Cardiac functional magnetic resonance imaging at 7T: Image quality optimization and ultra-high field capabilities

El-Sayed H Ibrahim, V Emre Arpinar, L Tugan Muftuler, Jadranka Stojanovska, Andrew S Nencka, Kevin M Koch

Abstract

Key Words: Magnetic resonance imaging; High-field; Cardiac function; Cine; Tagging;Strain

INTRODUCTION

Cardiac magnetic resonance imaging (MRI) is the gold standard for assessment of cardiac function due to its high resolution and tissue contrast. Cardiac MRI functional imaging can provide information not only about global heart function,, ejection fraction (EF), but also about regional tissue contractility,, myocardial strain using MRI tagging, where the latter has shown to reveal early manifestation of subclinical cardiac dysfunction that typically precedes EF reduction.

Cardiac function assessment using MRI has been established in clinical practice on 1.5T and 3T scanners, where it showed the capability for identification of different cardiovascular diseases, including coronary artery disease, cardiomyopathies, and different valvular, vascular, and congenital heart diseases. Nevertheless, the capabilities of ultra-high field (UHF) MRI have not been fully exploited for cardiac functional imaging, which are expected to improve image quality and provide more information for better understanding of heart mechanics in both normal and pathophysiological conditions; thus, opening the door for new cardiac MRI applications.

With 7T MRI scanners from different vendors receiving clearance for clinical applications, it might be expected that 7T MRI will soon be adopted in clinical practice. UHF MRI introduces several advantages, as well as some limitations,compared to lower-field imaging. As signal-to-noise ratio (SNR) is proportional to magnetic field strength, 7T MRI provides more than double SNR compared to 3T imaging. The enhanced SNR can be traded for improved image quality, higher spatial or temporal resolution, or shorter scan time. Furthermore, due to prolonged T1 relaxation times at 7T, improved tissue contrast can be achieved compared to lower magnetic fields. The advantages of UHF imaging could lead to improved image quality, illustration of anatomical details, and shorter scan time, which are of particular importance in cardiac functional imaging.

Despite its advantages, high-field imaging at 7T is challenging due to a number of technical issues. First, the applied radiofrequency (RF) field at such high frequency results in short wavelength (approximately 12 cm) and increased dielectric effect that can induce destructive and constructive wave interferences and results in distorted B1 field and non-uniform effective flip angle distribution with observed shading and signal drop-off effects. Another challenge of UHF imaging is RF penetration to the posterior wall of the heart, where coils with dipole arrays provide superior penetration depth. Imaging at UHF also results in increased B0 inhomogeneityand specific absorption ratio (SAR) and noisy electrocardiogram(ECG) signal, although these effects are not prohibiting factors of conducting cardiac MRI at 7T. Besides technical challenges, UHF imaging could result in some undesirable effects on imaged subjects, where dizziness, nausea, metallic taste, light flashes, and peripheral nerve stimulations have been reported. Nevertheless, there has been no significant clinical complications experienced at 7T MRI.

A promising technique for addressing B1 inhomogeneity in UHF imaging relies on parallel transmission methodsusing multiple transmit RF channels. Recent efforts have been made for developing multi-channel transceiver surface coil arrays tailored for UHF imaging. The capability of independently modulating each coil element’s magnitude and phase allows for producing more uniform B1 field with less signal inhomogeneity across the imaged region while maintaining SAR within allowable limits. Furthermore, the modular design of such multi-channel coils allows for close fitting with the body, more patient’s comfort, and suitability for clinical applications. The capabilities of combining multi-channel parallel imaging and simultaneous multi-slice acquisition for improving imaging efficiency have been recently investigated.

In this study, we provide preliminary results from phantom andscans using a multi-channel transceiver modular coil to optimize 7T cardiac MRI functional imaging without the need for conducting B1 shimming or subject-specific tuning,which improve scan efficiency. We investigate the effects of adding a dielectric pad at different locations next to the imaged region of interest on improving image quality in subjects with different body habitus. We also investigate the effects of adjusting the imaging flip angle in cine and tagging sequences on improving image quality, B1 field homogeneity, SNR, blood-myocardium contrast-to-noise ratio (CNR), and tagging persistence throughout the cardiac cycle.

MATERIALS AND METHODS

Experiments set-up

This study was conducted with approval from our Institutional Review Board and informed consent was obtained from scanned human subjects. A static phantom and twelve healthy subjects were scanned on a GE MR950 7T whole-body scanner (GE Healthcare, Milwaukee, United States) equipped with peak gradient amplitude and maximum slew rate of 50 mT/m and 200 T/m/s, respectively and using a 32-channel transceiver coil (MRI Tools, GmbH, Berlin, Germany). The modular coil array consists of 8 independent blocks: Four blocks located posteriorly in a planar fashion and four blocks located anteriorly in a bent fashion, which provide close fit to the chest with stable loading condition. Each coil block contains 4 transceiver elements (2 × 2 array), whose phase settings were optimized based on simulations for a multi-oblique plane mimicking a standard cardiac view. The coil elements are arranged in an interleaved fashion so that they are shifted from each other by a half-element size.

B1 mapping

We conducted phantom andscans to generate an estimate of the B1 transmission frequency field in the imaged slice using the actual flip-angle imaging B1 mapping method. A spoiled gradient echo cine sequence was used for repeated image acquisitions with nominal flip angles ranging from 1° to 120°, and forward simulation was conducted on the resulting images. To overcome the inherent motion problem in cardiac imaging, lowpass filtering was conducted to mitigate the motion problem and achieve better B1 estimates.

SAR calculations

The MRI system first looks at the predicted global SAR, which is vendor-provided SAR tables specific to the coil used and its imaging mode (cardiac mode in this case).The 32 channels of the coil are grouped in blocks of four elements each with fixed inter-element phases for the transmission mode. The MRI system then calculates local SAR over a 10 g mass sample for the worst-case scenario using different virtual body models, as previously explained. Upon comparing local and global SAR calculations, the more conservative one is taken into consideration and used for all scans.

Effect of imaging flip angle on image quality

Both cine and tagging images were acquired in the volunteers in standard cardiac short-axis and long-axis views, which are typically used for measuring cardiac functional parameters,, EF. The coil placement and prescription flip angle were adjusted to improve image quality. Specifically, the effect of modifying the prescribed flip angle from 10° to 90° on myocardium SNR and myocardium-to-blood CNR was studied. Myocardial SNR was measured as the ratio between mean signal intensity in the myocardium divided by standard deviation (SD) of background noise. CNR was measured as the difference between mean signal intensities in blood and myocardium divided by SD of background noise.

The imaging parameters for cine imaging were as follows: Fast spoiled gradient echo sequence, repetition time (TR) = 8 ms, echo time (TE) = 4 ms, flip angle = 60°,matrix = 256 × 256, field-of-view (FOV) = 380 mm × 380 mm, slice thickness = 8 mm,acquisition bandwidth = 244 Hz/pixel, number of averages = 1, and number of cardiac phases = 25. The imaging parameters for the tagging sequence were as follows: Fast gradient echo sequence, TR = 4.9 ms, TE = 2 ms, flip angle = 15°, matrix = 256 × 256,FOV = 380 mm × 380 mm, slice thickness = 8 mm, acquisition bandwidth = 488 Hz/pixel, number of averages = 1, and number of cardiac phases = 25.

Myocardial tagging persistence at 7T

The elevated Tvalue of normal myocardium at 7T (approximately 1900 ms at 7T compared to approximately 1150 ms and approximately 850 ms at 3T and 1.5T,respectively) results in slower magnetization recovery towards equilibrium, and thus helps reduce taglines fading during later phases of the cardiac cycle. We conducted Bloch simulation to investigate the effect of elevated Tvalue at 7T on improving tagging persistence compared to that at 1.5T. Furthermore, we used the sinusoidal modulation techniqueto analyze the tagged images and measure myocardial strain in a subject with low heart rate of 50 beats per minute (bpm; cardiac cycle length = 1200 ms).

Effect of using a dielectric pad on image quality

We investigated the effect of adding a dielectric pad (30 cm × 40 cm flexible pad from GE Healthcare, part number E8823JA) close to the imaged slice on improving B1 homogeneity. As moving the dielectric pad around the thorax area affects the presence and location of signal nulling regions, we studied the effect of changing the pad’s position in eight volunteers with different body habitus and chest size, which were divided into two groups. Group 1 consisted of four volunteers (2 males, 2 females)with small body habitus: Healthy-weight body mass index (BMI < 25 kg/m) = 22.5 ±2.5 kg/m, chest expansion in the anterior-posterior and left-right directions = 24.8 ±3.2 cm and 31.3 ± 2.2 cm, respectively. Group 2 consisted of four volunteers (2 males, 2 females) with larger body habitus: Overweight BMI (> 25 kg/m) = 26.4 ± 1.1 kg/m,chest expansion in the anterior-posterior and left-right directions = 28.8 ± 1.7 cm and 31.5 ± 2.4 cm, respectively.

RESULTS

With proper scan set-up and imaging parameter settings, all subjects were successfully scanned with good image quality. The ECG signal was reliable in all scans and image acquisition was correctly triggered at the R-wave, despite elevated T wave and noisier ECG signal compared to the case at lower magnetic fields.

B1 mapping

Figure 1 Estimation of the B1 transmission field in a homogeneous phantom. A: Gradient-echo magnitude image of the phantom; B: B1 scale factor map (range, 0 to 1) of the phantom; C: Proton density distribution map (arbitrary units; a.u.); D: R2 fitting map (range, 0 to 1) shows excellent simulation fittings; E:Example of signal intensity measurements (arbitrary units; a.u.) at different flip angles in degrees (dots) and the fitting curve inside the phantom. The results show altered B1 field across the imaged slice. FA: Flip angle.

Figures 1 and 2 show results from phantom and volunteer scans, respectively, to estimate the B1 field. The figures show signal intensity variation across the acquired slices, where the signal intensity profile changes with the prescribed flip angle. The estimated B1 map and proton density distribution reflect the observed signal intensity in the imaged slices, and the resulting Rfitting maps show excellent data fitting.

SAR calculations

Figure 3 shows maximum intensity projections of 10 g-averaged SAR normalized to 1W forward power at the coil plug using male and female virtual body models for a cardiac imaging. Differences between male and female body habitus were taken into consideration for the virtual model simulation. For example, a breast mass of 490 g was used for female body simulation to account for the effects of the mammary glands on resulting calculations and their effect on image characteristics,, signal nulling or contrast variation. During volunteer scans, SAR is limited based on the chosen excitation mode, where worst-case scenario among different body models is taken into consideration and used for all cases. Figure 3 also shows local and global SAR values as reported by the Dicom tags forcine imaging with different flip angles,where local SAR is the limiting factor for SAR calculations.

Figure 2 Estimation of the B1 transmission field in a volunteer scan. A: Gradient-echo short-axis image; B: B1 scale factor map (range, 0 to 1); C:Proton density distribution map (arbitrary units; a.u.); D: R2 fitting map (range, 0 to 1) shows excellent simulation fittings; E: Example of signal intensity measurements(arbitrary units; a.u.) at different flip angles in degrees (dots) and the fitting curve inside the heart region (red circle). The results show altered B1 field across the imaged slice. FA: Flip angle.

Experiments set-up and imaging flip angle effects on image quality

We found that moving the coil up towards the chin of the imaged subject (average of 5 cm offset shift of the coil center from heart center) resulted in improved signal intensity, especially at the basal and lateral regions of the heart, compared to when the coil was centered around the heart. The prescribed imaging flip angle played a key role in determining SNR and CNR (Figure 4). Due to the difference between nominal and actual flip angles at 7T imaging, as shown in Figures 1 and 2, the prescribed flip angle for gradient echo cine imaging at 7T needed to be much higher than that used at 1.5T and 3T fields (approximately 10°-20°). Based on results from this study, a prescribed flip angle of approximately 60° resulted in sufficient RF penetration and improved image quality. In the example shown in Figure 4, a 60° flip angle resulted in optimal SNR/CNR of 181/116, which is much higher than those reported at lower magnetic fields, for example SNR/CNR of 79/43 at 1.5T.

Figure 3 Specific absorption ratio calculations. Maximum intensity projections of 10 g-averaged specific absorption ratio (SAR) normalized to 1W forward power at the coil plug using male ‘Duke’ (A) and female ‘Ella’ (B) virtual body modes; C: Reported SAR values for different flip angle from the cine scan Dicom tags in the subject in Figure 2. SAR: Specific absorption ratio.

Improved cine and tagging imaging at 7T

With high SNR at 7T, high spatial resolution can be achieved compared to that available at lower field strength. Figure 5 shows a high-resolution cine image with voxel size of 0.75 mm × 0.75 mm × 2 mm and the same slice acquired with conventional resolution of 1.5 mm × 1.5 mm × 8 mm that is typically used in clinical practice on 1.5T and 3T scanners. The high-resolution image shows fine anatomical details of the trabecula, papillary muscles, and right ventricle that appear blurry at conventional resolution. Otherwise, high SNR can be traded for improved temporal resolution, where we were able to achieve cine imaging with 20 ms temporal resolution (50 frames for a heart rate of 60 bpm) at conventional spatial resolution reported above.

Figures 6 and 7 show the effect of elevated myocardial Tvalue and large field strength at 7T on improving tagging persistence. Figure 6 shows the results of Bloch simulation of the tagging pattern evolution during a 1200 ms cardiac cycle (50 bpm heart rate) for both 7T and 1.5T field strengths. The slow magnetization recovery at 7T resulted in maintaining more than half (53%) of the original tagging contrast(measured as the peak-to-peak difference in signal intensity of the tagging pattern) by the end of the 1200 ms cardiac cycle at 7T, compared to only 24% of the original tagging contrast at 1.5T. When taking the field strength effect into consideration, then there is a reduction of 90% in tagging contrast when switching from 7T to 1.5T by the end the 1200 ms cardiac cycle. Therefore, it is typically difficult to measure myocardial strain at later diastolic cardiac phases for low-field imaging due to fading of the tagging pattern, which is not the case at 7T, as shown by theresults in Figure 7 of a subject with heart rate of 50 bpm, where the tagging pattern was visible throughout the whole cardiac cycle and allowed for measuring strain throughout enddiastole. It should be noted that optimal prescribed flip angle for tagging MRI was 15°,as larger flip angles resulted in faster fading of the taglines. On the other hand, lower flip angles resulted in poor tissue contrast.

Figure 4 The effect of the prescribed flip angle on myocardium signal-to-noise ratio and blood-to-myocardium contrast-to-noise ratio.Optimal signal-to-noise ratio (SNR) was achieved at prescribed flip angle of approximately 60° (red framed image). Although higher flip angles resulted in better blood-to-myocardium contrast-to-noise ratio, this came at the cost of reduced SNR. SNR: Signal-to-noise ratio; CNR: Contrast-to-noise ratio.

Figure 5 Improved image resolution achieved at 7T cardiac magnetic resonance imaging. High signal-to-noise ratio (SNR) at 7T allows for achieving high spatial resolution with 16-fold reduction in voxel size (A) compared to standard clinical resolution in (B). Small voxel size illustrates anatomical details,such as the trabeculations and right ventricle details (arrows), that are not clearly visible at standard clinical resolution. Alternatively, high SNR can be traded for high temporal resolution (approximately 20 ms) imaging at conventional spatial resolution as in (B).

Figure 6 Improved tagging persistence at 7T cardiovascular magnetic resonance. Numerical simulation of the effect of magnetic field strength on the tagging pattern persistence. The tagging patterns (blue, 7T; red, 1.5T) have maximum contrast (peak-to-peak difference) immediately after tagging creation at the beginning of the cardiac cycle (time = 0 ms), as represented by the solid lines. Note the difference in tagging contrast (vertical solid arrows on the right) corresponding to the difference in field strength. With time, longitudinal magnetization experiences exponential relaxation trying to reach equilibrium with different T1 values of the myocardium depending on the magnetic field strength (T1 = 850 ms and 1900 ms are used for 1.5T and 7T, respectively). By the end of a 1200 ms cardiac cycle(assuming heart rate of 50 bpm), the tagging patterns have experienced fading (dotted lines), such that there is a significant difference in tagging contrast between 7T and 1.5T, as represented by the vertical dotted arrows on the right, which results in diminished visibility of the tagging pattern by the end of the cardiac cycle at the low field strength.

Improving B1 homogeneity using a dielectric pad

The effect of the dielectric pad’s position on improving B1 uniformity was impacted by the imaged subject’s body habitus (Figures 8 and 9). For volunteers with small-tomedium weight (BMI < 25 kg/m), placing the pad at the anterior left position of the chest (the volunteers were scanned in the supine position) resulted in improved B1 uniformity compared to other anterior and posterior positions, as shown in Figure 8.This behavior was consistent in all scanned volunteer with small-to-medium body habitus. On the other hand, in volunteers with larger body habitus (BMI > 25 kg/m),B1 uniformity was acceptable even without using the dielectric pad, and it was similar to the case when the pad was positioned in the anterior left position of the chest, as shown in Figure 9. Moving the pad to other positions resulted in less B1 uniformity and appearance of regions with signal nulling. This behavior was consistent in all scanned volunteers with large body habitus.

DISCUSSION

While the majority of UHF studies have focused on brain and orthopedic applications,recent improvements in multi-channel coil development opened the door for cardiac imaging to benefit from UHF MRI capabilities. The results from this study show that high-quality global (cine) and regional (tagging) cardiac functional imaging can be obtained at 7T by simple optimization of the scan set-up and imaging parameters,especially to mitigate B1-related signal inhomogeneity effects.

Adjusting the prescription flip angle and adding a dielectric pad next to the imaged region-of-interest helped improve B1 homogeneity and reduce signal nulling artifacts.The actual flip angle across the heart can vary by as much as 50% from the nominal flip angle, even at 3T, which is imperative in certain applications that use 180° RF pulses as in fast spin-echo imaging and inversion-recovery-based Tmapping.Nevertheless, these constraints can be loosened in gradient-echo-based cardiac functional imaging by increasing the prescription flip angle to ensure sufficient RF penetration to the whole heart and generation of images with good SNR and tissue contrast.

It should be noted that shallow flip angle (15°) was used in acquisition of the tagged images, compared to 60° in the case of cine images, in order to maintain the tagging pattern throughout the whole cardiac cycle. Although larger flip angle results in better myocardium-to-blood contrast, it results in more tipping of the magnetization vector into the transverse plane, and therefore the magnetization pattern fades quickly due to short T2 relaxation time of the myocardium (approximately 50 ms). On the contrary,using a shallow flip angle allows for maintaining the tagging pattern for a long time due to slow longitudinal magnetization recovery with long myocardial T1 relaxation time (approximately 1900 ms). It should be noted that the shallow flip angle does not affect the tagging-to-myocardium contrast as the tag lines appear dark due to magnetization saturation during the tagging preparation step. Furthermore, because the tagging pattern is maintained in the myocardium and destroyed in the blood pool,due to blood motion, there is still good contrast between myocardium and blood in the tagged images.

Figure 7 Strain analysis throughout the whole cardiac cycle at 7T cardiovascular magnetic resonance. A: A series of tagged images acquired at different timepoints of a mid-ventricular short-axis slice throughout a 1200 ms cardiac cycle, showing tagging persistence until the last timeframe (arrows), which allows for measuring strain throughout end-diastole, which is not feasible at low magnetic field strength where the tagging pattern fades before the end of the cardiac cycle; B: Circumferential strain curves showing strain evolution throughout the whole cardiac cycle in different left-ventricular myocardial segments of the slice in (A).Segments are numbered according to American Heart Association 17-segment model.

Figure 8 The effect of changing location of the dielectric pad on B1 field homogeneity in volunteers with small body habitus. The place of the pad is indicated by the orange arrow with respect to an axial cross-section of the subject’s chest region (white circle, where subject was scanned in the supine position; A: Anterior, P: Posterior, L: Left, R: Right). Results from an underweight volunteer [body mass index = 19 kg/m2, chest expansions = 20 cm (AP) and 30 cm(LR)], as shown on long-axis (A) and short-axis (B) slices. Placing the pad at the anterior left position of the chest (image with red frame) resulted in improved B1 uniformity compared to other anterior and posterior positions, which showed regions of signal nulling (white arrows). This behavior was consistent in all scanned subjects with small body habitus.

Adding a dielectric pad next to the imaged region of interest and properly adjusting its location based on body habitus resulted in generating a more homogeneous B1 field around the heart, rendering patient-specific tuning and matching of individual coil elements unnecessary in this study, which helps streamline UHF cardiac imaging.Specifically, the results showed that: (1) Adding a dielectric pad had more effect on improving B1 homogeneity in subjects with small body habitus compared to subjects with large body habitus; and (2) Placing the dielectric pad in the anterior left position of the chest resulted in improved B1 homogeneity compared to other anterior and posterior positions. These results can be understood in light of the dielectric pad’s effect on changing B1 distribution in its vicinity, which is affected by the coil loading as a result of specific body habitus. Generally, the dielectric pad helps improve impedance matching for B1 field propagation. Furthermore, the secondary local RF field in the pad enhances the original B1 field. The more effect noticed in subjects with small body habitus could be understood, in part, by the more pronounced standing wave effect in subjects with small chest area compared to those with larger chest area.The more effect of the dielectric pad when placed in the anterior left position could be understood because the pad is closest to the heart in this position, and thus has more effect on changing the B1 field around the heart.

Figure 9 The effect of changing location of the dielectric pad on B1 field homogeneity in volunteers with large body habitus. The place of the pad is indicated by the orange arrow with respect to an axial cross-section of the subject’s chest region (white circle, where subject was scanned in the supine position; A: Anterior, P: Posterior, L: Left, R: Right). Results from an overweight volunteer [body mass index = 26.1 kg/m2, chest expansions = 27 cm (AP) and 30 cm(LR)], as shown on long-axis (A) and short-axis (B) slices. B1 uniformity was acceptable without using the pad (image on the left), which was similar to the case when the pad was positioned in the anterior left position of the chest (image with red frame). Changing the pad position resulted in slightly worse B1 uniformity, as shown by regions of signal nulling (white arrows). This behavior was consistent in all scanned subjects with large body habitus.

Intrinsic characteristics of UHF imaging,, prolonged myocardium Tvalues, can be a key advantage for cardiac MRI tagging. As shown in this study, the prolonged myocardium Tvalue resulted in improved tagging persistence throughout the whole cardiac cycle even at slow heart rates, which allowed for analyzing the myocardial contractility pattern until end-diastole, an appreciated feature considering the rapid taglines fading during late cardiac phases in conventional low-field imaging.

In this study, we showed the capability of 7T cardiac MRI for generating highresolution cardiac cine images with voxel size that is 16 times smaller than that in clinical standards. Such high spatial resolution allows for visualizing detailed anatomical features without sacrificing SNR as one would expect in lower field MRI.This feature is appreciated in applications when high-fidelity anatomical details need to be imaged,, in pediatric imaging, congenital heart diseases, diffusion tensor imaging of myofiber tractography, right ventricle imaging, and for patient triaging in certain cardiomyopathies. Alternatively, the extra SNR in 7T MRI can be traded for high temporal resolution in applications where accurate measurements require high temporal resolution,, flow imagingand time-resolved cine imaging of patients with fast heart rate.

The transceiver modular coil used in this study allowed for obtaining high-qualityimages with high resolution and adequate myocardium-to-blood contrast.Future coil developments with increased number of RF transceiver elements would allow for even more improvement in scan performance and parallel imaging capability. Other advancements in developing shorter, actively shielded, and wider bore 7T magnets would allow for more adoption of UHF cardiac MRI in clinical practice.

One limitation of the current study is the limited number of studied subjects, which does not allow for conducting a thorough statistical analysis. Nevertheless, our goal in this study was to provide a proof-of-concept of improved quality 7T cardiac MRI cine and tagging imaging and illustrate achieved advantages compared to low-field imaging capabilities. To the best of our knowledge, this is the first study to focus on this important application, especially the effect of adding a dielectric pad on improving signal homogeneity and the capability of improving tagging imaging and strain analysis at 7T. Nevertheless, more studies on a larger cohort are warranted to confirm the results from this study and to investigate more details,, the effect of the dielectric pad size or material on the results.

CONCLUSION

In conclusions, improved cardiac functional imaging can be achieved at 7T through simple scan set-up and imaging parameter adjustments, which would allow for more streamlined and efficient UHF cardiac imaging with more adoption in clinical practice and access to more information and details compared to lower-field imaging.

ARTICLE HIGHLIGHTS

Research background

Magnetic resonance imaging (MRI) is the gold standard for assessment of cardiac function, which can provide information not only about global heart function, but also about regional tissue contractility patterns. With 7T MRI scanners from different vendors receiving clearance for clinical applications, it might be expected that 7T cardiac MRI will soon be adopted in clinical practice to get benefit from ultra-high field (UHF) capabilities.

Research motivation

The capabilities of UHF cardiac MRI have not been fully exploited in cardiac functional imaging, which are expected to improve image quality and provide more information compared to imaging capabilities at current clinical magnetic field strengths.

Research objectives

To optimize 7T cardiac MRI functional imaging without the need for conducting B1 shimming or subject-specific system tuning, which improves scan efficiency.

Research methods

We conducted both phantom and in vivo scans using a multi-channel transceiver modular coil. We investigated the effects of adding a dielectric pad at different locations next to the imaged region of interest on improving image quality in subjects with different body habitus. We also investigated the effects of adjusting the imaging flip angle in cine and tagging sequences on improving image quality, B1 field homogeneity, signal-to-noise ratio (SNR), blood-myocardium contrast-to-noise ratio(CNR), and tagging persistence throughout the cardiac cycle.

Research results

The results showed the capability of achieving improved image quality with high spatial resolution, high temporal resolution, and increased tagging persistence at 7T cardiac MRI after adjusting scan set-up and imaging parameters. Adjusting the imaging flip angle was essential for achieving optimal SNR and myocardium-to-blood CNR. Placing a dielectric pad at the anterior left position of the chest resulted in improved B1 homogeneity compared to other positions, especially in subjects with small chest size.

Research conclusions

Improved regional and global cardiac functional imaging can be achieved at 7T MRI through simple scan set-up adjustment and imaging parameter optimization, which allows for access to more information and details compared to lower-field MRI.

Research perspectives

The developed optimized MRI exam would allow for more streamlined and efficient UHF cardiac functional imaging. Future studies should investigate the clinical usefulness of the developed technique by implementing it on large number of patients with different cardiovascular diseases.