喜炎平聯(lián)合西咪替丁治療兒童手足口病療效分析

秦燕玲+寇建軍

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探討喜炎平聯(lián)合西咪替丁治療兒童手足口病的臨床療效。方法：2013年1月-2014年1月收治手足口病患兒120例，隨機(jī)分成觀察組和對照組，各60例。對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組治療5天。結(jié)果：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），有效22例（36.7%），無效10例，總有效率83.3%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：喜炎平聯(lián)合西咪替丁治療兒童手足口病癥狀緩解快，療效顯著，值得推廣。

關(guān)鍵詞 喜炎平 西咪替丁 利巴韋林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口?。℉FMD）是嬰幼兒常見的腸道引起的一種傳染病[1]，多發(fā)生于春秋季節(jié)[2]，主要表現(xiàn)為小兒手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，多數(shù)患者出現(xiàn)發(fā)熱，若不及時(shí)治療，很容易導(dǎo)致心肌炎、肺水腫等。特別是近年來，呈大面積傳播，發(fā)病率較高，應(yīng)該引起有關(guān)各部門的注意。在治療方面，我們采用喜炎平聯(lián)合西咪替丁進(jìn)行治療，療效顯著，現(xiàn)報(bào)告如下。

資料與方法

2013年1月-2014年1月收治手足口病患兒120例，男76例，女44例，年齡9個(gè)月～7歲，平均5.5歲，主要表現(xiàn)發(fā)熱、手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，患兒拒食等。血常規(guī)檢查：白細(xì)胞（4.0～10.0）×109/L，中性粒細(xì)胞<50%，淋巴細(xì)胞>50%。隨機(jī)分成觀察組和對照組，各60例。兩組患兒在年齡、性別、臨床表現(xiàn)、血常規(guī)檢查等方面差異無統(tǒng)計(jì)學(xué)意義，有可比性。

方法：①對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；②觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組均治療5天。

結(jié) 果

兩組患兒臨床癥狀改善情況比較：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較有統(tǒng)計(jì)學(xué)意義（P<0.05），見表1。

兩組臨床療效比較： 觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探討喜炎平聯(lián)合西咪替丁治療兒童手足口病的臨床療效。方法：2013年1月-2014年1月收治手足口病患兒120例，隨機(jī)分成觀察組和對照組，各60例。對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組治療5天。結(jié)果：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），有效22例（36.7%），無效10例，總有效率83.3%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：喜炎平聯(lián)合西咪替丁治療兒童手足口病癥狀緩解快，療效顯著，值得推廣。

關(guān)鍵詞 喜炎平 西咪替丁 利巴韋林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口?。℉FMD）是嬰幼兒常見的腸道引起的一種傳染病[1]，多發(fā)生于春秋季節(jié)[2]，主要表現(xiàn)為小兒手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，多數(shù)患者出現(xiàn)發(fā)熱，若不及時(shí)治療，很容易導(dǎo)致心肌炎、肺水腫等。特別是近年來，呈大面積傳播，發(fā)病率較高，應(yīng)該引起有關(guān)各部門的注意。在治療方面，我們采用喜炎平聯(lián)合西咪替丁進(jìn)行治療，療效顯著，現(xiàn)報(bào)告如下。

資料與方法

2013年1月-2014年1月收治手足口病患兒120例，男76例，女44例，年齡9個(gè)月～7歲，平均5.5歲，主要表現(xiàn)發(fā)熱、手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，患兒拒食等。血常規(guī)檢查：白細(xì)胞（4.0～10.0）×109/L，中性粒細(xì)胞<50%，淋巴細(xì)胞>50%。隨機(jī)分成觀察組和對照組，各60例。兩組患兒在年齡、性別、臨床表現(xiàn)、血常規(guī)檢查等方面差異無統(tǒng)計(jì)學(xué)意義，有可比性。

方法：①對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；②觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組均治療5天。

結(jié) 果

兩組患兒臨床癥狀改善情況比較：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較有統(tǒng)計(jì)學(xué)意義（P<0.05），見表1。

兩組臨床療效比較： 觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），

doi：10.3969/j.issn.1007-614x.2014.14.51

摘 要 目的：探討喜炎平聯(lián)合西咪替丁治療兒童手足口病的臨床療效。方法：2013年1月-2014年1月收治手足口病患兒120例，隨機(jī)分成觀察組和對照組，各60例。對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組治療5天。結(jié)果：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），有效22例（36.7%），無效10例，總有效率83.3%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：喜炎平聯(lián)合西咪替丁治療兒童手足口病癥狀緩解快，療效顯著，值得推廣。

關(guān)鍵詞 喜炎平 西咪替丁 利巴韋林 手足口病

Curative effect analysis of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease

Qin Yanling，Kou Jianjun

Pediatrics of The second people's Hospital of Anding District of Dingxi City in Gansu Province，743000

Abstract Objective：To explore the curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease.Methods：120 cases of hand foot and mouth disease were admitted and were randomly divided into the control group and the observation group.The control group were given Xiyanping injection of 0.2 to 0.4ml/kg，1 time/day，ribavirin joined in 10 to 15mg/（kg·day）5% GS for intravenous drip.The observation group added cimetidine 0.2 to 0.4mg/（kg·day）for intravenous drip on the basis of the control group.The treatment time of two groups was 5 days.Results：In the observation group，the remission time of oral symptoms was 1.74±0.51 days，and the turnaround time of rash was 3.1±1.2 days.In the control group，the remission time of oral symptoms was 3.3±1.4 days，and the turnaround time of rash was 4.8±1.6 days.There are statistically significant differences between two groups（P<0.05）.In the observation group，37 cases（61.7%） were markedly effective， 21 cases（35%）were effective，2 cases were ineffective，and the total efficiency was 96.7%.In the control group，28 cases（46.7%） were markedly effective，22 cases（36.7%） were effective，10 cases were ineffective，and the total efficiency was 83.3%.There are statistically significant differences between two groups（P<0.05）.Conclusion：The curative effect of Xiyanping combined with cimetidine in the treatment of children with hand foot and mouth disease is significant， and symptom relief is fast，so it is worthy of promotion.

Key words Xiyanping；Cimetidine；Ribavirin；Hand foot and mouth disease

手足口?。℉FMD）是嬰幼兒常見的腸道引起的一種傳染病[1]，多發(fā)生于春秋季節(jié)[2]，主要表現(xiàn)為小兒手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，多數(shù)患者出現(xiàn)發(fā)熱，若不及時(shí)治療，很容易導(dǎo)致心肌炎、肺水腫等。特別是近年來，呈大面積傳播，發(fā)病率較高，應(yīng)該引起有關(guān)各部門的注意。在治療方面，我們采用喜炎平聯(lián)合西咪替丁進(jìn)行治療，療效顯著，現(xiàn)報(bào)告如下。

資料與方法

2013年1月-2014年1月收治手足口病患兒120例，男76例，女44例，年齡9個(gè)月～7歲，平均5.5歲，主要表現(xiàn)發(fā)熱、手心、足底、口腔、臀部等部位出現(xiàn)皮疹、水皰，患兒拒食等。血常規(guī)檢查：白細(xì)胞（4.0～10.0）×109/L，中性粒細(xì)胞<50%，淋巴細(xì)胞>50%。隨機(jī)分成觀察組和對照組，各60例。兩組患兒在年齡、性別、臨床表現(xiàn)、血常規(guī)檢查等方面差異無統(tǒng)計(jì)學(xué)意義，有可比性。

方法：①對照組給予喜炎平0.2～0.4ml/kg肌注，1次/日，利巴韋林加入10～15mg/（kg·日）5%GS靜滴；②觀察組在對照組的基礎(chǔ)上加西咪替丁0.2～0.4mg/（kg·日）靜滴，兩組均治療5天。

結(jié) 果

兩組患兒臨床癥狀改善情況比較：觀察組口腔癥狀緩解時(shí)間（1.74±0.51）天，皮疹好轉(zhuǎn)時(shí)間（3.1±1.2）天；對照組口腔癥狀緩解時(shí)間（3.3±1.4）天，皮疹好轉(zhuǎn)時(shí)間（4.8±1.6）天，兩組比較有統(tǒng)計(jì)學(xué)意義（P<0.05），見表1。

兩組臨床療效比較： 觀察組顯效37例（61.7%），有效21例（35.0%），無效2例，總有效率96.7%；對照組顯效28例（46.7%），