• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Regularity of syndrome differentiation and treatment of traditional Chinese medicine for Henoch-Schonlein purpura based on data mining techniques

    2019-04-05 14:03:32ShuaiZhangYinglinQinJiaqiYangJieGuoXueshuaiDaiXiaomingJin
    Medical Data Mining 2019年4期

    Shuai Zhang ,Yinglin Qin ,Jiaqi Yang ,Jie Guo ,Xueshuai Dai ,Xiaoming Jin*

    1College of Chinese Medicine,Hebei University,Baoding,Hebei province,071000,China.

    Abstract Objective:This study aims to explore the regularity of syndrome differentiation and treatment of traditional Chinese medicine (TCM)for allergic purpura.Methods:CNKI,Weipu Chinese science and technology database,wanfang medical network database,and Chinese biomedical literature database were searched for eligible studies.Medical records including complete patient personal information,patient symptoms,TCM syndromes,treatment,and medication were included.The data was analyzed using the Chinese medicine heritage support platform provided by the Chinese Academy of Chinese medicine (V2.5).Results:Differentiation of health gas camp blood was the most commonly used method of differentiation of symptoms and signs in famous veteran TCM.The treatment included cooling blood,activating blood circulation,clearing heat and detoxifying toxins,removing blood stasis and stopping bleeding.Honeysuckle,Forsythia suspensa,cicada slough and other drugs were interrelated.Potential drug pair combinations and drug networks showed the basic drug composition of Qingying Decoction.According to the entropy cluster analysis,28 core drug combination and 12 new formulations were obtained.Conclusion:The regularity of syndrome differentiation and treatment of traditional Chinese medicine for Henoch-Schonlein purpura based on the famous and old TCM doctors was complex.Further researches are still needed.

    Keywords:syndrome differentiation and treatment;traditional Chinese medicine;Henoch-Schonlein purpura;data mining;

    Introduction

    Henoch-Schonlein purpura (HSP)is a comprehensive systemic inflammation mediated by immune complex.Its clinical manifestation is characterized by skin rash,often accompanied by joint,digestive tract,kidney and other organ damage.The pathogenesis of HSP is still unclear [1-3].At present,glucocorticoids and immunosuppressants are mostly used in the treatment of this disease,which belongs to symptomatic treatment.The use of glucocorticoids in children with HSP is still controversial.Some studies believe that glucocorticoids can not prevent the occurrence of kidney disease in HSP patients,and the recurrence of HSP [4].The overall prognosis of HSP is good.However,some researchers find that 67% of HSP children have the tendency of relapse,some of them turn to purpura nephritis.If the disease continues repeatedly,it can eventually develop to end-stage renal failure [5].Traditional Chinese medicine or the combination of Chinese and Western medicine in the treatment of HSP has incomparable efficacy and advantages,and has gradually become the basic consensus of many domestic experts.This study aimed to use data mining to explore the regularity of syndrome differentiation and treatment of traditional Chinese medicine (TCM)for allergic purpura.

    1 Materials and methods

    1.1 Literature search

    (1)keywords:“allergic purpura”and“ traditional Chinese medicine”;

    (2)Publication year:from 2000 to 2018;

    (3)Databases:CNKI,,Weipu Chinese science and technology database,wanfang medical network database,and Chinese biomedical literature database.

    1.2 Inclusion criteria

    (1)Henoch-Schonlein purpura without any other underlying diseases and complications.

    (2)The patient's attending physician was a master of Chinese medicine promulgated by the Ministry of Health,a national expert of traditional Chinese medicine,an instructor of academic experience inheritance,an expert enjoying special allowances from the State Council,a famous veteran Chinese medicine of provinces and municipalities,a tutor of doctoral students of traditional Chinese medicine,and an associate of all three-level comprehensive hospitals and hospitals of traditional Chinese medicine.

    (3)Medical records include complete patient personal information,patient symptoms,TCM syndromes,treatment,and medication.

    (4)There are clear criteria for evaluating the effect.

    1.3 Exclusion criteria

    (1)The literature is nonclinical experience or report,such as summary,animal experiment and TCM nursing.

    (2)The treatment plan is mainly western medicine,and Chinese medicine is subsidiary.

    (3)The curative effect is not clear or short time relapse.

    1.4 Research Tools and Data Mining

    This data was analyszed using the Chinese medicine heritage support platform provided by the Chinese Academy of Chinese medicine (V2.5).Because of the large number of medical cases,the“support”was set to“40”and the“confidence”was set to“0.7”.By the“rule analysis”function,the frequency of frequently used drug pairs,association rules and network between main drugs presented more than 40 times in medical cases were analyzed.According to the results,“correlation degree”was set to 8,and“punishment degree”was set to 4.The new prescriptions were clustered by entropy clustering analysis.

    2 Results

    2.1 Frequency of main symptoms in patients

    We identified 649 relevant literatures.The frequency of concurrent syndromes except skin rash in this study is shown in Table 1.In addition to skin rash manifestations such as blood stasis and ecchymosis,Henoch-Schonlein purpura often involves the kidney,gastrointestinal tract and joints,causes a series of concurrent syndromes such as hematuria,celiagia,constipation,joint swelling and pain.

    2.2 Methods of identifing different syndromes

    The methods of identifing different syndromes used by famous and old TCM doctors are shown in Table 2.

    2.3 Frequency of Main Syndromes

    There are 39 syndromes involved in this study.The frequency of main syndromes is shown in Table 3.

    2.4 Analysis of Association Rules for Important Drugs

    The distribution of high-frequency drug pairs showsd that high-frequency drug pairs were the combination of many dozens of important drugs.We used association rules to explore the combination rule.Confidence was set to 0.7.The results are shown in table 4 and figure 1.

    2.5 New Formula Mining

    According to the results,the correlation degree was set to 8,the confidence level was set to 4,and eight new prescriptions were obtained,which reflected the experience of famous and veteran TCM prescriptions.The results are shown in Table 5.

    3 Discussion

    3.1 Syndrome Differentiation and Treatment

    In this study,blood-heat rampancy,heat poison incandescence syndrome is the most common,such as the two syndromes as the main syndrome,should belong to the extreme stage of the development of the disease.The disease is mainly characterized by solid symptoms,heat syndrome,and blood syndrome[6].Ye Tianshi's“On Warming Heat”holds that“the heart governs the blood and belongs to the camp”,“those who are spotted and pyretic do not understand,and the stomach dies in yin.”It can be seen that the location of the disease is in the heart and stomach.Secondary symptoms may be hyperactivity of heart fire or gastric heat.They may be accompanied by fever,sore throat,excessive drinking,hematuria,abdominal distension and constipation.The spots are dense and bright compared with the initial and final stages.Wind-heat damaging collaterals syndrome is exogenous syndrome,when it is aimed at the initial stage of the disease or when the disease recurs.Because wind heat invades the lung and affects the lung collateral,the subcutaneous hemorrhage is seen.The location of the disease is in the lung,and the spots are not obvious,such as the tip of the needle,which is hidden.The location of the disease is Lung Wei,which can be accompanied by cold,fever,sore throat and other symptoms.Blood stasis,spleen deficiency and dampness accumulation,phlegm and blood stasis,and spleen and kidney deficiency are the late syndrome differentiation of the disease.At this time,the course of the disease is long,fever is not more,spots recede,and the disease is also developed from exogenous disease to internal injury syndrome,deficiency and excess are mixed,involving the heart,spleen and kidney.

    It can be concluded that this disease belongs to exogenous febrile disease.First of all,it has the characteristics of offending the lungs,and has the law of transformation ofhealth gas camp blood.In the initial stage of treatment,the method of clearing heat and dredging wind was adopted,followed by the method of clearing heat and detoxifying toxins and cooling blood to stop bleeding,which blocked the progress of the disease,while the method of clearing heat and nourishing Yin was obvious.With the development of the disease,the fever declines gradually,affecting the dysfunction of many viscera such as the spleen and kidney of middle and lower Jiao [7].Spleen deficiency is damp,dampness accumulates phlegm,phlegm and blood stasis are blocked each other.Kidney essence,essence and blood are homologous,blood fever bleeding for a long time,will inevitably injure the essence of kidney,the use of invigorating the spleen and dampness,promoting blood circulation and phlegm,invigorating the spleen and kidney and other treatment methods.

    3.2 Causes of Symptoms and Evolution of Febrile Diseases

    In this study,pharyngalgia occurred in 14.25% of patients.The cause of the symptoms was that windheat evil Qi violated Wei Fen,Wei Yang vigorously resisted evil Qi,and the superficial evil caused by the confrontation between right and evil [8].The patient may be accompanied by symptoms such as fever,tonsillar swelling,thirst and so on.The tongue is red and fur is white or has no obvious change,only the tongue surface is dry,the number of pulses floating or has no obvious change.Because wind and heat are easy to carry out and change rapidly,the simple Wei Fen is rare in this disease.Once it occurs,it often has Taiyin internal injury,damp and heat connotation,spleen and stomach qi dysfunction.Although the location of the disease is in the lung,it has spread to the spleen and stomach.Although the pathogen is divided into Wei,it has spread to Qi.At this time,the evil mainly lies in the surface,and the healthy qi is not fading [9].We should clear the heat and dredge the wind in time,and select Forsythia suspensa,cicada slough,burdock and other medicines to prevent the evil gas from penetrating into the gas.Celiagia,constipation,and anorexia often occur at the same time.They are caused by pharyngalgia.The pathogenic factors of wind and heat go deep into qi,heat enters Yangming,the Qi of spleen and stomach goes up and down imbalance,heat damaging intestines and collaterals.Therefore,celiagia can be seen,such as hemorrhage between intestines,even hematemesis and hematochezia [10].But at this time,the hemorrhage is still not caused by heat evil,which can be cured after clearing away heat and purging fire.Therefore,it is different from the blood-moving,blood-consuming and blood-stasis-heat internal obstruction of blood component,and should be emphasized on differential diagnosis.Constipation is the combination of intestinal evil heat and drugs,which consume body fluid,intestinal conduction loss,can be accompanied by belching,vomiting and anorexia,red tongue coating yellow dry,red spots or burrs on the tongue,patients with severe thirst,strong pulse counts.The treatment should be focused on clearing away heat and purging fire.Baihu Decoction is the first choice.Damp-heat pathogens directly offend the spleen and stomach,damp-heat pathogenic airflow is connected with qi,which invades the spleen,gastrointestinal tract,and may be accompanied by symptoms such as fecal stickiness,chest tightness and so on.The patient's tongue is yellow,thick and greasy,pulse slippery,slow onset and transmission,difficult to cure quickly,and is treated by clearing away heat and dampness,fragrance and rubella.Although the treatment of symptoms caused by two different reasons is different,they belong to Qi syndrome.The pathological changes of Qi syndrome are nothing more than the changes of human"Qi",which is the extreme stage of the disease.If healed in time,the positive Qi is not injured,the patient is only the loss of body fluid,if not cured in time,the positive Qi is depleted,the patient can see the fatigue of God,is a sign of the transition to camp.Insomnia can be seen in febrile disease and febrile disease syndrome of Weifen and Yingfen.Insomnia can be caused by wind-heat evil gas retrogressing pericardium,or by warming evil,Ying-heat injuring Yin and heat disturbing mind.The key of identification is whether the patient's tongue is red.Because the insomnia of patients is caused by heat disturbing the mind,it is often accompanied by restlessness.At the same time,because Yin-Fen Yin fluid injury is more serious,whether thirsty for drinking water is also an important sign of the division of patients who belong to the Wei-Fen syndrome or Ying-Fen syndrome [11].Urine blood,stool blood,hematemesis,back pain,and edema are all found in Yingxue.Warming pathogen goes deep into Yingxue.The substantial damage of organs and tissues is more obvious,and the related dysfunction is more serious.Urine blood,stool blood and hematemesis are the manifestations of the further deterioration of the disease.Patient's macula also develops from vague macula to bright red in color.Lumbago is caused by heat entering Yingxue,Yin drainage and liver and kidney manifestations,liver and kidney yin deficiency,so lumbago is sore.Edema is caused by the heat evil going deep into the lower coke,the disadvantage ofbladder gasification,the blood stasis of the lower coke,the water-heat junction and the obstruction of blood circulation.The occurrence of the above symptoms(except Yang Ming Qi and blood in stool)can indicate that the disease has developed to the late stage of febrile disease,the condition is mixed with deficiency and reality,and it is difficult to recover.On the basis of symptomatic treatment,we should focus on nourishing liver and kidney,clearing waste heat,and restoring the normal physiological function of the viscera.

    Table 1 Frequency of main symptoms in patients with HSP

    Table 2 Methods of identifing different syndromes

    Table 3 Frequency of main syndromes

    3.3 Relevance analysis of commonly used drugs

    Association rules were used to analyze the relationship among commonly used drugs.We found that rhizomz were associated with other drugs [12].They were related to Rhizoma Glycyrrhizae,Radix Glycyrrhizae,Radix Scutellariae,radix paeoniae rubra,radix rehmanniae,Radix Scutellariae and Scutellaria baicalensis Georgi.The commonly used combination of drugs is based on the prototype of Qingying Decoction,reducing bamboo leaves,Ophiopogon japonicus,Salvia miltiorrhiza,Coptis chinensis and cicada slough,Saposhnikovia divaricata,Radix Paeoniae Rubra,Angelica sinensis,Paeonia Alba root and Lithospermum.Combination of water ox horn,Rehmannia glutinosa extract,heat toxin,Radix et Rhizoma,Radix et Rhizoma,Radix et Rhizoma,radix paeoniae rubra,Rhizoma Coicis rhizome,clearing away heat and cooling blood,honeysuckle flower,forsythia diathermy and transforming Qi [13].All drugs are used together for playing the role of clearing away heat and cooling blood.Qingying Decoction is the representative prescription for treating fever in Yingfen syndrome.Modern pharmacological studies show that Qingying Decoction has obvious cooling and antipyretic effects on various febrile models,which can reduce the permeability of capillaries.In addition,it has anti-virus,anti-inflammation,changes

    in blood rheology and thrombolytic effects [4-6].So it has become the basic prescription for old Chinese medicine to treat this disease.Among the new medicines,Saposhnikovia divaricata has significant anti-allergic effect,and Lithospermum has inhibitory effect on specific allergic reaction.When using the two medicines we should not only consider the mechanism of TCM syndrome differentiation and treatment of the disease,but also the modern medical pharmacological research of the disease.

    Table 4 Analysis of Association Rules for Important Drugs

    Figure 1 Network of commonly used drugs

    Table 5 Core drug combinations in modern Chinese medicine prescriptions for seborrheic dermatitis

    3.4 Analysis of Four New Formulas

    Combination 1 is composed of Bamboo Leaf,RadiScrophulariae,Bupleurum chinense,Ulmus pumila,Typha.Bamboo leaf cold,return to heart,stomach meridian,clear heat and purge fire,relieve irritation and cough.Radix Scrophulariae is bitter and slight cold,return to heart,liver and kidney meridians,clear heat and cool blood,strong detoxification and dissolution of knots,used for eye swelling and pain,throat swelling and pain;[14]Bupleurum Bupleurum has strong antipyretic effect,which is used to disperse heart,stomach stagnation fire,heat stagnation in clearing,heat and breathing effect.Ulmus pumila and Typha are both good drugs for hemostasis and promoting blood circulation.It can induce blood to meridian and eliminate skin rash.According to the prescription,it is suitable for the extreme blood-heat delusion syndrome or heat-poisoning incandescence syndrome.The location of the disease is in the heart and stomach,the spots are bright,and may be accompanied by pharyngalgia,fever and other symptoms,such as pharyngalgia can be added to Daqingye as appropriate.Composition 3 is composed of Salvia miltiorrhiza,Phellodendron amurense,Leonurus japonicus and Sophora flavescens.Salvia miltiorrhiza is slightly cold,bitter and belongs to the heart and liver meridian.It has the functions of activating blood circulation,removing blood stasis,clearing heart and removing trouble.The modern pharmacological study of "good treatment of blood,eliminating stagnation and generating new,regulating meridians and collaterals" in the Commentary on Materia Medica shows that paeonol can significantly inhibit platelet aggregation caused by various factors [7].Phellodendron Phellodendri bitter cold,returning to kidney and bladder meridian can not only clear heat and dry dampness,but also be used for damp.It can clear the deficiency fire of liver and kidney;motherwort is bitter,slightly cold,belongs to liver,pericardium and bladder meridians,clears heat and activates blood circulation,has strong diuresis and detumescence effect,and is beneficial to the syndromes of water and heat.Sophora flavescens is bitter cold,belongs to heart and liver meridians,and has strong heat and dampness clearing force.For the late stage of this disease,liver and kidney deficiency,dampheat injection syndrome,may be accompanied by the emergence of urinary protein,the condition is lingering and repeated,and it is difficult to recover for a long time.

    Combination 4 consists of Poria cocos,Codonopsis pilosula,Ziziphus jujuba seed and Leonurus heterophyllus.Poria cocos are mild and mild,and can be used to soothe the dampness and strengthen the spleen and heart.It is used for the spleen deficiency and dampness;the dangshen Gan Ping,the spleen and lung meridian,the spleen and the lung,the Qi replenishing qi,the nourishing qi and blood,the Zizyphus jujube kernel acid,the Ningxin calming mind,and the compatibility of water and swelling.It is used for spleen deficiency,dampness,and excessive syndrome.All drugs are peaceful,tonifying deficiency and tonifying injury and strengthening qi.

    Composition 5 is composed of Gardenia jasminoides,Pogostemon vulgaris,Rehmannia glutinosa and Prunella vulgaris.Gardenia jasminoides and herbs are the ingredients of Xiehuang powder.Xiehuang powder is found in Zhizhi of Pediatric Medicine Syndrome.It is a good prescription for the treatment of spleen and stomach fire.[15]It can be combined with Rehmannia glutinosa with heat-cooling blood and Prunella vulgaris with heat-clearing and fire-clearing,which can strengthen the function of clearing fire in stomach,clearing heat in blood and nourishing yin and protecting liquid.For this disease,the location of the disease is mainly in the stomach,which may be accompanied by halitosis,celiagia,constipation and other symptoms.According to the severity of symptoms,we can add Yuzhu,Ophiopogon japonicus and other antipyretic and Yin-nourishing drugs as appropriate.

    Composition 8 consists of Angelica sinensis,cicada slough,thistle,Typha and Saposhnikovia divaricata.Small thistle and cattail are good at stopping urine and bleeding,cooperating with Angelica sinensis,quite similar to small thistle drinks,can play the role of blood induction and meridian tropism.Cicada slough and Saposhnikovia divaricata can make the heat of lower coke blood permeate outside.At the same time,modern pharmacological studies show that cicada slough and Saposhnikovia divaricata can play an immunoregulatory role to a certain extent.In addition,Angelica sinensis,which nourishes blood and promotes blood circulation,is suitable for the later stage of the disease.It has a long course of disease,insufficient Yin and blood,and blood-heat has not fallen into the syndrome of lower burning liver and kidney.Its pathogenesis is more complex.The main symptoms are liver and kidney.It can be seen that Urine-Blood and Deficiency-heat do not fade.It can be added with Artemisia annua,turtle shell and other heat-clearing and Yin-nourishing drugs as appropriate.Because of the long course and deep position of the disease,it is especially suitable for the use of visible products of flesh and blood.

    Conclusion

    This study searched a large number of literature on Chinese medicine treatment for allergic purpura.By the data mining techniques,It formed a more systematic medicine theory of syndrome differentation and treatment variation and used Traditional Chinese Medicine auxiliary system platform to identify a number of new prescriptions with characteristics for the development of clinical drugs and new drugs.There may be some unique therapeutic ideas.However,due to the small number of medical records collected,the efficacy of the new prescription has not been clinically evaluated.Further researches are still needed.

    精品电影一区二区在线| 亚洲一卡2卡3卡4卡5卡精品中文| 一本精品99久久精品77| 亚洲最大成人中文| 村上凉子中文字幕在线| 久久中文字幕人妻熟女| 欧美日韩福利视频一区二区| 国产精品电影一区二区三区| 国产成人欧美| 国产精品一区二区三区四区久久 | 99久久综合精品五月天人人| 国产熟女xx| 日本免费一区二区三区高清不卡| 日本精品一区二区三区蜜桃| 久久九九热精品免费| 丰满人妻熟妇乱又伦精品不卡| 少妇熟女aⅴ在线视频| 男女午夜视频在线观看| 免费高清在线观看日韩| 国产区一区二久久| 免费在线观看视频国产中文字幕亚洲| 亚洲国产精品999在线| 嫩草影院精品99| 欧美日韩福利视频一区二区| 色播在线永久视频| 亚洲精品一区av在线观看| 国产人伦9x9x在线观看| 国语自产精品视频在线第100页| 久久国产乱子伦精品免费另类| 国产精品爽爽va在线观看网站 | 黄色成人免费大全| 欧美午夜高清在线| 亚洲国产欧美一区二区综合| 熟女少妇亚洲综合色aaa.| 亚洲自偷自拍图片 自拍| 神马国产精品三级电影在线观看 | 亚洲一卡2卡3卡4卡5卡精品中文| 男男h啪啪无遮挡| ponron亚洲| 国产av不卡久久| 亚洲成av人片免费观看| 亚洲欧洲精品一区二区精品久久久| 亚洲午夜精品一区,二区,三区| 国产在线观看jvid| 精品免费久久久久久久清纯| 老司机福利观看| 天天一区二区日本电影三级| 国产又色又爽无遮挡免费看| 人成视频在线观看免费观看| 国产人伦9x9x在线观看| 老汉色∧v一级毛片| 88av欧美| 99在线视频只有这里精品首页| 国产aⅴ精品一区二区三区波| 黄色成人免费大全| 免费在线观看完整版高清| 久久久久九九精品影院| 久久人妻av系列| 日本成人三级电影网站| 99精品欧美一区二区三区四区| 一边摸一边抽搐一进一小说| 久久久久久久久免费视频了| 身体一侧抽搐| 午夜福利免费观看在线| 欧美丝袜亚洲另类 | 亚洲av电影不卡..在线观看| 女同久久另类99精品国产91| 久久久水蜜桃国产精品网| 麻豆成人午夜福利视频| 精品高清国产在线一区| 国产精品影院久久| 亚洲国产精品成人综合色| 色综合欧美亚洲国产小说| 欧美国产精品va在线观看不卡| 国产成人系列免费观看| 中亚洲国语对白在线视频| 国产精品永久免费网站| 99久久久亚洲精品蜜臀av| 免费高清视频大片| 97超级碰碰碰精品色视频在线观看| 精品卡一卡二卡四卡免费| 精品人妻1区二区| 亚洲性夜色夜夜综合| av片东京热男人的天堂| 亚洲最大成人中文| 黄片小视频在线播放| 91国产中文字幕| 夜夜躁狠狠躁天天躁| 成人av一区二区三区在线看| 欧美性猛交╳xxx乱大交人| av片东京热男人的天堂| 欧美乱色亚洲激情| 一a级毛片在线观看| 免费搜索国产男女视频| 午夜免费鲁丝| 国产亚洲精品第一综合不卡| 啪啪无遮挡十八禁网站| 欧美一级a爱片免费观看看 | 制服丝袜大香蕉在线| 欧美一级毛片孕妇| 成人国产综合亚洲| 久久中文看片网| 久久久久国内视频| 看片在线看免费视频| 亚洲av成人不卡在线观看播放网| 亚洲一码二码三码区别大吗| 日韩欧美国产在线观看| 天天躁夜夜躁狠狠躁躁| 日韩欧美免费精品| 午夜成年电影在线免费观看| 少妇粗大呻吟视频| 免费看美女性在线毛片视频| 老司机午夜福利在线观看视频| 曰老女人黄片| 亚洲第一青青草原| 亚洲欧美激情综合另类| 婷婷精品国产亚洲av| 国产一卡二卡三卡精品| x7x7x7水蜜桃| 国产精品1区2区在线观看.| 久久天堂一区二区三区四区| 亚洲人成伊人成综合网2020| 欧美日韩瑟瑟在线播放| 亚洲熟妇中文字幕五十中出| 十分钟在线观看高清视频www| 757午夜福利合集在线观看| 国产蜜桃级精品一区二区三区| 桃红色精品国产亚洲av| 亚洲av成人一区二区三| 午夜福利一区二区在线看| tocl精华| 亚洲va日本ⅴa欧美va伊人久久| 国内揄拍国产精品人妻在线 | 欧美性长视频在线观看| 欧美午夜高清在线| 亚洲成a人片在线一区二区| 亚洲国产精品合色在线| 美女高潮喷水抽搐中文字幕| 桃色一区二区三区在线观看| 久久香蕉精品热| 变态另类丝袜制服| 两人在一起打扑克的视频| 久久久久国产精品人妻aⅴ院| 国产免费av片在线观看野外av| 成人手机av| 99久久99久久久精品蜜桃| 搡老岳熟女国产| 欧美成人一区二区免费高清观看 | 成人18禁在线播放| 久久精品人妻少妇| 亚洲黑人精品在线| 日韩大尺度精品在线看网址| 久久欧美精品欧美久久欧美| av超薄肉色丝袜交足视频| 亚洲在线自拍视频| 18禁黄网站禁片免费观看直播| 一边摸一边抽搐一进一小说| av电影中文网址| 亚洲片人在线观看| 欧美成狂野欧美在线观看| 免费观看精品视频网站| 一区福利在线观看| 美女 人体艺术 gogo| 亚洲va日本ⅴa欧美va伊人久久| 香蕉av资源在线| 日韩有码中文字幕| 欧美绝顶高潮抽搐喷水| 亚洲激情在线av| 99在线视频只有这里精品首页| 午夜久久久久精精品| 免费在线观看视频国产中文字幕亚洲| 每晚都被弄得嗷嗷叫到高潮| 久久狼人影院| 极品教师在线免费播放| 久99久视频精品免费| 欧美国产日韩亚洲一区| 波多野结衣高清无吗| 国产高清有码在线观看视频 | 18禁国产床啪视频网站| 99国产综合亚洲精品| 老司机午夜十八禁免费视频| www.精华液| 国产人伦9x9x在线观看| 看免费av毛片| 国产精品亚洲美女久久久| 一本综合久久免费| 成人国产一区最新在线观看| 久久久久久久久久黄片| 欧美在线一区亚洲| 99热6这里只有精品| 天堂影院成人在线观看| 色婷婷久久久亚洲欧美| 午夜影院日韩av| 日韩视频一区二区在线观看| 人人澡人人妻人| 2021天堂中文幕一二区在线观 | 每晚都被弄得嗷嗷叫到高潮| 麻豆av在线久日| 精品久久久久久久人妻蜜臀av| 美女午夜性视频免费| 欧美乱妇无乱码| 韩国av一区二区三区四区| 他把我摸到了高潮在线观看| 少妇的丰满在线观看| 在线观看www视频免费| 国产精品av久久久久免费| 中文在线观看免费www的网站 | 国产精品自产拍在线观看55亚洲| 国产av一区在线观看免费| 18禁观看日本| av视频在线观看入口| 黄色a级毛片大全视频| 日韩成人在线观看一区二区三区| 亚洲人成电影免费在线| 熟女电影av网| 听说在线观看完整版免费高清| 黄色丝袜av网址大全| 亚洲成人久久性| 亚洲精品中文字幕一二三四区| 50天的宝宝边吃奶边哭怎么回事| av欧美777| 操出白浆在线播放| 成人特级黄色片久久久久久久| 国产精品av久久久久免费| 九色国产91popny在线| 村上凉子中文字幕在线| bbb黄色大片| 精品少妇一区二区三区视频日本电影| 亚洲九九香蕉| 国产1区2区3区精品| 欧美黑人精品巨大| 成人国语在线视频| 18禁观看日本| 国产av又大| 曰老女人黄片| 男女之事视频高清在线观看| 精品久久久久久久人妻蜜臀av| 午夜福利一区二区在线看| 亚洲欧美激情综合另类| 老熟妇仑乱视频hdxx| 亚洲黑人精品在线| 99国产精品一区二区三区| 国产欧美日韩精品亚洲av| 亚洲av电影不卡..在线观看| 久久久国产欧美日韩av| 无人区码免费观看不卡| 亚洲一区二区三区色噜噜| 狠狠狠狠99中文字幕| 国产99久久九九免费精品| 午夜a级毛片| 免费在线观看黄色视频的| 亚洲欧美精品综合一区二区三区| 欧美日韩乱码在线| 99久久99久久久精品蜜桃| 欧美激情 高清一区二区三区| 久久精品国产99精品国产亚洲性色| 久久精品91蜜桃| 亚洲一码二码三码区别大吗| 一区二区三区国产精品乱码| 一进一出好大好爽视频| 国产亚洲欧美精品永久| 日韩成人在线观看一区二区三区| 在线观看日韩欧美| 欧美三级亚洲精品| 男女视频在线观看网站免费 | 亚洲成人精品中文字幕电影| x7x7x7水蜜桃| 91字幕亚洲| 俺也久久电影网| 亚洲va日本ⅴa欧美va伊人久久| 美女高潮到喷水免费观看| 最近最新中文字幕大全电影3 | 日韩一卡2卡3卡4卡2021年| 成人特级黄色片久久久久久久| 欧美成人性av电影在线观看| 久久久久免费精品人妻一区二区 | 国产片内射在线| 亚洲国产毛片av蜜桃av| 免费在线观看黄色视频的| 亚洲中文字幕日韩| 国产精品 国内视频| 9191精品国产免费久久| 成人亚洲精品一区在线观看| 久久 成人 亚洲| 黄片小视频在线播放| 亚洲avbb在线观看| 日韩 欧美 亚洲 中文字幕| 99精品久久久久人妻精品| av免费在线观看网站| 露出奶头的视频| 国产高清videossex| 午夜影院日韩av| 一进一出抽搐动态| 999久久久国产精品视频| 在线观看午夜福利视频| 一级黄色大片毛片| 久久天躁狠狠躁夜夜2o2o| 日本熟妇午夜| 国产黄色小视频在线观看| 一级毛片高清免费大全| 亚洲熟妇中文字幕五十中出| 我的亚洲天堂| 亚洲久久久国产精品| 精品久久久久久成人av| 日韩 欧美 亚洲 中文字幕| av片东京热男人的天堂| 男女午夜视频在线观看| 亚洲免费av在线视频| 999久久久国产精品视频| 成年人黄色毛片网站| 少妇 在线观看| 精品国产乱码久久久久久男人| 一级毛片高清免费大全| 国产精品久久视频播放| 无限看片的www在线观看| 亚洲中文av在线| 淫妇啪啪啪对白视频| 国产欧美日韩一区二区三| 成熟少妇高潮喷水视频| av在线播放免费不卡| 欧美色欧美亚洲另类二区| 黄网站色视频无遮挡免费观看| 亚洲aⅴ乱码一区二区在线播放 | www日本黄色视频网| 成年免费大片在线观看| 国产野战对白在线观看| av片东京热男人的天堂| 伊人久久大香线蕉亚洲五| 最近在线观看免费完整版| 国产视频一区二区在线看| a级毛片在线看网站| 少妇熟女aⅴ在线视频| 天天添夜夜摸| 成人永久免费在线观看视频| 国产精品av久久久久免费| 色播在线永久视频| 99国产综合亚洲精品| 色综合婷婷激情| 国产av不卡久久| 亚洲在线自拍视频| 久久精品影院6| 精品一区二区三区av网在线观看| 天堂动漫精品| 成人一区二区视频在线观看| 国产黄a三级三级三级人| 精品久久久久久久久久免费视频| 亚洲久久久国产精品| 欧美久久黑人一区二区| 国产精品二区激情视频| 久久热在线av| 亚洲av成人av| 久久 成人 亚洲| 国产黄a三级三级三级人| 夜夜躁狠狠躁天天躁| 亚洲av美国av| 免费在线观看日本一区| 国产午夜精品久久久久久| 人妻丰满熟妇av一区二区三区| 国产精品免费一区二区三区在线| 成人18禁高潮啪啪吃奶动态图| 香蕉av资源在线| 级片在线观看| 日本精品一区二区三区蜜桃| 99精品在免费线老司机午夜| 亚洲精品国产精品久久久不卡| 啦啦啦观看免费观看视频高清| 色综合亚洲欧美另类图片| 欧美国产日韩亚洲一区| 宅男免费午夜| 国产在线精品亚洲第一网站| 长腿黑丝高跟| 看片在线看免费视频| 欧美日韩中文字幕国产精品一区二区三区| 99久久99久久久精品蜜桃| 国产一区二区三区在线臀色熟女| 91九色精品人成在线观看| 国产精品精品国产色婷婷| 欧美日本视频| 18禁美女被吸乳视频| 亚洲自偷自拍图片 自拍| 精品免费久久久久久久清纯| 老司机在亚洲福利影院| 十八禁人妻一区二区| 亚洲五月色婷婷综合| 99riav亚洲国产免费| 亚洲人成网站在线播放欧美日韩| 午夜精品在线福利| 999久久久国产精品视频| 黄色片一级片一级黄色片| 久久欧美精品欧美久久欧美| 性欧美人与动物交配| 亚洲欧美日韩无卡精品| 99热这里只有精品一区 | 欧美精品亚洲一区二区| 18美女黄网站色大片免费观看| 在线观看66精品国产| 18禁裸乳无遮挡免费网站照片 | 99国产精品一区二区蜜桃av| 一级黄色大片毛片| 欧美成狂野欧美在线观看| 亚洲成人久久性| 国产极品粉嫩免费观看在线| av天堂在线播放| 十分钟在线观看高清视频www| 在线视频色国产色| 亚洲国产精品久久男人天堂| 黄片小视频在线播放| 午夜免费鲁丝| 亚洲av电影在线进入| 一本综合久久免费| 欧美在线一区亚洲| 黄网站色视频无遮挡免费观看| 久久九九热精品免费| 12—13女人毛片做爰片一| 国产极品粉嫩免费观看在线| 久久久国产欧美日韩av| 国产成人啪精品午夜网站| 在线永久观看黄色视频| 怎么达到女性高潮| 嫩草影院精品99| 久久久久免费精品人妻一区二区 | 国产成人精品久久二区二区免费| 国产伦人伦偷精品视频| 久久精品亚洲精品国产色婷小说| 久久中文字幕一级| 精品国产国语对白av| 99国产综合亚洲精品| 看免费av毛片| 黄色视频不卡| 50天的宝宝边吃奶边哭怎么回事| 中文字幕人妻丝袜一区二区| 久久午夜综合久久蜜桃| 他把我摸到了高潮在线观看| 50天的宝宝边吃奶边哭怎么回事| 精品久久久久久久毛片微露脸| 中文字幕精品免费在线观看视频| cao死你这个sao货| 亚洲电影在线观看av| 欧美日韩一级在线毛片| 亚洲第一青青草原| 夜夜躁狠狠躁天天躁| 国产亚洲欧美在线一区二区| 免费在线观看视频国产中文字幕亚洲| 午夜福利在线观看吧| 精品国产超薄肉色丝袜足j| 日韩有码中文字幕| 美女大奶头视频| 欧美中文综合在线视频| 免费在线观看完整版高清| 日日摸夜夜添夜夜添小说| av在线天堂中文字幕| 成人国产综合亚洲| 久久九九热精品免费| 久久精品人妻少妇| 婷婷丁香在线五月| 亚洲第一青青草原| 在线国产一区二区在线| cao死你这个sao货| 不卡一级毛片| 国产日本99.免费观看| www日本黄色视频网| 日韩欧美国产在线观看| 女性生殖器流出的白浆| 757午夜福利合集在线观看| 丝袜人妻中文字幕| 自线自在国产av| 精品欧美一区二区三区在线| 黄片小视频在线播放| 国产激情偷乱视频一区二区| 制服丝袜大香蕉在线| 亚洲专区国产一区二区| 欧美日韩福利视频一区二区| 搡老岳熟女国产| 正在播放国产对白刺激| 国产午夜精品久久久久久| 成人永久免费在线观看视频| 一边摸一边抽搐一进一小说| 成人av一区二区三区在线看| 可以免费在线观看a视频的电影网站| 久久99热这里只有精品18| 精品久久久久久久久久免费视频| 日韩视频一区二区在线观看| 亚洲精品一卡2卡三卡4卡5卡| 1024手机看黄色片| 久久人人精品亚洲av| 国内久久婷婷六月综合欲色啪| 亚洲熟妇中文字幕五十中出| 国产成+人综合+亚洲专区| 一级片免费观看大全| 麻豆久久精品国产亚洲av| 在线看三级毛片| 欧美黑人精品巨大| 丁香六月欧美| 欧美zozozo另类| 日本黄色视频三级网站网址| xxxwww97欧美| 国产欧美日韩一区二区三| 亚洲av中文字字幕乱码综合 | 亚洲 欧美 日韩 在线 免费| 免费在线观看亚洲国产| 久久婷婷人人爽人人干人人爱| 成人一区二区视频在线观看| а√天堂www在线а√下载| 黄网站色视频无遮挡免费观看| 久久这里只有精品19| av在线播放免费不卡| 午夜免费鲁丝| 一夜夜www| 亚洲电影在线观看av| 欧美色欧美亚洲另类二区| 两个人免费观看高清视频| 亚洲精品av麻豆狂野| 满18在线观看网站| 中文亚洲av片在线观看爽| 午夜激情福利司机影院| 久久亚洲精品不卡| 亚洲av中文字字幕乱码综合 | 老汉色∧v一级毛片| 国产成人欧美在线观看| 在线免费观看的www视频| 国产亚洲精品av在线| 欧美成人一区二区免费高清观看 | 麻豆成人av在线观看| 男人操女人黄网站| 巨乳人妻的诱惑在线观看| 我的亚洲天堂| 51午夜福利影视在线观看| 中文亚洲av片在线观看爽| 国产日本99.免费观看| 一进一出好大好爽视频| 91在线观看av| 十八禁人妻一区二区| 日本五十路高清| 丰满人妻熟妇乱又伦精品不卡| videosex国产| av免费在线观看网站| 午夜老司机福利片| 国产蜜桃级精品一区二区三区| 99国产精品99久久久久| 精品久久久久久久末码| 国产精品久久久久久亚洲av鲁大| 久久久久精品国产欧美久久久| 亚洲熟妇中文字幕五十中出| www日本在线高清视频| 欧美色视频一区免费| 美女免费视频网站| 久久青草综合色| 欧美成人性av电影在线观看| 国产高清视频在线播放一区| 午夜久久久在线观看| 欧美日韩中文字幕国产精品一区二区三区| 婷婷精品国产亚洲av| 久久久精品国产亚洲av高清涩受| 国产精品久久久人人做人人爽| 色播在线永久视频| 一本久久中文字幕| 亚洲国产精品999在线| 国内精品久久久久精免费| 欧美成人性av电影在线观看| 午夜视频精品福利| 久久伊人香网站| 视频区欧美日本亚洲| 日本成人三级电影网站| 十分钟在线观看高清视频www| 欧美黑人欧美精品刺激| 亚洲国产精品合色在线| 18禁黄网站禁片午夜丰满| 国产免费av片在线观看野外av| 亚洲午夜理论影院| 久久性视频一级片| www日本黄色视频网| 日日摸夜夜添夜夜添小说| a级毛片在线看网站| av天堂在线播放| 国产精品一区二区免费欧美| 日日干狠狠操夜夜爽| 12—13女人毛片做爰片一| 亚洲国产中文字幕在线视频| 亚洲人成77777在线视频| 国产精品亚洲一级av第二区| 亚洲成国产人片在线观看| 亚洲精品美女久久av网站| 白带黄色成豆腐渣| 很黄的视频免费| 欧美黄色片欧美黄色片| 又黄又爽又免费观看的视频| 无人区码免费观看不卡| 18禁国产床啪视频网站| 天天一区二区日本电影三级| 亚洲成人久久爱视频| 久久天堂一区二区三区四区| 搞女人的毛片| 久99久视频精品免费| 香蕉av资源在线| 免费在线观看视频国产中文字幕亚洲| 国产真实乱freesex| 国产高清激情床上av| 色播在线永久视频| 给我免费播放毛片高清在线观看| 巨乳人妻的诱惑在线观看| 成人精品一区二区免费| 午夜免费激情av| 99re在线观看精品视频| 色综合婷婷激情| 欧美乱妇无乱码| 亚洲片人在线观看| 久久久久免费精品人妻一区二区 | 亚洲五月色婷婷综合| 可以免费在线观看a视频的电影网站| 国产精品九九99| 国产精品亚洲一级av第二区| 99久久综合精品五月天人人| 午夜福利免费观看在线| 亚洲熟女毛片儿| 欧美成人免费av一区二区三区|