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    Removal of pediatric stage IV neuroblastoma by robot-assisted laparoscopy:A case report and literature review

    2019-08-14 09:22:34DiXiangChenYiHanHouYaNanJiangLiWeiShaoShanJieWangXianQiangWang
    World Journal of Clinical Cases 2019年12期

    Di-Xiang Chen,Yi-Han Hou,Ya-Nan Jiang,Li-Wei Shao,Shan-Jie Wang,Xian-Qiang Wang

    Abstract

    Key words: Robot-assisted surgery; Retroperitoneal neuroblastoma; Children; Case report

    INTRODUCTION

    Neuroblastoma (NB) is a highly heterogeneous tumor.Some tumors can spontaneously subside without treatment.However,most tumors are occult and rapidly metastasize throughout the body,ultimately becoming life-threatening.Surgical resection is an effective treatment for children with NB.Minimally invasive surgery has unique advantages in NB resection,and case reports of laparoscopic NB resection confirm its safety and feasibility[1].Robot-assisted laparoscopic surgery is a new method and is superior to conventional laparoscopic surgery,which has been preliminarily applied in clinical practice,yielding significant curative effects[2].This method can further promote the resection of pediatric tumors in a minimally invasive manner.

    Robot-assisted surgery has been widely used in adult surgery,including general surgery[3-5],urinary surgery[6-8],and cardiac surgery[9-11].Currently,robot-assisted systems,either alone or in combination with laparoscopic surgery,have been relatively mature in adult surgery,especially in the field of urology[12].There are many retrospective clinical case reports comparing the safety and efficacy of robotic surgery in adult surgery through randomized controlled studies[13-15],which have confirmed its safety and feasibility.

    Compared with adults,the age,physio-pathological conditions,and lesion location of children are unique and complex,rendering the advantages of robot-assisted surgery more prominent in the field of pediatric surgery.Pediatric surgeries involving the abdominal cavity,pelvic cavity,and thoracic cavity have been reported in China and abroad[16-18].It is confirmed that with robot-assisted systems,pediatric surgery is safe and feasible.

    In the field of pediatric NB,Yuet al[1]from the University of Oklahoma reported the first robot-assisted resection of pediatric NB in theJournal of Robotic Surgeryin 2014.In that study,the prenatal ultrasound already suggested bilateral hydronephrosis in the patient,and a left adrenal gland mass with a size of 2.5 cm × 1.5 cm was found in the subsequent examinations.Therefore,when the patient was 15 mo old,robotic-assisted left adrenal gland mass resection and ipsilateral retroperitoneal lymph node dissection were performed.The transumbilical approach was used to perform the surgery.The robotic cannula was placed and the surgery was successfully performed using the Da Vinci robotic system.Pathological examination confirmed that the tumor was an NB (stage 2b).The patient did not have intraoperative or postoperative complications and was discharged 24 h after surgery.The patient resumed all activities within one week after the surgery,and no signs of recurrence were found during the regular postoperative follow-ups.This case shows that,compared with open surgery,robot-assisted surgery can not only successfully yield the same oncological results but also help reduce the disease recurrence rate and shorten the durations of surgery,hospitalization stay,and postoperative recovery.

    Zhuet al[19]from Tongji Hospital of Huazhong University of Science and Technology reported the application of a robotic surgical system in the surgical treatment of pediatric NB in 2017 in China.The outcomes of three cases of pediatric adrenal pheochromocytoma treated using the Da Vinci robot system were reported.Among the patients,one was male and the other two were female,with an average age of 5.2 years.The tumors were all on the right side,with a size of (2.0-3.6) cm × (1.0-3.6) cm.The Da Vinci robotic system was used to successfully complete the surgery,and the robotic surgery advantages of minimal trauma and quick recovery were confirmed.The study by Zhuet al[19]provided practical experience in applying robot-assisted surgery in the field of pediatric NB resection.

    We successfully completed a stage IV pediatric NB resection using the Da Vinci Si robot system.The purpose of this study was to explore the feasibility and effectiveness of robotic surgery in the treatment of complicated NB in children and to summarize the preliminary experience in applying this technique.

    CASE PRESENTATION

    Chief complaints

    The patient was a girl aged 3 years and 5 mo.At the end of 2017,the patient was admitted due to abdominal discomfort,and a mass in the right upper quadrant of the abdomen was found.After supraclavicular lymph node biopsy,the patient was diagnosed with stage IV retroperitoneal NB.After chemotherapy (four cycles),the tumor shrank significantly,but the primary tumor behind the inferior vena cava remained.

    Physical examination

    The abdomen was soft,without tenderness,rebound pain,or an obvious mass.The liver and spleen were impalpable,Murphy's sign was negative,and the bowel sounds were normal.

    Laboratory examinations

    The laboratory values were the following:Serum ferratin,1957.00 ng/mL; alanine transaminase,31.2 U/L; aspartate transaminase,38.9 U/L; alkaline phosphatase,165.2 U/L; urea,3.06 mmol/L; SCr,33.4 μmol/L; hemoglobin,87 g/L; red blood cell count,2.78 × 1012/L; and white blood cell count,9.24 × 109/L.

    Imaging examination

    Before chemotherapy,abdominal enhanced computed tomography showed a middle line retroperitoneal neoplasm with the inferior vena cava,right renal vessels,and abdominal aorta traversing in it.After chemotherapy,the tumor shrank considerably and the above-mentioned vessels were still encased by the tumor.After surgery,the clearance of the tumor around the vessels was achieved (Figure 1).

    Figure1 Abdominal enhanced computed tomography images.

    Preoperative biopsy pathological diagnosis

    The preoperative biopsy pathological diagnosis from the left cervical lymph nodes,combined with the pathological morphology and immune phenotype,was consistent with an undifferentiated NB metastasis.The immunohistochemical results were CD-56 (+),CD-ROM9 (+,spotty),nuclear CgA (+),CKpan (-),HMB-45 (-),Ki-67 (+,>95%),LCA (-),NSE (+,focal and weak),S-100 (-),and Syn (+).

    FINAL DIAGNOSIS

    The preoperative diagnosis was NB.

    TREATMENT

    Anesthesia and position

    Tracheal intubation was performed under general anesthesia,followed by urinary catheterization.The catheterization of the right internal jugular vein and blood pressure monitoring of the right radial artery were performed routinely.The left lateral position at an angle of 45o was used.Stretch socks were worn on the lower extremities to prevent thrombosis.The robot was put on the patient’s back,the first assistant was located on the ventral side of the patient,and the instrument nurse was close to the patient’s feet.

    Trocar location

    The five-port technique was used (Figure 2).Starting from the middle point between the navel and the anterior superior iliac spine to the left lower abdomen,the pneumoperitoneum and observation hole (10 mm) were established using the Hasson technique.Operation arm #1 was located between the left anterior axillary line,the navel,and the costal margin (8 mm); operation arm #2 was located at the intersection of the right anterior axillary line and Pfannenstiel line (8 mm); one auxiliary hole was located between arm #2 (on the Pfannenstiel line) and the observation hole (12 mm);and another auxiliary hole (5 mm) (initially taken as arm 3,changing into auxiliary hole because of the narrow space leading to collision of the robotic arms) was located slightly below the left side of the xiphoid.

    Surgical procedure

    Along the right line of Toldt and the hepatic flexure of the transverse colon,the colon was turned to the left and below with a hook electrode.Through Kocher's incision,the duodenum and the pancreatic head were turned to the left to expose the inferior vena cava and the abdominal aorta.The vein was separated along the right external iliac,and the inferior vena cava was then lifted to expose the right renal vein from the bottom to the top.The tumor was transected horizontally below the renal vein and was first cut into pieces and then resected.The right renal artery and the left renal vein were also exposed,and the retrohepatic inferior vena cava was isolated.The tumor was resected along the surface of the psoas muscle,the back of the inferior vena cava,and the right side of the abdominal aorta.Finally,the lymph node metastases in front of the abdominal aorta and left renal vein were completely removed.The specimens were loaded into a disposable specimen retrieval bag and removed from the enlarged auxiliary hole.T-tube drainage was placed and brought out through a hole in the right lower quadrant of the abdomen.Each puncture hole was sutured using a 3-0 absorbable suture.

    Postoperative management

    Conventional administrations of anti-inflammatory medications,fluid replacement,gastrointestinal decompression,acid suppression,and enzymatic inhibition were performed.The abdominal drainage volume and amylase level were monitored.The gastric tube was extracted on the third day after surgery,and the patient was placed on a liquid diet.After eating a normal diet,the abdominal drainage tube was removed when no lymphatic leakage or exudate was observed,and the patient was discharged(Figure 3).

    OUTCOME AND FOLLOW-UP

    Intraoperative status

    The operative time was 389 min,the time of pneumoperitoneum was 360 min,and the intraoperative blood loss was approximately 200 mL.

    Postoperative status

    Immediately after surgery,the blood amylase level was 1426.3 U/L (normal range,0-150),the blood lipase level was 54.6 U/L (normal range,23-300),the blood alanine aminotransferase level was 197.6 U/L (normal range,0-40),and the blood aspartate aminotransferase level was 302.7 U/L (normal range,0-40).The gastric tube was extracted on the third day after surgery,and no abdominal discomfort was found after drinking water.A liquid diet was administered to the patient on the fourth day.The blood amylase level was 64.3 U/L (normal range,0-150),the blood lipase level was 240.6 U/L (normal range,23-300),the blood alanine aminotransferase level was 73.7 U/L (normal range,0-40),and the blood aspartate aminotransferase level was 49.1 U/L (normal range,0-40) on the fourth day.The patient was given pediatric food on the seventh day.The fluid in the retroperitoneal drainage tube gradually decreased; therefore,on the tenth day,the retroperitoneal drainage tube was removed,and the patient was discharged.The patient continued to receive chemotherapy after discharge.A follow-up visit was performed 2 months later.Contrast-enhanced computed tomography showed that no tumor recurrence was observed,and no effusion was found in the surgical area.

    Postoperative pathological examination

    On June 29,2018,the pathological (conventional) examination results for the right adrenal gland and retroperitoneum were obtained.Degenerated small-round cells,ganglion cells with foam cell aggregation,and hemosiderosis were scattered in the adrenal tissue and hyperplastic fibrous tissue.Locally degenerated and necrotic nodules with a large amount of foam cell aggregation and scattered calcification were found,which is consistent with postoperative changes in NB.Immunohistochemistry results were:CD56 (+),CD99 (-),NSE (+),Ki-67 (+,2%),Syn (+),CgA (-),NF (+),S-100(+) (Tumor metastasis in the left abdominal aorta).Necrosis and calcification of small lesions in fibrous connective tissues were present,but no tumor cells were found(Figure 4).

    Figure2 Trocar locations.

    DISCUSSION

    NB is the most common extracranial solid tumor in children,with an incidence of approximately 1/10000.It is also one of the most challenging operations in pediatric surgery.Traditional open surgery has disadvantages,such as the creation of a large incision,difficulty achieving deep exposure,severe trauma,and a long recovery period.Since the first report of laparoscopic adrenalectomy[20],laparoscopic adrenalectomy has been frequently reported[21-23].The application of laparoscopy in NB resection is very extensively reported in the literature; however,if the NB is closely associated with important blood vessels,the use of a laparoscope in NB resection is still challenging and has limitations.Robotic surgery is a minimally invasive surgery with greater convenience and effectiveness[24].Robot-assisted laparoscopic resection of retroperitoneal NB is rarely reported[1].

    The resection of the primary foci of stage IV NB is still a controversial issue,with some studies suggesting that it is only superior to a simple biopsy,and the prognosis is more dependent on biological characteristics rather than the number of resected primary foci[25,26].However,most researchers still suggest the resection of over 95% of the tumor foci[27,28].The primary foci of stage IV NB are often large and envelope important blood vessels,and different five-year survival rates after complete primary tumor resection (26%,30%,52%,and 65%) have been reported[29-31].To achieve a good prognosis,the resection of 95% of the tumor tissue is the goal of tumor surgeons.However,Kiely and Sultan reported that this goal can only be achieved in 89% and 58% of patients,respectively.

    La Quagliaet al[32]reported the effect of aggressive surgical resection of the tumor on the prognosis.For children with a diagnosis of stage IV NB,complete removal of the tumor is unachievable.Delayed surgery or a second surgery can improve local tumor shrinkage and the metastasis disappearance rate after preoperative chemotherapy and prolong survival.However,the study by Castelet al[26]denied the therapeutic effect of surgical resection of stage IV NB and suggested that age,N-myc gene amplification,and distant metastasis have a much greater influence on the prognosis of stage IV NB than complete resection.Therefore,the treatment of stage IV NB should be a combination of surgery,radiotherapy,chemotherapy,and other treatments.Preoperative chemotherapy is necessary to remove the NB that envelopes important peritoneal blood vessels.Through chemotherapy,tumors can shrink significantly and harden,and the blood supply and other risk factors can decrease,making the resection of unresectable tumors possible[33,34].

    Separation is one of the techniques used to protect important blood vessels.We started from the relatively normal right common iliac vein,separated the inferior vena cava from bottom to top,ligated the right gonadal vein,and separated the right renal vein and left renal vein.Horizontal tumor transection was performed below the right renal vein to facilitate the exposure of the right renal artery and the right superior mesenteric artery.The inferior vena cava was lifted again,and the tumor above the right renal vein and on the right side of the abdominal aorta was resected.During the resection,the right adrenal gland covered the top of the tumor in the form of a sheet,and there was no significant thickened right middle adrenal vein.It is considered that the tumor originated from the retroperitoneal sympathetic nerve chain instead of the right adrenal gland.Finally,metastatic tumors in front of the left kidney were excised.During the separation process,we found that the stability of the hook electrode was better than that of electric scissors,and the hemostatic effect of the bipolar electrosurgical knife was good.

    Figure3 lncision healing at 2 mo after five-port laparoscopic surgery.

    Piecemeal resection is a necessary technique[35].Because the tumor envelopes the blood vessels,the vessels cannot be preserved without opening the tumor; thus,the tumor cannot be removed wholly.During NB resection in the advanced stages,en blocresection cannot be achieved; therefore,piecemeal resection is necessary to improve the prognosis.

    Maximization of the operating space should be considered.Children are typically short,and the abdominal space is small.The appropriate Trocar positions are below and to the left of the umbilicus.After placing the Trocar and the lens under the umbilicus,two auxiliary holes (left lower abdomen and left lateral xiphoid) should be arranged,since the operation is mainly performed in the right upper abdomen and behind the inferior vena cava.Arms #1 and #2 were arranged on the left side of the abdomen and the right lower abdomen,respectively,which can operate on the lesions on the right side and upper abdomen.During the operation,a cold lens was placed in the left lower abdomen,expanding the operating space.The operation was completed using the five-port approach,and no instruments collided with each other.

    Robot assistance is the key to the skeletonization of blood vessels.Conventional laparoscopic surgery is difficult and cannot achieve the resection of complex tumors.During the operation,the inferior vena cava,the bilateral renal veins,and the right renal artery are skeletonized; therefore,surgery is difficult,and the risk is high.Robots can provide a three-dimensional view with 10 × magnification.Shaking can be eliminated,and hand actions can be simulated.The robots can complete clamping,suturing,knotting,and other operations and achieve results similar to those of open surgery.Robotic surgery can preserve the aesthetic characteristics of the laparoscopic surgical incision.We placed arm #2 and auxiliary hole #1 on the Pfannenstiel line,and the tumor specimens were obtained from this line,which improves the postoperative appearance.No common complications,such as postoperative diarrhea[36],lymphatic fistula,or intestinal obstruction,were found.However,due to the long operative time,redness and swelling of the left waist skin occurred but completely disappeared after one week.Because of the isolation of the pancreas and liver,the amylase and transaminase levels also showed a transient increase but soon returned to normal.Robotic-assisted surgery not only maintains the advantages of minimally invasive surgery,such as small wounds,good aesthetics,and short operative time,hospitalization stay,and postoperative recovery time,but also addresses the limitations of open surgery and laparoscopic technology.

    This case is the first pediatric robot-assisted laparoscopic resection of stage IV NB(according to the International Neuroblastoma Staging System criteria) at our hospital,and no serious complications during or after surgery were found.The surgical experience of this case showed that robot-assisted resection of retroperitoneal NB is feasible and can be a new approach for the treatment of advanced NB.

    Figure4 Pathological images.

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