• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?

    2010-06-29 10:12:16SivanpillayMahadevanSivarajVelayuthamVimalrajPalanichamySaravanaboopathyShanmugasundaramRajendranSathyanesanJeswanthPalaniappanRavichandranRosyVennillaandRajagopalanSurendran

    Sivanpillay Mahadevan Sivaraj, Velayutham Vimalraj, Palanichamy Saravanaboopathy, Shanmugasundaram Rajendran, Sathyanesan Jeswanth, Palaniappan Ravichandran, Rosy Vennilla and Rajagopalan Surendran

    Chennai, India

    Original Article / Pancreas

    Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?

    Sivanpillay Mahadevan Sivaraj, Velayutham Vimalraj, Palanichamy Saravanaboopathy, Shanmugasundaram Rajendran, Sathyanesan Jeswanth, Palaniappan Ravichandran, Rosy Vennilla and Rajagopalan Surendran

    Chennai, India

    BACKGROUND:Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy, its association with infective complications and non-infective complications like pancreatic fistula is still controversial.

    METHODS:Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed. In all patients intraoperative bile from the bile duct was cultured. Preoperative, intra-operative, and post-operative variables were recorded and analyzed.

    RESULTS:Bile culture showed positive growth in 35 patients and negative growth in 41. Twenty patients in the positive group underwent ERCP and stenting. The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8), wound infection (n=27), bacteremia (n=10), and renal insufficiency (n=9). There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7), delayed gastric emptying (n=9), and post-operative hemorrhage (n=3). The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).

    CONCLUSIONS:Pre-operative biliary drainage is significantly associated with bile infection, and bile infection increases the overall rates of infective complications and renalinsufficiency. Because of the high incidence of complications is associated with infected bile, routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy. Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intraoperative bile culture report. Because of its significant association with infected bile, biliary stenting should be used in strictly selected cases.

    (Hepatobiliary Pancreat Dis Int 2010; 9: 65-68)

    bactibilia; Whipples pancreaticoduodenectomy; perioperative outcomes

    Introduction

    Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy,[1]its association with infective and non-infective complications like pancreatic fistula is still controversial.[2-8]Jagannath et al[4]in a study on the outcome of pancreaticoduodenectomy following stenting concluded that biliary stenting was not significantly associated with a positive culture. But others[2,3,5-8]suggested preoperative biliary drainage was associated with bile infection. Some studies[2,6-8]associated infected bile with increased incidence of post-operative infective complications, whereas other studies[3,5]did not record such an association. Recently few studies have related the higher incidence of pancreatic fistula with bile infection.[5]Hence, the aim of this study was to analyze the effect of bile infection in the immediate outcome of pancreaticoduodenectomy, both infective and non-infective.

    Methods

    Seventy-six patients who had undergone pancreatico-duodenectomy between July 2007 and December 2008 were included in a prospective database, and their data were analyzed. The patients were given prophylatic antibiotics. Intravenous injection of Cephazolin 2 g was given before induction of anesthesia. All patients underwent standard Whipple pancreaticoduodenectomy,[9]after which, the pancreatic remnant was mobilized proximally, a posterior gastrostomy was made, and a pancreaticogastrostomy was performed to invaginate the remnant into the stomach. Anastomosis was made with 3-0 polyglactin (vicryl). Gastrojejunostomy and hepaticojejunostomy were performed on the same jejunal loop. Two drains were placed to drain the pancreatic and biliary anastomosis. In all patients, intraoperative bile culture from the bile duct was collected.

    The preoperative variables analyzed were age, gender, serum bilirubin, serum albumin, and diabetes mellitus, which are associated with post-operative complications.[5,8]Intra-operatively, the nature of the pancreatic remnant, the size of the main pancreatic duct, operative time, blood loss, and transfusions were recorded. Post-operatively, also recorded were death caused by complications, pancreatic fistula, hemorrhage, delayed gastric emptying, intra-abdominal abscess, wound infection, septicemia, renal insufficiency, and pulmonary complications. Post-operative hospital stay was also observed.

    Pancreatic fistula was defined by the level of drained fluid amylase more than three times the level of serum amylase 3 days after operation.[10]Delayed gastric emptying was defined by drainage with a nasogastric tube for more than 10 days after operation with one of the following signs: emesis after removal of the nasogastric tube, reinsertion of a nasogastric tube, use of prokinetic agents after post-operative day 10, or failure to progress with diet.[11]Wound infection, intraabdominal abscess, and bacteremia were recognized as infectious complications, which were confirmed by microbial cultures. Complications other than wound infection (death, pancreatic fistula, hemorrhage, delayed gastric emptying, intra-abdominal abscess, bacteremia, renal insufficiency, and pulmonary complications) were considered as major complications.

    Values were expressed as median and ranged appropriately. Discrete variables were analyzed statistically using the two-tailed Fisher's exact test, and continuous variables using Student'sttest. A difference was considered statistically significant whenP<0.05.

    Results

    Bile culture showed positive growth in 35 patients and negative one in 41. Twenty patients in the positive group underwent ERCP and stenting.

    The mean age of patients was 53.42 years in the positive group and 52.24 in the negative group. No significant difference was seen in sex distribution in the two groups. The distribution of diabetes mellitus in both groups was not different significantly. No significant difference was observed in the levels of serum bilirubin and albumin between the two groups (Table 1).

    Pre-operative biliary drainage

    In our series, 20 patients underwent ERCP and sphincterotomy, 18 underwent the procedures before being refered to our centre; the indications were not unified. Of the 18 patients, 2 had a history of fever and rigor. Since preoperative drainage was performed selectively for those with cholangitis non-responding to medical management, only 2 patients underwent ERCP and stenting for cholangitis in our institution.

    Intra-operative variables

    All of our patients underwent a standard pancreaticoduodenectomy. Their median operative time and blood loss were not different. No blood transfusion was given. There was no significant difference in the nature of the pancreatic remnant and main pancreatic duct size between the two groups (Table 2).

    Table 1. Demography and preoperative variables

    Table 2. Intra-operative variables

    Table 3. Post-operative complications

    Table 4. Preoperative biliary drainage and complications

    Mortality

    One of the 35 patients died of pancreatic fistula and septicemia on postoperative day 35. One of the 41 patients died of polycystic kidney disease and chronic renal failure on postoperative day 16 after development of pulmonary edema (Table 3).

    Morbidity

    In 20 patients of the positive group one or more postoperative complications developed, and infectious complications were seen in 18 of them. They included intra-abdominal abscess (n=8), wound infection (n=27), bacteremia (n=10), and renal insuf ficiency (n=9). The rates of non-infective complications such as pancreatic fistula, delayed gastric emptying, and postoperative hemorrhage were not increased in patients after pancreaticoduodenectomy. Hospital stay was prolonged in the positive group (Table 3).

    Table 5. Microorganisms isolated from bile cultures

    Table 6. Antibiotic sensitivity pattern of organisms isolated from bile

    The rates of complications such as wound infection, intra-abdominal abscess, and septicemia in the patients who had undergone ERCP and preoperative drainage were significantly higher than in those who had undergone ERCP and biliary drainage. Other complications including pancreatic fistula, hemorrhage, and pulmonary complications were not significantly different in both groups, but delayed gastric emptying was found in the patients with biliary drainage (Table 4).

    Escherichia coli,Klebsiellawere commonly seen organisms. In stented patientsPsuedomonaswere isolated. About 91% of the isolates were sensitive to piperacillintazobactum, followed by amikacin, gentamicin, and ciprofloxacin. Only 6% of the organisms were sensitive to cefazolin (Table 5 and 6).

    Discussion

    In our study, we did not find an association of bile infection with preoperative comorbid illness, biochemical parameters, or pathological type of malignancy as reported elsewhere.[3]It was reported that bile infection was associated with pathological type,[2,8]age,[5]preoperative levels of serum bilirubin and albumin,[5]and coronary artery disease.[8]In the present study, bile infection was not significantly associated with pathologic types, because of few patients with ampullary carcinomas undergoing ERCP for diagnosis/drainage. During the operation, operative time and blood loss were not affected by bile infection. Postoperative mortality was not influenced bybile infection.[2,3,5,8]One study reported[4]positive intraoperative bile culture was related to operative mortality. The rate of infectious complications was significantly increased in the positive bile culture group,[2,4,6,8]but few studies showed this relation insignificant.[1,5]The specific complications of pancreaticoduodenectomy included pancreatic fistula, hemorrhage, and delayed gastric emptying, the rates of these complications were not increased by bile infection.[2,3-8]

    The sensitivity of organisms may underscore the need for routine bile culture as most of them are resistant to the commonly used antibiotics. Before a culture, perioperative antibiotic therapy must be dependent on the sensitivity of antibiotics.

    In our study, preoperative biliary drainage was significantly associated with bile infection, which increased the rates of overall complications, infective complications, and renal insufficiency. There was no increase in the incidence of pancreatic fistula, hemorrhage, or delayed gastric emptying, but ERCP and biliary stenting contribute to delayed gastric emptying. In view of the high incidence of complications associated with infected bile, it is thus recommended to avoid bile spillage, take a routine intra-operative bile culture in all patients undergoing pancreaticoduodenectomy, preoperative antibiotic prophylaxis, and peri-operative antibiotic treatment depending on bile culture. Since biliary stenting is significantly associated with infected bile, it should be used only in strictly selected cases of cholangitis inresponsible to medical management.

    Funding:None.

    Ethical approval:Not needed.

    Contributors:SR proposed the study. SSM wrote the first draft. SSM and VV analyzed the data. All authors contributed to the design and interpretation of the study and to further drafts. SSM is the guarantor.

    Competing interest:No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

    1 Povoski SP, Karpeh MS Jr, Conlon KC, Blumgart LH, Brennan MF. Preoperative biliary drainage: impact on intraoperative bile cultures and infectious morbidity and mortality after pancreaticoduodenectomy. J Gastrointest Surg 1999;3:496-505.

    2 Cortes A, Sauvanet A, Bert F, Janny S, Sockeel P, Kianmanesh R, et al. Effect of bile contamination on immediate outcomes after pancreaticoduodenectomy for tumor. J Am Coll Surg 2006;202:93-99.

    3 Grizas S, Stakyte M, Kincius M, Barauskas G, Pundzius J. Etiology of bile infection and its association with postoperative complications following pancreatoduodenectomy. Medicina (Kaunas) 2005;41:386-391.

    4 Jagannath P, Dhir V, Shrikhande S, Shah RC, Mullerpatan P, Mohandas KM. Effect of preoperative biliary stenting on immediate outcome after pancreaticoduodenectomy. Br J Surg 2005;92:356-361.

    5 Isla AM, Griniatsos J, Riaz A, Karvounis E, Williamson RC. Pancreaticoduodenectomy for periampullary malignancies: the effect of bile colonization on the postoperative outcome. Langenbecks Arch Surg 2007;392:67-73.

    6 Lermite E, Pessaux P, Teyssedou C, Etienne S, Brehant O, Arnaud JP. Effect of preoperative endoscopic biliary drainage on infectious morbidity after pancreatoduodenectomy: a case-control study. Am J Surg 2008;195:442-446.

    7 Howard TJ, Yu J, Greene RB, George V, Wairiuko GM, Moore SA, Madura JA. Influence of bactibilia after preoperative biliary stenting on postoperative infectious complications. J Gastrointest Surg 2006;10:523-531.

    8 Limongelli P, Pai M, Bansi D, Thiallinagram A, Tait P, Jackson J, et al. Correlation between preoperative biliary drainage, bile duct contamination, and postoperative outcomes for pancreatic surgery. Surgery 2007;142:313-318.

    9 Rajarathinam G, Kannan DG, Vimalraj V, Amudhan A, Rajendran S, Jyotibasu D, et al. Post pancreaticoduodenectomy haemorrhage: outcome prediction based on new ISGPS Clinical severity grading. HPB (Oxford) 2008;10:363-370.

    10 Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005;138:8-13.

    11 Yeo CJ, Barry MK, Sauter PK, Sostre S, Lillemoe KD, Pitt HA, et al. Erythromycin accelerates gastric emptying after pancreaticoduodenectomy. A prospective, randomized, placebo-controlled trial. Ann Surg 1993;218:229-238.

    June 30, 2009

    Accepted after revision December 12, 2009

    Author Affiliations: Institute of Surgical Gastroenterology and Liver Transplantation, New Gastroenterology Block, Government Stanley Medical College Hospital, Chennai 600 001, India (Sivaraj SM, Vimalraj V, Saravanaboopathy P, Rajendran S, Jeswanth S, Ravichandran P, Vennilla R and Surendran R)

    Rajagopalan Surendran, Professor, Institute of Surgical Gastroenterology and Liver Transplantation, New Gastroenterology Block, Government Stanley Medical College, Royapuram, Chennai 600 001, India (Tel: 0091-44-25289595; Fax: 0091-44-25289595; Email: Stanleygastro@yahoo.com)

    ? 2010, Hepatobiliary Pancreat Dis Int. All rights reserved.

    日韩精品免费视频一区二区三区| 国产99久久九九免费精品| 在线十欧美十亚洲十日本专区| 在线观看www视频免费| 搡老岳熟女国产| 90打野战视频偷拍视频| 亚洲欧美激情综合另类| 亚洲中文日韩欧美视频| 99国产极品粉嫩在线观看| 国产不卡av网站在线观看| 日本五十路高清| 国产熟女午夜一区二区三区| 男女下面插进去视频免费观看| 香蕉丝袜av| 性色av乱码一区二区三区2| 久久精品人人爽人人爽视色| 成人免费观看视频高清| 亚洲成av片中文字幕在线观看| 亚洲av日韩精品久久久久久密| 99国产综合亚洲精品| 51午夜福利影视在线观看| 亚洲第一青青草原| 欧美成人午夜精品| 久久久精品区二区三区| videos熟女内射| 一区福利在线观看| 亚洲av美国av| 亚洲性夜色夜夜综合| 大型av网站在线播放| a在线观看视频网站| 99久久国产精品久久久| 欧美国产精品一级二级三级| 免费在线观看日本一区| 老司机亚洲免费影院| 国产精品免费视频内射| 国产欧美日韩一区二区三区在线| 亚洲成人免费av在线播放| 精品一区二区三卡| 午夜福利,免费看| 免费高清在线观看日韩| 一级片免费观看大全| 欧美日韩成人在线一区二区| 久久精品成人免费网站| a在线观看视频网站| 91国产中文字幕| 精品无人区乱码1区二区| 狂野欧美激情性xxxx| 多毛熟女@视频| 精品国产乱子伦一区二区三区| 久久精品国产综合久久久| 下体分泌物呈黄色| 12—13女人毛片做爰片一| 精品国产一区二区三区四区第35| 久久中文看片网| 女性生殖器流出的白浆| 叶爱在线成人免费视频播放| 中文字幕人妻熟女乱码| 我的亚洲天堂| 在线观看66精品国产| 老熟女久久久| 一a级毛片在线观看| 国产不卡av网站在线观看| 亚洲中文av在线| 性色av乱码一区二区三区2| 在线观看午夜福利视频| 很黄的视频免费| 亚洲欧洲精品一区二区精品久久久| 一级毛片精品| 欧美日韩av久久| 老熟妇仑乱视频hdxx| 国产精品久久久av美女十八| 国产一卡二卡三卡精品| 色94色欧美一区二区| 这个男人来自地球电影免费观看| 美女 人体艺术 gogo| 欧美国产精品一级二级三级| 久久国产亚洲av麻豆专区| 国产精品亚洲av一区麻豆| 成人免费观看视频高清| 国产av精品麻豆| 国产精品久久视频播放| 亚洲欧美激情综合另类| 最近最新中文字幕大全电影3 | 日韩欧美在线二视频 | 精品久久久久久久毛片微露脸| 亚洲av成人一区二区三| 欧美日韩瑟瑟在线播放| 成人av一区二区三区在线看| 丁香欧美五月| 午夜福利,免费看| 少妇裸体淫交视频免费看高清 | 亚洲午夜精品一区,二区,三区| 黄色 视频免费看| 国产淫语在线视频| av有码第一页| 老鸭窝网址在线观看| 韩国精品一区二区三区| 国产成人系列免费观看| 亚洲av美国av| 欧美激情高清一区二区三区| 成人手机av| 精品欧美一区二区三区在线| 淫妇啪啪啪对白视频| 在线十欧美十亚洲十日本专区| 国产欧美日韩一区二区三区在线| 日韩欧美三级三区| а√天堂www在线а√下载 | 超碰97精品在线观看| 天天影视国产精品| 在线天堂中文资源库| 免费人成视频x8x8入口观看| 日韩一卡2卡3卡4卡2021年| 色尼玛亚洲综合影院| 黑人操中国人逼视频| 一边摸一边做爽爽视频免费| 日本五十路高清| 高清视频免费观看一区二区| 男女下面插进去视频免费观看| 大香蕉久久成人网| 亚洲成a人片在线一区二区| 黄片播放在线免费| 成人永久免费在线观看视频| 亚洲精品中文字幕在线视频| 国产一区在线观看成人免费| 另类亚洲欧美激情| 天天添夜夜摸| 亚洲国产精品一区二区三区在线| 一边摸一边抽搐一进一小说 | 欧美 日韩 精品 国产| 一a级毛片在线观看| 国产免费现黄频在线看| 男女下面插进去视频免费观看| 制服诱惑二区| 欧美一级毛片孕妇| 中文字幕av电影在线播放| 久久国产精品影院| 色在线成人网| 亚洲中文av在线| 欧美乱妇无乱码| 少妇猛男粗大的猛烈进出视频| 久久久国产欧美日韩av| 日韩大码丰满熟妇| 啦啦啦视频在线资源免费观看| 亚洲少妇的诱惑av| 国产成人影院久久av| 91麻豆av在线| 国产精品乱码一区二三区的特点 | 一级毛片高清免费大全| 久久久国产欧美日韩av| 欧美成狂野欧美在线观看| 在线国产一区二区在线| 国产精品久久久人人做人人爽| 高清毛片免费观看视频网站 | 无限看片的www在线观看| 久久亚洲精品不卡| 18禁黄网站禁片午夜丰满| 成人永久免费在线观看视频| 日本精品一区二区三区蜜桃| 99久久综合精品五月天人人| 悠悠久久av| 俄罗斯特黄特色一大片| 黄色丝袜av网址大全| 午夜视频精品福利| 国产成人精品无人区| 最新美女视频免费是黄的| 久久人人97超碰香蕉20202| а√天堂www在线а√下载 | 在线看a的网站| 国产精品一区二区在线不卡| 免费看a级黄色片| 90打野战视频偷拍视频| 黄片大片在线免费观看| 777米奇影视久久| 亚洲色图综合在线观看| 一二三四在线观看免费中文在| 成人国产一区最新在线观看| 美女高潮喷水抽搐中文字幕| 又大又爽又粗| 欧美国产精品一级二级三级| 欧美性长视频在线观看| 亚洲中文字幕日韩| 一a级毛片在线观看| 国产精品一区二区在线观看99| 久久午夜亚洲精品久久| 成人18禁在线播放| 在线十欧美十亚洲十日本专区| 村上凉子中文字幕在线| 亚洲精品国产精品久久久不卡| 桃红色精品国产亚洲av| 男女高潮啪啪啪动态图| 久久精品亚洲熟妇少妇任你| 乱人伦中国视频| 女人久久www免费人成看片| 国产国语露脸激情在线看| 最近最新中文字幕大全电影3 | 9热在线视频观看99| 一级a爱片免费观看的视频| 国产精品自产拍在线观看55亚洲 | 丝袜在线中文字幕| 国产不卡av网站在线观看| 国产精品久久久久久人妻精品电影| 亚洲精品乱久久久久久| 王馨瑶露胸无遮挡在线观看| 国产乱人伦免费视频| 国产欧美日韩一区二区三区在线| 99精品欧美一区二区三区四区| 久久精品成人免费网站| 中文字幕最新亚洲高清| 亚洲五月色婷婷综合| 午夜福利视频在线观看免费| 一个人免费在线观看的高清视频| 国产欧美日韩综合在线一区二区| 人妻丰满熟妇av一区二区三区 | 国产不卡av网站在线观看| 久久国产亚洲av麻豆专区| 亚洲三区欧美一区| 另类亚洲欧美激情| 1024视频免费在线观看| 亚洲国产中文字幕在线视频| 丝袜美足系列| 悠悠久久av| 18禁国产床啪视频网站| 亚洲av欧美aⅴ国产| 国产成人欧美在线观看 | 亚洲中文av在线| 午夜老司机福利片| 亚洲 欧美一区二区三区| 亚洲国产欧美日韩在线播放| 国产精品 国内视频| 黄色毛片三级朝国网站| 欧美老熟妇乱子伦牲交| 欧美成人免费av一区二区三区 | a级毛片在线看网站| 一级毛片精品| 99精品欧美一区二区三区四区| 国产成人欧美在线观看 | 18禁裸乳无遮挡动漫免费视频| 精品一区二区三区视频在线观看免费 | 欧美乱码精品一区二区三区| 黄色视频不卡| 国产精品 欧美亚洲| 十八禁高潮呻吟视频| a在线观看视频网站| 亚洲专区字幕在线| 国产免费现黄频在线看| av国产精品久久久久影院| 久久精品熟女亚洲av麻豆精品| 精品熟女少妇八av免费久了| 亚洲精品在线美女| 电影成人av| 欧美乱码精品一区二区三区| 久久久久久久午夜电影 | 一边摸一边做爽爽视频免费| 日韩欧美免费精品| 在线国产一区二区在线| 国产精品二区激情视频| 丰满人妻熟妇乱又伦精品不卡| 人人妻,人人澡人人爽秒播| 亚洲五月婷婷丁香| 一二三四在线观看免费中文在| 国产精品av久久久久免费| 黄片播放在线免费| 久久久精品免费免费高清| 国产欧美日韩综合在线一区二区| 天天躁日日躁夜夜躁夜夜| 涩涩av久久男人的天堂| 99国产综合亚洲精品| 首页视频小说图片口味搜索| 9热在线视频观看99| 他把我摸到了高潮在线观看| 高清毛片免费观看视频网站 | 国产精品美女特级片免费视频播放器 | 一本综合久久免费| 99国产极品粉嫩在线观看| 免费观看人在逋| 校园春色视频在线观看| 变态另类成人亚洲欧美熟女 | 在线观看免费高清a一片| 国产在线一区二区三区精| 国内毛片毛片毛片毛片毛片| 成人三级做爰电影| 国产精品亚洲一级av第二区| 国产一卡二卡三卡精品| 男人操女人黄网站| 色综合婷婷激情| 国产日韩欧美亚洲二区| 狠狠狠狠99中文字幕| 成人18禁高潮啪啪吃奶动态图| 亚洲成人免费电影在线观看| 久久久水蜜桃国产精品网| 黄色片一级片一级黄色片| 成人永久免费在线观看视频| 国产不卡一卡二| 亚洲一区二区三区欧美精品| 欧美成人免费av一区二区三区 | 亚洲精品久久成人aⅴ小说| 久久精品91无色码中文字幕| 9色porny在线观看| 美女视频免费永久观看网站| 亚洲av日韩精品久久久久久密| 欧美丝袜亚洲另类 | 精品国产亚洲在线| 岛国毛片在线播放| 亚洲成a人片在线一区二区| 老熟妇乱子伦视频在线观看| 国产精品二区激情视频| 亚洲成a人片在线一区二区| 777久久人妻少妇嫩草av网站| 亚洲av美国av| 精品一区二区三区四区五区乱码| 老司机深夜福利视频在线观看| 国产主播在线观看一区二区| 女人被狂操c到高潮| 欧美日韩瑟瑟在线播放| 久久天堂一区二区三区四区| 青草久久国产| av国产精品久久久久影院| 国产日韩欧美亚洲二区| 中亚洲国语对白在线视频| 人妻丰满熟妇av一区二区三区 | 国产亚洲欧美在线一区二区| 大码成人一级视频| 久久久久久久国产电影| 一级片免费观看大全| 在线观看免费高清a一片| 九色亚洲精品在线播放| 热99国产精品久久久久久7| 80岁老熟妇乱子伦牲交| 午夜精品久久久久久毛片777| 亚洲av成人一区二区三| 国产高清激情床上av| 欧美亚洲 丝袜 人妻 在线| 黄片播放在线免费| 国产日韩欧美亚洲二区| 亚洲一区二区三区欧美精品| 99国产精品99久久久久| 一a级毛片在线观看| 精品免费久久久久久久清纯 | 水蜜桃什么品种好| 老汉色av国产亚洲站长工具| 国产亚洲欧美98| 黄色成人免费大全| 欧美日韩中文字幕国产精品一区二区三区 | 成人特级黄色片久久久久久久| 少妇被粗大的猛进出69影院| 如日韩欧美国产精品一区二区三区| 一区二区三区国产精品乱码| 亚洲国产毛片av蜜桃av| 欧美亚洲 丝袜 人妻 在线| 国产亚洲精品一区二区www | www.熟女人妻精品国产| 999久久久国产精品视频| 国产伦人伦偷精品视频| 国产97色在线日韩免费| 在线观看66精品国产| 亚洲精品一二三| 日本vs欧美在线观看视频| 欧美日韩av久久| 五月开心婷婷网| 亚洲第一欧美日韩一区二区三区| 久久久精品区二区三区| 日韩欧美免费精品| 亚洲情色 制服丝袜| 十八禁高潮呻吟视频| 超色免费av| 久久精品亚洲精品国产色婷小说| 国产不卡av网站在线观看| 免费在线观看亚洲国产| 九色亚洲精品在线播放| 女人久久www免费人成看片| 亚洲精品国产一区二区精华液| 一进一出抽搐gif免费好疼 | 一区二区三区精品91| 亚洲av片天天在线观看| 国产精品国产av在线观看| 午夜精品在线福利| 国产无遮挡羞羞视频在线观看| 一区二区三区精品91| 激情视频va一区二区三区| 最新的欧美精品一区二区| 侵犯人妻中文字幕一二三四区| 久久久久久久久久久久大奶| 久热爱精品视频在线9| 久久精品91无色码中文字幕| 一边摸一边抽搐一进一出视频| 亚洲成av片中文字幕在线观看| 日韩一卡2卡3卡4卡2021年| 国产亚洲av高清不卡| 久久久久久久精品吃奶| 一二三四在线观看免费中文在| 久久精品91无色码中文字幕| 97人妻天天添夜夜摸| 黄色视频,在线免费观看| 99久久国产精品久久久| 久久久国产成人免费| 曰老女人黄片| 免费高清在线观看日韩| 丰满人妻熟妇乱又伦精品不卡| 亚洲精品成人av观看孕妇| 黄片小视频在线播放| 免费在线观看亚洲国产| 亚洲一区二区三区不卡视频| 日本五十路高清| 久久中文字幕一级| 伦理电影免费视频| 十八禁高潮呻吟视频| 麻豆国产av国片精品| 国产亚洲精品久久久久5区| 女人爽到高潮嗷嗷叫在线视频| 欧美激情高清一区二区三区| 亚洲色图av天堂| 亚洲精品自拍成人| 激情视频va一区二区三区| 久9热在线精品视频| 日韩免费av在线播放| 精品久久久久久电影网| 在线视频色国产色| 国产精品亚洲av一区麻豆| 少妇粗大呻吟视频| 美女国产高潮福利片在线看| 久久精品国产亚洲av香蕉五月 | 久久国产精品人妻蜜桃| 久久精品国产a三级三级三级| 日韩大码丰满熟妇| 欧美 亚洲 国产 日韩一| 一二三四社区在线视频社区8| 午夜成年电影在线免费观看| av线在线观看网站| 男人的好看免费观看在线视频 | 色综合婷婷激情| 中文字幕制服av| 国产极品粉嫩免费观看在线| 免费黄频网站在线观看国产| 18禁裸乳无遮挡动漫免费视频| 国产不卡一卡二| av一本久久久久| 男女床上黄色一级片免费看| 色综合婷婷激情| 国产亚洲精品久久久久5区| 757午夜福利合集在线观看| 久久精品91无色码中文字幕| 婷婷成人精品国产| 精品国产一区二区久久| 日韩 欧美 亚洲 中文字幕| 国产精品 欧美亚洲| 亚洲男人天堂网一区| 中文字幕av电影在线播放| 精品国产一区二区三区久久久樱花| 搡老熟女国产l中国老女人| 亚洲欧美一区二区三区黑人| 欧美不卡视频在线免费观看 | 色尼玛亚洲综合影院| 美女高潮喷水抽搐中文字幕| 在线观看免费高清a一片| 少妇裸体淫交视频免费看高清 | 国产亚洲av高清不卡| 桃红色精品国产亚洲av| 每晚都被弄得嗷嗷叫到高潮| e午夜精品久久久久久久| 国产精品香港三级国产av潘金莲| 久久人人爽av亚洲精品天堂| 国产免费现黄频在线看| 激情在线观看视频在线高清 | 精品久久久精品久久久| 一级黄色大片毛片| 精品免费久久久久久久清纯 | 伊人久久大香线蕉亚洲五| 欧美亚洲 丝袜 人妻 在线| 91九色精品人成在线观看| 午夜免费观看网址| 久久久国产成人精品二区 | 伊人久久大香线蕉亚洲五| 免费在线观看黄色视频的| 一进一出抽搐gif免费好疼 | 欧美精品av麻豆av| 欧美老熟妇乱子伦牲交| 丰满迷人的少妇在线观看| 亚洲熟妇中文字幕五十中出 | 欧美日韩av久久| 久久精品成人免费网站| 久久久精品区二区三区| 欧美色视频一区免费| 免费在线观看影片大全网站| 一进一出抽搐动态| 国产深夜福利视频在线观看| 精品一区二区三区四区五区乱码| 亚洲伊人色综图| 国产单亲对白刺激| 久久精品熟女亚洲av麻豆精品| 男女高潮啪啪啪动态图| 人妻一区二区av| 一级毛片女人18水好多| 国产亚洲欧美在线一区二区| 在线观看舔阴道视频| 久久国产精品大桥未久av| 人人妻人人添人人爽欧美一区卜| 欧美黑人精品巨大| 日本vs欧美在线观看视频| 少妇粗大呻吟视频| 两性夫妻黄色片| 在线观看66精品国产| 大型av网站在线播放| 欧美精品啪啪一区二区三区| 日韩视频一区二区在线观看| 男男h啪啪无遮挡| 亚洲中文av在线| 99精品在免费线老司机午夜| 日本黄色日本黄色录像| 欧美最黄视频在线播放免费 | 欧美日韩中文字幕国产精品一区二区三区 | 在线看a的网站| 国产99白浆流出| 亚洲免费av在线视频| 日韩精品免费视频一区二区三区| 99精品在免费线老司机午夜| 亚洲av熟女| 国产成人欧美| 亚洲综合色网址| 亚洲熟妇中文字幕五十中出 | 亚洲国产毛片av蜜桃av| 国产在线精品亚洲第一网站| 免费观看人在逋| 丰满饥渴人妻一区二区三| 性少妇av在线| 日韩欧美一区二区三区在线观看 | 欧美老熟妇乱子伦牲交| 91九色精品人成在线观看| 18在线观看网站| av天堂在线播放| 亚洲欧洲精品一区二区精品久久久| 正在播放国产对白刺激| 国产精品一区二区在线观看99| 水蜜桃什么品种好| 无人区码免费观看不卡| 午夜福利一区二区在线看| 日日夜夜操网爽| 亚洲精品中文字幕一二三四区| 国产无遮挡羞羞视频在线观看| 18禁裸乳无遮挡动漫免费视频| 午夜福利,免费看| 国产成+人综合+亚洲专区| 久久性视频一级片| 午夜福利视频在线观看免费| 亚洲在线自拍视频| 天堂中文最新版在线下载| 亚洲精品国产区一区二| 免费女性裸体啪啪无遮挡网站| 9热在线视频观看99| 一级作爱视频免费观看| 女人高潮潮喷娇喘18禁视频| 国产日韩一区二区三区精品不卡| 欧美激情高清一区二区三区| 国产无遮挡羞羞视频在线观看| 久久久久视频综合| 国产欧美日韩精品亚洲av| 欧美人与性动交α欧美软件| 香蕉国产在线看| 波多野结衣av一区二区av| 最近最新中文字幕大全电影3 | 50天的宝宝边吃奶边哭怎么回事| 亚洲七黄色美女视频| 女人被躁到高潮嗷嗷叫费观| 亚洲综合色网址| 国产一区二区激情短视频| 国产精品一区二区精品视频观看| 免费在线观看亚洲国产| 日韩欧美三级三区| 热99国产精品久久久久久7| 午夜精品久久久久久毛片777| 日韩精品免费视频一区二区三区| 一级毛片高清免费大全| 日韩人妻精品一区2区三区| 成人国产一区最新在线观看| 成人影院久久| 黄频高清免费视频| 亚洲熟妇熟女久久| av不卡在线播放| 欧美日韩视频精品一区| 天天影视国产精品| 日日摸夜夜添夜夜添小说| 国产精品久久视频播放| 91成人精品电影| xxxhd国产人妻xxx| 母亲3免费完整高清在线观看| 亚洲全国av大片| 国产精品 欧美亚洲| 黄色视频,在线免费观看| 国产99白浆流出| 国产男女内射视频| 日韩视频一区二区在线观看| 亚洲精品在线美女| 美女扒开内裤让男人捅视频| av有码第一页| 国产视频一区二区在线看| 国产区一区二久久| 天堂√8在线中文| a级毛片黄视频| 美女 人体艺术 gogo| 国产91精品成人一区二区三区| 超碰成人久久| 18禁黄网站禁片午夜丰满| 久久中文看片网| 757午夜福利合集在线观看| 精品国产一区二区久久| 国产精品免费一区二区三区在线 | 久久国产精品大桥未久av| 国产无遮挡羞羞视频在线观看| 国产精品免费大片| 女人久久www免费人成看片| 亚洲三区欧美一区| 人妻久久中文字幕网| 一个人免费在线观看的高清视频| 精品国产超薄肉色丝袜足j| 国产男女内射视频| 国产av精品麻豆|