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    Effect of a long-term modified Tai Chi-based intervention in attenuating bone mineral density in postmenopausal women in southeast China: study protocol for a randomized controlled trial

    2017-04-09 06:35:37LiyeZouChaoyiWangHuiruWang
    關(guān)鍵詞:醬香弱小茅臺(tái)酒

    Li-ye Zou, Chao-yi Wang, Hui-ru Wang

    1 Department of Physical Education, Sun Yat-sen University, Guangzhou, Guangdong Province, China

    2 College of Physical Education, Jilin University, Changchun, Jilin Province, China

    3 Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China

    INTRODUCTION

    Osteoporosis is a degenerative bone disease that has become a major public health issue in the globe. According to Chinese White Paper on Osteoporosis Prevention(2009),1an estimated number of 69 million Chinese people are experiencing osteoporosis caused by loss and deterioration of bone mineral density (BMD). With respect to sex perspective, middle-aged women have a greater possibility in developing osteoporosis in comparison with men, which is attributed to that these aging women are suffering a decreased estrogen level resulting from a normal menopause.2In addition, because these aging women are also experiencing a degeneration in physical fitness level (e.g., muscular strength, balance,flexibility, power, speed, agility, muscular endurance,and coordination), fall episodes causing fractures are more often observed in postmenopausal women, which could produce a significant amount of medical expenses for their families.3,4

    There were a variety of long-term pharmacological therapies utilized for attenuating BMD loss or preventing osteoporosis in postmenopausal women, including levothyroxine, parathyroid hormone, raloxifene, oral alendronate,tamoxifen, and testosterone.5-8Aside from expensive drug therapies producing financial burden for their families, the positive results after the long-term drug therapies usage are not obvious with potential side effects.9

    To gain better understanding regarding how to attenuate BMD loss or prevent osteoporosis in postmenopausal women, researchers conducted randomized controlled trials examining whether calcium supplementation, green tea polyphenols, dietary intervention, and other physical activity/exercise program (e.g., resistance training, jumping exercise, and walking) were effective in slowing down BMD loss.10-13Of these intervention programs, physical activity/exercise seems to be more cost-effective and easily manageable in long-run perspective.

    Tai Chi is a traditional health-promoting exercise that originated from mainland China, characterized by a graceful, mindful, slow, coordinated, and flowing movements along with shifting of body weight.14As Tai Chi has become a popular physical activity, it attracts researchers worldwide and has been shown to have positive impact on physical, physiological, and psychological changes in healthy and clinical populations (e.g., Parkinson’s disease, cardiovascular diseases, breast cancer survivor,and mental illness).15-20In recent years, some researchers also attempted to determine whether Tai Chi has a protective effect in attenuating BMD loss in postmenopausal women.12,21,22Based on a number of randomized controlled studies on this topic, researchers conducted a systematic review and gave a hint that a long-term (at least 24 weeks) Tai Chi-based intervention program containing resistance training-based component is required to obtain protective effect in attenuating BMD loss in postmenopausal women.23Therefore, in this study a Tai Chi-based intervention will be created based on four components consisting of fall-prevention/balance training, stretching/ flexibility training, resistance training (Tai Chi push hand), and strength training. Tai Chi push hand training is relatively equivalent to resistance training (moderateto-high impact, weight-bearing) that may be effective in stimulating bone modeling and therefore attenuate BMD loss in postmenopausal women.

    Strengths and limitations

    ? This trial will be the first prospective randomized controlled study to provide the long-term follow-up results of bone mineral density in postmenopausal women receiving modified Tai Chi-based intervention.

    ? Focusing on modified Tai Chi-based intervention consisting of fall-prevention/balance training,stretching/ flexibility training, resistance training (Tai Chi push hand), and strength training to increase bone mineral density of postmenopausal women.

    ? A small sample size may reduce the reliability of the study results.

    METHODS/DESIGN

    Study design

    A prospective three-arm parallel randomized controlled trial (RCT) will be conducted to evaluate the efficacy and safety of Tai Chi-based intervention in attenuating BMD loss in postmenopausal women. Each eligible participant will sign the consent form approved by Institutional Review Board of Shanghai Sports University (approval No.11290502800) prior to intervention. The followings will be conducted sequentially in this study∶ (1) baseline assessment; (2) random allocation; (3) Tai Chi-based intervention;(4) post-intervention assessment. All outcome measures will take place in the sports science lab of Shanghai Sports University, China (Figure 1).

    Study population

    All study participants will be recruited from ten community centers in the southeast of China. People will be asked if they are willing to participate in this research project. All volunteers will go through a prescreening based on inclusion and exclusion criteria. Participants will be eligible if they∶ (1) are willing to participate in this research project regarding the effect of Tai Chi-based intervention on BMD;(2) are women aged between 50 and 65 years; (3) have been postmenopausal for 6–12 months; (4) are not involved in regular physical activity or other instructor-led exercise program before and during Tai Chi-based intervention period.

    Figure 1: Trial flow chart.

    Participants will be excluded if they∶ (1) are currently diagnosed with osteoporosis (osteoporotic fracture) or prior to this research project; (2) are regularly taking any medications or calcium supplementations that stimulates bone structure change and bone metabolism; (3) are diagnosed with the diseases (e.g., primary or secondary hyperthyroidism, skeletal metastases from cancer, multiple myeloma,pyogenic spondylitis) that limit physical function for participating in Tai Chi-based intervention program; (4) are currently practicing any other traditional ChineseQigongexercises (e.g., Baduanjin, Wuqinxi, Daoyinshu, Tai Chi Chuan, Tai Chi fan, Tai Chi softball, and Tai Chi push hand)for more than 3 months.

    Recruitment

    A questionnaire explaining osteoporosis and the purpose of the present study will be randomly sent to 1,200 people in ten community centers in the southeast of China. Those people who are interested in this research project will be invited to attend a free special lecture reporting knowledge of osteoporosis (e.g., osteoporosis as a major public health problem, who are at risk for osteoporosis, how to attenuate BMD loss for osteoporosis prevention, and the aim of the present study and procedures). Participants who are willing to participate will be asked to review and sign the written informed consent.

    Baseline assessment

    Except for the primary and secondary outcome measures,the demographic information of the eligible participants will be collected during baseline, including age, weight,and height.

    Randomization

    Each eligible participant will be randomly assigned to three groups according to 1∶1∶1 equal proportion rule. The sequence of random allocation will be generated using an online random sequence generator by a graduate with no clinical involvement in this trial. The random code will be kept by an independent investigator not involving in the care or assessment of the participants, or in the data collection and analysis.

    Blinding

    In this trial, both the outcome assessors and the statistical analyst will be blinded to the randomization allocation and will not be involved in performance of the interventions. It will be, nevertheless, impossible to blind the participants and practitioners since they will perform the interventional protocols. Random parameters would be kept in the blind codes, using sealed opaque envelopes to conceal random allocation. Unblinding will only occur once all the outcome data collection is completed.

    Interventions

    The eligible participants will be randomly assigned into three groups with the allocation ratio of 1∶1∶1, including two experimental groups (traditional Tai Chi group and modified Tai Chi-based intervention group) and a control group. Participants in the control group will be asked to maintain their original lifestyle during 12-month intervention period. The present study includes two experimental groups because researchers want to determine whether modified Tai Chi-based intervention program is more effective in attenuating BMD loss in postmenopausal compared with traditionalYang-style Tai Chi, providing a guideline for preventing osteoporosis. Those participants who are assigned into the experimental group II modified Tai Chi-based intervention containing four components∶(1) eight Tai Chi-based fall-prevention movements; (2) tenQigong-based stretching/ flexibility movements; (3) eight resistance training-based Tai Chi push hand movements;(4) eight Chen style-based Tai Chi movements. Resistance training-based Tai Chi movements are added in this group to determine whether the resistance training-based Tai Chi intervention is more effective than the traditional Yangstyle Tai Chi forms. For both experimental groups, study participants experience four 60-minute Tai Chi training sessions weekly for 12 months. To ensure the relatively consistent instruction for Tai Chi sessions, all instructors consisting of Tai Chi champions will receive 2-week training, instructed by a sophisticated Health-Qigongmaster in China.

    Outcomes and participant timeline

    BMD at multiple skeletal regions including lumbar levels L1, L2, L3, L4, L1–4, L2–4, and femoral neck, Ward's triangle,femoral shaft, greater trochanter of the femur (primary outcome measure) will be measured by a dual-energy X-ray absorptiometry (DXA) instrument (DPX-L scanner; GE Lunar, Madison, WI, USA). A doctor who has an instruction experience of more than 10 years is responsible for measuring BMD. Secondary outcome measures include low limb muscle strength, physical function, and reaction time at both upper and low limbs, administered by three trained graduate students at the Human Performance Laboratory.After completing the baseline assessment, study participants are arranged at predetermined locations for 12-month Tai Chi training program (four 60-minute sessions weekly),respectively. All Tai Chi training sessions will take place at martial arts training center of Shanghai Sports University.

    Researchers will use Dual-Energy X ray absorptiometry(DXA) because it has been recognized as a reliable assessment tool for measuring BMD at skeletal regions such as femoral neck.24A specialist is blinded to the purpose of the present study who is responsible for measuring BMD for obtaining precise data.

    A quadriceps device will be used to measure low-limb muscle strength. Each participant will be asked to sit on the exam table and hang over the edge of the table while bending at 90 degrees; the foot is placed within a dynamometer;both hands hold handles on two sides of the exam table with keeping their back straight. When the participant is ready,he or she is asked to extend his or her knee to ensure a maximum strength can be measured (kg, weight is recorded to the nearest 0.1 kg). There are three trials for each leg and a mean value will be used for data analysis.

    為“做強(qiáng)茅臺(tái)酒,做大系列酒”,2014年12月,茅臺(tái)集團(tuán)把醬香系列酒單獨(dú)從銷(xiāo)售公司的部門(mén)中劃撥出來(lái),成立獨(dú)立的營(yíng)銷(xiāo)體系,醬香系列酒銷(xiāo)售實(shí)現(xiàn)獨(dú)立經(jīng)營(yíng)、核算、激勵(lì)的運(yùn)營(yíng)模式。自此,作為占據(jù)“33”部分的茅臺(tái)醬香系列酒,不再是茅臺(tái)弱小的業(yè)務(wù)板塊,而是和茅臺(tái)酒一樣,成為了推動(dòng)茅臺(tái)這輛戰(zhàn)車(chē)馳騁酒業(yè)市場(chǎng)不可或缺的雙輪之一。

    Star Excursion Balance Test (SEBT) will be used to measure physical balance.25Prior to this test, a star pattern in eight directions (anterior, posterior, medial, lateral, posterolateral, posteromedial, anterolateral, and anteromedial)is created based on 45 degrees between each two directional lines. Each participant will be asked to place his or her one foot in the middle of the start pattern. When the participant is ready, he or she is instructed to reach his or her another foot as far as possible for the eight directions according to clockwise principle. There are three trials for each participant and a mean value is used for data analysis.

    Study participants who are able to complete 12-month intervention program will be compensated with money and souvenir. If these pragmatic conditions (e.g., job relocation, schedule con flict, or lacking motivation) are present,they are allowed to withdraw from the present study at any time. In addition, a predesigned worksheet is given toeach participant to record his/her adverse events during the 12-month intervention period. When fall-related fracture,musculoskeletal injuries, or hospitalization required occurs,the participants will be immediately notified to see a doctor. Muscle-related soreness, pain, or discomfort is present 3 days after Tai Chi session will not be considered as the adverse events.

    Table 1: Bone mineral density in postmenopausal women at baseline and 12-month follow-up

    Sample size

    Based on the results of a previous study by Yamazaki et al.,26we assume a between-group difference in the change in BMD is 0.5%. Since an overall dropout rate of 20%was anticipated, the required sample size will be 150 (75 patients per group) with a false-positive error of 5% and power of 80%.

    Statistical analysis

    Statistical analyses will be performed using SPSS 20.0 software. Normal distribution will be examined with Shapiro-Wilk Test. Paired Student’st-test will be used to compare the intra-group differences in primary and secondary outcomes between baseline and 12-month follow-up.Inter-group difference in all outcome measures will be compared with analysis of variance. In particular, to detect whether 12-month Tai Chi-based training is effective in attenuating BMD loss, percentage change will be calculated by BMD at baseline minus BMD at 12-month follow-up dividing by BMD at baseline.

    Data monitoring

    An independent data monitoring committee (DMC) consisting of seven experts (two medical doctors, two physicians,two ethicists, and a statistician) will periodically review and assess available study data for safety, conduct and efficacy.Based on predetermined date, the DMC will meet and discuss the study results. The termination of the study project can be recommended by the DMC if serious adverse events,overwhelming benefits (participants in the experimental group is shown to be undoubtedly superior to those in the control group), and futility (when approximately half of all the expected events have been recorded) are monitored.

    Harms

    Tai Chi-based intervention as a moderate intensity exercise will be administered by several experiencedQigonginstructors and monitored by medical doctors from Shanghai Renji Hospital, which ensure the safety of all study participants.In case the study participants experienced any body damages, they will be suggested to withdraw from this study.Any muscle-related soreness following the Tai Chi-based training sessions will not be considered harms.

    Auditing

    Two physicians from Shanghai Renji Hospital will be responsible for auditing the entire process of the study project,particularly data collection and analysis.

    Ethics and dissemination

    Research ethics approval

    This research project was approved by Institutional Review Board of Shanghai Sports University (approval No.11290502800).

    Consent or assent

    Each participant will sign a consent form approved by Institution Review Board of Shanghai Sports University before intervention.

    Access to data

    All data will be accessible two months after the publication of study results.

    RESULTS

    Trial status∶ Patient recruitment started in August 2017. The analysis of primary outcome measures will be completed in October 2018. The estimated study completion date is June 2019. Pilot results are shown in Table 1.

    DISCUSSION

    Postmenopausal osteoporosis is a prominent public health problem. The purpose of this study is to assess the efficacy and safety of 12-month Tai Chi-based intervention in attenuating BMD in postmenopausal women. To our knowledge,this is the first prospective randomized controlled study to provide the long-term follow-up results of changes in BMD in multiple musculoskeletal regions of postmenopausal women receiving modified Tai Chi-based intervention containing fall-prevention/balance training, stretching/flexibility training, resistance training (Tai Chi push hand),and strength training.

    We hope this RCT will provide scientific evidence to an effective intervention for attenuating BMD loss in postmenopausal women regarding modified Tai Chi-based intervention in managing bone mineral loss.

    Author contributions

    LYZ and HRW designed the trial protocol. LYZ and CYW wrote the manuscript. All authors approved the final version of the manuscript.

    Conflicts of interest

    The authors declare that they have no conflicts of interest.

    Research ethics

    This study protocol was approved by the Institution Review Board of Shanghai Sports University (approval No. 11290502800) and will be performed in accordance with theDeclaration of Helsinki.Written and signed informed consent will be obtained from all participants prior to inclusion in the study. This trial was registered in the Chinese Clinical Trial Registry (registration No. ChiCTRIOR-15005887).

    Declaration of participant consent

    The authors certify that they will obtain all appropriate participant consent forms. In the form, participants will give their consent for their images and other clinical information to be reported in the journal. Participants understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

    Data sharing statement

    No additional data available.

    Plagiarism check

    Checked twice by iThenticate.

    Peer review

    Externally peer reviewed.

    Open access statement

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under identical terms.

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