• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Surgical resection of gastric stump cancer following proximal gastrectomy for adenocarcinoma of the esophagogastric junction

    2019-06-11 07:30:30FuHaiMaLiYanXueYingTaiChenWeiKunLiYangLiWenZheKangYiBinXieYuXinZhongQuanXuYanTaoTian

    Fu-Hai Ma, Li-Yan Xue, Ying-Tai Chen, Wei-Kun Li, Yang Li, Wen-Zhe Kang, Yi-Bin Xie, Yu-Xin Zhong,Quan Xu, Yan-Tao Tian

    Fu-Hai Ma, Ying-Tai Chen, Wei-Kun Li, Yang Li, Wen-Zhe Kang, Yi-Bin Xie, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

    Li-Yan Xue, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

    Abstract

    Key words:Gastric stump cancer; Proximal gastrectomy; Esophagogastric junction; Distal gastrectomy

    INTRODUCTION

    Although the prevalence of gastric cancer is decreasing, the incidence of esophagogastric junction (EGJ) adenocarcinoma is increasing[1]. The choice of surgical techniques for EGJ adenocarcinoma is controversial, yet proximal gastrectomy (PG)remains an important surgical option[2,3]. PG is also widely used as a functionpreserving approach for early-stage proximal stomach cancer[4]. The incidence of gastric stump cancer (GSC) after PG is growing[5-8], and GSC following PG may thus be increasingly encountered by surgeons in the coming years.

    The clinicopathological characteristics, treatment, and prognosis of GSC after distal gastrectomy (DG) have been well investigated[9-11]; however, there is limited information on GSC after PG. To our knowledge, there are only few studies have been published on GSC following PG[8,12,13]. As such, we conducted a single-center retrospective study to understand the associated clinicopathological features, surgical results and long-term outcomes of GSC following PG.

    MATERIALS AND METHODS

    This retrospective study was approved by the Institutional Review Board of Cancer Hospital of the Chinese Academy of Medical Sciences and was based on demographic and pathological data retrieved from a computerized database of all patients with gastric cancer treated at this facility between January 1998 and December 2016. The need for informed consent was waived due to the retrospective nature of the study,and the data were anonymously analyzed.

    PG or PG plus esophagectomy followed by esophagogastrostomy reconstructionare usually indicated for EGJ adenocarcinoma and gastric cancer located in the upper third of the stomach. We defined GSC according to the Japanese Classification and Treatment Guidelines for Gastric Cancer (14thedition), in which GSC is defined as a cancer arising in the gastric stump after gastrectomy, regardless of the histology of the previous lesion (benign or malignant), risk of recurrence, extent of initial resection, or method of reconstruction[14]. Thirty-five patients who had undergone resection of the gastric stump for GSC following PG at Cancer Hospital of the Chinese Academy of Medical Sciences were eligible for inclusion in the study.

    To investigate whether the time interval significantly influenced survival, we divided the patients into 2 groups:Interval < 5 years (n= 21) and ≥ 5 years (n= 14).We also divided the patients into 2 groups to investigate whether the tumor location significantly impacted survival:Tumors located in anastomotic sites (n= 14) and tumors located in nonanastomotic sites (n= 20). Medical records were reviewed with regard to preoperative medical conditions, perioperative complications,histopathological results and follow-up data.

    Statistical analysis

    Cumulative survival rates were obtained using the Kaplan-Meier method and compared using the log-rank test to evaluate statistically significant differences. Cox proportional hazards regression analysis was used to evaluate factors affecting overall survival (OS). P < 0.05 was considered significant. The statistical analysis was performed with SPSS for Windows version 22.0.

    RESULTS

    Patients and clinical characteristics

    The demographic and clinical characteristics of 35 patients with GSC following PG are shown in Table 1. The mean age was 60 ± 11 years, and the male-to-female ratio was 7.75 to 1. Of the 35 patients, the mean interval between primary PG and the development of GSC was 4.9 (range 0.7-12) years. The time to treatment of GSC was within 5 years in 21 patients, within 5-10 years in 10 patients, and longer than 10 years in 4 patients. Regarding the initial EGJ adenocarcinoma, 2 patients had type I, 29 had type II, and 4 had type III disease according to Siewert Classification. All of the patients underwent PG with esophagogastrostomy. With regard to the site of tumors in the gastric stump, 14 and 21 were in anastomotic and nonanastomotic sites, respectively.

    Surgical characteristics and short-term outcomes

    Total gastrectomy as the primary procedure for GSC was performed in 27 patients(77.1%) of all patients; partial resection of the gastric remnant was performed in 8 patients (22.9%). In 5 patients, resection of one or more adjacent organs was performed together with gastrectomy. The mean operation time was 343 ± 132 min.The mean intraoperative blood loss volume was 513 ± 383 ml. Postoperative complications were detected in 6 patients (17.1%):4 patients developed leakage from the anastomotic site, 1 developed wound infection, 1 developed hemorrhage, and 1 developed postoperative ileus. However, none of these patients died (Table 2).

    Histopathological characteristics

    Histological analysis revealed 26 adenocarcinomas and 9 adenocarcinomas with signet ring cells. Analysis of histological differentiation revealed 3 well-differentiated tumor types, 11 moderately differentiated tumor types, and 21 poorly differentiated tumor types. The disease stage according to the depth of tumor invasion was T1 in 6 patients, T2 in 3 patients, T3 in 9 patients, T4a in 11 patients, and T4b in 6 patients.The median number of dissected lymph nodes was 11.1 ± 7.4, and the median number of lymph node metastases was 2.9 ± 4.2. Lymph node metastasis was observed in 18 patients (Table 3).

    Long-term outcomes and factors affecting survival

    The 1-, 3-, and 5-year OS rates were 86.5%, 62.3%, and 54.2%, respectively. The results of the Cox proportional hazards model demonstrated T stage to be a significant independent prognostic factor for survival (Table 4). The 5-year survival rates for patients with T1/T2, T3 and T4 disease were 85.7%, 72.0% and 30.6%, respectively.

    DISCUSSION

    GSC was originally defined as gastric cancer occurring at least five years after afterDG for benign disease[15,16]. Recently, GSC has been used to refer to all cancers detected in the gastric stump, irrespective of the primary disease or initial operation[17]. The incidence of GSC following PG is increasing, and that of GSC is reportedly higher after PG (3.6%-9.1%) than after DG (0.4%-2.5%)[18]. Moreover, Nozakiet al[19]found that PG is an independent risk factor for GSC. Compared to DG, PG may result in an additional risk for GSC[11]. Surgery, pathogenesis, and prognosis of GSC after DG are well investigated; however, little is known about GSC following PG because very few studies have been conducted on the disease. To the best of our knowledge, this is the first study investigating GSC following PG for EGJ adenocarcinoma.

    Table 1 Clinical characteristics of patients

    Resection of GSC is associated with intra-abdominal adhesion after the initial procedure. Surgeons sometimes encounter technical difficulties during resection,which leads to prolonged operation time and excessive blood loss. Furthermore,intraoperative surgical complications, such as intestinal injury, may occur. Previous studies have reported an overall surgical complication rate of 19%-47% for GSC, with operation-related mortality rates of 2%-13%[20]. However, little is known about the complication rate of GSC following PG. In our study, the overall complication rate was 17.1%, which is relatively low. Additionally, 5 of 35 patients (14.3%) required additional organ resection; this rate is also lower than that reported for GSC after DG[21]. The need for additional organ resection may complicate surgery in patients with GSC.

    Ohyamaet al[12]identified almost the same numbers of differentiated and undifferentiated tumors in GSC. However, in our study, 21 of 35 tumors were poorly differentiated. Because only a few studies have been published on the pathological type of GSC, the characteristics of this disease remain unclear. In the present study,early GSC was diagnosed in 6 (17%) of 35 patients, whereas T4 disease was identified in 17 (48.6%). As GSC is more likely to be diagnosed at an advanced stage, endoscopic follow-up of the gastric stump is necessary to detect GSC at an early stage. The incidence of metastasis to lymph nodes was 54.3% (19/35) in the present study, which is higher than that of GSC after DG[11].

    Although the number of patients in our study was small, the results showed a 5-year OS rate of 54.2%. In addition, the results of the Cox proportional hazards model showed only T stage to be a significantly independent prognostic factor for survival.In contrast, the time interval or location did not affect survival, which may partly justify the definition of GSC, whereby time interval, tumor location and method of reconstruction are not considered.

    Table 2 Surgical characteristics and short-term outcomes

    Nevertheless, this study has several limitations. First, because not all patients in our study underwent PG at Cancer Hospital of the Chinese Academy of Medical Sciences,some important information on the initial operation was missing, such as the extent of lymphadenectomy, histology type, and pathologic stage. Second, the number of patients enrolled was small, mostly because of the rarity of the disease. Third, there is no standardized definition of GSC, which make our study not able to be accurately compared with previous studies on GSC.

    Here, we reveal characteristics of GSC following PG in detail with the largest number of patients to date.Our results suggest that surgical approaches can achieve satisfactory outcomes in GSC following PG, similar to those in patients with typical gastric cancer. GSC is more likely to be diagnosed at an advanced stage, and thus,endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Further larger-scale studies are necessary to clarify the characteristics of the disease.

    Table 3 Histopathological characteristics

    Table 4 Univariate and Multivariate analyses of clinicopathologic factors associated with overall survival

    ARTICLE HIGHLIGHTS

    Research background

    Proximal gastrectomy (PG) is performed widely as a function-preserving operation for early gastric cancer located in the upper third of the stomach and is an important function-preserving approach for esophagogastric junction (EGJ) adenocarcinoma. The incidence of gastric stump cancer (GSC) after PG is increasing. However, little is known about the GSC following PG because very few studies have been conducted on the disease. To our knowledge, there are only few studies have been published on GSC following PG.

    Research motivation

    The clinicopathological characteristics, treatment, and prognosis of GSC after distal gastrectomy have been well investigated; however, there is limited information on GSC after PG. As such, we conducted a single-center retrospective study to understand the associated clinicopathological features, surgical results and long-term outcomes of GSC following PG.

    Research objectives

    The aim of this study is to clarify clinicopathologic features, perioperative complications, and long-term survival rates after resection of GSC following PG. We revealed characteristics of GSC following PG in detail with the largest number of patients to date.

    Research methods

    This is a retrospective study. Thirty-five patients who had undergone resection of the gastric stump for GSC following PG at Cancer Hospital of the Chinese Academy of Medical Sciences were eligible for inclusion in the study. Medical records were reviewed with regard topreoperative medical conditions, perioperative complications, histopathological results and follow-up data. Cumulative survival rates were obtained using the Kaplan-Meier method and compared using the log-rank test to evaluate statistically significant differences. Cox proportional hazards regression analysis was used to evaluate factors affecting overall survival(OS).

    Research results

    This study reveals the characteristics of GSC following PG for adenocarcinoma of the EGJ and suggests that a surgical approach can lead to a satisfactory outcome. GSC is more likely to be diagnosed at an advanced stage, and thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Further larger-scale studies are necessary to clarify the characteristics of the disease.

    Research conclusions

    We revealed the characteristics of GSC following PG for adenocarcinoma of the EGJ and suggests that a surgical approach can lead to a satisfactory outcome. GSC is more likely to be diagnosed at an advanced stage, and thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. The incidence of GSC after PG is increasing. Surgical approach can lead to a satisfactory outcome. This is the first study investigating GSC following PG for EGJ adenocarcinoma. GSC following PG should be compared with initial distal gastric cancer. We defined GSC according to the Japanese Classification and Treatment Guidelines for Gastric Cancer (14thedition). Our results suggest that surgical approaches can achieve satisfactory outcomes in GSC following PG, similar to those in patients with typical gastric cancer. There are only few studies have been published on GSC following PG. This study reveals the characteristics of GSC following PG for adenocarcinoma of the EGJ. Endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage. Surgical approach should be performed for patients with GSC following PG.

    Research perspectives

    The factor associated with OS based on multivariate analysis was advanced T stage and GSC is more likely to be diagnosed at an advanced stage. Thus, endoscopic follow-up of the gastric stump should be conducted to detect GSC at an early stage.

    国产成人欧美在线观看| 免费女性裸体啪啪无遮挡网站| 久久中文字幕人妻熟女| 男人的好看免费观看在线视频 | 真人做人爱边吃奶动态| 搞女人的毛片| 99久久99久久久精品蜜桃| 久久精品国产综合久久久| 午夜福利影视在线免费观看| 欧美精品亚洲一区二区| 纯流量卡能插随身wifi吗| 人人妻人人澡欧美一区二区 | av片东京热男人的天堂| 欧洲精品卡2卡3卡4卡5卡区| 国产成人精品久久二区二区免费| 国语自产精品视频在线第100页| 国产午夜福利久久久久久| 国产精品久久久久久亚洲av鲁大| 久久天堂一区二区三区四区| 久久人妻福利社区极品人妻图片| 高清毛片免费观看视频网站| 日本vs欧美在线观看视频| 少妇的丰满在线观看| 在线播放国产精品三级| 多毛熟女@视频| 欧美最黄视频在线播放免费| 欧美性长视频在线观看| 亚洲全国av大片| 波多野结衣av一区二区av| 国产真人三级小视频在线观看| 精品一区二区三区视频在线观看免费| 国产精品久久视频播放| 亚洲精品国产精品久久久不卡| 欧美日韩乱码在线| 黄色视频不卡| 两个人免费观看高清视频| 色婷婷久久久亚洲欧美| 亚洲国产精品合色在线| 国产精品乱码一区二三区的特点 | 亚洲欧美精品综合一区二区三区| 香蕉久久夜色| 一区二区三区国产精品乱码| 午夜久久久久精精品| 国产精品电影一区二区三区| 欧美精品啪啪一区二区三区| 一进一出抽搐gif免费好疼| 国产三级在线视频| 久久久水蜜桃国产精品网| 久久人妻熟女aⅴ| 亚洲一卡2卡3卡4卡5卡精品中文| 国产av一区在线观看免费| 久久精品国产综合久久久| 成人特级黄色片久久久久久久| 亚洲精品中文字幕在线视频| 亚洲五月色婷婷综合| 99久久国产精品久久久| 1024香蕉在线观看| 免费av毛片视频| 天天躁狠狠躁夜夜躁狠狠躁| 久久狼人影院| 男女做爰动态图高潮gif福利片 | 久久亚洲精品不卡| 无遮挡黄片免费观看| 男女午夜视频在线观看| 亚洲熟女毛片儿| 国产一区二区三区视频了| 久久久久久人人人人人| 97碰自拍视频| 久久久国产欧美日韩av| 美女午夜性视频免费| 宅男免费午夜| 十八禁网站免费在线| 欧美日韩亚洲综合一区二区三区_| 51午夜福利影视在线观看| 欧美成人性av电影在线观看| av网站免费在线观看视频| 久久亚洲真实| 视频在线观看一区二区三区| 老鸭窝网址在线观看| 国内毛片毛片毛片毛片毛片| 免费高清在线观看日韩| 国产精品免费一区二区三区在线| 精品人妻在线不人妻| av片东京热男人的天堂| 美女 人体艺术 gogo| 欧洲精品卡2卡3卡4卡5卡区| 午夜福利18| 91成人精品电影| 成人特级黄色片久久久久久久| 亚洲专区国产一区二区| 超碰成人久久| 欧美性长视频在线观看| 搞女人的毛片| 老司机深夜福利视频在线观看| 中文字幕高清在线视频| 精品国产乱子伦一区二区三区| 女人精品久久久久毛片| 看黄色毛片网站| 亚洲欧美激情在线| 精品国产一区二区三区四区第35| 午夜福利免费观看在线| 日本 欧美在线| 亚洲七黄色美女视频| 欧美乱妇无乱码| 亚洲精品国产一区二区精华液| 色播在线永久视频| 亚洲全国av大片| 黄片小视频在线播放| 亚洲一码二码三码区别大吗| 性欧美人与动物交配| 国产在线精品亚洲第一网站| 九色亚洲精品在线播放| 国产高清激情床上av| 久久久国产精品麻豆| 国产色视频综合| 国产精品永久免费网站| 9191精品国产免费久久| 侵犯人妻中文字幕一二三四区| 亚洲国产毛片av蜜桃av| 男女下面进入的视频免费午夜 | 一边摸一边抽搐一进一出视频| 婷婷精品国产亚洲av在线| 国产一区二区在线av高清观看| 久久婷婷成人综合色麻豆| 精品人妻1区二区| 国产一区二区在线av高清观看| 黄片大片在线免费观看| 国产在线精品亚洲第一网站| 日本黄色视频三级网站网址| АⅤ资源中文在线天堂| 狠狠狠狠99中文字幕| 国产精品日韩av在线免费观看 | 色综合欧美亚洲国产小说| 99香蕉大伊视频| 桃色一区二区三区在线观看| 精品熟女少妇八av免费久了| 自拍欧美九色日韩亚洲蝌蚪91| 两人在一起打扑克的视频| 可以在线观看的亚洲视频| 国产麻豆成人av免费视频| 中出人妻视频一区二区| 亚洲第一欧美日韩一区二区三区| 欧美日韩福利视频一区二区| 久久久国产成人免费| 久久香蕉激情| 性色av乱码一区二区三区2| 丝袜美腿诱惑在线| 国产精品久久久av美女十八| 搞女人的毛片| 精品久久久久久成人av| 麻豆av在线久日| 十八禁网站免费在线| 亚洲国产精品sss在线观看| 日韩精品中文字幕看吧| 看免费av毛片| 国产亚洲欧美98| 男女之事视频高清在线观看| 国产主播在线观看一区二区| 夜夜看夜夜爽夜夜摸| 国产精品野战在线观看| 大码成人一级视频| 女人精品久久久久毛片| 日本一区二区免费在线视频| 国内毛片毛片毛片毛片毛片| 国产精品,欧美在线| 久久婷婷成人综合色麻豆| 99国产精品一区二区三区| 久久久久久久久免费视频了| 亚洲avbb在线观看| 亚洲欧美日韩高清在线视频| 每晚都被弄得嗷嗷叫到高潮| 亚洲中文av在线| e午夜精品久久久久久久| 级片在线观看| 12—13女人毛片做爰片一| 午夜福利,免费看| www.www免费av| 欧美国产日韩亚洲一区| 久久精品91蜜桃| 免费av毛片视频| 在线观看免费日韩欧美大片| 久久国产精品人妻蜜桃| 91字幕亚洲| 视频区欧美日本亚洲| 亚洲专区中文字幕在线| 黄色视频不卡| 亚洲精品国产一区二区精华液| 欧美精品啪啪一区二区三区| 深夜精品福利| 99在线视频只有这里精品首页| 久久青草综合色| 12—13女人毛片做爰片一| 国产黄a三级三级三级人| 成年人黄色毛片网站| 亚洲欧美日韩高清在线视频| 日本五十路高清| 成在线人永久免费视频| 婷婷丁香在线五月| 欧美成人午夜精品| 人人妻人人澡欧美一区二区 | 国产欧美日韩综合在线一区二区| 在线观看舔阴道视频| 亚洲自拍偷在线| 51午夜福利影视在线观看| 人妻久久中文字幕网| 亚洲国产精品合色在线| 国产亚洲精品第一综合不卡| 免费女性裸体啪啪无遮挡网站| 女人被狂操c到高潮| 超碰成人久久| 一进一出好大好爽视频| 亚洲黑人精品在线| 黑人欧美特级aaaaaa片| 嫩草影视91久久| 女生性感内裤真人,穿戴方法视频| 操出白浆在线播放| 免费观看精品视频网站| 欧美一区二区精品小视频在线| videosex国产| 亚洲av电影不卡..在线观看| 精品国产超薄肉色丝袜足j| 久久精品影院6| 可以在线观看的亚洲视频| 国产亚洲精品综合一区在线观看 | 免费搜索国产男女视频| 欧美国产日韩亚洲一区| 夜夜看夜夜爽夜夜摸| 久久精品国产清高在天天线| 一进一出抽搐动态| 一本大道久久a久久精品| 国产在线观看jvid| cao死你这个sao货| 国产日韩一区二区三区精品不卡| 久久久久国产精品人妻aⅴ院| 97人妻精品一区二区三区麻豆 | 99re在线观看精品视频| 免费人成视频x8x8入口观看| 在线播放国产精品三级| 精品电影一区二区在线| 亚洲av日韩精品久久久久久密| x7x7x7水蜜桃| 美国免费a级毛片| 无遮挡黄片免费观看| 满18在线观看网站| 国内久久婷婷六月综合欲色啪| 精品少妇一区二区三区视频日本电影| 久久久水蜜桃国产精品网| 三级毛片av免费| 久久久久久久久中文| 国产亚洲精品第一综合不卡| 桃红色精品国产亚洲av| 男男h啪啪无遮挡| 最好的美女福利视频网| 欧美日韩亚洲综合一区二区三区_| 成人亚洲精品av一区二区| 成年版毛片免费区| 亚洲激情在线av| 一本久久中文字幕| 久久 成人 亚洲| 婷婷精品国产亚洲av在线| 18禁美女被吸乳视频| 欧美中文日本在线观看视频| 人人妻,人人澡人人爽秒播| 亚洲精品久久国产高清桃花| 亚洲一区中文字幕在线| 国产精品自产拍在线观看55亚洲| 免费一级毛片在线播放高清视频 | 亚洲情色 制服丝袜| 在线视频色国产色| 99久久国产精品久久久| 精品一区二区三区视频在线观看免费| 欧美日韩亚洲综合一区二区三区_| 首页视频小说图片口味搜索| 少妇 在线观看| www.999成人在线观看| 午夜免费激情av| 看免费av毛片| 精品国产一区二区三区四区第35| 后天国语完整版免费观看| 久久久久久亚洲精品国产蜜桃av| 在线观看66精品国产| 久久精品国产亚洲av香蕉五月| 男人操女人黄网站| 欧美国产精品va在线观看不卡| 亚洲第一青青草原| 欧美日韩福利视频一区二区| av电影中文网址| av欧美777| 给我免费播放毛片高清在线观看| 亚洲国产欧美网| 亚洲全国av大片| 亚洲欧美一区二区三区黑人| 天堂影院成人在线观看| 乱人伦中国视频| 久久精品国产亚洲av高清一级| 亚洲欧洲精品一区二区精品久久久| 亚洲国产高清在线一区二区三 | av天堂在线播放| а√天堂www在线а√下载| 天堂影院成人在线观看| 欧美日本亚洲视频在线播放| 久久精品91无色码中文字幕| 搡老熟女国产l中国老女人| 美女大奶头视频| 久久久久国内视频| 久久精品国产综合久久久| 18禁观看日本| 天天躁狠狠躁夜夜躁狠狠躁| 国产精品电影一区二区三区| 久久精品亚洲熟妇少妇任你| 在线观看www视频免费| 国产精品香港三级国产av潘金莲| 母亲3免费完整高清在线观看| 欧美黄色淫秽网站| 两人在一起打扑克的视频| 日日夜夜操网爽| 亚洲国产高清在线一区二区三 | 国产午夜精品久久久久久| 高清黄色对白视频在线免费看| 非洲黑人性xxxx精品又粗又长| 午夜免费鲁丝| 美女国产高潮福利片在线看| 纯流量卡能插随身wifi吗| 久久精品国产清高在天天线| 欧美黄色片欧美黄色片| 国内毛片毛片毛片毛片毛片| 久久久精品国产亚洲av高清涩受| 91在线观看av| av天堂在线播放| 90打野战视频偷拍视频| 无人区码免费观看不卡| 免费在线观看日本一区| 欧美日韩黄片免| 少妇被粗大的猛进出69影院| 午夜亚洲福利在线播放| 婷婷丁香在线五月| www日本在线高清视频| 国产精品久久久av美女十八| 中文字幕另类日韩欧美亚洲嫩草| 三级毛片av免费| 99国产精品99久久久久| 日韩精品青青久久久久久| 亚洲精品美女久久av网站| 一区在线观看完整版| 亚洲第一电影网av| 日本黄色视频三级网站网址| 国产精品一区二区三区四区久久 | 中文字幕久久专区| 伊人久久大香线蕉亚洲五| 色精品久久人妻99蜜桃| 精品国产国语对白av| 国产精品久久久久久精品电影 | 欧美成人一区二区免费高清观看 | 黑人巨大精品欧美一区二区蜜桃| 免费搜索国产男女视频| 丝袜美足系列| 长腿黑丝高跟| 欧美成人免费av一区二区三区| 久久久久久人人人人人| 欧美成狂野欧美在线观看| 欧美国产精品va在线观看不卡| 国产午夜精品久久久久久| 麻豆国产av国片精品| 女性被躁到高潮视频| 19禁男女啪啪无遮挡网站| 国内久久婷婷六月综合欲色啪| 最好的美女福利视频网| 波多野结衣一区麻豆| 国语自产精品视频在线第100页| 亚洲人成77777在线视频| 午夜久久久久精精品| 天天躁狠狠躁夜夜躁狠狠躁| 99久久国产精品久久久| 欧美亚洲日本最大视频资源| 亚洲黑人精品在线| 少妇的丰满在线观看| 亚洲国产日韩欧美精品在线观看 | 又黄又粗又硬又大视频| 久久精品国产亚洲av香蕉五月| 日韩高清综合在线| 亚洲av五月六月丁香网| 露出奶头的视频| 久久久精品国产亚洲av高清涩受| 一级毛片精品| 久久精品aⅴ一区二区三区四区| 欧美人与性动交α欧美精品济南到| 午夜激情av网站| 俄罗斯特黄特色一大片| 色综合欧美亚洲国产小说| 亚洲专区中文字幕在线| 国产成人影院久久av| 99久久99久久久精品蜜桃| 亚洲久久久国产精品| 午夜免费观看网址| 国产单亲对白刺激| 婷婷六月久久综合丁香| 亚洲精品国产色婷婷电影| 亚洲国产毛片av蜜桃av| 人人妻人人澡人人看| 久久婷婷成人综合色麻豆| 亚洲一卡2卡3卡4卡5卡精品中文| 免费在线观看影片大全网站| 在线观看免费午夜福利视频| 午夜精品国产一区二区电影| 男人的好看免费观看在线视频 | 狂野欧美激情性xxxx| 国产99白浆流出| www.www免费av| 精品一区二区三区视频在线观看免费| 欧美日韩福利视频一区二区| 国产男靠女视频免费网站| 久久久久久亚洲精品国产蜜桃av| 中文字幕人成人乱码亚洲影| 伦理电影免费视频| 天堂动漫精品| 日日爽夜夜爽网站| 一个人免费在线观看的高清视频| 免费在线观看视频国产中文字幕亚洲| 大型av网站在线播放| 国产精品98久久久久久宅男小说| 午夜福利视频1000在线观看 | 国产精品亚洲av一区麻豆| 国产男靠女视频免费网站| 99精品久久久久人妻精品| 99久久久亚洲精品蜜臀av| 电影成人av| 又紧又爽又黄一区二区| 真人一进一出gif抽搐免费| 亚洲国产欧美日韩在线播放| 午夜老司机福利片| 国产精品久久久av美女十八| 国产av一区在线观看免费| 亚洲av美国av| 中文字幕久久专区| 大陆偷拍与自拍| 国产精品亚洲美女久久久| 日韩欧美国产一区二区入口| 少妇的丰满在线观看| 精品一品国产午夜福利视频| 制服人妻中文乱码| av有码第一页| 精品卡一卡二卡四卡免费| 国产亚洲精品久久久久5区| 亚洲一区中文字幕在线| 亚洲五月婷婷丁香| 成人国产一区最新在线观看| 大码成人一级视频| 18禁国产床啪视频网站| 精品国内亚洲2022精品成人| 久久中文字幕人妻熟女| 日韩国内少妇激情av| 69av精品久久久久久| 国产视频一区二区在线看| tocl精华| 伊人久久大香线蕉亚洲五| 国产精品亚洲av一区麻豆| 国产一区在线观看成人免费| 久久午夜综合久久蜜桃| 久久久水蜜桃国产精品网| 91在线观看av| 男女下面插进去视频免费观看| 激情在线观看视频在线高清| 午夜免费激情av| 日韩免费av在线播放| 日韩一卡2卡3卡4卡2021年| 色在线成人网| 欧美国产日韩亚洲一区| 亚洲熟妇中文字幕五十中出| 女人爽到高潮嗷嗷叫在线视频| 久久久久久久精品吃奶| 夜夜看夜夜爽夜夜摸| 久99久视频精品免费| 亚洲成人精品中文字幕电影| 久久久久精品国产欧美久久久| 天堂√8在线中文| 咕卡用的链子| 国产精品久久久久久人妻精品电影| 欧美日韩精品网址| 国产熟女午夜一区二区三区| 亚洲美女黄片视频| 亚洲精品国产色婷婷电影| 变态另类丝袜制服| 欧美性长视频在线观看| 一本久久中文字幕| 人人妻,人人澡人人爽秒播| 欧美日韩亚洲国产一区二区在线观看| 亚洲男人天堂网一区| 一级毛片高清免费大全| 亚洲精品中文字幕一二三四区| 久久香蕉精品热| 三级毛片av免费| 美女午夜性视频免费| 黄片播放在线免费| 嫩草影院精品99| 日韩国内少妇激情av| 十八禁人妻一区二区| 亚洲专区中文字幕在线| 欧美另类亚洲清纯唯美| 老汉色av国产亚洲站长工具| 一本综合久久免费| 又大又爽又粗| 亚洲专区中文字幕在线| 亚洲精品国产一区二区精华液| 中文字幕人妻丝袜一区二区| 韩国av一区二区三区四区| a级毛片在线看网站| 欧美亚洲日本最大视频资源| 中文字幕色久视频| 国产成年人精品一区二区| 丝袜美足系列| 日本 欧美在线| 久久久久久人人人人人| 亚洲av电影不卡..在线观看| 亚洲熟妇中文字幕五十中出| 欧美 亚洲 国产 日韩一| 亚洲五月婷婷丁香| 婷婷精品国产亚洲av在线| www.精华液| 国产午夜精品久久久久久| 欧美精品啪啪一区二区三区| 波多野结衣一区麻豆| 亚洲国产毛片av蜜桃av| 精品第一国产精品| 免费看美女性在线毛片视频| 精品少妇一区二区三区视频日本电影| 非洲黑人性xxxx精品又粗又长| 一区二区日韩欧美中文字幕| 亚洲色图综合在线观看| 亚洲七黄色美女视频| 国产一区二区三区视频了| 国产成人欧美在线观看| 国产精品二区激情视频| 99国产精品一区二区三区| 日韩大码丰满熟妇| 欧美日本亚洲视频在线播放| 久久人妻av系列| 久久中文字幕人妻熟女| 精品少妇一区二区三区视频日本电影| 亚洲人成伊人成综合网2020| 国产精品久久久人人做人人爽| 丁香六月欧美| 99国产精品一区二区蜜桃av| 精品电影一区二区在线| 多毛熟女@视频| 亚洲无线在线观看| 亚洲五月色婷婷综合| 亚洲欧美激情综合另类| 日本 av在线| 可以在线观看毛片的网站| 欧美在线一区亚洲| 女人被躁到高潮嗷嗷叫费观| 欧美另类亚洲清纯唯美| 欧美日韩中文字幕国产精品一区二区三区 | 亚洲欧美日韩高清在线视频| 日韩欧美免费精品| 亚洲欧美激情在线| 性欧美人与动物交配| 91精品三级在线观看| 色婷婷久久久亚洲欧美| 精品熟女少妇八av免费久了| 一区二区日韩欧美中文字幕| 色播在线永久视频| 黄片大片在线免费观看| 91成人精品电影| 淫妇啪啪啪对白视频| 精品免费久久久久久久清纯| 亚洲电影在线观看av| 欧美中文日本在线观看视频| АⅤ资源中文在线天堂| 老司机在亚洲福利影院| 国内精品久久久久久久电影| 91麻豆精品激情在线观看国产| 亚洲一区二区三区不卡视频| 后天国语完整版免费观看| 午夜福利欧美成人| 中文字幕高清在线视频| 麻豆av在线久日| 91成人精品电影| 久久人妻熟女aⅴ| 精品不卡国产一区二区三区| 桃色一区二区三区在线观看| 日韩精品中文字幕看吧| 中文字幕人妻熟女乱码| av视频免费观看在线观看| 国产熟女xx| 亚洲色图 男人天堂 中文字幕| 一a级毛片在线观看| 久久久久久久久中文| 亚洲精华国产精华精| 亚洲av成人不卡在线观看播放网| www.熟女人妻精品国产| 国内毛片毛片毛片毛片毛片| 12—13女人毛片做爰片一| 日本三级黄在线观看| 国产精品爽爽va在线观看网站 | 午夜视频精品福利| 免费久久久久久久精品成人欧美视频| 91成年电影在线观看| 一区二区三区激情视频| 欧美一级毛片孕妇| 亚洲精品国产精品久久久不卡| 少妇 在线观看| www国产在线视频色| 美女高潮到喷水免费观看| 国产精品免费视频内射| 国产精品亚洲av一区麻豆| 日韩三级视频一区二区三区| 国产精品99久久99久久久不卡| 国产区一区二久久| 欧美激情 高清一区二区三区| 女性被躁到高潮视频| 国产成人一区二区三区免费视频网站| 在线免费观看的www视频| 国产精品国产高清国产av| x7x7x7水蜜桃|