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    Effect of acupuncture plus Tai Ji Quan on the recovery of neurological function and depression state in post-stroke depression patients

    2018-04-28 03:27:14ZhangLin張林ZhaoJing趙靜QuanShulin全淑林LiuYehui劉葉輝ShiXuehui石學(xué)慧LiZhenguang李振光WangJingjing王凈凈ZhongYan鐘艷
    關(guān)鍵詞:張林趙靜重點(diǎn)學(xué)科

    Zhang Lin (張林), Zhao Jing (趙靜), Quan Shu-lin (全淑林), Liu Ye-hui (劉葉輝), Shi Xue-hui (石學(xué)慧), Li Zhen-guang(李振光), Wang Jing-jing (王凈凈), Zhong Yan (鐘艷)

    1 Hunan University of Chinese Medicine, Changsha 410007, China

    2 School of Medicine, Southeast University, Nanjing 210009, China

    3 Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China

    4 Brain Hospital of Hunan Province, Changsha 410007, China

    Post-stroke depression (PSD) is a common complication after stroke, with an incidence up to 30%-50%[1], mainly manifested by persistent low mood,loss of interest, and even abnormal behavior or suicide attempt[2]. PSD not only directly influences the rehabilitation, but also brings heavy burden to family and society. Intervention in early stage is significant in preventing and treating PSD. Our research group adopted acupuncture plus Tai Ji Quan in treating PSD,and the report is given as follows.

    1 Clinical Materials

    1.1 Diagnostic criteria

    1.1.1 Diagnostic criteria of Western medicine

    The diagnostic criteria of stroke referred toChinese Prevention and Treatment Guidance for Cerebrovascular Diseases[3]; the diagnostic criteria of depression referred to theChinese Classification and Diagnosis of Mental Diseases-3 (CCMD-3)[4].

    1.1.2 Pattern differentiation criteria of traditional Chinese medicine (TCM)

    The TCM pattern differentiation criteria were based on the differentiation criteria of depression syndrome in theCriteria of Diagnosis and Therapeutic Effects of Diseases and Syndromes in Traditional Chinese Medicine[5].

    1.2 Inclusion criteria

    Conforming to the above diagnostic criteria of both Western and Chinese medicine; head CT or MRI records available; the score of Hamilton depression rating scale(HAMD) ≥17; muscle strength of the affected limb ≥grade Ⅲ, and the grading of modified Ashworth scale ≤grade Ⅰ; age ≤75 years old; not on any psychotropic substances during the recent 2 weeks prior to the recruitment; approved of the treatment protocol and signed the informed consent form.

    1.3 Exclusion criteria

    Accompanied by systemic and primary diseases such as tumor, hematological and endocrine systems, or severe organic disorders involving heart, liver and kidney; those unable to cooperate due to severe mental retardation, speech dysfunction or mental disorders;with a history of psychosis.

    1.4 Rejection criteria

    Those with poor compliance, unable to strictly follow the treatment protocol; those lost to follow-up, quitted,or with incomplete information; those who used other medications during the research that may affect the study results.

    1.5 Statistical method

    The SPSS 21.0 version software was used for statistical analysis. The measurement data were expressed by mean ± standard deviation, and analyzed byt-test if the data conformed to normal distribution and homogeneity of variance;nonparametric test was used when the data were of abnormal distribution and heterogeneity of variance.The enumeration data were analyzed by Chi-square test;the ranked data by rank-sum test.P<0.05 was considered to indicate a statistical significance.

    1.6 General data

    The patients were all diagnosed with post-stroke depression and recruited from the Stroke Department,the Second Affiliated Hospital of Hunan University of Chinese Medicine between September of 2014 and June of 2016. Initially, there were 200 subjects enrolled,but only 105 conformed to the inclusion criteria and were then randomized into a group of acupuncture plus Tai Ji (53 cases) and a control group (52 cases) based on the visiting sequence. However, at the end of the intervention, only 90 subjects completed the study and were recruited for statistical analysis, 45 cases in each group. The flow chart of the whole study is shown in Figure 1.

    Figure 1. Study flow chart

    There were no significant differences in the data of age, gender, disease duration and stroke type between the two groups (P>0.05), indicating the comparability(Table 1).

    Table 1. Comparison of the general data

    2 Treatment Methods

    All the subjects were given routine and basic treatment for stroke by following theChinese Prevention and Treatment Guidance for Cerebrovascular Diseases[3], together with rehabilitation if necessary and possible.

    2.1 Acupuncture plus Tai Ji group

    2.1.1 Acupuncture treatment

    The acupuncture treatment was conducted on the purpose of awakening the brain and opening the orifices.

    Points or areas on the head: Middle Line of Forehead(MS 1), Anterior Oblique Line of Vertex- temporal (MS 6),Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24)and Yintang (GV 29).

    Body points: Bilateral Shenmen (HT 7), Neiguan(PC 6), Taichong (LR 3) and Hegu (LI 4); Chize (LU 5),Quchi (LI 11), Shousanli (LI 10), Fengshi (GB 31), Xuehai(SP 10), Yanglingquan (GB 34) and Qiuxu (GB 40), all on the affected side.

    Adjunct points based on pattern differentiation:Fenglong (ST 40) was added for pattern of wind-phlegm obstructing collaterals; Zusanli (ST 36) for pattern of qi deficiency and blood stagnation.

    Method: The points were located according to theNomenclature and Location of Acupuncture Points(GB/T12345-2006)[6]. Patient took a supine position.After proper sterilization for the to-be-treated areas,disposable filiform needles of 0.35 mm in diameter and 25 mm or 40 mm in length were used for acupuncture.For points on the head, needles were inserted horizontally by 5-15 mm; for body points, needles were punctured perpendicularly by 10-15 mm, according to the thickness of muscles in the area. When needling qi was obtained, even reinforcing-reducing manipulation(twirling manipulation for points on the head;lifting-thrusting and twirling manipulations for points on limbs) were performed for 1-3 min. The needles were then retained for 30 min. Five successive sessions of acupuncture treatment were given every week followed by a 2-day interval. One-month treatment was taken as a course, and the patients were given 1 course of treatment in total.

    2.1.2 Tai Ji Quan practice

    The patients were taught and guided to practice Yang’s 24-form simplified Tai Ji Quan (Figure 2-Figure 25)by professional teachers during hospitalization. They were also supervised and guided via telephone after discharged from hospital. The Tai Ji Quan practice was performed 5 times a week, 40 min each time, for 12 months in total.

    Figure 2. Beginning form

    Figure 3. Part wild horse’s mane

    Figure 4. A white crane spreads its wings

    Figure 5. Brush knee and step forward

    Figure 6. Play the lute

    Figure 7. Reverse reeling forearm

    Figure 8. Left grasp sparrow’s tail

    Figure 9. Right grasp sparrow’s tail

    Figure 10. Single whip

    Figure 11. Wave hands like clouds

    Figure 12. Single whip

    Figure 13. High pat on horse

    Figure 14. Right heel kick

    Figure 15. Strike to ears with both fists

    Figure 16. Turn body and left heel kick

    Figure 17. Left lower body and stand on one leg

    Figure 18. Right lower body and stand on one leg

    Figure 19. Shuttle back and forth

    Figure 20. Needle at sea bottom

    Figure 21. Fan through the back

    Figure 22. Turn body, deflect,parry and punch

    Figure 23. Appears closed

    Figure 24. Cross hands

    Figure 25. Closing form

    2.2 Control group

    Patients in the control group were asked to orally take citalopram hydrobromide tablets (lot No.H20120457, Xi’an Janssen Pharmaceutical Co. Ltd.,China), at 20 mg/d but tailored by 10 mg each week according to the patient’s condition (no more than 40 mg/d). One-month treatment was taken as a course,and a total of 3 courses were observed. If the treatment was satisfactory, the dosage of the medication would be reduced by 10 mg per week till termination. A 1-year follow-up study was conducted.

    3 Therapeutic Observation

    3.1 Observation items

    Each observation item was scored prior to the treatment, after 1-month treatment, and 12 months later, respectively.

    3.1.1 National Institutes of Health stroke scale(NIHSS)[7]

    NIHSS is composed of 11 items including level of consciousness, horizontal eye movement, visual field test, facial palsy, motor arm, motor leg, limb ataxia, and sensory, etc. Each item scores a specific ability. The total score ranges from 0 to 42. A higher score is indicative of a severer neurologic deficit. A score from 0-1: no stroke symptoms; 1-4: minor stroke; 5-15: moderate stroke;16-20: moderate to severe stroke; 21-42: severe stroke.

    3.1.2 Barthel index (BI)[7]

    BI consists of 10 variables, which are feeding, bathing,grooming, dressing, presence or absence of fecal incontinence, presence or absence of urinary incontinence, walking, and climbing stairs, etc. Each item is scored according to the level of accomplishment in order to evaluate the activities of daily living (ADL).The maximum total BI score is 100, and a higher score indicates a higher level of independence. Total BI score >60 points: mild dysfunction; 60-41 points:moderate dysfunction; ≤40 points: severe dysfunction.

    3.1.3 HAMD[4]

    HAMD contains 24 items, such as depressed mood,feelings of guilt, difficulty in falling asleep,anxiety-psychic, insight and feelings of despair, to estimate the severity of depression. A higher total HAMD score is indicative of severer depression. Total HAMD score <8 points: no depression; ≥8 points but<20 points: possible existence of depression; ≥20 points but <35 points: mild or moderate depression; ≥35 points: severe depression.

    3.2 Criteria of therapeutic efficacy

    The evaluation of clinical efficacy in improving neurological function referred to the criteria of therapeutic efficacy for stroke recommended by the World Health Organization (WHO)[7], i.e. by taking the reduction rate of NIHSS score as the evaluation index.Reduction rate of NIHSS score = (Pre-treatment total NIHSS score – Post-treatment total NIHSS score) ÷ Pretreatment total NIHSS score × 100%.

    Basically recovered: Reduction rate of NIHSS score≥91%.

    Markedly effective: Reduction rate of NIHSS score≥46% but <91%.

    Effective: Reduction rate of NIHSS score ≥18% but<46%.

    Failure: Reduction rate of NIHSS score <18%, or NIHSS score increased rather than dropped.

    The evaluation of efficacy in treating depression was based on the reduction rate of HAMD score[4].Reduction rate of HAMD score = (Pre-treatment total HAMD score – Post-treatment total HAMD score) ÷ Pretreatment total HAMD score × 100%.

    Recovered: Reduction rate of HAMD score ≥75%.

    Markedly effective: Reduction rate of HAMD score≥50% but <75%.

    Effective: Reduction rate of HAMD score ≥25% but<50%.

    Failure: Reduction rate of HAMD score <25%.

    3.3 Results

    3.3.1 Comparison of NIHSS score

    NIHSS score decreased after 1-month treatment as well as in the 12-month follow-up in both groups compared to the score before the intervention, with statistical significances (allP<0.01). Before the treatment, there was no significant difference in NIHSS score between the two groups (P>0.05); after 1-month treatment, the between-group difference in the score was statistically significant (P<0.05); the 1-year followup showed that there was a significant difference in NIHSS score between the two groups (P<0.01),(Table 2).

    3.3.2 Comparison of the clinical efficacy in treating stroke

    The 12-month follow-up study showed that the total effective rate in treating stroke was 84.4% in the acupuncture plus Tai Ji group, versus 68.9% in the control group, and the between-group difference was statistically significant (Z=–2.418,P=0.016), suggesting that the acupuncture plus Tai Ji group should be superior to the control group in comparing the therapeutic efficacy (Table 3).3.3.3 Comparison of BI score

    BI score was found increased in both groups after 1-month treatment and in the 12-month follow-up study compared with the score before the treatment,with statistical significances (allP<0.01). Before the treatment, there was no significant difference in BI score between the two groups (P>0.05); the betweengroup difference in BI score was statistically significant after 1-month treatment and in the follow-up study(bothP<0.01), (Table 4).

    Table 2. Comparison of NIHSS score

    Table 2. Comparison of NIHSS score

    Note: Ⅰntra-group comparison, 1) P<0.01; compared with the control group at the same time point, 2) P<0.05, 3) P<0.01

    Group n Pre-treatment After 1-month treatment Follow-up Acupuncture plus Tai Ji 45 11.82±5.06 6.26±3.181)2) 2.17±1.261)3)Control 45 12.43±4.81 7.86±3.291) 5.24±3.121)

    Table 3. Comparison of the clinical efficacy in treating stroke (case)

    Table 4. Comparison of BI score

    Table 4. Comparison of BI score

    Note: Ⅰntra-group comparison, 1) P<0.01; compared with the control group at the same time point, 2) P<0.01

    Group n Pre-treatment After 1-month treatment Follow-up Acupuncture plus Tai Ji 45 55.91±6.41 68.21±6.331)2) 79.73±6.941)2)Control 45 56.12±6.36 62.28±5.761) 72.43±7.311)

    3.3.4 Comparison of HAMD score

    HAMD score was found decreased after 1-month treatment as well as in the 12-month follow-up in both groups compared to the score before the intervention,with statistical significances (allP<0.01). Before the treatment, there was no significant difference in HAMD score between the two groups (P>0.05); the betweengroup difference in HAMD score was statistically significant after 1-month treatment and in the follow-up study (bothP<0.01), (Table 5).

    3.3.5 Comparison of therapeutic efficacy in treating depression

    The 12-month follow-up showed that the toal effective rate in treating depression was 86.7% in the acupuncture plus Tai Ji group, versus 77.8% in the control group, and the between-group difference was statistically significant (Z=–2.056,P=0.040), indicating that the acupuncture plus Tai Ji group should be superior to the control group in treating depression(Table 6).

    Table 5. Comparison of HAMD score

    Table 5. Comparison of HAMD score

    Note: Ⅰntra-group comparison, 1) P<0.01; compared with the control group at the same time point, 2) P<0.01

    Group n Pre-treatment After 1-month treatment Follow-up Acupuncture plus Tai Ji 45 25.60±4.44 12.33±4.721)2) 6.31±3.211)2)Control 45 24.44±4.58 15.68±4.591) 8.26±3.321)

    Table 6. Comparison of the therapeutic efficacy in treating depression

    4 Discussion

    Patients after stroke may experience emotional dysfunctions, such as PSD and anxiety. The pathogenesis of PSD is not completely clear yet, though it possibly involves brain injuries, neurologic deficit[8-10],stress response, and irregular secretion of neurotransmitters including norepinephrine (NE),5-hydroxytryptamine (5-HT) and dopamine (DA)[11].

    Treatment for PSD mainly includes medication,psychotherapy, and behavioral therapy. Medication is the most popular treatment, and selective serotonin reuptake inhibitors (SSRIs) are often used, though it may cause side effects or adverse events, such as mouth dryness, poor appetite, dizziness, and insomnia[12]. PSD belongs to the scope of depression syndrome in TCM,and phlegm and stasis obstructing meridians and collaterals, and yin-yang and qi-blood imbalance are considered to be the basic pathogenesis. PSD affects the brain, with wind-phlegm obstructing collaterals and disharmonious qi-blood as the root cause and liver-qi stagnation as the superficial cause. Therefore, the treatment should focus on soothing liver and relieving depression, calming mind and opening orifices,regulating qi and activating blood circulation to unblock collaterals. Acupuncture has been extensively used in rehabilitation for stroke[13-16]. It’s known that acupuncture-moxibustion is effective for PSD, with minor adverse reactions. It can boost the recovery of neurological function and improve depression symptoms, which has been well verified at home and abroad[13-16]. Waiguan (TE 5), Hegu (LI 4), Baihui (GV 20),Quchi (LI 11) plus Chize (LU 5) can produce a significant efficacy in improving the limb function in stroke[17-18].Modern mechanism research has found that acupuncture can protect brain neurons, inhibit cell apoptosis[19], promote the establishment of compensatory circulation[20], increase blood supply to brain, and modulate blood lipids[21]. Meanwhile, as a safe effective treatment for PSD[22-23], acupuncture may play its role via regulating neurotransmitters such as NE,5-HT and DA[24-25].

    In this study, points on the head were selected according to the function zones of brain and the routes of meridians: Middle Line of Forehead (MS 1) governs emotions; Anterior Oblique Line of Vertex-temporal(MS 6) is in charge of motor function; Baihui (GV 20), a point of Governor Vessel, acts to open orifices and awaken brain; Sishencong (EX-HN 1), Shenting (GV 24)and Yintang (GV 29) can calm the mind and open orifices, regulate and unblock meridians and collaterals.Of the selected body points, Neiguan (PC 6), the Luo-Connecting point of the Pericardium Meridian, and Shenmen (HT 7), the Yuan-Primary point of the Heart Meridian, can soothe the heart and calm the mind;Taichong (LR 3) can soothe the liver, resolve depression and regulate qi. Among all the body points, the points of Yangming meridians were mostly selected since these meridians are rich in qi and blood. Points around the affected joints were also used, including Chize (LU 5),Quchi (LI 11) and Shousanli (LI 10) on the upper limb,and Fengshi (GB 31), Xuehai (SP 10), Yanglingquan(GB 34) and Qiuxu (GB 40) on the lower limb, to regulate qi, activate blood flow and unblock collaterals.These points were used together to soothe the liver and resolve depression, calm the mind and open orifices,regulate qi and activate blood flow to unblock collaterals.

    Tai Ji Quan originates in China and has a long history.It’s composed of three factors, physical practice, mind practice and qi practice, which integrate both mental regulation and physiological regulation, and conform to the holism theory in TCM. During the practice of Tai Ji Quan, practitioners always have a high subjectivity, and such an active exercise can boost the activity of the motor center in cerebral cortex, increase the nerve excitability and promote the recovery of limb function[26]. Hart J,et al[26]found that Chen’s Tai Ji can help recover the balance function. McGibbon CA,et al[27]discovered that Yang’s Tai Ji can regulate the pattern of nerve and muscle movement, promote the restoration of patient’s function, and improve depression and anxiety. Wang W,et al[28]found that Yang’s Tai Ji can help the recovery of cognition after stroke, and improve sleep quality and depressive symptoms. Li Y,et al[29]and Rosenbaum S,et al[30]revealed that Tai Ji Quan in community sports can regulate neurotransmitters such as NE, 5-HT and DA,and a long-term practice can achieve an even better result. Therefore, the current study aimed to observe the short-term (1 month) and long-term (12 months)effects of acupuncture plus Tai Ji Quan in recovering neurological function and mental health in PSD, for achieving an aggregate treatment, merging the rehabilitation of hospital, community and family, and displaying the advantage of TCM.

    Subjects recruited in this trial were majorly in sub-acute and remission stages with moderate-severe depression. During the study, we found that the rhythm,consistency and even speed of Tai Ji Quan enabled the patients to better control the muscles of upper and lower limbs. In clinic, patients with high muscle tension,spasm and low muscle strength can start from easy forms and practice gradually, to promote the disengaging movement and reduce spasm. The results after 1-month treatment and the 12-month follow-up all showed that acupuncture plus Tai Ji Quan is effective in restoring the limb function and improving depression in PSD patients, and thus it’s worthy of further promotion.

    Conflict of Interest

    The authors declared that there was no potential conflict of interest in this article.

    This work was supported by Wang Jing-jing’s Ⅰnheritance Studio of National Famous Traditional Chinese Medicine Experts (王凈凈全國(guó)名老中醫(yī)藥專家傳承工作室);Graduate Student Research Ⅰnnovation Project of Hunan Province (湖南省研究生科研創(chuàng)新項(xiàng)目, No.CX2016B354); Open Fund for National Key Discipline of Diagnostics of Traditional Chinese Medicine (中醫(yī)診斷學(xué)國(guó)家重點(diǎn)學(xué)科開(kāi)放基金資助項(xiàng)目, No. 2015ZYZD27).

    Statement of Informed Consent

    Ⅰnformed consent was obtained from all individual participants or their relatives included in this study.

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    [26] Hart J, Kanner H, Gilboa-Mayo R, Haroeh-Peer O,Rozenthul-Sorokin N, Eldar R. Tai Chi Chuan practice in community-dwelling persons after stroke. Ⅰnt J Rehabil Res,2004, 27(4): 303-304.

    [27] McGibbon CA, Krebs DE, Parker SW, Scarborough DM,Wayne PM, Wolf SL. Tai Chi and vestibular rehabilitation improve vestibulopathic gait via different neuromuscular mechanisms: preliminary report. BMC Neurol, 2005, 5(1):3.

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    [29] Li Y, Su Q, Guo H, Wu H, Du H, Yang G, Meng G, Li C,Nagatomi R, Niu K. Long-term Tai Chi training is related to depressive symptoms among Tai Chi practitioners. J Affect Disord, 2014, 169: 36-39.

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