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    Surgical resection of gastric stump cancer following proximal gastrectomy for adenocarcinoma of the esophagogastric junction

    2019-06-11 07:30:30FuHaiMaLiYanXueYingTaiChenWeiKunLiYangLiWenZheKangYiBinXieYuXinZhongQuanXuYanTaoTian

    Fu-Hai Ma, Li-Yan Xue, Ying-Tai Chen, Wei-Kun Li, Yang Li, Wen-Zhe Kang, Yi-Bin Xie, Yu-Xin Zhong,Quan Xu, Yan-Tao Tian

    Fu-Hai Ma, Ying-Tai Chen, Wei-Kun Li, Yang Li, Wen-Zhe Kang, Yi-Bin Xie, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

    Li-Yan Xue, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

    Abstract

    Key words:Gastric stump cancer; Proximal gastrectomy; Esophagogastric junction; Distal gastrectomy

    INTRODUCTION

    Although the prevalence of gastric cancer is decreasing, the incidence of esophagogastric junction (EGJ) adenocarcinoma is increasing[1]. The choice of surgical techniques for EGJ adenocarcinoma is controversial, yet proximal gastrectomy (PG)remains an important surgical option[2,3]. PG is also widely used as a functionpreserving approach for early-stage proximal stomach cancer[4]. The incidence of gastric stump cancer (GSC) after PG is growing[5-8], and GSC following PG may thus be increasingly encountered by surgeons in the coming years.

    The clinicopathological characteristics, treatment, and prognosis of GSC after distal gastrectomy (DG) have been well investigated[9-11]; however, there is limited information on GSC after PG. To our knowledge, there are only few studies have been published on GSC following PG[8,12,13]. As such, we conducted a single-center retrospective study to understand the associated clinicopathological features, surgical results and long-term outcomes of GSC following PG.

    MATERIALS AND METHODS

    This retrospective study was approved by the Institutional Review Board of Cancer Hospital of the Chinese Academy of Medical Sciences and was based on demographic and pathological data retrieved from a computerized database of all patients with gastric cancer treated at this facility between January 1998 and December 2016. The need for informed consent was waived due to the retrospective nature of the study,and the data were anonymously analyzed.

    PG or PG plus esophagectomy followed by esophagogastrostomy reconstructionare usually indicated for EGJ adenocarcinoma and gastric cancer located in the upper third of the stomach. We defined GSC according to the Japanese Classification and Treatment Guidelines for Gastric Cancer (14thedition), in which GSC is defined as a cancer arising in the gastric stump after gastrectomy, regardless of the histology of the previous lesion (benign or malignant), risk of recurrence, extent of initial resection, or method of reconstruction[14]. Thirty-five patients who had undergone resection of the gastric stump for GSC following PG at Cancer Hospital of the Chinese Academy of Medical Sciences were eligible for inclusion in the study.

    To investigate whether the time interval significantly influenced survival, we divided the patients into 2 groups:Interval < 5 years (n= 21) and ≥ 5 years (n= 14).We also divided the patients into 2 groups to investigate whether the tumor location significantly impacted survival:Tumors located in anastomotic sites (n= 14) and tumors located in nonanastomotic sites (n= 20). Medical records were reviewed with regard to preoperative medical conditions, perioperative complications,histopathological results and follow-up data.

    Statistical analysis

    Cumulative survival rates were obtained using the Kaplan-Meier method and compared using the log-rank test to evaluate statistically significant differences. Cox proportional hazards regression analysis was used to evaluate factors affecting overall survival (OS). P < 0.05 was considered significant. The statistical analysis was performed with SPSS for Windows version 22.0.

    RESULTS

    Patients and clinical characteristics

    The demographic and clinical characteristics of 35 patients with GSC following PG are shown in Table 1. The mean age was 60 ± 11 years, and the male-to-female ratio was 7.75 to 1. Of the 35 patients, the mean interval between primary PG and the development of GSC was 4.9 (range 0.7-12) years. The time to treatment of GSC was within 5 years in 21 patients, within 5-10 years in 10 patients, and longer than 10 years in 4 patients. Regarding the initial EGJ adenocarcinoma, 2 patients had type I, 29 had type II, and 4 had type III disease according to Siewert Classification. All of the patients underwent PG with esophagogastrostomy. With regard to the site of tumors in the gastric stump, 14 and 21 were in anastomotic and nonanastomotic sites, respectively.

    Surgical characteristics and short-term outcomes

    Total gastrectomy as the primary procedure for GSC was performed in 27 patients(77.1%) of all patients; partial resection of the gastric remnant was performed in 8 patients (22.9%). In 5 patients, resection of one or more adjacent organs was performed together with gastrectomy. The mean operation time was 343 ± 132 min.The mean intraoperative blood loss volume was 513 ± 383 ml. Postoperative complications were detected in 6 patients (17.1%):4 patients developed leakage from the anastomotic site, 1 developed wound infection, 1 developed hemorrhage, and 1 developed postoperative ileus. However, none of these patients died (Table 2).

    Histopathological characteristics

    Histological analysis revealed 26 adenocarcinomas and 9 adenocarcinomas with signet ring cells. Analysis of histological differentiation revealed 3 well-differentiated tumor types, 11 moderately differentiated tumor types, and 21 poorly differentiated tumor types. The disease stage according to the depth of tumor invasion was T1 in 6 patients, T2 in 3 patients, T3 in 9 patients, T4a in 11 patients, and T4b in 6 patients.The median number of dissected lymph nodes was 11.1 ± 7.4, and the median number of lymph node metastases was 2.9 ± 4.2. Lymph node metastasis was observed in 18 patients (Table 3).

    Long-term outcomes and factors affecting survival

    The 1-, 3-, and 5-year OS rates were 86.5%, 62.3%, and 54.2%, respectively. The results of the Cox proportional hazards model demonstrated T stage to be a significant independent prognostic factor for survival (Table 4). The 5-year survival rates for patients with T1/T2, T3 and T4 disease were 85.7%, 72.0% and 30.6%, respectively.

    DISCUSSION

    GSC was originally defined as gastric cancer occurring at least five years after afterDG for benign disease[15,16]. Recently, GSC has been used to refer to all cancers detected in the gastric stump, irrespective of the primary disease or initial operation[17]. The incidence of GSC following PG is increasing, and that of GSC is reportedly higher after PG (3.6%-9.1%) than after DG (0.4%-2.5%)[18]. Moreover, Nozakiet al[19]found that PG is an independent risk factor for GSC. Compared to DG, PG may result in an additional risk for GSC[11]. Surgery, pathogenesis, and prognosis of GSC after DG are well investigated; however, little is known about GSC following PG because very few studies have been conducted on the disease. To the best of our knowledge, this is the first study investigating GSC following PG for EGJ adenocarcinoma.

    Table 1 Clinical characteristics of patients

    Resection of GSC is associated with intra-abdominal adhesion after the initial procedure. Surgeons sometimes encounter technical difficulties during resection,which leads to prolonged operation time and excessive blood loss. Furthermore,intraoperative surgical complications, such as intestinal injury, may occur. Previous studies have reported an overall surgical complication rate of 19%-47% for GSC, with operation-related mortality rates of 2%-13%[20]. However, little is known about the complication rate of GSC following PG. In our study, the overall complication rate was 17.1%, which is relatively low. Additionally, 5 of 35 patients (14.3%) required additional organ resection; this rate is also lower than that reported for GSC after DG[21]. The need for additional organ resection may complicate surgery in patients with GSC.

    Ohyamaet al[12]identified almost the same numbers of differentiated and undifferentiated tumors in GSC. However, in our study, 21 of 35 tumors were poorly differentiated. Because only a few studies have been published on the pathological type of GSC, the characteristics of this disease remain unclear. In the present study,early GSC was diagnosed in 6 (17%) of 35 patients, whereas T4 disease was identified in 17 (48.6%). As GSC is more likely to be diagnosed at an advanced stage, endoscopic follow-up of the gastric stump is necessary to detect GSC at an early stage. The incidence of metastasis to lymph nodes was 54.3% (19/35) in the present study, which is higher than that of GSC after DG[11].

    Although the number of patients in our study was small, the results showed a 5-year OS rate of 54.2%. In addition, the results of the Cox proportional hazards model showed only T stage to be a significantly independent prognostic factor for survival.In contrast, the time interval or location did not affect survival, which may partly justify the definition of GSC, whereby time interval, tumor location and method of reconstruction are not considered.

    Table 2 Surgical characteristics and short-term outcomes

    Nevertheless, this study has several limitations. First, because not all patients in our study underwent PG at Cancer Hospital of the Chinese Academy of Medical Sciences,some important information on the initial operation was missing, such as the extent of lymphadenectomy, histology type, and pathologic stage. Second, the number of patients enrolled was small, mostly because of the rarity of the disease. Third, there is no standardized definition of GSC, which make our study not able to be accurately compared with previous studies on GSC.

    Here, we reveal characteristics of GSC following PG in detail with the largest number of patients to date.Our results suggest that surgical approaches can achieve satisfactory outcomes in GSC following PG, similar to those in patients with typical gastric cancer. GSC is more likely to be diagnosed at an advanced stage, and thus,endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Further larger-scale studies are necessary to clarify the characteristics of the disease.

    Table 3 Histopathological characteristics

    Table 4 Univariate and Multivariate analyses of clinicopathologic factors associated with overall survival

    ARTICLE HIGHLIGHTS

    Research background

    Proximal gastrectomy (PG) is performed widely as a function-preserving operation for early gastric cancer located in the upper third of the stomach and is an important function-preserving approach for esophagogastric junction (EGJ) adenocarcinoma. The incidence of gastric stump cancer (GSC) after PG is increasing. However, little is known about the GSC following PG because very few studies have been conducted on the disease. To our knowledge, there are only few studies have been published on GSC following PG.

    Research motivation

    The clinicopathological characteristics, treatment, and prognosis of GSC after distal gastrectomy have been well investigated; however, there is limited information on GSC after PG. As such, we conducted a single-center retrospective study to understand the associated clinicopathological features, surgical results and long-term outcomes of GSC following PG.

    Research objectives

    The aim of this study is to clarify clinicopathologic features, perioperative complications, and long-term survival rates after resection of GSC following PG. We revealed characteristics of GSC following PG in detail with the largest number of patients to date.

    Research methods

    This is a retrospective study. Thirty-five patients who had undergone resection of the gastric stump for GSC following PG at Cancer Hospital of the Chinese Academy of Medical Sciences were eligible for inclusion in the study. Medical records were reviewed with regard topreoperative medical conditions, perioperative complications, histopathological results and follow-up data. Cumulative survival rates were obtained using the Kaplan-Meier method and compared using the log-rank test to evaluate statistically significant differences. Cox proportional hazards regression analysis was used to evaluate factors affecting overall survival(OS).

    Research results

    This study reveals the characteristics of GSC following PG for adenocarcinoma of the EGJ and suggests that a surgical approach can lead to a satisfactory outcome. GSC is more likely to be diagnosed at an advanced stage, and thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Further larger-scale studies are necessary to clarify the characteristics of the disease.

    Research conclusions

    We revealed the characteristics of GSC following PG for adenocarcinoma of the EGJ and suggests that a surgical approach can lead to a satisfactory outcome. GSC is more likely to be diagnosed at an advanced stage, and thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. The incidence of GSC after PG is increasing. Surgical approach can lead to a satisfactory outcome. This is the first study investigating GSC following PG for EGJ adenocarcinoma. GSC following PG should be compared with initial distal gastric cancer. We defined GSC according to the Japanese Classification and Treatment Guidelines for Gastric Cancer (14thedition). Our results suggest that surgical approaches can achieve satisfactory outcomes in GSC following PG, similar to those in patients with typical gastric cancer. There are only few studies have been published on GSC following PG. This study reveals the characteristics of GSC following PG for adenocarcinoma of the EGJ. Endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Surgical approach should be performed for patients with GSC following PG.

    Research perspectives

    The factor associated with OS based on multivariate analysis was advanced T stage and GSC is more likely to be diagnosed at an advanced stage. Thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage.

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