in adults: is

    it neurologic or not?

    2016;2016:2856128.

    5 Kumar N, Kaur S, Raj S, Lal V, Sukhija J. Causes and outcomes of patients presenting with diplopia: a hospital-based study.

    2021;45(4):238-245.

    6 Oghene J, Boppana SH, Reddy P, Beutler BD, Dalal D. Double down on double vision: an unusual case of painful diplopia.

    2021;13(12):e20838.

    7 Meng YF, Hu XM, Huang XQ, Zhao YJ, Ye MH, Yi BX, Zhou LH.Clinical characteristics and aetiology of acute acquired comitant esotropia.

    2022;105(3):293-297.

    8 Gupta S, Gan J, Jain S. Efficacy of botulinum toxin in the treatment of convergence spasm.

    2018;26(3):122-125.

    9. Shklarov S. Double vision uncertainty.

    2007;17(4):529-538.

    10 Gisselbaek S, Hoeckele N, Klainguti G, Kaeser PF. Clinical classification of acquired concomitant esotropia.

    2021;238(4):482-487.

    11 Zhu MY, Tang Y, Wang ZH, Shen T, Qiu X, Yan JH, Chen JC. Clinical characteristics and risk factors of acute acquired concomitant esotropia in last 5 years: a retrospective case-control study.

    2022:Epub ahead of print.

    12 Hao R, Zhang W, Zhao KX. Clinical analysis and surgical treatment of atypical acute acquired concomitant esotropia.

    2021;57(5):348-352.

    13 Shi MH, Zhou YX, Qin AJ, Cheng J, Ren HX. Treatment of acute acquired concomitant esotropia.

    2021;21(1):9.

    14 Kimura A. Age-related Strabismus.

    2015;119(9):611.

    15 Chang F, Wang T, Yu J, Li M, Lu N, Chen X. Prism treatment of acute acquired concomitant esotropia precipitated by visual confusion.

    2020;28(1):7-12.

    16 Zhao KX.

    . Beijing: People’s Medical Publishing House. 2011:26-27.

    17 Noorden GKV, Campos EC.

    St Louis,Missouri 63141, United States of America. 2002.

    18 Yekta A, Khabazkhoob M, Hashemi H,

    . Binocular and accommodative characteristics in a normal population.

    2017;25(1):5-11.

    19 Scheiman M, Wick B. Diagnostic testing. In: Scheiman M, Wick B, eds.

    Philadelphia:Lippincott Williams & Wilkins;2008:3-49.

    20 Darko-Takyi C, Moodley VR, Boadi-Kusi SB. Normative data for nonstrabismic binocular vision parameters in African schoolchildren.

    2021;98(6):620-628.

    21 VanderVeen DK, Bremer DL, Fellows RR, Hardy RJ, Neely DE,Palmer EA, Rogers DL, Tung B, Good WV. Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial.

    2011;15(6):536-540.

    22 O’Day R, Roelofs K, Negretti G, Hay G, Arora A. Long-term visual outcomes after ruthenium plaque brachytherapy for posterior choroidal melanoma.

    2022: Epub ahead of print.

    23 Topcu Yilmaz P, Ural Fatihoglu ?, Sener EC. Acquired comitant esotropia in children and young adults: clinical characteristics,surgical outcomes, and association with presumed intensive near work with digital displays.

    2020;57(4):251-256.

    24 Papageorgiou E, Kardaras D, Kapsalaki E, Dardiotis E, Mataftsi A,Tsironi EE. Spasm of the near reflex: a common diagnostic dilemma?

    2021;14(4):541-546.

    25 Escuder AG, Hunter DG. The role of botulinum toxin in the treatment of strabismus.

    2019;34(4):198-204.

    猜你喜歡
    鬼子應用型院校
    一個人的抗戰(zhàn)
    百花園(2022年7期)2022-12-29 05:38:28
    關于應用型復合人才培養(yǎng)的教學模式探討
    遼寧絲綢(2022年1期)2022-03-29 00:59:06
    “5-2-1”應用型人才培養(yǎng)模式探索實踐
    萬國造槍打鬼子
    牛山魁打鬼子
    艱難的行走(隨筆)
    作品(2018年9期)2018-09-10 21:13:47
    第8講 “應用型問題”復習精講
    基于應用型的成本會計教學改革
    院校傳真
    院校傳真
    国产爱豆传媒在线观看| 国产又色又爽无遮挡免| 干丝袜人妻中文字幕| 91在线精品国自产拍蜜月| 91在线精品国自产拍蜜月| 最后的刺客免费高清国语| 精品久久久久久久末码| 国产精品女同一区二区软件| 久久久久久国产a免费观看| 亚洲国产av新网站| 精品久久久久久电影网| 日韩三级伦理在线观看| 国产精品人妻久久久影院| 国产欧美另类精品又又久久亚洲欧美| 国产一区二区亚洲精品在线观看| 亚洲国产精品成人久久小说| 日韩一区二区视频免费看| 99视频精品全部免费 在线| 黄片wwwwww| 欧美一区二区亚洲| 久久草成人影院| 在线播放无遮挡| 久久热精品热| 日韩强制内射视频| 免费在线观看成人毛片| 国产伦理片在线播放av一区| 国产真实伦视频高清在线观看| 色综合站精品国产| 久久久久性生活片| 亚洲无线观看免费| 国产真实伦视频高清在线观看| 国产高清国产精品国产三级 | 日韩av免费高清视频| 一区二区三区免费毛片| 九九爱精品视频在线观看| 不卡视频在线观看欧美| 免费播放大片免费观看视频在线观看| 日日干狠狠操夜夜爽| 女人被狂操c到高潮| 国产精品不卡视频一区二区| 日韩av不卡免费在线播放| 久久人人爽人人爽人人片va| 国产麻豆成人av免费视频| 成人一区二区视频在线观看| 亚洲精品亚洲一区二区| 少妇裸体淫交视频免费看高清| 少妇熟女欧美另类| 欧美高清成人免费视频www| 在线观看av片永久免费下载| 欧美性猛交╳xxx乱大交人| 午夜激情欧美在线| 亚洲性久久影院| 2022亚洲国产成人精品| 少妇裸体淫交视频免费看高清| 干丝袜人妻中文字幕| 亚洲无线观看免费| 少妇人妻一区二区三区视频| 国产免费视频播放在线视频 | 亚洲国产av新网站| 日韩欧美精品免费久久| 精品久久久噜噜| 欧美xxⅹ黑人| 白带黄色成豆腐渣| 国产伦一二天堂av在线观看| 久久久欧美国产精品| 亚洲,欧美,日韩| 亚洲,欧美,日韩| 美女脱内裤让男人舔精品视频| 日韩一本色道免费dvd| 九九久久精品国产亚洲av麻豆| 精品久久国产蜜桃| 天天躁日日操中文字幕| 一级毛片我不卡| 超碰av人人做人人爽久久| 久久午夜福利片| 午夜福利成人在线免费观看| 国产成人一区二区在线| 国产女主播在线喷水免费视频网站 | 亚洲欧美一区二区三区黑人 | 天堂中文最新版在线下载 | 免费观看精品视频网站| 美女被艹到高潮喷水动态| 久久久精品免费免费高清| 国产精品.久久久| 国产亚洲5aaaaa淫片| 国产国拍精品亚洲av在线观看| 亚洲国产欧美在线一区| 丝袜美腿在线中文| 一本久久精品| 成人二区视频| 51国产日韩欧美| 国产乱来视频区| 国产精品熟女久久久久浪| 男女视频在线观看网站免费| 亚洲av一区综合| 18禁裸乳无遮挡免费网站照片| 麻豆乱淫一区二区| 精品99又大又爽又粗少妇毛片| 欧美潮喷喷水| 网址你懂的国产日韩在线| 少妇丰满av| 一区二区三区免费毛片| 日本一本二区三区精品| 午夜日本视频在线| 99九九线精品视频在线观看视频| 亚洲美女搞黄在线观看| 日本黄大片高清| 色综合站精品国产| 午夜福利成人在线免费观看| 欧美区成人在线视频| 亚洲精品色激情综合| 麻豆成人午夜福利视频| 欧美高清成人免费视频www| 2021天堂中文幕一二区在线观| 久久综合国产亚洲精品| 日韩欧美国产在线观看| 亚洲精品乱码久久久久久按摩| 亚洲av电影在线观看一区二区三区 | 免费看日本二区| www.av在线官网国产| 国产精品av视频在线免费观看| 精品久久久久久久末码| 中文字幕av在线有码专区| 婷婷色麻豆天堂久久| 免费不卡的大黄色大毛片视频在线观看 | 免费观看的影片在线观看| 国产精品久久久久久久久免| 国产乱人偷精品视频| 夜夜爽夜夜爽视频| 亚洲,欧美,日韩| 22中文网久久字幕| 久久这里只有精品中国| 日本猛色少妇xxxxx猛交久久| 卡戴珊不雅视频在线播放| 秋霞在线观看毛片| 国产大屁股一区二区在线视频| 中文资源天堂在线| 在线天堂最新版资源| 一级毛片 在线播放| 婷婷色综合www| 美女被艹到高潮喷水动态| 国产爱豆传媒在线观看| 欧美zozozo另类| 国产在视频线在精品| 国产精品一区二区性色av| 夫妻午夜视频| 18禁动态无遮挡网站| 波野结衣二区三区在线| 成人特级av手机在线观看| 欧美3d第一页| 亚洲欧美精品自产自拍| 搡老妇女老女人老熟妇| 亚洲精品一区蜜桃| 亚洲av日韩在线播放| 精品一区在线观看国产| 又爽又黄无遮挡网站| 亚洲av二区三区四区| 国产精品人妻久久久影院| 少妇熟女欧美另类| 国产熟女欧美一区二区| 亚洲av一区综合| 直男gayav资源| 三级国产精品欧美在线观看| 69人妻影院| 日韩欧美国产在线观看| 中文天堂在线官网| 卡戴珊不雅视频在线播放| 日本一本二区三区精品| 国产真实伦视频高清在线观看| 亚洲高清免费不卡视频| 日韩一区二区视频免费看| 街头女战士在线观看网站| 91久久精品国产一区二区成人| 高清在线视频一区二区三区| 久久热精品热| 大片免费播放器 马上看| 99热这里只有是精品50| 美女大奶头视频| 丰满少妇做爰视频| 97超碰精品成人国产| 91av网一区二区| 色哟哟·www| 51国产日韩欧美| 日本熟妇午夜| 国产成人精品婷婷| 建设人人有责人人尽责人人享有的 | av国产久精品久网站免费入址| 精品久久久噜噜| 亚洲真实伦在线观看| 一个人观看的视频www高清免费观看| 男女那种视频在线观看| 国产真实伦视频高清在线观看| 亚洲va在线va天堂va国产| 亚洲av中文字字幕乱码综合| 久久久成人免费电影| 国产精品久久久久久精品电影小说 | 午夜爱爱视频在线播放| 亚洲经典国产精华液单| 2018国产大陆天天弄谢| 国产精品久久久久久久久免| 日韩av不卡免费在线播放| 亚洲欧美日韩卡通动漫| 91精品一卡2卡3卡4卡| 精品国产三级普通话版| 国产麻豆成人av免费视频| 岛国毛片在线播放| 亚洲av福利一区| 婷婷色av中文字幕| 国内少妇人妻偷人精品xxx网站| 国产黄色小视频在线观看| 99热这里只有是精品50| 97人妻精品一区二区三区麻豆| 亚洲va在线va天堂va国产| 国产精品不卡视频一区二区| 国产精品久久久久久精品电影| 久久人人爽人人片av| 免费av不卡在线播放| 一级a做视频免费观看| 国产v大片淫在线免费观看| 午夜福利在线观看免费完整高清在| 欧美一区二区亚洲| 免费人成在线观看视频色| 美女大奶头视频| 老司机影院成人| 国产成人freesex在线| 精品午夜福利在线看| 99热这里只有是精品在线观看| 欧美日韩一区二区视频在线观看视频在线 | 亚洲一级一片aⅴ在线观看| 三级国产精品片| 女人久久www免费人成看片| 日本猛色少妇xxxxx猛交久久| 亚洲av电影不卡..在线观看| 国产亚洲5aaaaa淫片| 亚洲精品国产av成人精品| 国产午夜精品论理片| 日韩大片免费观看网站| 国产一级毛片在线| 日日啪夜夜撸| 国产精品嫩草影院av在线观看| 亚洲在久久综合| 在线免费观看的www视频| 美女高潮的动态| 成年女人看的毛片在线观看| 91久久精品国产一区二区成人| 久久久精品免费免费高清| 久久这里只有精品中国| 免费黄色在线免费观看| 亚洲欧美精品自产自拍| 能在线免费看毛片的网站| 国产成人一区二区在线| 在线免费观看的www视频| 嘟嘟电影网在线观看| 我的老师免费观看完整版| 亚洲aⅴ乱码一区二区在线播放| 日韩视频在线欧美| 亚洲国产精品专区欧美| 久久精品久久久久久久性| 国产午夜福利久久久久久| 国精品久久久久久国模美| 成人欧美大片| 亚洲av.av天堂| 蜜桃亚洲精品一区二区三区| 只有这里有精品99| 最近的中文字幕免费完整| 色综合色国产| 搡老乐熟女国产| 亚洲在线自拍视频| 亚洲国产精品专区欧美| 精品久久久久久成人av| 97人妻精品一区二区三区麻豆| 亚洲欧美中文字幕日韩二区| 亚洲第一区二区三区不卡| 久久97久久精品| 波多野结衣巨乳人妻| 高清日韩中文字幕在线| 蜜桃久久精品国产亚洲av| 久久99精品国语久久久| 日韩欧美精品免费久久| 老司机影院毛片| 青青草视频在线视频观看| 午夜精品一区二区三区免费看| 久久久久精品久久久久真实原创| 成人二区视频| 只有这里有精品99| 97精品久久久久久久久久精品| 大陆偷拍与自拍| 深爱激情五月婷婷| 久久久欧美国产精品| 免费不卡的大黄色大毛片视频在线观看 | 天堂网av新在线| 九草在线视频观看| 亚洲精品日韩av片在线观看| 天堂√8在线中文| 中文乱码字字幕精品一区二区三区 | 大香蕉久久网| 九九久久精品国产亚洲av麻豆| 18禁裸乳无遮挡免费网站照片| 国产色爽女视频免费观看| 免费观看在线日韩| 国产一区二区亚洲精品在线观看| 麻豆av噜噜一区二区三区| 免费av不卡在线播放| 又粗又硬又长又爽又黄的视频| a级毛色黄片| 久久久久国产网址| 日韩制服骚丝袜av| 日本欧美国产在线视频| 午夜免费观看性视频| av在线观看视频网站免费| 一个人观看的视频www高清免费观看| 丝袜喷水一区| 亚洲精品日韩在线中文字幕| 性色avwww在线观看| 国产精品一区二区三区四区免费观看| 国产黄片视频在线免费观看| 色5月婷婷丁香| 亚洲欧洲日产国产| 联通29元200g的流量卡| 国产亚洲91精品色在线| 国产成人精品一,二区| 国产伦精品一区二区三区视频9| 欧美丝袜亚洲另类| 久久久亚洲精品成人影院| 婷婷色综合www| .国产精品久久| 久久精品久久精品一区二区三区| 伊人久久精品亚洲午夜| 校园人妻丝袜中文字幕| 欧美激情国产日韩精品一区| 欧美性感艳星| 91狼人影院| 久久久久久久午夜电影| 久久久久久久亚洲中文字幕| 国产成人91sexporn| 极品教师在线视频| av.在线天堂| 大片免费播放器 马上看| 久久鲁丝午夜福利片| 中国国产av一级| 大又大粗又爽又黄少妇毛片口| 亚洲av男天堂| 午夜久久久久精精品| 成人国产麻豆网| 久久草成人影院| 自拍偷自拍亚洲精品老妇| 51国产日韩欧美| av在线蜜桃| 午夜福利视频1000在线观看| 全区人妻精品视频| 免费观看的影片在线观看| 成人亚洲欧美一区二区av| 日韩av在线大香蕉| 岛国毛片在线播放| 少妇猛男粗大的猛烈进出视频 | 欧美日韩在线观看h| 午夜激情欧美在线| 2022亚洲国产成人精品| 狂野欧美白嫩少妇大欣赏| 日韩欧美 国产精品| 亚洲综合精品二区| 免费观看在线日韩| 精品欧美国产一区二区三| 久久久久久久久久人人人人人人| 大片免费播放器 马上看| 亚洲色图av天堂| 色播亚洲综合网| 伦精品一区二区三区| 青春草亚洲视频在线观看| 欧美潮喷喷水| 欧美精品国产亚洲| 中文字幕久久专区| 九色成人免费人妻av| 夜夜爽夜夜爽视频| 麻豆国产97在线/欧美| 免费少妇av软件| 亚洲精品乱久久久久久| 国产成人a区在线观看| 丰满人妻一区二区三区视频av| 伊人久久国产一区二区| 国产成人免费观看mmmm| 免费黄频网站在线观看国产| 亚州av有码| 国产综合懂色| 99热网站在线观看| 国产一区有黄有色的免费视频 | 直男gayav资源| 日本wwww免费看| 精品久久久久久成人av| 亚洲国产av新网站| 真实男女啪啪啪动态图| 777米奇影视久久| 国产成人a区在线观看| 免费电影在线观看免费观看| 日本一本二区三区精品| 2018国产大陆天天弄谢| 欧美变态另类bdsm刘玥| 国产高清国产精品国产三级 | 最近最新中文字幕大全电影3| 国产精品一及| 国产探花在线观看一区二区| 久久久精品94久久精品| 欧美人与善性xxx| 观看美女的网站| 内射极品少妇av片p| 嫩草影院新地址| 日本熟妇午夜| 卡戴珊不雅视频在线播放| 久久久久久久久久久免费av| 在线观看免费高清a一片| 国产白丝娇喘喷水9色精品| av卡一久久| 一个人看的www免费观看视频| 六月丁香七月| 国产熟女欧美一区二区| 国产片特级美女逼逼视频| 纵有疾风起免费观看全集完整版 | 老司机影院毛片| 久久午夜福利片| 精品国产一区二区三区久久久樱花 | 精品熟女少妇av免费看| 成年人午夜在线观看视频 | 欧美成人一区二区免费高清观看| 国产精品一区二区在线观看99 | 伊人久久精品亚洲午夜| 嫩草影院入口| 日本免费在线观看一区| 成人性生交大片免费视频hd| 免费高清在线观看视频在线观看| 嘟嘟电影网在线观看| 男人舔女人下体高潮全视频| 亚洲人成网站在线播| 搡女人真爽免费视频火全软件| 欧美高清性xxxxhd video| 久久99热这里只有精品18| 精品久久久久久久久久久久久| 99久久中文字幕三级久久日本| 国产成人精品一,二区| 日韩av免费高清视频| 男女国产视频网站| 亚洲av中文字字幕乱码综合| 99九九线精品视频在线观看视频| 色综合色国产| 午夜老司机福利剧场| 色网站视频免费| 日本欧美国产在线视频| 男人舔奶头视频| 亚洲一区高清亚洲精品| 亚洲乱码一区二区免费版| 麻豆乱淫一区二区| 97人妻精品一区二区三区麻豆| 亚洲人成网站在线播| 亚洲av男天堂| 秋霞伦理黄片| 日本免费a在线| 国产精品.久久久| 一本久久精品| 久久久亚洲精品成人影院| 99热这里只有是精品在线观看| 亚洲熟女精品中文字幕| 国产成人aa在线观看| 国产成人精品久久久久久| 午夜老司机福利剧场| 成年版毛片免费区| 亚洲国产欧美人成| 观看免费一级毛片| 男人舔女人下体高潮全视频| 麻豆乱淫一区二区| 日韩欧美 国产精品| 最后的刺客免费高清国语| 九草在线视频观看| 欧美一区二区亚洲| 小蜜桃在线观看免费完整版高清| 亚洲18禁久久av| 高清在线视频一区二区三区| 亚洲成人中文字幕在线播放| 熟女人妻精品中文字幕| 亚洲电影在线观看av| 天天躁日日操中文字幕| 日本熟妇午夜| 久久久精品欧美日韩精品| 啦啦啦韩国在线观看视频| 色吧在线观看| 精品人妻一区二区三区麻豆| 少妇被粗大猛烈的视频| 亚洲精品中文字幕在线视频 | 91精品伊人久久大香线蕉| 欧美区成人在线视频| 久久久久精品性色| 亚洲自拍偷在线| 亚洲精品一区蜜桃| 男女边吃奶边做爰视频| 国产成人一区二区在线| 欧美日韩国产mv在线观看视频 | 成人亚洲欧美一区二区av| 中文乱码字字幕精品一区二区三区 | 国产在视频线精品| 91午夜精品亚洲一区二区三区| 超碰97精品在线观看| 日日撸夜夜添| 免费看不卡的av| 色播亚洲综合网| 三级国产精品欧美在线观看| 女人被狂操c到高潮| 色吧在线观看| 国产午夜精品论理片| 97热精品久久久久久| 国国产精品蜜臀av免费| 国产精品人妻久久久久久| 卡戴珊不雅视频在线播放| 三级国产精品欧美在线观看| 超碰97精品在线观看| 高清日韩中文字幕在线| 国产精品不卡视频一区二区| videossex国产| 午夜福利高清视频| 午夜精品国产一区二区电影 | 国产精品日韩av在线免费观看| 国产成人freesex在线| 禁无遮挡网站| 国产精品福利在线免费观看| 精品人妻一区二区三区麻豆| 国产亚洲最大av| 白带黄色成豆腐渣| 能在线免费观看的黄片| 日韩伦理黄色片| 成人综合一区亚洲| 啦啦啦中文免费视频观看日本| 日本免费在线观看一区| 婷婷色av中文字幕| 国产欧美另类精品又又久久亚洲欧美| 亚洲丝袜综合中文字幕| 在线观看免费高清a一片| 91久久精品电影网| 午夜精品国产一区二区电影 | 日日干狠狠操夜夜爽| 亚洲欧美精品自产自拍| 晚上一个人看的免费电影| 国产精品人妻久久久影院| 国产午夜精品论理片| 亚洲精品国产av成人精品| 国产亚洲5aaaaa淫片| 中文字幕人妻熟人妻熟丝袜美| 91久久精品国产一区二区三区| av福利片在线观看| 99热全是精品| av免费在线看不卡| 91狼人影院| 免费观看的影片在线观看| 黄片无遮挡物在线观看| 日本一本二区三区精品| 搡老妇女老女人老熟妇| 1000部很黄的大片| 午夜福利成人在线免费观看| 色综合站精品国产| 九九在线视频观看精品| a级毛色黄片| 亚洲国产精品专区欧美| 欧美高清成人免费视频www| 18禁裸乳无遮挡免费网站照片| 日本与韩国留学比较| 亚洲在线观看片| av在线播放精品| av网站免费在线观看视频 | 哪个播放器可以免费观看大片| 国产一区有黄有色的免费视频 | 91精品一卡2卡3卡4卡| 婷婷色综合www| 国产精品日韩av在线免费观看| 噜噜噜噜噜久久久久久91| 老师上课跳d突然被开到最大视频| 又粗又硬又长又爽又黄的视频| 欧美 日韩 精品 国产| 欧美日韩精品成人综合77777| 乱码一卡2卡4卡精品| 日本猛色少妇xxxxx猛交久久| 国产淫语在线视频| 亚洲av一区综合| 99视频精品全部免费 在线| 春色校园在线视频观看| av在线蜜桃| 99久国产av精品国产电影| 欧美xxⅹ黑人| 好男人在线观看高清免费视频| 别揉我奶头 嗯啊视频| 天天一区二区日本电影三级| 一级二级三级毛片免费看| 欧美不卡视频在线免费观看| 一级毛片电影观看| 亚洲三级黄色毛片| 一级毛片久久久久久久久女| 亚洲国产日韩欧美精品在线观看| 噜噜噜噜噜久久久久久91| 国产淫语在线视频| 2021天堂中文幕一二区在线观| 18禁动态无遮挡网站| 精品久久久久久久久亚洲| 国产精品蜜桃在线观看| 欧美精品一区二区大全| 一级二级三级毛片免费看| 国产午夜精品一二区理论片| 菩萨蛮人人尽说江南好唐韦庄| 国产免费又黄又爽又色| 日韩大片免费观看网站| 国产成人午夜福利电影在线观看| 亚洲最大成人av| 精品酒店卫生间| 嫩草影院入口| av网站免费在线观看视频 | 天堂俺去俺来也www色官网 | 亚洲精品色激情综合| 乱码一卡2卡4卡精品| 日本猛色少妇xxxxx猛交久久| 亚洲精品久久午夜乱码| 赤兔流量卡办理|