自擬益氣養(yǎng)陰清利方治療慢性腎炎蛋白尿的療效觀察

陳建萍

摘 要 目的：觀察自擬益氣養(yǎng)陰清利方治療慢性腎炎蛋白尿的臨床療效。方法 選取2015年10月至2017年2月收治的慢性腎炎蛋白尿患者60例，按照隨機(jī)數(shù)字表法分為對(duì)照組和治療組各30例。在常規(guī)治療基礎(chǔ)上，對(duì)照組口服腎炎康復(fù)片治療，每天3次，每次5片；治療組給予自擬益氣養(yǎng)陰清利方治療，用水煎服，每天1劑（400 mL），分早晚2次溫服；兩組均治療3個(gè)月。比較兩組患者的療效、中醫(yī)證候評(píng)分、實(shí)驗(yàn)室檢查指標(biāo)及治療期間的不良反應(yīng)發(fā)生情況。結(jié)果 治療組總有效率為87.1%（24/30），高于對(duì)照組的43.0%（13/30，P<0.05）。 治療后，治療組的尿液紅細(xì)胞數(shù)量、24 h尿蛋白定量低于對(duì)照組，且中醫(yī)證候評(píng)分改善亦優(yōu)于對(duì)照組（P<0.05）。結(jié)論 治療組的實(shí)驗(yàn)室指標(biāo)和中醫(yī)證候評(píng)分改善效果及療效較好。

關(guān)鍵詞 慢性腎炎；蛋白尿；中醫(yī)藥治療；益氣養(yǎng)陰清利方

中圖分類號(hào)：R277 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1006-1533（2021）20-0027-03

基金項(xiàng)目：上海市靜安區(qū)衛(wèi)生及健康委員會(huì)中醫(yī)藥三年行動(dòng)計(jì)劃（杏林新星JA2015-R002）

Observation of therapeutic effect of self-made Yiqi yangyin qingli recipe in the treatment of chronic nephritis proteinuria

CHEN Jianping

（Department of Traditional Chinese Medicine of Gonghui Hospital， Shanghai 200041， China）

ABSTRACT Objective： To observe the clinical effect of Yiqi yangyin qingli recipe in the treatment of chronic nephritis proteinuria. Methods： Sixty patients with chronic nephritis proteinuria treated from October 2015 to February 2017 were selected and according to the random number table method， divided into a control group and a treatment group with 30 cases in each group. On the basis of conventional treatment， the control group was treated with Shenyankangfu tablets， 3 times a day， 5 tablets each time； the treatment group was treated with self-made Yiqi yangyin qingli recipe， decocted with water， 1 dose （400 mL） a day， twice in the morning and evening； both groups were treated for 3 months. The curative effect， TCM syndrome score， laboratory test indicators and adverse reactions during the treatment period were compared between the two groups. Results： The total effective rate of the treatment group was 87.1% （24 / 30）， which was higher than that of the control group 43.0% （13 / 30 P<0.05）. After treatment， the number of urine red blood cells and 24-hour urine protein quantitative of the treatment group were lower than those of the control group， and the improvement of TCM syndrome score of the treatment group was also better than that of the control group （P<0.05）. Conclusion： The improvement effect and curative effect of laboratory indexes and TCM syndrome score of the treatment group are better.

KEY WORDS chronic nephritis； proteinuria； traditional Chinese medicine treatment； Yiqi yangyin qingli recipe

近年來，隨著我國(guó)社會(huì)經(jīng)濟(jì)發(fā)展及人們生活節(jié)奏日益加快，生活水平逐漸提高，慢性腎炎蛋白尿患者的發(fā)病人數(shù)呈逐年上升趨勢(shì)。慢性腎炎蛋白尿患者持續(xù)存在的大量蛋白尿是慢性腎炎不良預(yù)后的危險(xiǎn)因素。因此，對(duì)于慢性腎炎患者，阻止尿蛋白漏出是治療的一大重點(diǎn)。中醫(yī)學(xué)理論認(rèn)為，慢性腎炎蛋白尿隸屬祖國(guó)醫(yī)學(xué)“石水”“虛勞” “精微外泄”范疇，主要病機(jī)特點(diǎn)為本虛標(biāo)實(shí)證，脾腎氣虛為本，風(fēng)邪、濕熱、瘀毒為標(biāo)，濕熱貫穿于病程的始終。本研究觀察自擬益氣養(yǎng)陰清利方治療慢性腎炎蛋白尿的臨床療效，現(xiàn)報(bào)道如下。