前列地爾聯(lián)合硫辛酸治療糖尿病神經(jīng)病變的療效

王保安

[摘要] 目的 探討前列地爾聯(lián)合硫辛酸治療糖尿病神經(jīng)病變的療效。 方法 選取本院2017年4月～2018年4月期間糖尿病神經(jīng)病變患者96例，隨機分為觀察組與對照組，各48例。給予觀察組前列地爾聯(lián)合硫辛酸治療、給予對照組僅前列地爾治療。對比兩組患者臨床治療效果，并觀察組治療前后患者神經(jīng)傳導(dǎo)速度水平以及疼痛程度。結(jié)果 ①觀察組治療總有效率高達97.92%，高于對照組的83.33%（χ2=12.527，P<0.05）。②兩組治療后神經(jīng)傳導(dǎo)速度較治療前均有所提高;且觀察組治療后神經(jīng)傳導(dǎo)速度、治療前后傳導(dǎo)速度差值高于對照組，差異均有統(tǒng)計學(xué)意義（t=13.837、15.828，P<0.05）。③兩組治療后VAS評分低于治療前均顯著;且觀察組治療后VAS評分較對照組更低，差異均有統(tǒng)計學(xué)意義（t=10.387，P<0.05）。 結(jié)論 糖尿病神經(jīng)病變可采用前列地爾聯(lián)合硫辛酸治療，效果確切，可有效降低患者疼痛程度，改善神經(jīng)傳導(dǎo)速度，臨床實用價值較高，可推廣使用。

[關(guān)鍵詞] 前列地爾;硫辛酸;糖尿病;神經(jīng)病變

[中圖分類號] R587.1 ? ? ? ? ?[文獻標識碼] B ? ? ? ? ?[文章編號] 1673-9701（2019）08-0112-03

[Abstract] Objective To investigate the efficacy of alprostadil combined with lipoic acid in the treatment of diabetic neuropathy. Methods 96 patients with diabetic neuropathy received in our hospital from April 2017 to April 2018 were randomLy divided into observation group and control group， 48 cases in each group. The observation group was treated with Alprostadil Combined with lipoic acid， and the control group was treated with alprostadil only. The clinical effects of the two groups were compared， and the level of nerve conduction velocity and the degree of pain in the observation group before and after treatment were compared. Results ①The total effective rate of the observation group was 97.92%， which was significantly higher than that of the control group （83.33%） （χ2=12.527， P<0.05）. ②After treatment，the nerve conduction velocity of the two groups was higher than that of the control group， and the difference of nerve conduction velocity between the two groups was higher after treatment（t=13.837， 15.828， P<0.05）.③After treatment，the VAS scores of the two groups were significantly lower than those before treatment，and the VAS scores of the observation group were lower than those of the control group after treatment， the difference was statistically significant（t=10.387， P<0.05）. Conclusion Alprostadil combined with lipoic acid can be used to treat diabetic neuropathy with definite effect. It can effectively reduce pain and improve nerve conduction velocity in patients with diabetic neuropathy. It has high clinical practical value and can be widely used.

[Key words] Alprostadil; Lipoic acid; Diabetes mellitus; Neuropathy

糖尿病是我國臨床上極為常見的一種疾病，遺傳因素、肥胖因素、年齡因素等均可引發(fā)糖尿病，給患者的日常生活帶來了嚴重的影響和極大的不便[1-3]。糖尿病患者常伴隨神經(jīng)病變，導(dǎo)致周圍神經(jīng)病變的最主要原因就是高血糖，使得患者神經(jīng)受到了一定的損傷，不利于患者的恢復(fù)和預(yù)后[4]。近年來臨床上常采用前列地爾、硫辛酸等藥物治療糖尿病神經(jīng)病變，但單用前列地爾僅可改善患者微循環(huán)，并不具備清除患者體內(nèi)抗氧化劑的作用，臨床治療效果欠缺，因此提出了聯(lián)用硫辛酸治療的方式，有效的改善患者的病情[5-7]。基于此，本研究主要探討前列地爾聯(lián)合硫辛酸治療糖尿病神經(jīng)病變的療效，現(xiàn)報道如下。