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    Current technical aspects of oncological hepatic surgery

    2017-02-23 05:14:13AhmedSalemandEmilyWinslow

    Ahmed I Salem and Emily R Winslow

    Madison, USA

    Current technical aspects of oncological hepatic surgery

    Ahmed I Salem and Emily R Winslow

    Madison, USA

    BACKGROUND: With the recent advances in oncological hepatic surgery, major liver resections became more widely utilized procedures. The era of modern hepatic surgery witnessed improvements in patients care in preoperative, intraoperative and postoperative aspects. This significantly improved surgical outcomes regarding morbidity and mortality. This review article focuses on the recent advances in oncological hepatic surgery.

    DATA SOURCES: This review includes only data from peer-reviewed articles and journals. PubMed database was utilized as the primary source of the supporting literature to this review article on the latest advances in oncological hepatic surgery. Comprehensive and high sensitivity search strategies were performed to search related studies exhaustively up till June 2016. We critically and independently assessed over 50 recent publications written on this topic according to the selection criteria and quality assessment standard. We paid particular attention to the studies published in high impact journals that address the use of the surgical techniques mentioned in the articles in well-known institutions.

    RESULTS: Among all utilized approaches aiming at the preoperative assessment of the liver function, Child-Turcotte-Pugh classification remains the most reliable tool correlating with survival outcome. Although the primary radiological tools including ultrasonography, computed tomography and magnetic resonance imaging remain on top of the menu of tests utilized in assessment of focal hepatic lesions, intraoperative ultrasonography projects to be a powerful additional tool in terms of sensitivity and specificity compared to the other conventional techniques in assessment of the liver in the operative setting, a procedure that can change the surgical strategy in 27.2% of the cases and consequently improve the oncological surgical outcome. In addition to the conventional surgical techniques of liver resection and portal vein embolization, associating liver partition and portal vein ligation for staged hepatectomy “ALPPS” projects to be an alternative option in patients with marginally resectable tumors with an inadequate size of future liver remnant with an accepted surgical oncological outcome.

    CONCLUSIONS: Considering the clinicopathological nature of hepatic lesions, the comprehensive assessment and proper choice of the liver resection technique in highly selected patients is associated with improved surgical oncological outcome. Patients with underlying marginal future liver remnant volumes can now safely benefit from a wider range of surgical intervention, a breakthrough that significantly improved morbidity and mortality in this group of patients.

    (Hepatobiliary Pancreat Dis Int 2017;16:147-154)

    liver surgery;

    liver neoplasms;

    technical aspects;

    oncosurgery;

    liver metastasis

    Introduction

    Liver resection has long presented challenges for surgeons due to the liver’s complex anatomy, unique vasculature and need for preservation of adequate functional reserve after resection. With the advances in surgical techniques utilized in liver surgery in recent years, hepatic resection is being undertaken more often, in a wider range of disease states, and with improved outcomes. Improvements in preoperative assessment, operative technique, and postoperative care have allowed for more aggressive resections to be offered to patients with equivalent, or perhaps better, outcomes. This article reviews recent literature regarding preoperative hepatic assessment, optimization of operative conditions, and a detailed discussion on the most current techniques used for hepatic resections.

    Preoperative functional assessment of the liver

    Both qualitative and quantitative evaluation of the liver preoperatively is of pivotal importance when planning a hepatic resection. Determination of the future liver remnant (FLR) can be done using indocyanine green (ICG) clearance rate, the lidocaine-MEGX test, or volumetrically using axial imaging. Regardless of the method chosen, it is essential to assure that an adequate volume of functional hepatic parenchyma will remain after resection.[1,2]Although volumetric measurements perform well for the majority of patients, it is important to note that patients with liver function compromised by underlying disease may have inadequate functional reserve despite preservation of an otherwise “adequate” volume. For patients with borderline FLRs (e.g. 20% of the original volume of a normal liver or 40% of the original volume of a cirrhotic liver), preoperative portal vein embolization (PVE, see below) can be considered in an effort to induce hypertrophy of the FLR up to 12% of the total hepatic volume.[3]

    Regarding predicting rates of morbidity and mortality of hepatic resection preoperatively, the Child-Turcotte-Pugh (CTP) classification has remained the most studied classifications in the literature that was found to correlate well with survival outcome after liver surgery. Estimates for one- and two-year survival can be made on a basis of the CTP class: 95% and 90% for class A, 80% and 70% for class B, and 45% and 38% for class C, respectively.[4]

    Preoperative PVE

    The use of preoperative PVE has significantly changed the approach to major hepatectomy and has made extended resections safer for patients.[5]Percutaneous PVE is minimally invasive procedure that can be easily performed in the radiology suite with local anesthesia or under conscious sedation.[6]PVE is most useful for patients with underlying marginal FLR volumes (i.e., FLR <20% in patients with a normal liver, FLR <30% for patients with non-alcoholic steatohepatitis, and FLR <40% in patients with cirrhosis). So it facilitates hepatectomy with much less risk of postoperative liver failure and consequently lower rates of postoperative morbidity and mortality.[7-10]Success rates of PVE vary widely according to the underlying liver condition. While liver cirrhosis was found to have an adverse effect on PVE outcome, cholestasis and chemotherapy were not associated with worse observed outcome compared to normal liver condition.[11]While PVE can induce up to 12% hypertrophy of the total hepatic volume, it takes a mean interval of 31 days between PVE and surgery to allow for adequate FLR.[3,12]

    Preoperative assessment of the liver

    Ultrasonography (US) remains the easiest, fastest and the most non-invasive modality for liver imaging. With jaundice being a typical presentation of hepatic disease, US can determine whether this is obstructive versus non-obstructive jaundice and evaluate other possible accompanying conditions namely evidence of fibrosis or cirrhosis and the presence or absence of mass lesions.

    Computed tomography (CT) is the standard examination for most hepatic mass lesions due to its ability to provide excellent visualization of the hepatic parenchyma and vasculature as well as to identify extrahepatic diseases. Tri-phasic thin slice CT scan of the liver is a useful dedicated technique to utilize for patients with known or suspected hepatic lesions.

    Magnetic resonance imaging (MRI) plays a significant role in the assessment of hepatic lesions and can help in distinguishing the malignant lesions in the liver from the benign ones. The use of hepatobiliary-specific contrast agents and the acquisition of delayed imaging helps the abdominal radiology to make a well-informed assessment of the nature of hepatic lesions, even as small as 10 mm in size.[13]

    Choosing abdominal approach

    Hepatic resections can be approached in either a traditional open fashion or via a laparoscopic approach. The choice of technique depends on the surgeon’s experience, the nature, and location of the hepatic lesions and the patient’s underlying medical condition. For the open approach, the most preferred one among surgeons is a right subcostal incision which enables easy and safe access to the liver. A right subcostal incision may be extended either in the midline towards the xiphoid process or to the left side. A hybrid approach with laparoscopic hepatic mobilization followed by open surgery through a more limited incision has also been described.

    Intraoperative ultrasonography (IOUS)

    IOUS is an important tool to utilize both before and during hepatic resection. The use of IOUS early in the case helps to identify any previously undetected lesions, to map the transection plane, and to determine the relevant vasculature in relation with the hepatic surface. Ferrero et al described IOUS sensitivity/specificity of 92%/97.8% compared to 63.6%/91%, 68.8%/92.3%, and 53.6%/95.8% for CT, MRI, and fluorodeoxyglucose positron emission tomography respectively.[14]Also, in the same study surgical strategy was changed in 27.2% of thecases in light of the new findings on IOUS.[14]Looking at the pattern of recurrence with utilizing IOUS, Santambrogio et al[15]performed a study on 377 patients all of whom had hepatocellular carcinoma with 42% treated with hepatic resection and the remaining 58% with surgical radiofrequency ablation. All patients underwent IOUS examination. With a median follow-up period of 19.6 months, 52.2% of all patients had a recurrence, 36.5% of those recurrences were located in segments that are different from that of the primary tumor while 16% were found in the same segment as the primary tumor.[15]The use of contrast-enhanced US in the operating room is currently undergoing investigation and may help the surgeon and the radiologists to identify small and subtle hepatic lesions more reliably.[16]

    Three-dimensional pre-resection planning software has been marketed in recent years to help surgeons better visualize the transection plane considering the relation to the key vasculature and the patient’s specific lesions. Although this is intuitively appealing and generates excellent images that are useful to the surgical trainee, it has not yet been shown to impact patient care and has not been incorporated into most center’s routine practice.[17]Also, the use of image guided resections using real-time intraoperative axial imaging has been studied and utilized in some centers.[18]

    Liver mobilization

    Liver mobilization is a major step that aims to provide better visualization of the hepatic pathology and to allow safer transection of the liver. Complete liver mobilization is achieved through division of the falciform, triangular and coronary ligaments; this allows freeing the liver from its attachments to the diaphragm and retroperitoneum, exposing the bare area of the liver and the short hepatic veins draining from the right liver into the inferior vena cava (IVC).

    Techniques for parenchymal transection

    Crushing technique

    Crushing liver resection techniques have been introduced as the earliest methods utilized for isolation and division of small vessels and biliary radicals.[19]This includes “finger-fracture” and “clamp-crush” techniques with the clamp-crush showing better hemostatic control over finger-fracture.[19]Although it is the oldest technique in liver surgery, it is still widely used by surgeons since it is simple, inexpensive, quick and easy to learn. Several randomized controlled trials and meta-analyses failed to show superior benefit for some of the modern techniques including the vessel sealing system (LigaS-ure), Cavitron ultrasonic surgical aspirator (CUSA) or Hydrojet when compared to the conventional crushing techniques.[20-22]

    Ultrasonic dissection

    Using a broad range of ultrasonic frequencies, CUSA can fragment liver parenchymal tissue leaving structures like blood vessels and bile ducts intact. It is useful when a very-well defined transection plan is required as in cases where tumors are in proximity to major vascular structures.[19]CUSA allows for customization of the fragmentation power according to the nature of tumor tissue. While the 24 kHz hand-piece provides fragmentation power that suits fibrous or calcified tumors, the 35 kHz hand-piece provides precision, tactile feedback, and fine control.[23]Comparing it with the clamp-crushing, the clamp-crushing technique had the highest transection velocity (3.9 ±0.3 cm2/min) and lowest blood loss (1.5±0.3 mL/cm2) compared with CUSA (2.3±0.2 cm2/min and 4 .0±0.7 mL/cm2).[21]

    Sealing devices

    Electrothermal bipolar vessel sealing (EBVS) is a technology that is based on starting a sealing cycle under a generator control, the generated electrical current travels through the vessel wall and works on creating an electromagnetic field that is capable of energizing the electrons within the blood vessels. These energized electrons release their energy as heat resulting in denaturation of the proteins found in the structure of collagen and elastin components present in the blood vessels.[24]The power generated is enough to seal vessels with a diameter of up to 7 mm.[25]One advantage of this system is that it performs both the parenchymal resection function along with vascular sealing at the same time; a dual function that at one time was believed to be timesaving in comparison to the gold-standard clamp-crush. However, recent randomized controlled trials comparing these two approaches failed to show an advantage of the vessel sealing system (LigaSure) over the conventional clamp-crush.[22,26]A recent randomized controlled trial by Muratore and colleges showed no differences regarding blood loss, transection time, transection speed or rates of mortality, morbidity or bile leak.[27]

    Radiofrequency-assisted liver resection

    An additional technique that impacted the performance of liver surgery utilized radiofrequency waves to aid in the safe resection and was first introduced by Habib and colleagues in 2002.[28]This technique usesradio waves delivered to the parenchyma at very high frequencies that may reach up to 500 kHz through various probes designed to suit different surgical conditions. The technique allows for pre-coagulation of the intended transection plane by generating temperatures up to 300 ℃ causing coagulative necrosis of tissues.[29]This technique has been used in standard open surgery, in minimally invasive resections, and in CT-guided percutaneous liver ablation. A recent randomized controlled study by Li and colleagues[30]from 2013 compared outcomes from resection of hepatocellular carcinoma in cirrhotic patients using radiofrequency-assisted parenchyma transection to gold-standard clamp-crushing technique and found the radiofrequency-assisted liver resection was associated with significantly less blood loss with no significant change in rates of morbidity.

    Saline-linked radiofrequency sealer

    In contrast to the radiofrequency-assisted liver resection, the saline-linked radiofrequency sealer depends on the transmission of 480 kHz radiofrequency energy through saline dripping from the tip of the handpiece.[29]Saline dripping allows for maintaining the tissue temperature at or below 100 ℃, a temperature that is enough for sealing of the vessels through collagen and elastin shrinkage but not enough to cause the tissue fragmentation observed in the conventional radiofrequency-assisted liver resection.[29]These changes on the molecular and tissue levels are believed to create better hemostatic conditions especially if an underlying liver disease is present at the time of surgery. In the controlled study by Xia and colleagues, the potential benefit of the saline-linked radiofrequency sealer was examined in cases with cirrhotic livers. They found that saline-linked radiofrequency sealer was associated with significantly less blood loss and reperfusion-related liver injury with the longer resection time being the only drawback limiting the use of this technique.[31]

    Water-jet dissection

    Water-jet dissection is a concept that has been employed in so many aspects of the recent scientific applications including surgery.[32]This technique depends on a high-velocity current of water pointed at a small surface area allowing for high-pressure energy. Water-jet dissection minimizes vascular damage at the time of hepatic parenchymal dissection because it cuts the parenchyma, preserving the integrity of the vascular components. One drawback of this technique is that it requires manual ligation of these vascular components which is expected to prolong the time of dissection. This technique has been utilized in particular circumstances in hepatic resection, such as the procurement of a hepatic graft from a living donor.

    Minimally invasive liver surgery

    Minimally invasive liver surgery is a term that describes a broad range of techniques starting from total laparoscopy, hand-assisted laparoscopy, to the most recent robotic technique.[19]According to the International “Louisville Statement” regarding laparoscopic liver surgery published in 2009, 20%-80% of the total volume of liver surgery performed at a particular center is carried out laparoscopically.[33]In the population-based analysis utilizing data from the Nationwide Inpatient Sample (NIS, 2000-2012) and the National Surgical Quality Improvement Project (NSQIP, 2005-2012) by Pawlik et al, the annual volume of laparoscopic liver resection has increased from 52-63 cases annually between 2000-2008 to 127-168 cases annually between 2009-2012 representing 2.4-2.7 folds increase since the release of the “Louisville Statement” in 2009.[34]Minimally invasive liver surgery carries the advantages of a better cosmetic outcome, faster recovery, less postoperative pain and less operative blood loss and transfusion compared to the open approach without compromising morbidity or mortality.[34,35]Of note that laparoscopic repeat hepatectomy was associated with less blood loss and lower rates of transfusion in patients who had undergone previous laparoscopic surgery compared to patients who had undergone previous open surgery.[36]Current literature has shown a learning curve for laparoscopic liver resection ranging between 45 to 75 cases.[37]The risk-adjusted cumulative sum analysis by van der Poel et al suggested a learning curve of 55 laparoscopic hemihepatectomies.[38]The largest review of laparoscopic liver resection in 2804 patients by Nguyen et al shows that the most common laparoscopic liver resection was wedge resection (45%) followed by laparoscopic liver segmentectomy (20%), right hepatectomy (9%) and left hepatectomy (7%).[39]The conversion rate within the same study cohort from laparoscopic to open laparotomy and from laparoscopic to hand-assisted approach was 4.1% and 0.7% respectively with no reported intraoperative death.[39]For cancer patients, negative resection margins were achieved in 82%-100% associated in patients with hepatocellular carcinoma with overall and disease-free survival rates of 50%-75% and 31%-38.2% respectively.[39]The “Louisville Statement” recommended the utilization of laparoscopic liver resection for solitary lesions, 5 cm or less, located in the peripheral liver segments 2 to 6.[33]Larger tumors (>5 cm), central, multiple, bilateral or anatomically in contact with the liver hilum, major hepatic veins or the IVC are not recommended for laparoscopic resectionalthough they might be part of the everyday practice of highly experienced centers.[33]The matched comparison between robotic versus laparoscopic hepatectomy by Tsung et al displayed no significant difference regarding operative and postoperative outcome measured by operative blood loss, transfusion rate, resection margin status, length of hospital stay, or 90-day mortality.[40]Patients undergoing robotic liver surgery have longer operative time compared to the laparoscopic approach (253 min vs 199 min, however the robotic approach allowed for completion of major hepatectomies in a purely minimally invasive fashion in 81% of the cases compared to 7.1% of the cases performed laparoscopically (P<0.05).[40]

    Maneuvers for effective control of hepatic vasculature

    Pedicle ligation and extrahepatic ligation techniques for hemihepatectomies

    Minimizing blood loss during liver surgery is a variable associated with favorable outcomes regarding both morbidity and mortality.[41,42]For this reason, wise utilization of various intraoperative techniques for hemodynamic control is essential for better operative outcomes. Two main methods for inflow control to the liver to be resected are available. Extrahepatic dissection of the portal pedicle with ligation and division of the arterial and venous inflow is the standard technique utilized for hepatic resection. An alternative technique is the use of mass ligation of the pedicle to the corresponding segment or segments of the liver.[43]This latter technique provides for more rapid inflow control and allows the surgeon to avoid the risk of injury to the contralateral pedicle to the FLR, but is limited in its application to patients whose tumors are not in proximity to the inflow and who have conventional venous and arterial anatomy.

    Alternative types of liver resection

    Liver hanging maneuver (LHM)

    Although complete liver mobilization is traditionally an early step in hepatic resection, the position and size of some tumors make safe mobilization of the liver difficult (e.g. large bulky right-sided tumors that involve the diaphragm). Concern for the risk of tumor rupture during mobilization as well as the general principle of use of a“no-touch” technique in oncologic surgery prompted the introduction of the anterior approach. Described by Lai and colleges in 1996,[44]this concept is considered one of the major recent advances in the field of liver resection. In 2001 the LHM was introduced by Belghiti and colleagues to allow for a better control of the transection plane during the anterior approach.[45]This technique requires lifting the liver with a tape passed between the anterior surface of the IVC and the liver parenchyma so as to define the transection plane and better control the vasculature during transaction.[45]Further, it allows improvement in hemodynamic stability and provides better protection of IVC from accidental injuries.

    Associating liver partition and portal vein ligation for staged hepatectomy “ALPPS”

    The so-called “ALPPS” procedure is a 2-phase procedure that was first described by Schnitzbauer and colleges in 2012.[46]This procedure was designed to be used as an alternative to PVE in patients with marginally resectable tumors with an inadequate size FLR.

    Phase I

    This phase starts with real-time evaluation using IOUS for precise assessment of tumor extent across liver lobes. Following this step, resection of the tumor from the FLR is performed along with ligation of the portal veins feeding the remaining diseased liver. A parenchymal transection is then performed between the FLR and the diseased liver. This step is necessary to ensure no collateral portal flow takes place between the FLR and the diseased liver compromising the intended surgical anatomical isolation between both.

    As a result of the above-described procedure, the patient is left with an “auxiliary” liver that has hepatic arterial inflow, venous outflow,and biliary drainage, despite being “de-portalized”. This helps to minimize the chance of potential liver failure during the 1-2 weeks before the second stage of the operation. Further, there is rapid hypertrophy of the FLR during the window between the 2 phases of the operation allowing for median volume increase of 74% (range 21%-192%) during a median waiting period of 9 days (range 5-28).[46]

    Phase II

    This phase is performed 1-2 weeks after Phase I and entails removal of the diseased part of the liver using simple transection of the hepatic artery, duct and veins leaving the healthy and newly hypertrophied FLR to support the patient.

    Since the initial introduction of the ALPPS technique, there have been several modifications suggested by other authors and a fair amount of controversy over its specific applications in the field of hepatic surgery including the concerns about the effect of ALPPS on tumor proliferation.[47-49]

    Liver perfusion techniques

    For unresectable liver tumors, isolated liver perfusion is a novel and alternative option in some cases.[50]The technology aims to isolate the liver from the systemic circulation and connects it into another external mechanical perfusion system. Heated chemotherapy is then infused through this system into the hepatic vasculature. This technique helps selectively deliver chemotherapy only to the liver which allows drug delivery at higher concentrations than can be tolerated through the systemic infusion. The heated chemotherapy increases the susceptibility of malignant liver cells towards the toxic effect of chemotherapy through by enhancing its absorption. This eliminates most of the systemic side effects associated with delivering chemotherapy through systemic infusion. Many groups have reported survival benefit from this technique, but still more data are needed to establish the role of this technology in the treatment of hepatic malignancies.[51]

    Ex vivo resections

    Ex vivo resection is a novel surgical technique that has been introduced to the field of liver surgery by Pichlmayr and colleagues.[52]This technique was developed to address liver tumors that are not resectable due to an involvement of the major vascular components including the IVC, superior vena cava, and major hepatic veins. Four crucial steps constitute the backbone of this operation: veno-venous bypass, perfusion of the liver with preservation solution under hypothermic conditions, resection of the hepatic tumor with vascular reconstruction and reimplantation of the remnant liver.[53]Although this technique is associated with less blood loss compared to in vivo resection, the operation time is much longer, and there is some risk of hepatic injury from the period of cold preservation to the future liver remnant. Compared to total vascular exclusion, ex vivo resection was associated with better tolerance to ischemia represented as better postoperative hepatic and renal function, as well as less postoperative morbidity.[54]

    Conclusion

    Considering the clinicopathological nature of hepatic lesions, the comprehensive assessment and proper choice of the liver resection technique in highly selected patients is associated with improved surgical oncological outcome. Patients with underlying marginal future liver remnant volumes can now safely benefit from a wider range of surgical intervention, a breakthrough that significantly improved morbidity and mortality in this group of patients.

    Contributors: SAI proposed the study, performed the research, collected and analyzed the data, and wrote the first draft. Both authors contributed to the design and interpretation of the study and to further drafts. WER is the guarantor.

    Funding: None.

    Ethical approval: Not needed.

    Competing interest: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

    1 Feng HL, Li Q, Wang L, Yuan GY, Cao WK. Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure. Hepatobiliary Pancreat Dis Int 2014;13:271-275.

    2 Ercolani G, Grazi GL, Callivà R, Pierangeli F, Cescon M, Cavallari A, et al. The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery. Surgery 2000;127:464-471.

    3 Vilgrain V, Sibert A, Zappa M, Belghiti J. Sequential arterial and portal vein embolization in patients with cirrhosis and hepatocellular carcinoma: the hospital beaujon experience. Semin Intervent Radiol 2008;25:155-161.

    4 D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006;44:217-231.

    5 Massimino KP, Kolbeck KJ, Enestvedt CK, Orloff S, Billingsley KG. Safety and efficacy of preoperative right portal vein embolization in patients at risk for postoperative liver failure following major right hepatectomy. HPB (Oxford) 2012;14:14-19.

    6 Imamura H, Shimada R, Kubota M, Matsuyama Y, Nakayama A, Miyagawa S, et al. Preoperative portal vein embolization: an audit of 84 patients. Hepatology 1999;29:1099-1105.

    7 Ferrero A, Viganò L, Polastri R, Muratore A, Eminefendic H, Regge D, et al. Postoperative liver dysfunction and future remnant liver: where is the limit? Results of a prospective study. World J Surg 2007;31:1643-1651.

    8 van den Esschert JW, de Graaf W, van Lienden KP, Busch OR, Heger M, van Delden OM, et al. Volumetric and functional recovery of the remnant liver after major liver resection with prior portal vein embolization: recovery after PVE and liver resection. J Gastrointest Surg 2009;13:1464-1469.

    9 Ribero D, Chun YS, Vauthey JN. Standardized liver volumetry for portal vein embolization. Semin Intervent Radiol 2008;25:104-109.

    10 Zorzi D, Laurent A, Pawlik TM, Lauwers GY, Vauthey JN, Abdalla EK. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 2007;94:274-286.

    11 van Lienden KP, van den Esschert JW, de Graaf W, Bipat S, Lameris JS, van Gulik TM, et al. Portal vein embolization before liver resection: a systematic review. Cardiovasc Intervent Radiol 2013;36:25-34.

    12 Yoo H, Kim JH, Ko GY, Kim KW, Gwon DI, Lee SG, et al. Sequential transcatheter arterial chemoembolization and portal vein embolization versus portal vein embolization only before major hepatectomy for patients with hepatocellular carcinoma.Ann Surg Oncol 2011;18:1251-1257.

    13 Albiin N. MRI of focal liver lesions. Curr Med Imaging Rev 2012;8:107-116.

    14 Ferrero A, Langella S, Giuliante F, Viganò L, Vellone M, Zimmitti G, et al. Intraoperative liver ultrasound still affects surgical strategy for patients with colorectal metastases in the modern era. World J Surg 2013;37:2655-2663.

    15 Santambrogio R, Costa M, Strada D, Barabino M, Conti M, Bertolini E, et al. Intraoperative ultrasound patterns predict recurrences after surgical treatments for hepatocellular carcinoma. J Ultrasound 2010;13:150-157.

    16 Arita J, Ono Y, Takahashi M, Inoue Y, Takahashi Y, Matsueda K, et al. Routine preoperative liver-specific magnetic resonance imaging does not exclude the necessity of contrast-enhanced intraoperative ultrasound in hepatic resection for colorectal liver metastasis. Ann Surg 2015;262:1086-1091.

    17 Hallet J, Gayet B, Tsung A, Wakabayashi G, Pessaux P; 2nd International Consensus Conference on Laparoscopic Liver Resection Group. Systematic review of the use of pre-operative simulation and navigation for hepatectomy: current status and future perspectives. J Hepatobiliary Pancreat Sci 2015;22:353-362.

    18 Clements LW, Dumpuri P, Chapman WC, Dawant BM, Galloway RL, Miga MI. Organ surface deformation measurement and analysis in open hepatic surgery: method and preliminary results from 12 clinical cases. IEEE Trans Biomed Eng 2011;58(8).

    19 Aragon RJ, Solomon NL. Techniques of hepatic resection. J Gastrointest Oncol 2012;3:28-40.

    20 Rahbari NN, Koch M, Schmidt T, Motschall E, Bruckner T, Weidmann K, et al. Meta-analysis of the clamp-crushing technique for transection of the parenchyma in elective hepatic resection: back to where we started? Ann Surg Oncol 2009;16: 630-639.

    21 Lesurtel M, Selzner M, Petrowsky H, McCormack L, Clavien PA. How should transection of the liver be performed?: a prospective randomized study in 100 consecutive patients: comparing four different transection strategies. Ann Surg 2005;242: 814-823.

    22 Ikeda M, Hasegawa K, Sano K, Imamura H, Beck Y, Sugawara Y, et al. The vessel sealing system (LigaSure) in hepatic resection: a randomized controlled trial. Ann Surg 2009;250:199-203.

    23 Feldman L. The SAGES Manual on the Fundamental Use of Surgical Energy (FUSE). Dordrecht: Springer; 2012.

    24 Massarweh NN, Cosgriff N, Slakey DP. Electrosurgery: history, principles, and current and future uses. J Am Coll Surg 2006;202:520-530.

    25 Kennedy JS, Stranahan PL, Taylor KD, Chandler JG. Highburst-strength, feedback-controlled bipolar vessel sealing. Surg Endosc 1998;12:876-878.

    26 Chapman WC. No silver bullet in liver transection: what has 35 years of new technology added to liver surgery? Ann Surg 2009;250:204-205.

    27 Muratore A, Mellano A, Tarantino G, Marsanic P, De Simone M, Di Benedetto F. Radiofrequency vessel-sealing system versus the clamp-crushing technique in liver transection: results of a prospective randomized study on 100 consecutive patients. HPB (Oxford) 2014;16:707-712.

    28 Buscarini L, Buscarini E. Radiofrequency thermal ablation of hepatocellular carcinoma. In: Habib N, ed. Multi-treatment modalities of liver tumours. New York: Kluver Academic/Plenum Publishers; 2002:119-129.

    29 Arita J, Hasegawa K, Kokudo N, Sano K, Sugawara Y, Makuuchi M. Randomized clinical trial of the effect of a saline-linked radiofrequency coagulator on blood loss during hepatic resection. Br J Surg 2005;92:954-959.

    30 Li M, Zhang W, Li Y, Li P, Li J, Gong J, et al. Radiofrequencyassisted versus clamp-crushing parenchyma transection in cirrhotic patients with hepatocellular carcinoma: a randomized clinical trial. Dig Dis Sci 2013;58:835-840.

    31 Xia F, Wang S, Ma K, Feng X, Su Y, Dong J. The use of salinelinked radiofrequency dissecting sealer for liver transection in patients with cirrhosis. J Surg Res 2008;149:110-114.

    32 Vollmer CM, Dixon E, Sahajpal A, Cattral MS, Grant DR, Gallinger S, et al. Water-jet dissection for parenchymal division during hepatectomy. HPB (Oxford) 2006;8:377-385.

    33 Buell JF, Cherqui D, Geller DA, O’Rourke N, Iannitti D, Dagher I, et al. The international position on laparoscopic liver surgery: The Louisville Statement, 2008. Ann Surg 2009;250:825-830.

    34 He J, Amini N, Spolverato G, Hirose K, Makary M, Wolfgang CL, et al. National trends with a laparoscopic liver resection: results from a population-based analysis. HPB (Oxford) 2015;17:919-926.

    35 Chen J, Bai T, Zhang Y, Xie ZB, Wang XB, Wu FX, et al. The safety and efficacy of laparoscopic and open hepatectomy in hepatocellular carcinoma patients with liver cirrhosis: a systematic review. Int J Clin Exp Med 2015;8:20679-20689.

    36 Shafaee Z, Kazaryan AM, Marvin MR, Cannon R, Buell JF, Edwin B, et al. Is laparoscopic repeat hepatectomy feasible? A triinstitutional analysis. J Am Coll Surg 2011;212:171-179.

    37 Cheek SM, Geller DA. The learning curve in laparoscopic major hepatectomy: what is the magic number? JAMA Surg 2016 Jul 6.

    38 van der Poel MJ, Besselink MG, Cipriani F, Armstrong T, Takhar AS, van Dieren S, et al. Outcome and learning curve in 159 consecutive patients undergoing total laparoscopic hemihepatectomy. JAMA Surg 2016 Jul 6.

    39 Nguyen KT, Gamblin TC, Geller DA. World review of laparoscopic liver resection-2,804 patients. Ann Surg 2009;250:831-841. 40 Tsung A, Geller DA, Sukato DC, Sabbaghian S, Tohme S, Steel J, et al. Robotic versus laparoscopic hepatectomy: a matched comparison. Ann Surg 2014;259:549-555.

    41 Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397-407.

    42 Katz SC, Shia J, Liau KH, Gonen M, Ruo L, Jarnagin WR, et al. Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma. Ann Surg 2009;249:617-623.

    43 Yamamoto M, Katagiri S, Ariizumi S, Kotera Y, Takahashi Y. Glissonean pedicle transection method for liver surgery (with video). J Hepatobiliary Pancreat Sci 2012;19:3-8.

    44 Lai EC, Fan ST, Lo CM, Chu KM, Liu CL. Anterior approach for difficult major right hepatectomy. World J Surg 1996;20:314-318.

    45 Belghiti J, Guevara OA, Noun R, Saldinger PF, Kianmanesh R. Liver hanging maneuver: a safe approach to right hepatectomy without liver mobilization. J Am Coll Surg 2001;193:109-111.

    46 Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobehypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 2012;255:405-414.

    47 Gauzolino R, Castagnet M, Blanleuil ML, Richer JP. The ALPPS technique for bilateral colorectal metastases: three “variations on a theme”. Updates Surg 2013;65:141-148.

    48 Robles Campos R, Paricio PP, Conesa AL, Hernández CM, Pérez RG, Qui?onero MF. A new surgical strategy for multiple multiple bilobular liver metastases: right portal occlusion and torniquet in the parenchyma section line. Cir Esp 2012;90:191-196.

    49 Ielpo B, Caruso R, Ferri V, Quijano Y, Duran H, Diaz E, et al. ALPPS procedure: our experience and state of the art. Hepatogastroenterology 2013;60:2069-2075.

    50 Bartlett DL, Libutti SK, Figg WD, Fraker DL, Alexander HR. Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer. Surgery 2001;129:176-187.

    51 Alexander HR Jr, Butler CC. Development of isolated hepatic perfusion via the operative and percutaneous techniques for patients with isolated and unresectable liver metastases. Cancer J 2010;16:132-141.

    52 Pichlmayr R, Grosse H, Hauss J, Gubernatis G, Lamesch P, Bretschneider HJ. Technique and preliminary results of extracorporeal liver surgery (bench procedure) and of surgery on the in situ perfused liver. Br J Surg 1990;77:21-26.

    53 Raab R, Schlitt HJ, Oldhafer KJ, Bornscheuer A, Lang H, Pichlmayr R. Ex-vivo resection techniques in tissue-preserving surgery for liver malignancies. Langenbecks Arch Surg 2000;385: 179-184.

    54 Azoulay D, Eshkenazy R, Andreani P, Castaing D, Adam R, Ichai P, et al. In situ hypothermic perfusion of the liver versus standard total vascular exclusion for complex liver resection. Ann Surg 2005;241:277-285.

    Received March 3, 2016

    Accepted after revision September 30, 2016

    Learn to enjoy every minute of your life. Be happy now. Don’t wait for something outside of yourself to make you happy in the future. Think how really precious is the time you have to spend, whether it’s at work or with your family. Every minute should be enjoyed and savored.

    —Earl Nightingale

    Author Affiliations: Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue BX7375 CLINICAL SCIENCE CNTR Madison, WI 53792-7375, USA (Salem AI and Winslow ER)

    Emily R Winslow, MD, FACS, Assistant Professor, Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue BX7375 CLINICAL SCIENCE CNTR Madison, WI 53792-7375, USA (Email: winslow@surgery.wisc. edu)

    ? 2017, Hepatobiliary Pancreat Dis Int. All rights reserved.

    10.1016/S1499-3872(16)60147-9

    Published online November 4, 2016.

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