• 
    

    
    

      99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

      Immune regulation of different genotypes of bone marrow mesenchymal stem cells on allogenic islet transplanio

      2011-08-15 00:54:32LinYujia林雨佳2ndAffilHospHarbinMedUnivHarbin150080ChinOrganTransplant201132172176
      外科研究與新技術(shù) 2011年4期

      Lin Yujia(林雨佳,2nd Affil Hosp Harbin Med Univ,Harbin 150080,)…∥Chin J Organ Transplant.-2011,32(2).-172 ~176

      Immune regulation of different genotypes of bone marrow mesenchymal stem cells on allogenic islet transplanio

      Lin Yujia(林雨佳,2nd Affil Hosp Harbin Med Univ,Harbin 150080,)…∥Chin J Organ Transplant.-2011,32(2).-172 ~176

      ObjectiveTo compare the immune regulation of syngenic and allogenic mesenchymal stem cells(MSCs)in the transplantation combined with islets.MethodsAfter induction of diabetes in 30 Lewis rats with streptozotocin(STZ),the recipient Lewis rats received islets from SD rats combined with syngenic(group B)or allogenic(group C)MSCs injection via the portal vein.The group ofislets transplanted alone served as control(group A).The survival time of grafts in all groups was assessed by the level of blood glucose.ELISA was used to detect the levels of interferon-γ(IFN -γ),interleukin 2(IL-2),IL-4 and IL-10 in the peripheral blood on the 1st and 3rd day after transplantation.ResultsThe blood glucose levels in all three groups were decreased in a normal range(13.9 mmol/L)and the survival time of grafts in group B(11.38 ±4.03 days)was significantly longer than in group C(5.50 ±2.07 days)as well as group A(2.88 ±1.25 dayS).On the 1st and 3rd day after transplantation,the levels of TH 1 cytokines IFN-γ and IL-2 in group A were significantly higher than those in groups C and B P < 0.05.Meanwhile the levels of TH2 cytokine IL-10 were increased in group B,but there was no significant difference between groups A and C P <0.05.The levels of IL -4 had no significant difference among these three groups P<0.05.ConclusionIslet transplantation combined with MSCs could prolong survival time of grafts.Syngenic MSCs,superior to allogenic ones,are more effective in changing the balance of TH 1/TH2 to TH2.Decreased expression of TH 1 cytokine(IFN - γ,IL-2),which is closely related to the induction of immune tolerance,is beneficial to the long - term survival of grafts.24 refs,3 figs,3 tabs.

      (Authors)

      大洼县| 涪陵区| 阜宁县| 郧西县| 鲁甸县| 阆中市| 霞浦县| 景德镇市| 内江市| 宾川县| 康保县| 盱眙县| 济阳县| 梧州市| 赤水市| 张掖市| 北安市| 互助| 山丹县| 神农架林区| 甘德县| 普兰县| 织金县| 瓮安县| 潮州市| 济宁市| 博爱县| 阜阳市| 云和县| 二手房| 浪卡子县| 应城市| 阿尔山市| 张掖市| 彰武县| 三都| 繁峙县| 思茅市| 沙雅县| 海阳市| 民和|