綜合治療對(duì)多囊卵巢綜合征合并糖尿病患者妊娠結(jié)局的影響研究

朱莉　劉桂艷　翟燕　王雪冬　關(guān)丹丹

[摘要] 目的 應(yīng)用綜合治療方案治療多囊卵巢綜合征（polycystic ovarian syndrome，PCOS）合并糖尿?。╠iabetes mellitus，DM）患者，觀察治療對(duì)妊娠結(jié)局的影響。 方法 納入PCOS患者124例，篩選自2015年7月—2017年7月間患者，合并DM，均在該院接受治療，詢問患者意見，獲許可后，按來院時(shí)間排序編號(hào)，經(jīng)抽簽隨機(jī)確定分組。對(duì)照組予單一治療，研究者予綜合治療，對(duì)比兩組妊娠結(jié)局。 結(jié)果 研究組患者1年后妊娠成功率高于對(duì)照組，差異無統(tǒng)計(jì)學(xué)意義（P>0.05）;研究組自然流產(chǎn)率、妊娠高血壓發(fā)生率及妊娠糖尿病發(fā)生率均低于對(duì)照組，兩組不良妊娠結(jié)局發(fā)生率差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。 結(jié)論 綜合治療方案能有效改善PCOS合并DM患者的妊娠結(jié)局，值得推廣。

[關(guān)鍵詞] 綜合治療;PCOS;DM;妊娠成功率;不良妊娠結(jié)局發(fā)生率

[中圖分類號(hào)] R714.2? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1672-4062（2019）05（b）-0042-02

[Abstract] Objective To observe the effect of comprehensive treatment on pregnancy outcome in patients with polycystic ovarian syndrome （PCOS） and diabetes mellitus （DM）. Methods A total of 124 patients with PCOS were enrolled in this study. From July 2015 to July 2017， patients with DM were selected and treated in our hospital. The patients' opinions were inquired. After obtaining permission， the patients were numbered according to the time of admission and randomly divided into groups by drawing lots. The control group received a single treatment， while the study group received comprehensive treatment. The pregnancy outcomes of the two groups were compared. Results One year later， the success rate of pregnancy in the study group was higher than that in the control group， but there was no statistically significant difference （P>0.05）. The spontaneous abortion rate， the incidence of pregnancy hypertension and the incidence of gestational diabetes in the study group were lower than those in the control group， and the incidence of adverse pregnancy outcomes in the two groups had statistically significant difference （P<0.05）. Conclusion Comprehensive treatment can effectively improve the pregnancy outcome of patients with PCOS and DM， which is worthy of promotion.

[Key words] Comprehensive treatment; PCOS; DM; Pregnancy success rate; Incidence of adverse pregnancy outcomes

PCOS為婦科常見病，患者內(nèi)分泌異常，會(huì)影響妊娠，而若患者合并DM，則不良妊娠結(jié)局發(fā)生幾率也顯著提升，對(duì)母兒健康與安全均有嚴(yán)重威脅，臨床重視疾病治療[1]。常規(guī)治療以孕激素類藥物為主，但效果并不十分理想，綜合治療方案的應(yīng)用，提升了治療效果。該研究就PCOS合并DM患者治療中，實(shí)施綜合治療方案的實(shí)踐價(jià)值展開探究，分析2015年7月—2017年7月間該院收治的PCOS患者124例合并DM的臨床資料，現(xiàn)報(bào)道如下。

1? 資料與方法

1.1? 一般資料

患者94例，該院接收患者，臨床明確診斷，存在PCOS并合并DM。經(jīng)患者同意，按來院順序編號(hào)，抽簽分兩組。對(duì)照組62例，年齡21～38歲，平均（30.23±2.19）歲，病程6個(gè)月～5年，平均（3.12±0.47）年;研究組62例，年齡22～37歲，平均（30.49±2.07）歲，病程8個(gè)月～5年，平均（3.17±0.45）年;患者無排卵，確認(rèn)多囊卵巢病變，符合DM診斷標(biāo)準(zhǔn)[2]，患者對(duì)研究所用藥物不過敏，未合并其他基礎(chǔ)疾病，無流產(chǎn)史、無輸卵管堵塞，配偶無生殖障礙，夫妻共同生活，未實(shí)施避孕，排除合并心血管疾病、精神系統(tǒng)疾病者，無失訪者。研究符合醫(yī)學(xué)倫理，患者知情同意，有關(guān)證明文書由患者親自簽署。